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Associations of genetic polymorphisms of the transporters organic cation transporter 2(OCT2),multidrug and toxin extrusion 1(MATE1),and ATP-binding cassette subfamily C member 2(ABCC2) with platinum-based chemotherapy response and toxicity in non-small cel

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Chinese Journal of Cancer 2016年第11期35卷 604-616页

作者： Chen-Yue qian Yi Zheng Ying Wang Juan Chen Jun-Yan liu Hong-Hao Zhou Ji-Ye Yin zhao-qian liu Department of Clinical Pharmacology Xiangya HospitalCentral South Uni-versityChangsha 410008HunanP.R.China. Institute of Clinical Pharmacol-ogy Hunan Key Laboratory of PharmacogeneticsCentral South UniversityChangsha 410078HunanP.R.China. Hunan Province Cooperation Innovation Center for Molecular Target New Drug Study Hengyang 421001HunanP.R.China. Key Laboratory of Hunan Province for Traditional Chinese Medicine in Obstetrics&Gynecology Research The Maternal and Child Health Hospital of Hunan ProvinceChangsha 410008HunanP.R.China. The affiliated Cancer Hospital of Xiangya School of Medicine Central South UniversityChangsha 410008HunanP.R.China. Xiangya School of Medicine Central South UniversityChangsha 410008HunanP.R.China.

Background:Platinum-based chemotherapy is the first-line treatment of non-small cell lung cancer(NSCLC);it is therefore important to discover biomarkers that can be used to predict the efficacy and toxicity of this *** important transporter genes are expressed in the kidney,including organic cation transporter 2(OCT2),multidrug and toxin extrusion 1(MATEl),ATP-binding cassette subfamily B member 1 {ABCB1),and ATP-binding cassette subfamily C member 2(ABCC2),and genetic polymorphisms in these genes may alter the efficacy and adverse effects of platinum *** study aimed to evaluate the association of genetic polymorphisms of these transporters with platinumbased chemotherapy response and toxicity in NSCLC ***:A total of 403 Chinese NSCLC patients were recruited for this *** patients were newly diagnosed with NSCLC and received at least two cycles of platinum-based *** tumor response and toxicity were evaluated after two cycles of treatment,and the patients' genomic DNA was *** single-nucleotide polymorphisms in four transporter genes were selected to investigate their associations with platinum-based chemotherapy toxicity and ***:OCT2 rs316019 was associated with hepatotoxicity(P = 0.026) and hematological toxicity(P = 0.039),and MATEl rs2289669 was associated with hematological toxicity induced by platinum(P = 0.016).In addition,ABCC2rs717620 was significantly associated with the platinum-based chemotherapy response(P = 0.031).ABCB1 polymorphisms were associated with neither response nor ***:OCT2 rs316019,MATEl rs2289669,and ABCC2 rs717620 might be potential clinical markers for predicting chemotherapy toxicity and response induced by platinum-based treatment in NSCLC *** registration Chinese Clinical Trial Registry

关键词： OCT2 MATE1 ABCC2 Non-small cell lung cancer Platinum-based chemotherapy

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Early Devonian Post-collisional Granitic Magmatism in the North Qilian Orogenic Belt,Western China:Insights into Lithospheric Delamination and Orogenic Collapse

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Acta Geologica Sinica(English Edition) 2024年第2期98卷 352-367页

作者： WANG qian zhao Xilin MENG Yuanku YU Shengyao liu Yanan College of Earth Science and Engineering Shandong University of Science and TechnologyQingdaoShandong 266590China Nanjing Center China Geological SurveyNanjing 210016China Key Laboratory of Submarine Geosciences and Prospecting Techniques MOEInstitute for Advanced Ocean StudyCollege of Marine GeosciencesOcean University of ChinaQingdaoShandong 266100China Sinopec Qingdao Liquefied Natural Gas Co. Ltd.QingdaoShandong 266400China

Post-collisional magmatism contains important clues for understanding the reworking and growth of continental crust,as well as lithospheric delamination and orogenic *** Devonian magmatism has been identified in the North Qilian Orogenic Belt(NQOB).This paper reports an integrated study of petrology,whole-rock geochemistry,Sm-Nd isotope and zircon U-Pb dating,as well as Lu-Hf isotopic data,for two Early Devonian intrusive *** Yongchang and Chijin granites yield zircon U-Pb ages of 394-407 Ma and 414 Ma,*** of them are characterized by weakly peraluminous to metaluminous without typical aluminium-rich minerals,LREE-enriched patterns with negative Eu anomalies and a negative correlation between P_(2)O_(5) and SiO_(2) contents,consistent with geochemical features of I-type *** from the studied granites display negative to weak positive ε_(Hf)(t)values(−5.7 to 2.1),which agree well with those of negative ε_(Nd)(t)values(−6.4 to−2.9)for the whole-rock samples,indicating that they were derived from the partial melting of Mesoproterozoic ***,low Sr/Y ratios(1.13-21.28)and high zircon saturation temperatures(745℃ to 839℃,with the majority being>800℃)demonstrated a relatively shallow depth level below the garnet stability field and an additional heat *** together,the Early Devonian granitic magmatism could have been produced by the partial melting of ancient crustal materials heated by mantle-derived magmas at high-temperature and low-pressure conditions during postcollisional extensional *** data obtained in this study,when viewed in conjunction with previous studies,provides more information about the tectonic processes that followed the closure of the North Qilian *** tectonic transition from continental collision to post-collisional delamination could be constrained to~430 Ma,which is provided by the sudden decrease of Sr/Y and La/Yb ratios and an increase in zircon ε_(Hf)(t)values for

关键词： post-collisional magmatism lithospheric delamination extensional collapse North Qilian Orogenic Belt

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The joint knowledge reasoning model based on knowledge representation learning for aviation assembly domain

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Science China(Technological Sciences) 2024年第1期67卷 143-156页

作者： liu PeiFeng qian Lu LU Hu XUE Lei zhao XingWei TAO Bo State Key Laboratory of Digital Manufacturing Equipment and Technology Department of MechanicalHuazhong University of Science and TechnologyWuhan 430074China School of Transportation and Logistics Engineering Wuhan University of Technology(WHUT)Wuhan 430063China Shanghai Aircraft Manufacturing Co. Ltd.Shanghai 201324China

Knowledge graph technology is widely applied in the domain of general knowledge reasoning with an excellent *** fine-grained professional fields,professional knowledge graphs can provide more accurate information in practical industrial *** on an aviation assembly domain-specific knowledge graph,the article constructs a joint knowledge reasoning model,which combines a named entity recognition model and a subgraph embedding learning *** performing knowledge reasoning tasks,the two models vectorize entities,relationships and entity attributes in the same space,so as to share parameters and optimize learning *** knowledge reasoning model,which provides intelligent question answering services,is able to reduce the assembly error rate and improve the assembly *** system can accurately solve general knowledge reasoning problems in the assembly process in actual industrial scenarios of general assembly and component assembly under interference-free ***,this paper compares the proposed knowledge reasoning model based on knowledge representation learning and the question-answering system based on large-scale pre-trained *** the application scenario of system functional testing in general assembly,the joint model attains an accuracy rate of 95%,outperforming GPT with 78%accuracy and enhanced representation through knowledge integration with 71%accuracy.

关键词： intelligent manufacturing knowledge graph aviation assembly knowledge representation knowledge-based question an-swering

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Deformation mechanism and limit support pressure of cutting steel plate during connection between pipes in large spacing using pipe curtain structure method

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Underground Space 2024年第5期18卷 83-96页

作者： Xiang liu Rui Zhang Jun Huang Guang zhao qian Fang Annan Jiang Liaoning Key Laboratory of Marine Environmental Bridge and Tunnel Engineering Dalian Maritime UniversityDalian 116026China JSTI Group Nanjing 210017China Key Laboratory for Urban Underground Engineering of Ministry of Education Beijing Jiaotong UniversityBeijing 100044China

The pipe curtain structure method(PSM)is a novel construction method to control ground deformation *** with the traditional pipe-roofing and pipe jacking method,the connection between pipes in large spacings using PSM is widely acknowledged as a unique construction *** study on this connection procedure is needed to resolve similar cases in that the pipes are inevitably constructed on both sides of existing *** the steel plate during the connection procedure is the first step,which is crucial to control the safety and stability of the surrounding environment and existing *** deformation mechanism and limit support pressure of the cutting steel plate during the connection between pipes in large spacings are studied in this paper,relying on the undercrossing Yifeng gate tower project of Jianning West Road River Crossing Channel in Nanjing,China.A modified 3D wedge-prism failure model is proposed using the 3D discrete element *** with Terzaghi loose earth pressure theory and the limit equilibrium theory,the analytical solutions for the limit support pressure of the excavation face of the cutting steel plate are *** modified 3D wedge-prism failure model and corresponding analytical solutions are categorised into two cases:(a)unilateral cutting scheme,and(b)bilateral cutting *** analytical solutions for the two cases are verified from the numerical simulation and in-situ data and compared with the previous *** comparative analysis between the unilateral and bilateral cutting schemes indicates that the bilateral cutting scheme can be adopted as a *** bilateral cutting scheme saves more time and induces less ground deformation than the unilateral one due to the resistance generated from the superimposed *** addition,the parametric sensitivity analysis is carried out using an orthogonal experimental *** main influencing factors arranged from high to low are the pipe sp

关键词： Pipe curtain structure method Wedge-prism failure model Limit support pressure Discrete element method Connection between pipes

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The Neurovascular Unit Dysfunction in the Molecular Mechanisms of Epileptogenesis and Targeted Therapy

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Neuroscience Bulletin 2024年第5期40卷 621-634页

作者： Xiuxiu liu Ying Zhang Yanming zhao qian Zhang Feng Han Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases Ministry of EducationNanjing211166China International Joint Laboratory for Drug Target of Critical Illnesses School of PharmacyNanjing Medical UniversityNanjing211166China Institute of Brain Science The Affiliated Brain Hospital of Nanjing Medical UniversityNanjing211166China Gusu School Nanjing Medical UniversitySuzhou Municipal HospitalThe Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou210019China

Epilepsy is a multifaceted neurological syndrome characterized by recurrent,spontaneous,and synchronous *** pathogenesis of epilepsy,known as epileptogenesis,involves intricate changes in neurons,neuroglia,and endothelium,leading to structural and functional disorders within neurovascular units and culminating in the development of spontaneous *** current research on epilepsy treatments primarily centers around anti-seizure drugs,it is imperative to seek effective interventions capable of disrupting *** this end,a comprehensive exploration of the changes and the molecular mechanisms underlying epileptogenesis holds the promise of identifying vital biomarkers for accurate diagnosis and potential therapeutic *** early diagnosis and timely intervention is paramount,as it stands to significantly improve patient prognosis and alleviate the socioeconomic *** this review,we highlight the changes and molecular mechanisms of the neurovascular unit in epileptogenesis and provide a theoretical basis for identifying biomarkers and drug targets.

关键词： Epileptogenesis Neurovascular unit Molecular mechanisms Drug targets

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Characteristics and distribution of microstructures in high pressure die cast alloys with X-ray microtomography:A review

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China Foundry 2024年第5期21卷 427-444页

作者： Hai-dong zhao Xue-ling Wang qian Wan Wen-hui Bai Fei liu School of Mechanical and Automotive Engineering South China University of TechnologyGuangzhou 510640China

Al and Mg alloy high pressure die castings(HPDC)are increasingly used in automotive *** microstructures in the castings have decisive effect on the casting mechanical properties,in which the microstructure characteristics are fundamental for the investigation of the microstructure-property *** the past decade,the microstructure characteristics of HPDC Al and Mg alloys,especially micro-pores andα-Fe,have been investigated from two-dimensional(2D)to threedimensional with X-ray micro-computed tomography(μ-CT).This paper provides an overview of the current understanding regarding the 3D characteristics and formation mechanisms of microstructures in HPDC alloys,their spatial distributions,and the impact on mechanical ***,it outlines future research directions for the formation and control of heterogeneous microstructures in HPDC alloys.

关键词： high pressure die casting microstructure three-dimensional characteristics distribution Al and Mg alloys

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Optimizing Electrocatalytic Hydrogen Evolution Stability via Minimal Bubble Adhesion at Electrodeposited Crack-Structured NiPx Catalysts

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Energy & Environmental Materials 2024年第5期7卷 248-258页

作者： qian Sun Xiaoyu Hao Dina Zhang Tianyi Zhang Yuanfang zhao Xiaolei Huang Xuqing liu State Key Laboratory of Solidification Processing Center of Advanced Lubrication and Seal Materials Northwestern Polytechnical University College of Art and Design Shenzhen University Institute of Material and Chemistry Ganjiang Innovation Academy Chinese Academy of Sciences Shandong Laboratory of Yantai Advanced Materials and Green Manufacture

In response to the ongoing energy crisis, advancing the field of electrocatalytic water splitting is of utmost significance, necessitating the urgent development of high-performance, cost-effective, and durable hydrogen evolution reaction catalysts. But the generated gas bubble adherence to the electrode surface and sluggish separation contribute to significant energy loss, primarily due to the insufficient exposure of active sites, thus substantially hindering electrochemical performance. Here, we successfully developed a superaerophobic catalytic electrode by loading phosphorus-doped nickel metal （NiPx） onto various conductive substrates via an electrodeposition method. The electrode exhibits a unique surface structure, characterized by prominent surface fissures, which not only exposes additional active sites but also endows the electrode with superaerophobic properties. The NiPx/Ti electrode demonstrates superior electrocatalytic activity for hydrogen evolution reaction, significantly outperforming a platinum plate, displaying an overpotential of mere 216 mV to achieve a current density of-500 mA cm-2in 1 M KOH. Furthermore,the NiPx/Ti electrode manifests outstanding durability and robustness during continuous electrolysis, maintaining stability at a current density of-10 mA cm-2over a duration of 2000 h. Owing to the straightforward and scalable preparation methods, this highly efficient and stable NiPx/Ti electrocatalyst offers a novel strategy for the development of industrial water electrolysis.

关键词： electrocatalyst gas bubble adhesion hydrogen evolution reaction long-term durability superaerophobic surface

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Mechanical properties and thermal deformation behavior of low-cost titanium matrix composites prepared by a structure-optimized Y_(2)O_(3) crucible

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Journal of Iron and Steel Research International 2024年第3期31卷 738-751页

作者： qian Dang Gang Huang Ye Wang Chi Zhang Guo-huai liu zhao-dong Wang The State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819LiaoningChina School of Materials Science and Chemical Engineering Harbin University of Science and TechnologyHarbin 150004HeilongjiangChina School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870LiaoningChina

A porous yttrium oxide crucible with both thermal shock resistance and erosion resistance was developed by structural *** structure-optimized yttrium oxide crucible was proved to be suitable for melting highly reactive titanium ***-cost(TiB+Y2O_(3))-reinforced titanium matrix composites were prepared by vacuum induction melting using the prepared *** thermal deformation behavior and microstructure evolution of(TiB+Y2O_(3))-reinforced tita-nium matrix composites were investigated at deformation temperatures of 900-1100℃with strain rates of 0.001-1 *** results showed that the prepared yttrium oxide crucible had both thermal shock and erosion resistance,the low-cost titanium matrix composites could be prepared by the developed yttrium oxide crucibles which were homogeneous in composition and highly sensitive to strain rate and deformation temperature,and the peak and theological stresses decreased with increasing deformation temperature or decreasing strain *** addition,the average thermal deformation activation energy of the composites was calculated to be 574.6 kJ/mol by establishing the Arrhenius constitutive equation in consideration of the strain variables,and the fitting goodness between the predicted stress value and the measured value was 97.624%.The calculated analysis of the hot processing map showed that the best stable thermal deformation zone was located in the deformation temperature range of 1000-1100℃and strain rate range of 0.001-0.01 s^(-1),where the peak dissipation coefficient wasη=71%.In this zone,the deformation of the reinforcement and matrix was harmonious,the reinforcement was less likely to fracture,dynamic recrystallization occurred more fully and the alloy exhibited near steady rheological characteristics.

关键词： Yttrium oxide crucible Titanium matrix composite Thermal deformation behavior Constitutive equation Hot processing map Microstructure evolution

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Adsorption behavior of CO2/H2S mixtures in calcite slit nanopores for CO2 storage:An insight from molecular perspective

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Petroleum Science 2024年第4期21卷 2444-2456页

作者： Cheng qian Zhen-Hua Rui Yue-Liang liu Kai Du Chen liu Yang zhao Xiao-Min Ma State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum College of Petroleum Engineering China University of Petroleum College of Carbon Neutrality Future Technology China University of Petroleum College of Petroleum China University of Petroleum-Beijing at Karamay College of Mining Engineering Taiyuan University of Technology

It is acknowledged that injecting CO2into oil reservoirs and saline aquifers for storage is a practical and affordable method for *** CO2produced from industrial exhaust contains impurity gases such as H2S that might impact CO2sequestration due to competitive *** study makes a commendable effort to explore the adsorption behavior of CO2/H2S mixtures in calcite slit *** Canonical Monte Carlo（GCMC） simulation is employed to reveal the adsorption of CO2,H2S as well as their binary mixtures in calcite *** show that the increase in pressure and temperature can promote and inhibit the adsorption capacity of CO2and H2S in calcite nanopores,***2exhibits stronger adsorption on calcite surface than *** energy plays the dominating role in the adsorption *** energy accounts for 97.11% of the CO2-calcite interaction energy and 56.33% of the H2S-calcite interaction energy at 10 MPa and 323.15 *** presence of H2S inhibits the CO2adsorption in calcite nanopores due to competitive adsorption,and a higher mole fraction of H2S leads to less *** quantity of CO2adsorbed is lessened by approximately 33% when the mole fraction of H2S reaches ***2molecules preferentially occupy the regions near the po re wall and H2S molecules tend to reside at the center of nanopore even when the molar ratio of CO2is low,indicating that CO2has an adsorption priority on the calcite surface over *** addition,moisture can weaken the adsorption of both CO2and H2S,while CO2is more *** interestingly,we find that pure CO2is more suitable to be sequestrated in the shallower formations,i.e.,500-1500 m,whereas CO2with H2S impurity should be settled in the deeper reservoirs.

关键词： Adsorption behavior CO2/H2S binary mixtures Molecular perspective Calcite slit nanopores CO2 sequestration

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Janus Quasi‑Solid Electrolyte Membranes with Asymmetric Porous Structure for High‑Performance Lithium‑Metal Batteries

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Nano-Micro Letters 2024年第6期16卷 221-232页

作者： Zerui Chen Wei zhao qian liu Yifei Xu Qinghe Wang Jinmin Lin Hao Bin Wu Institute for Composites Science Innovation(InCSI)and State Key Laboratory of Silicon and Advanced Semiconductor Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China

Quasi-solid electrolytes(QSEs)based on nanoporous materials are promising candidates to construct high-performance Limetal batteries(LMBs).However,simultaneously boosting the ionic conductivity(σ)and lithium-ion transference number(t^(+)) of liquid electrolyte confined in porous matrix remains ***,we report a novel Janus MOFLi/MSLi QSEs with asymmetric porous structure to inherit the benefits of both mesoporous and microporous *** Janus QSE composed of mesoporous silica and microporous MOF exhibits a neat Li^(+) conductivity of 1.5.10^(–4)S cm^(−1) with t^(+) of 0.71.A partially de-solvated structure and preference distribution of Li^(+)near the Lewis base O atoms were depicted by MD ***,the nanoporous structure enabled efficient ion flux regulation,promoting the homogenous deposition of Li^(+).When incorporated in Li||Cu cells,the MOFLi/MSLi QSEs demonstrated a high Coulombic efficiency of 98.1%,surpassing that of liquid electrolytes(96.3%).Additionally,NCM 622||Li batteries equipped with MOFLi/MSLi QSEs exhibited promising rate performance and could operate stably for over 200 cycles at 1 *** results highlight the potential of Janus MOFLi/MSLi QSEs as promising candidates for next-generation LMBs.

关键词： Metal-organic frameworks Mesoporous silicas Quasi-solid electrolytes Janus structure Lithium-metal battery

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