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Verifying Contextual Refinement with Ownership Transfer

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Journal of Computer Science & Technology 2021年第6期36卷 1342-1366页

作者： zhao-hui li Xin-Yu Feng School of Computer Science and Technology University of Science and Technology of ChinaHefei 230026China Department of Computer Science and Technology Nanjing UniversityNanjing 210023China State Key Laboratory for Novel Software Technology Nanjing UniversityNanjing 210023China

Contextual refinement is a compositional approach to compositional verification of concurrent *** has been much work designing program logics to prove the contextual refinement between the object implementation and its abstract ***,these program logics for contextual refinement verification cannot support objects with resource ownership transfer,which is a common pattern in many concurrent objects,such as the memory management module in OS kernels,which transfers the allocated memory block between the object and *** this paper,we propose a new approach to give abstract and implementation independent specifications to concurrent objects with ownership *** also design a program logic to verify contextual refinement of concurrent objects *** abstract *** have successfully applied our logic to verifying an implementation of the memory management module,where the implementation is an appropriately simplified version of the original version from a real-world preemptive OS kernel.

关键词： contextual refinement program logic concurrent object ownership transfer verification

A program logic for obstruction-freedom

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Frontiers of Computer Science 2024年第6期18卷 85-100页

作者： zhao-hui li Xin-Yu FENG School of Computer Science and Technology University of Science and Technology of ChinaHefei 230026China Department of Computer Science and Technology Nanjing UniversityNanjing 210023China State Key Laboratory for Novel Software Technology Nanjing UniversityNanjing 210023China

Though obstruction-free progress property is weaker than other non-blocking properties including lock-freedom and wait-freedom,it has advantages that have led to the use of obstruction-free implementations for software transactional memory(STM)and in anonymous and fault-tolerant distributed ***,existing work can only verify obstruction-freedom of specific data structures(e.g.,STM and list-based algorithms).In this paper,to fill this gap,we propose a program logic that can formally verify obstruction-freedom of practical implementations,as well as verify linearizability,a safety property,at the same *** also propose informal principles to extend a logic for verifying linearizability to verifying *** this approach,the existing proof for linearizability can be reused directly to construct the proof for both linearizability and ***,we have successfully applied our logic to verifying a practical obstruction-free double-ended queue implementation in the first classic paper that has proposed the definition of obstruction-freedom.

关键词： verification program logic progress properties obstruction-freedom concurrent objects

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L-R smash products for multiplier Hopf algebras

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Applied Mathematics(A Journal of Chinese Universities) 2008年第1期23卷 83-90页

作者： zhao li-hui LU Di-ming FANG Xiao-li Dept. of Math. Zhejiang Univ. Hangzhou 310027 China. Dept. of Math. NIT Zhejiang Univ. Ningbo 315100 China.

The theory of L-R smash product is extended to multiplier Hopf algebras and a sufficient condition for L-R smash product to be regular multiplier Hopf algebras is given. In particular, the result of the paper implies ... 详细信息

关键词： multiplier Hopf algebral bimodule bialgebra L-R smash product.

Effect of cooling parameters on the microstructure and properties of Mo-bearing and Cr-bearing steels

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International Journal of Minerals,Metallurgy and Materials 2011年第5期18卷 551-556页

作者： Xiang-dong Huo Yu-qian li Yu-tao zhao Hai-wang Zhang zhao-hui li School of Material Science and Engineering Jiangsu University Zhenjiang 212013 China Technology Center of Handan Iron and Steel Corp. Handan 056002 China

To develop low-cost low carbon bainitic steel,Mo-bearing and Cr-bearing steels were melted in a vacuum induction furnace and were researched by thermal simulation and hot rolling at the *** the cooling rate increases from 0.2 to 50°C/s,the transformation temperatures of two steels lie between 650 and 400°C,and the final microstructures of them change from quasi-polygonal ferrite and granular bainite to lath *** with cooling in air or by interrupted cooling,Mo-bearing and Cr-bearing steel plates cooled by sprayed water boast higher strength and superior toughness,for large-size islands are responsible for the poor mechanical *** to Mo,Cr is effective to isolate the bainitic reaction in low carbon steel,and the bainitic microstructure can also be obtained in Cr-bearing steel cooled at a wide range of cooling rate.

关键词： low carbon steel bainite phase transformations chromium microstructure mechanical properties

Postoperative efficacy,safety,predictability,and visual quality of implantable collamer lens implantation versus small incision lenticule extraction in myopic eyes:a Meta-analysis

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International Journal of Ophthalmology(English edition) 2023年第3期16卷 442-452页

作者： Hong-Yu li Zi Ye zhao-hui li Medical School of Chinese PLA Beijing 100853China Senior Department of Ophthalmology the Third Medical Center of PLA General HospitalBeijing 100853China

AIM:To compare the postoperative efficacy,safety,predictability,and visual quality of implantable collamer lens(ICL)implantation versus small incision lenticule extraction(SMILE)in myopia ***:Pub Med,EMBASE,Web of Science,Cochrane library and several Chinese databases were searched at May 2021 to select relevant studies in comparison of clinical outcomes between ICL implantation and SMILE for *** primary outcomes were efficacy,safety,and *** the secondary outcomes were postoperative higher-order ocular aberrations(HOAs),modulation transfer function cutoff frequency(MTF),objective scatter index(OSI),contrast sensitivity and a quality of vision(Qo V)***:A total of 1036 eyes from 10 studies,of which 503 eyes underwent ICL implantation and 533 eyes underwent SMILE,were enrolled in this *** results revealed that ICL group had a better safety index and post-corrected distance visual acuity(CDVA)(P=0.007,line(P=0.007)than the SMILE *** significant differences were found in comparison of the other primary *** the longterm follow-up(>6mo),ICL group had a lower total HOA,coma,and spherical aberration than SMILE group(P=0.003,lity for correcting high ***,ICL group is relatively safer and also has better visual quality in comparison of SMILE group.

关键词： implantable collamer lens small incision lenticule extraction myopia refractive surgery Meta-analysis

Clinical study of customized aspherical intraocular lens implants

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International Journal of Ophthalmology(English edition) 2014年第5期7卷 816-821页

作者： lie-Xi Jia zhao-hui li Department of Ophthalmology Chinese PLA General Hospital

AIM:To compare if there is an improvement in visual functions with age-related cataracts between patients receiving a aspherical intraocular lens(IOL) based on corneal wavefront aberration and patients randomly assigned ***:A total of 124 eyes of 124 patients with age-related cataracts were placed in experimental group and a group receiving randomly assigned(RA) *** experimental group was undergone Pentacam corneal spherical aberration measurement before surgery; the targeted range for residual total spherical aberration after surgery was set to 0-0.3 μm. Patients with a corneal spherical aberration <0.3 μm were implanted with a zero-spherical aberration advanced optics(AO) aspherical IOL and patients with an aberration ≥0.3 μm received a Tecnis Z9003 aspherical lens in experimental group. RA patients were randomly implanted with an AO lens or a Tecnis Z9003 lens. Three months after surgery total spherical aberration, photopic/mesopic contrast sensitivities, photopic/mesopic with glare contrast sensitivities, and logMAR vision were ***:Statistical analysis on logMAR vision showed no significant difference between two groups(P =0.413). The post-surgical total spherical aberration was 0.126 ±0.097 μm and 0.152 ±0.151 μm in the experimental and RA groups, respectively(P =0.12). The mesopic contrast sensitivities at spatial frequencies of 6,12 and 18 c/d in the experimental group were significantly higher than of the RA group(P =0.00; P =0.04;P =0.02). The mesopic with glare contrast sensitivity in the experimental group at a spatial frequency of 18 c/d was also significantly higher vs the RA group(P =0.01).CONCLUSION:Pre-surgical corneal spherical aberration measurement in cataract patients followed bycustomized selection of aspherical IOL implants improved mesopic contrast sensitivities at high spatial frequencies, and thus is a superior strategy compared to the random selection of aspherical intraocular lens implants.

关键词： intraocular lens cataract extraction corneal wavefront aberration mesopic vision night vision

Effect of Aβ protein on inhibiting proliferation and promoting apoptosis of retinal pigment epithelial cells

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International Journal of Ophthalmology(English edition) 2018年第6期11卷 929-934页

作者： Zi Ye Shou-Zhi He zhao-hui li Department of Ophthalmology the Chinese PLA General Hospital

AIM： To identify the effect and regulatory mechanism of amyloid β （Aβ） protein on retinal pigment epithelial （RPE） cells in cell proliferation and apoptosis, and clarify Aβ role in the pathogenesis of age-related macular degeneration （AMD）. METHODS： The model of Aβ25-35 protein cytotoxicity in RPE cell was successfully established to investigate the effect of Aβ protein on RPE cells in vitro. Based on Aβ protein, the specific inhibitors （HY-50682 or BAY11-7082） or activating agent （lipopolysaccharide） was used to analyze the regulatory mechanism of Aβ protein to RPE cells on cell proliferation and apoptosis by flow cytometry, real-time polymerase chain reaction, Western blotting, enzyme-linked immunosorbent assay and dual-luciferase reporter gene assay. RESULTS： The number of RPE cells, treated with Aβ25-35 from 0.3 to 60 μmol/L, significantly reduce （P〈0.01）, and had the dose-dependent effect. Aβ protein 60 μmol/L inhibits the G1/S phase transition （P〈0.01） and down-regulated cyclin E mRNA level （P〈0.01）. Similarly, Aβ25-35 induced a significant increase of cell apoptosis, accompanied by the significantly higher level of activated caspase 3 protein. Furthermore, nuclear factor-kappaB （NF-κB） activity and hosphorylated Iκ-Ba level would significantly lower in treated RPE cells. Using specific inhibitors or activating agent based on the Aβ, the cell numbers, NF-κB activity, phosphorylated Iκ-Ba level, receptor for advanced glycation endproducts （RAGE） gene expression levels, cyclin E mRNA level and activated caspase 3 level had accordingly changed by different methods, confirming that RAGE/NF-κB signaling pathway involved in the regulation of Aβ protein on RPE cell apoptosis and proliferation. CONCLUSION： Aβ protein inhibits cell proliferation and activates apoptosis via inactivation of the RAGE/NF-κB signaling pathway in RPE cell.

关键词： amyloid β protein retinal pigment epithelialcells proliferation apoptosis receptor for advanced glycation endproducts nuclear factor-kappaB age-related macular degeneration

Phenotype of Usher syndrome type Ⅱ assosiated with compound missense mutations of c.721 C>T and c.1969 C>T in MYO7A in a Chinese Usher syndrome family

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International Journal of Ophthalmology(English edition) 2015年第4期8卷 670-674页

作者： Wei Zhai Xin Jin Yan Gong ling-hui Qu Chen zhao zhao-hui li Department of Ophthalmology General Hospital of Chinese PLA School of Medicine Nan Kai University Key Lab of Visual Damage and Regeneration & Restoration of Chongqing Department of Ophthalmology No.181 Hospital of Guilin

·AIM: To identify the pathogenic mutations in a Chinese pedigree affected with Usher syndrome type II(USH2).· METHODS: The ophthalmic examinations and audiometric tests were performed to ascertain the phenotype of the family. To detect the genetic defect,exons of 103 known RDs-associated genes including 12 Usher syndrome(USH) genes of the proband were captured and sequencing analysis was performed to exclude known genetic defects and find potential pathogenic mutations. Subsequently, candidate mutations were validated in his pedigree and 100 normal controls using polymerase chain reaction(PCR) and Sanger sequencing.·RESULTS: The patient in the family occurred hearing loss(HL) and retinitis pigmentosa(RP) without vestibular dysfunction, which were consistent with standards of classification for USH2. He carried the compound heterozygous mutations, c.721 C >T and c.1969 C >T, in the MYO7 A gene and the unaffected members carried only one of the two mutations. The mutations were not present in the 100 normal controls.· CONCLUSION: We suggested that the compound heterozygous mutations of the MYO7 A could lead to USH2, which had revealed distinguished clinical phenotypes associated with MYO7 A and expanded the spectrum of clinical phenotypes of the MYO7 A mutations.

关键词： Usher syndrome mutation MYO7A next-generation sequencing

Generation of Leydig-like cells:approaches,characterization,and challenges

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Asian Journal of Andrology 2022年第4期24卷 335-344页

作者： zhao-hui li Jun-Dong Lu Shi-Jun li Hao-lin Chen Zhi-Jian Su Guangdong Provincial Key Laboratory of Bioengineering Medicine Department of Cell BiologyJinan UniversityGuangzhou 510632China lnstitute of life Sciences Wenzhou UniversityWenzhou 325035China Department of Gynecology and Obstetrics The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical UniversityWenzhou 325027China National Engineering Research Center of Genetic Medicine Jinan UniversityGuangzhou 510632China

Testosterone production by Leydig cells(LCs)plays a crucial role in male *** functional degeneration of LCs can cause testosterone deficiency,ultimately resulting in primary male *** of exogenous LCs with the ability to produce testosterone in response to the regulation of the hypothalamus-pituitary-gonad axis could be a promising alternative option to treat male primary *** studies have shown that it is possible to generate Leydig-like cells from stem cells by various *** addition,somatic cells,such as embryonic or adult fibroblasts,have also been successfully reprogrammed into Leydig-like *** this review,we summarized the recent advances in the generation of Leydig-like cells,with an emphasis on comparing the effectiveness and safety of different protocols used and the cells *** further analyzing the characteristics of Leydig-like cells generated from fibroblasts based on small signaling molecules and regulatory factors,we found that although the cells may produce testosterone,they are significantly different from real *** future in vivo applications,it is important that the steroidogenic cells generated be evaluated not only for their steroidogenic functions but also for their overall cell metabolic state by proteomics or transcriptomic tools.

关键词： fibroblasts hypogonadism Leydig-like cells reprogramming stem cells