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Anisometropia magnitude and visual deficits in previously untreated anisometropic amblyopia

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International Journal of Ophthalmology(English edition) 2013年第5期6卷 606-610页

作者： Bin-Bin Chen Feng-Wei Song zhao-hui sun Yi Yang Eye Center the Second Affiliated HospitalSchool of MedicineZhejiang University Department of Ophthalmology the First Affiliated Hospital of Huzhou Teachers College

AIM:To assess the quantitative association between anisometropia magnitude(AM) and the losses of resolution and contrast sensitivity;and to exemplify how the function of fusion and stereopsis vary with AM in previously untreated anisometropic amblyopia. METHODS:A total of 57 patients with previously untreated anisometropic amblyopia without strabismus(range:8-35 years),were measured refractive error,best corrected visual acuity(BCVA),fusion and stereopsis,and 48 patients have completed contrast sensitivity function *** was determined by dioptric vector addition model,and the amblyopia depth was determined by the difference of BCVA in logMAR units between the amblyopic and fellow ***:AM was significantly correlated with both amblyopia depth(Pearson R=0.728,P<0.001) and the inter-ocular difference of the area under the log contrast sensitivity function(AULCSF)(R=0.505,P<0.001).Depth of amblyopia and the inter-ocular difference of AULCSF was also significantly correlated(R=0.761,P<0.001).The more severity of amblyopia,the poorer levels of contrast *** pure anisometropes with AM was less than 3.0D retain fusion and some stereopsis,but when AM were more than 3.0D,especially for the anisometropes whose AM was more than 6.0D,fusion and stereopsis function were seriously ***:In the patients with previously untreated anisometropic amblyopia,higher degree of anisometropia is significantly associated with deeper amblyopia,worse contrast sensitivity,fusion and stereopsis functions.

关键词： anisometropia amblyopia area under the log contrast senility function fusion stereopsis

Novel mutation c.980_983delATTA compound with c.986C>A mutation of the FRMD7 gene in a Chinese family with X-linked idiopathic congenital nystagmus

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第6期14卷 479-486页

作者： Feng-wei SONG Bin-bin CHEN zhao-hui sun Li-ping WU Su-juan zhao Qi MIAO Xia-jing TANG Eye Center the Second Affiliated HospitalSchool of MedicineZhejiang University Department of Ophthalmology the First Affiliated Hospital of Huzhou Teachers College Department of Otolaryngology-Head and Neck Surgery the First Affiliated HospitalWenzhou Medical College

Objective:To screen mutations in FERM domain-containing protein 7(FRMD7) gene in two Chinese families with X-linked idiopathic congenital nystagmus(XLICN).Methods:Common ophthalmic data and peripheral blood of two Chinese XLICN families(families A and B) were collected after informed *** DNA was prepared from the peripheral blood of members of the two families and from 100 normal *** in the FRMD7 gene were determined by directly sequencing polymerase chain reaction(PCR) ***:We identified a novel mutation c.980_983delATTA compound with c.986C>A mutation in the 11th exon of FRMD7 in family B,and a previously reported splicing mutation c.782G>C(p.R261G) in family *** mutations were detected in patients and female carriers,while they were absent in other relatives or in the 100 normal ***:Our results expand the spectrum of FRMD7 mutations in association with XLICN,and further confirm that the mutations of FRMD7 are the underlying molecular mechanism for XLICN.

关键词： Mutation Idiopathic congenital nystagmus FERM domain-containing protein 7(FRMD7)

Paratesticular liposarcoma: Two case reports

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World Journal of Clinical Cases 2021年第2期9卷 457-462页

作者： Qi-Gang Zheng zhao-hui sun Jia-Jian Chen Jia-Cheng Li Xiao-Jun Huang The Second Clinical Medical College Zhejiang Chinese Medical UniversityHangzhou 310011Zhejiang ProvinceChina Department of Urology The Second Clinical Medical College of Zhejiang Chinese Medical UniversityThe Second Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310011Zhejiang ProvinceChina

BACKGROUND Paratesticular liposarcoma accounts for approximately 7%of scrotal *** are rare lesions of the reproductive system with approximately 90%of the lesions originating from the spermatic ***,with the goal of complete resection,is the mainstay for treatment of this ***,treatment consisting of extended resection to decrease local recurrence remains *** SUMMARY We report the cases of two patients with paratesticular liposarcomas who were treated with radical testicular tumor resection without adjuvant *** investigations at 9 mo showed no sign of *** Surgery is the first-line treatment,regardless of whether it is a recurrent or primary *** resection carries a higher risk of complications and should not be performed *** radiotherapy can reduce the local recurrence rate without affecting the overall survival.

关键词： Case report Paratesticular liposarcoma Andrology Radiotherapy Surgery Extended resection

Ln_2MO_4 cathode materials for solid oxide fuel cells

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Science China Chemistry 2011年第6期54卷 898-910页

作者： zhao hui, LI Qiang & sun LiPing Key Laboratory of Functional Inorganic Material Chemistry, Ministry of Education School of Chemistry and Materials Science, Heilongjiang University, Harbin 150080, China 1. Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education School of Chemistry and Materials Science Heilongjiang University Harbin 150080 China

One of the major challenges to develop "intermediate temperature" solid oxide fuel cells is finding a novel cathode material, which can meet the following requirements: (1) high electronic conductivity; (2) chemical compatibility with the electrolyte; (3) a matched thermal expansion coefficient (TEC); (4) stability in a wide range of oxygen partial pressure; and (5) high catalytic activity for the oxygen reduction reaction (ORR). In this short review, a survey of these requirements for K2NiF4-type material with the formula Ln2MO4, Ln = La, Pr, Nd, Sm; M = Ni, Cu, Fe, Co, Mn, is presented. The composition-dependent TEC, electrical conductivity and oxygen transport property are considered. The Ln2MO4 materials exhibit improved chemical stability and compatibility with most of the traditional electrolytes. The complete fuel cells integrated with Ln2MO4 materials as cathodes show promising results. Furthermore, these materials are considered as cathodes of protonic ceramic fuel cell (PCFC), and/or anodes of high temperature steam electrolysis (HTSE). First results show excellent performances. The versatility of these Ln2MO4 materials is explained on the basis of structural features and the ability to accommodate oxygen non-stoichiometry.

关键词： intermediate temperature solid oxide fuel cells (ITSOFCs) cathode K2NiF4-type structure oxygen non-stoichiometry

Uretero-lumbar artery fistula: A case report

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World Journal of Clinical Cases 2021年第32期9卷 10013-10017页

作者： Jia-Jian Chen Jian Wang Qi-Gang Zheng zhao-hui sun Jia-Cheng Li Zi-Lei Xu Xiao-Jun Huang The Second Clinical Medical College of Zhejiang Chinese Medical University Hangzhou 310053Zhejiang ProvinceChina Department of Urology The Second Clinical Medical College of Zhejiang Chinese Medical UniversityThe Second Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310005Zhejiang ProvinceChina

BACKGROUND Uretero-arterial fistula(UAF)is a disease that usually involves the aorta,common iliac artery,external iliac artery,hypogastric artery,and lumbar *** them,uretero-lumbar artery fistula(ULAF)is the most unusual ***,both in China and around the world,the diagnosis and treatment of ULAF is a big *** SUMMARY A 55-year-old female patient with a history of pelvic radiotherapy developed unexplained massive hemorrhage during replacement of the right Resonance metallic ureteral double-J tubes due to a long-standing indwelling ureteral stent for ureteral ***,we found contrast extravasation from the patient's right L4 artery into the ureter under digital subtraction angiography(DSA)and administered polyvinyl alcohol particle embolic agent and coil embolization;hematuria was ***-up investigations at 18 mo showed no sign of *** DSA is very important in the diagnosis and treatment of UAF,and DSA should be preferred when UAF is *** addition,the use of softer ureteral stents in patients with primary disease and risk factors for UAF should be considered to avoid increasing the risk of the development of the disease;endovascular treatment should be preferred in patients who have developed UAF.

关键词： Uretero-arterial fistula Uretero-lumbar artery fistula Hematuria Diagnosis Endovascular treatment Case report

How do groups of red imported fire ants （Hymenoptera： Formicidae） feed on a droplet of sugar water？

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Insect Science 2018年第3期25卷 499-507页

作者： Cai Wang Xuan Chen Linda M. Hooper-Bùi Rachel Strecker Yu-Zhen Wen Wen-Quan Qin Tao Ma zhao-hui sun Xiao-Yang Chen Xiu-Jun Wen Guangdong Key Laboratory for Innovation Development and Utilization of Forest Plant Germplasm College of Forestry and Landscape Architecture South China Agricultural University Guangzhou China Department of Entomology Louisiana State University Agricultural Center Baton Rouge LA USA Department of Environmental Sciences Louisiana State University Baton Rouge LA USA

Many previous studies have focused on the foraging behaviors and strategies of the red imported fire ants, Solenopsis invicta Buren on solid food or granular bait; little attention has been paid to how liquid sugar is fed upon. In the present study, behavioral responses ofS. invicta to 25% sucrose water droplets were observed. Five foraging patterns were identified in S. invicta colonies under laboratory conditions：（i） no feeding, no sucrose water feeding was observed; （ii） surround feeding, ants surrounded and fed along the edge of the sucrose droplet; （iii） stacked feeding, ants stacked and fed along the edge of the sucrose droplet; （iv） droplet-break feeding, ants broke the liquid droplet and sucked sucrose water that spread on surface of the substance or soil particles previously transported by ants; and （v） cover feeding, whole surface of the sucrose droplet was covered by layers of feeding ants. This is the first time cover feeding in S. invicta has been reported, which obviously requires more ants compared to the other patterns. In addition, individual ants were tracked in videos under laboratory conditions, and behavioral repertoires that led to stacking, covering and droplet-breaking were identified and described. The field investigation showed that surround feeding was most frequently performed by S. invicta foragers; however, cover feeding was not observed under field conditions during this study. Both laboratory and field studies showed colony-level variations in sugar-water feeding.

关键词： colony variation foraging liquid food Solenopsis invicta sugar water

Detection of hepatitis D virus by cDNA microarray method

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Hepatobiliary & Pancreatic Diseases International 2004年第3期3卷 423-427页

作者： zhao-hui sun Wen-Ling Zheng Bao Zhang Liang Lu Xiao-Dong Mao Rong Shi Wen-Li Ma Institute of Molecular Oncology General Hospital of Guangzhou Military Command Guangzhou 510010 China. zhaohui2@***

BACKGROUND: Viral hepatitis is considered a major public health problem in most areas of the world. In acute and chronic infections, hepatitis D virus (HDV) infection often leads to a more severe disease. This study was designed to prepare microarrays for HDV detection.METHODS: The specific primers of PCR were designed according to the conserved region of HDV. The cDNA microarrays were prepared by spotting PCR products onto the surface of glass slides by robotics. Restriction display PCR (RD-PCR) was used to label the samples.RESULTS: Sequences were aligned, and the results showed that the products of PCR amplification were the specific gene fragments of HDV. Hybridizing signals on gene chip showed the specificity and sensitivity in detecting HDV were satisfactory.CONCLUSION: Using PCR amplified products to construct gene chips for clinical diagnosis of HDV is a quick, simple and effective method.

关键词： hepatitis D virus PCR microarray hybridization

Application of restriction display PCR technique in the preparation of cDNA microarray probes

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World Journal of Gastroenterology 2005年第48期11卷 7579-7584页

作者： zhao-hui sun Wen-Li Ma Bao Zhang Yi-Fei Peng Wen-Ling Zheng Institute of Genetic Engineering Southern Medical University Guangzhou 510515 Guangdong Province China Institute of Molecular Oncology Guangzhou General Hospital of Guangzhou Military Area Command Guangzhou 510010 Guangdong Province China

AIM: To develop a simplified and efficient method for the preparation of hepatitis C virus (HCV) cDNA microarray ***: With the technique of restriction display PCR (RD-PCR), restriction enzyme Sau3A I was chosen to digest the full-length HCV cDNAs. The products were classified and re-amplified by RD-PCR. We separated the differential genes by polyacrylamide gel electrophoresis and silver staining. Single bands cut out from the polyacrylamide gel were isolated. The third-round PCR was performed using the single bands as PCR *** RD-PCR fragments were purified and cloned into the pMD18-T vector. The recombinant plasmids were extracted from positive clones, and the target gene fragments were sequenced. The cDNA microarray was prepared by spotting RD-PCR products to the surface of amino-modified glass slides using a robot. We validated the detection of microarray by hybridization and sequence ***: A total of 24 different cDNA fragments ranging from 200 to 800 bp were isolated and sequenced,which were the specific gene fragments of HCV. These fragments could be further used as probes in microarray preparation. The diagnostic capability of the microarray was evaluated after the washing and scanning steps. The results of hybridization and sequence analysis showed that the specificity, sensitivity, accuracy, reproducibility,and linearity in detecting HCV RNA were ***: The RD-PCR technique is of great value in obtaining a large number of size-comparable gene probes, which provides a speedy protocol in generating probes for the preparation of microarrays. Microarray prepared as such could be further optimized and applied in the clinical diagnosis of HCV.

关键词： Restriction display PCR HCV Microarray Probes

Jian-Gan-Xiao-Zhi decoction ameliorates high-fat high-carbohydrate diet-induced non-alcoholic fatty liver disease and insulin resistance by regulating the AMPK/JNK pathway

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Traditional Medicine Research 2021年第1期6卷 16-26页

作者： Xue-Hua Xie Jia-Bao Liao Fang Fang Jie zhao Yong-Jun Cao Huan-Tian Cui Hong-Wu Wang Zhai-Yi Zhang zhao-hui sun Yuan Yin Wei-Bo Wen Department of Endocrinology Yunnan Provincial Hospital of Traditional Chinese MedicineKunming 650021China Department of Emergency Jiaxing Hospital of Traditional Chinese MedicineJiaxing 314001China Department of Nephrology Nantong Hospital of Traditional Chinese MedicineNantong 226001China College of Integrated Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Endocrinology Suzhou Hospital of Traditional Chinese MedicineSuzhou 215001China

Background:Non-alcoholic fatty liver disease(NAFLD)can cause insulin resistance(IR)and *** previous studies have demonstrated that Jian-Gan-Xiao-Zhi decoction(JGXZ)could be effective for the treatment of NAFLD and ***,the possible mechanism underlying the effects of JGXZ on NAFLD and IR remains ***:Fifty rats received a high-fat high-carbohydrate(HFHC)diet for 12 weeks to induce *** 4 weeks of HFHC treatment,rats were orally treated with JGXZ(8,16,and 32 g/kg weight)for 8 *** rats in the control group received standard *** the positive control group,rats were orally treated with metformin(90 mg/kg weight)for 8 *** JGXZ and metformin treatment,H&E staining was conducted on rat livers and serum biochemical markers,including alanine aminotransferase(ALT),aspartate aminotransferase(AST),triglyceride(TG),and total cholesterol(TC),were measured using test ***,a fasting blood glucose test and an oral glucose tolerance test(OGTT)were *** levels of insulin were determined using ELISA kit,and the homeostatic model assessment of insulin resistance(HOMA-IR)was *** levels of total insulin receptor substrate-1(IRS1),AMP-activated protein kinase-α(AMPKα)and c-Jun N-terminal kinase(JNK)as well as the levels of phosphorylation of IRS1(p-IRS1),phosphorylation of AMPK(p-AMPK)and phosphorylation of JNK(p-JNK)were measured using western ***:The body weights in JGXZ low-,middle-,and high-dose groups were lower than those in the model group(P<0.05,P<0.01,P<0.01,respectively).The serum levels of AST(P<0.05 in JGXZ middle-and high-dose groups),ALT(P<0.01 in JGXZ middle-dose group and P<0.05 in JGXZ high-dose group),TG(P<0.01 in JGXZ middle-and high-dose groups),and TC(P<0.01)upon JGXZ treatment were lower those than in NAFLD model rats.H&E staining showed that JGXZ treatment reduced steatosis of the hepatocytes in NAFLD model *** decreased the levels of fasting blood glucose(P<0.01),HOM

关键词： Jian-Gan-Xiao-Zhi decoction Non-alcoholic fatty liver disease Insulin resistance AMPK/JNK pathway