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Presepsin as a biomarker for risk stratification for acute cholangitis in emergency department: A single-center study

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World Journal of Clinical Cases 2021年第32期9卷 9857-9868页

作者： Han-Yu Zhang zhao-qing lu Guo-Xing Wang Miao-Rong Xie Chun-Sheng Li Department of Emergency Medicine Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

BACKGROUND Acute cholangitis is caused by bacterial infection and has high morbidity and mortality *** grade of cholangitis can guide clinical treatment from single antibiotic treatment to biliary *** the introduction of white blood cell(WBC)count,C-reactive protein(CRP),and total bilirubin(T-Bil)into the diagnostic criteria and severity grading for acute cholangitis,the diagnosis rate and grading have significantly ***,early risk stratification assessments are challenging in the emergency ***,we hope to find an ideal predictive biomarker for cholangitis *** is a promising biomarker for the early diagnosis,severity,and prognosis of acute bacterial *** To assess the grading value of presepsin in patients with acute *** This clinical study was conducted at the Beijing Friendship Hospital,a 2000-bed teaching hospital with approximately 200000 emergency admissions per *** this prospective observational study,336 patients with acute cholangitis meeting the Tokyo Guidelines 2018 diagnostic criteria in the emergency department from May 2019 to December 2020 were *** count,CRP,procalcitonin(PCT),presepsin,T-Bil,and blood culture results were *** values were compared using the Pearsonχ2 test,Fisher’s exact test,or Mann-Whitney U *** area under the receiver operating characteristic curve(AUC)of the value was examined using the Delong *** correlations among the key research indicators were determined using Pearson *** In total,336 patients were examined,which included 107,106,and 123 patients classified as having mild,moderate,and severe cholangitis,*** count,CRP,PCT,presepsin,T-Bil,direct bilirubin,and sequential organ failure assessment scores of moderate and severe cholangitis patients were higher than those of mild cholangitis patients(P=0.000).The AUC of presepsin in predicting moderate acute cholangitis was 0.728,which was high

关键词： C-reactive protein Procalcitonin Presepsin Acute cholangitis Risk stratification

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Predictive value of presepsin and acylcarnitines for severity and biliary drainage in acute cholangitis

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World Journal of Gastroenterology 2023年第16期29卷 2502-2514页

作者： Han-Yu Zhang Hong-Li Xiao Guo-Xing Wang zhao-qing lu Miao-Rong Xie Chun-Sheng Li Department of Emergency Medicine Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

BACKGROUND Bacteremia,which is a major cause of mortality in patients with acute cholangitis,induces hyperactive immune response and mitochondrial *** is responsible for pathogen recognition by innate *** are established mitochondrial *** To clarify the early predictive value of presepsin and acylcarnitines as biomarkers of severity of acute cholangitis and the need for biliary *** Of 280 patients with acute cholangitis were included and the severity was stratified according to the Tokyo Guidelines *** presepsin and plasma acylcarnitines were tested at enrollment by chemiluminescent enzyme immunoassay and ultra-high-performance liquid chromatography-mass spectrometry,*** The concentrations of presepsin,procalcitonin,short-and medium-chain acylcarnitines increased,while long-chain acylcarnitines decreased with the severity of acute *** areas under the receiver operating characteristic curves(AUC)of presepsin for diagnosing moderate/severe and severe cholangitis(0.823 and 0.801,respectively)were greater than those of conventional *** combination of presepsin,direct bilirubin,alanine aminotransferase,temperature,and butyryl-L-carnitine showed good predictive ability for biliary drainage(AUC:0.723).Presepsin,procalcitonin,acetyl-L-carnitine,hydroxydodecenoyl-Lcarnitine,and temperature were independent predictors of bloodstream *** adjusting for severity classification,acetyl-L-carnitine was the only acylcarnitine independently associated with 28-d mortality(hazard ratio 14.396;P<0.001)(AUC:0.880).Presepsin concentration showed positive correlation with direct bilirubin or *** Presepsin could serve as a specific biomarker to predict the severity of acute cholangitis and need for biliary ***-L-carnitine is a potential prognostic factor for patients with acute *** immune response was associated with mitoc

关键词： Acute cholangitis Severity Biliary drainage Presepsin Acylcarnitines

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Optimal timing of biliary drainage based on the severity of acute cholangitis:A single-center retrospective cohort study

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World Journal of Gastroenterology 2022年第29期28卷 3934-3945页

作者： zhao-qing lu Han-Yu Zhang Chen-Fen Su Yue-Yan Xing Guo-Xing Wang Chun-Sheng Li Department of Emergency Medicine Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Emergency and Critical Care Center Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

BACKGROUND Biliary decompression is well known to greatly decrease the risks of mortality in acute cholangitis(AC).Although early biliary drainage is recommended by the treatment guidelines for AC,the best time for performing this procedure is yet to be ***,since the clinical outcomes of patients with severe AC vary dramatically,screening for patients that could benefit the most from early drainage would be more beneficial than the drainage performed based on the severity grade *** To investigate the optimal drainage timing for AC patients with each disease severity grade and organ *** In this retrospective monocenter cohort analysis,we reviewed 1305 patients who were diagnosed with AC according to the Tokyo guidelines 2018 at a Chinese tertiary hospital between July 2016 and December *** characteristics including age and sex,clinical and laboratory characteristics,and imaging findings of each patient were obtained from electronic medical *** investigated the all-cause in-hospital mortality(IHM),hospital length of stay(LOS),and hospitalization costs associated with the timing of biliary drainage according to the severity grading and different dysfunctioning organs and predictors[age,white blood cell(WBC)count,total bilirubin,albumin,lactate,malignant obstruction,and Charlton comorbidity index(CCI)].RESULTS Biliary drainage within 24 or 48 h in Grade Ⅲ AC patients could dramatically decrease IHM(3.9%vs 9.0%,P=0.041;4%vs 9.9%,P=0.018,respectively),while increasing LOS and hospitalization *** logistic analysis revealed that neurological,respiratory,renal,and cardiovascular dysfunctions,hypoalbuminemia,and malignant obstruction were significantly associated with IHM(odds ratio=5.32,2.541,6.356,4.021,5.655,and 7.522;P<0.001,P=0.016,P<0.001,P=0.012,P<0.001,and P<0.001;respectively).Biliary decompression performed within 12 h of admission significantly decreased the IHM in AC patients with neur

关键词： Acute cholangitis Endoscopic retrograde cholangiopancreatography Mortality Biliary drainage Organ dysfunction

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槽式集热器聚光过程误差因素耦合研究

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工程热物理学报 2017年第10期38卷 2074-2080页

作者：王志赵力赵晴卢培邓帅天津大学中低温热能高效利用教育部重点实验室天津300072

在实际运行过程中,槽式太阳能集热器的聚光过程可能受到太阳光入射角、安装误差、镜面误差和跟踪误差等各种实际因素的影响。本文用空间坐标变换的方法结合蒙特卡罗光线追踪法,分别计算出了各种实际因素单独存在时和多种实际因素耦合时... 详细信息

在实际运行过程中,槽式太阳能集热器的聚光过程可能受到太阳光入射角、安装误差、镜面误差和跟踪误差等各种实际因素的影响。本文用空间坐标变换的方法结合蒙特卡罗光线追踪法,分别计算出了各种实际因素单独存在时和多种实际因素耦合时的槽式集热器热流分布。结果显示,安装误差和跟踪误差使聚焦热流的不均匀性增大,镜面误差使聚焦热流的不均匀性减小;计算出的实际因素耦合热流分布,可以为槽式集热器光学性能和热性能的分析提供依据。

关键词：槽式集热器聚光过程热流分布光学误差

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Understanding the local structure and thermophysical behavior of Mg-La liquid alloys via machine learning potential

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 439-449页

作者： Jia zhao Taixi Feng Guimin lu National Engineering Research Center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China Joint International Laboratory for Potassium and Lithium Strategic Resources East China University of Science and TechnologyShanghai 200237China

The local structure and thermophysical behavior of Mg-La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg-La alloys. The robustness of the trained deep potential(DP) model was thoroughly evaluated through several aspects, including root-mean-square errors(RMSEs), energy and force data, and structural information comparison results;the results indicate the carefully trained DP model is reliable. The component and temperature dependence of the local structure in the Mg-La liquid alloy was analyzed. The effect of Mg content in the system on the first coordination shell of the atomic pairs is the same as that of temperature. The pre-peak demonstrated in the structure factor indicates the presence of a medium-range ordered structure in the Mg-La liquid alloy, which is particularly pronounced in the 80at% Mg system and disappears at elevated temperatures. The density, self-diffusion coefficient, and shear viscosity for the Mg-La liquid alloy were predicted via DPMD simulation, the evolution patterns with Mg content and temperature were subsequently discussed, and a database was established accordingly. Finally, the mixing enthalpy and elemental activity of the Mg-La liquid alloy at 1200 K were reliably evaluated,which provides new guidance for related studies.

关键词： magnesium-lanthanum liquid alloys local structure macroscopic properties thermodynamic behavior deep potential mo-lecular dynamic simulation

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太原地区3173名老年人睡眠障碍现况调查

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中华流行病学杂志 2011年第3期32卷 260-263页

作者：赵路清胡凤云山西省人民医院太原030012

目的了解太原地区老年人各种睡眠障碍的流行病学特点及失眠的相关因素.方法采用多级抽样方法,对太原地区3173名60～100岁的老年人进行人户调查,筛选出有睡眠障碍症状者,由专科医生复查并作出诊断.结果（1）3173名老年人中,有各种睡... 详细信息

目的了解太原地区老年人各种睡眠障碍的流行病学特点及失眠的相关因素.方法采用多级抽样方法,对太原地区3173名60～100岁的老年人进行人户调查,筛选出有睡眠障碍症状者,由专科医生复查并作出诊断.结果（1）3173名老年人中,有各种睡眠障碍症状者2132例,患病率为67.2%;其中失眠症、多梦、习惯性打鼾、日间嗜睡的患病率均较高,分别为39.65%、38.58%、26.66%、34.32%.（2）随着年龄的增长,男性老年人早醒、起夜次数多、日间嗜睡、睡眠呼吸障碍及睡眠节律紊乱的患病率有明显上升趋势（P＜0.01）;随着年龄的增长,女性老年人早醒、日间嗜睡及睡眠节律紊乱的患病率也有明显上升趋势（P＜0.01）.（3）经logistic回归分析,独居、情绪障碍、躯体疼痛、夜尿次数多（P＜0.01）与男性老年人失眠的发病有关;独居及麻/瘙痒等感觉异常（P＜0.01）、情绪障碍（P＜0.05）与女性老年人失眠的发病有关.结论太原地区老年人中各种睡眠障碍的患病率有上升趋势;应注重老年人情绪、躯体疾病对睡眠的影响.

关键词：睡眠障碍老年人现况调查

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不宁腿综合征与帕金森病的相关临床研究

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中华内科杂志 2010年第11期49卷 947-950页

作者：赵路清王鲁宁胡凤云山西省人民医院神经内科太原030012 解放军总医院南楼神经内科

目的了解帕金森病（PD）合并不宁腿综合征（RLS）患者的临床特点并探索RLS发病机制.方法采用横断面对照研究.选取31例中老年PD合并RLS的患者为病例组,39例单纯PD患者为对照组,分别比较两组的病史、临床表现、合并症、实验室检查等临... 详细信息

目的了解帕金森病（PD）合并不宁腿综合征（RLS）患者的临床特点并探索RLS发病机制.方法采用横断面对照研究.选取31例中老年PD合并RLS的患者为病例组,39例单纯PD患者为对照组,分别比较两组的病史、临床表现、合并症、实验室检查等临床资料,并设立健康对照组进一步行实验室检查比较.结果所有RLS患者均在PD症状出现后才出现RLS症状.PD合并RLS组与单纯PD组比较,在统一帕金森评定量表-Ⅲ、汉宾尔顿焦虑及抑郁评分、匹兹堡睡眠质量指数及吞咽障碍、便秘、幻觉等合并症方面差异有统计学意义（P＜0.05）,而在主要症状、简易精神状态量表、Epworth睡眠调查表评分等方面则差异无统计学意义（P＞0.05）;与单纯PD组及健康对照组比较,PD合并RLS组的血清铁蛋白水平明显降低、胫神经H-反射潜伏期明显缩短（P＜0.05）.结论 RLS是PD病程中出现的一种并发症.PD患者合并出现RLS可能与铁缺乏及脊髓水平抑制功能减弱有关.PD患者运动症状较严重、并发症较多时合并出现RLS的可能性相对较大.

关键词：不宁腿综合征帕金森病铁蛋白质类

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Preparation of FeCoNi medium entropy alloy from Fe^(3+)-Co^(2+)-Ni^(2+)solution system

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 92-101页

作者： Zongyou Cheng qing zhao Mengjie Tao Jijun Du Xingxi Huang Chengjun Liu Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-carbon Steelmaking(Ministry of Education) Shenyang 110819China

In recent years,medium entropy alloys have become a research hotspot due to their excellent physical and chemical *** controlling reasonable elemental composition and processing parameters,the medium entropy alloys can exhibit similar properties to high entropy alloys and have lower *** this paper,a FeCoNi medium entropy alloy precursor was prepared via sol-gel and coprecipitation methods,respectively,and FeCoNi medium entropy alloys were prepared by carbothermal and hydrogen *** phases and magnetic properties of FeCoNi medium entropy alloy were *** showed that FeCoNi medium entropy alloy was produced by carbothermal and hydrogen reduction at 1500℃.Some carbon was detected in the FeCoNi medium entropy alloy prepared by carbothermal *** alloy prepared by hydrogen reduction was uniform and showed a relatively high ***,the hydrogen reduction product exhibited better saturation magnetization and lower coercivity.

关键词： medium entropy alloy sol-gel co-precipitation carbothermal hydrogen reduction

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凌霄花喷雾剂的药效学

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中国医院药学杂志 2000年第12期20卷 726-728页

作者：楚敏赵鲁青慕红丹青岛市药品检验所山东青岛266071

目的 :研究凌霄花喷雾剂用于蚊虫叮咬所致局部红肿痒痛的药效。方法 :用动物实验的方法评价凌霄花喷雾剂的抗炎镇痛止痒作用。结果 :对组织胺所致小鼠皮肤毛细血管通透性增加有显著作用 ,能使慢性疼痛模型痛阈值有显著的提高。结论 :凌... 详细信息

目的 :研究凌霄花喷雾剂用于蚊虫叮咬所致局部红肿痒痛的药效。方法 :用动物实验的方法评价凌霄花喷雾剂的抗炎镇痛止痒作用。结果 :对组织胺所致小鼠皮肤毛细血管通透性增加有显著作用 ,能使慢性疼痛模型痛阈值有显著的提高。结论 :凌霄花喷雾剂对于临床蚊虫叮咬所致局部痛、痒、肿。

关键词：凌霄花喷雾剂抗炎镇痛动物实验药效学

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南仓特大桥桥上无缝线路设计

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铁道工程学报 2007年第6期24卷 42-47页

作者：陈淑娟赵陆青铁道第三勘察设计院集团有限公司天津300142

研究目的:研究刚构连续梁桥上无缝线路伸缩力的计算方法以及在曲线桥上不能设置伸缩调节器的情况下,如何加强无缝线路稳定性。研究方法:通过对结构进行分析,建立刚构连续梁力学计算模型,利用计算机程序计算伸缩力;通过分析结构稳定性,... 详细信息

研究目的:研究刚构连续梁桥上无缝线路伸缩力的计算方法以及在曲线桥上不能设置伸缩调节器的情况下,如何加强无缝线路稳定性。研究方法:通过对结构进行分析,建立刚构连续梁力学计算模型,利用计算机程序计算伸缩力;通过分析结构稳定性,研究桥上无缝线路线路加强设备。研究结果:研制出在路基和桥梁地段都适用的无缝线路加强设备,即横向阻力器,通过实测阻力检算无缝线路稳定性。研究结论:刚构连续梁可根据其结构建立计算模型计算伸缩力,计算参数宜采用实测数据,线路纵、横向阻力现场实测更重要;桥墩对梁的变形影响随墩刚度增加而增大,当采用高墩即墩顶纵向刚度较小时,影响也较小;横向阻力器制造、搬运和安装均较简单,而且对保证无缝线路稳定性有很大作用。

关键词：刚构连续梁稳定性横向阻力器

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