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Quercetin Alleviates Lipopolysaccharide-Induced Cardiac Inflammation via Inhibiting Autophagy and Programmed Cell Death

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Biomedical and Environmental Sciences 2024年第1期37卷 54-70页

作者： YU jin Hai HU Guo Liang GUO Xiao Quan CAO Hua Bin XIA zhao Fei AMIN Buhe Jiangxi Provincial Key Laboratory for Animal Health Institute of Animal Population HealthCollege of Animal Science and TechnologyJiangxi Agricultural UniversityNanchang 330045JiangxiChina Internal Medicine Laboratory Department of Veterinary Clinical MedicineCollege of Veterinary MedicineChina Agricultural UniversityBeijing 100091China Department of Cancer Surgery Beijing Shijitan Hospital Affiliated with Capital Medical UniversityBeijing 100038China

Objective The aim of this study is to explore the potential modulatory role of quercetin against Endotoxin or lipopolysaccharide(LPS)induced septic cardiac *** Specific pathogen-free chicken embryos(n=120)were allocated untreated control,phosphate buffer solution(PBS)vehicle,PBS with ethanol vehicle,LPS(500 ng/egg),LPS with quercetin treatment(10,20,or 40 nmol/egg,respectively),Quercetin groups(10,20,or 40 nmol/egg).Fifteenday-old embryonated eggs were inoculated with abovementioned solutions via the allantoic *** embryonic day 19,the hearts of the embryos were collected for histopathological examination,RNA extraction,real-time polymerase chain reaction,immunohistochemical investigations,and Western *** They demonstrated that the heart presented inflammatory responses after LPS *** LPS-induced higher mRNA expressions of inflammation-related factors(TLR4,TNFα,MYD88,NF-κB1,IFNγ,IL-1β,IL-8,IL-6,IL-10,p38,MMP3,and MMP9)were blocked by quercetin with three *** significantly decreased immunopositivity to TLR4 and MMP9 in the treatment group when compared with the LPS *** significantly decreased protein expressions of TLR4,IFNγ,MMP3,and MMP9 when compared with the LPS *** treatment prevented LPS-induced increase in the mRNA expression of Claudin 1 and ZO-1,and significantly decreased protein expression of claudin 1 when compared with the LPS *** significantly downregulated autophagyrelated gene expressions(PPARα,SGLT1,APOA4,AMPKα1,AMPKα2,ATG5,ATG7,Beclin-1,and LC3B)and programmed cell death(Fas,Bcl-2,CASP1,CASP12,CASP3,and RIPK1)after LPS *** significantly decreased immunopositivity to APOA4,AMPKα2,and LC3-II/LC3-I in the treatment group when compared with the LPS *** significantly decreased protein expressions of AMPKα1,LC3-I,and *** significantly decreased the protein expression to CASP1 and CASP3 by immunohistochemical investigation or

关键词： Quercetin Lipopolysaccharide Inflammation Autophagy Programmed cell death Myocardiocytes permeability

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Continuous synthesis of N,N-dicyanoethylaniline in microreactors:Reaction kinetics and process intensification

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Chinese Journal of Chemical Engineering 2024年第8期72卷 95-105页

作者： Pengcheng Lu Yaoyao Li Jianjun Zhang Yuchao zhao Qingqiang Wang Ying Chen Nan jin Xiugang Yu Shandong Provincial Key Laboratory of Chemical Engineering and Process College of Chemistry and Chemical EngineeringYantai UniversityYantai 264005China Shandong ANOKY Chemical Technology Research Co. Ltd.Yantai 265601China Yantai Guobang Chemical Machinery Technology Co. Ltd.Yantai 264000China

Cyanoethylation of phenylamine is one of the important steps for the production of dicyanoethyl-based disperse ***,the exothermic nature of this reaction and the inherent instability of intermittent dynamic operation pose challenges in achieving both high safety and reaction *** this study,a continuous cyanoethylation of phenylamine for synthesizing N,N-dicyanoethylaniline in a microreactor system has been *** optimizing the reaction conditions,the reaction time was significantly reduced from over 2 h in batch operation to approximately 14 min in the microreactor,while high conversion and selectivity were *** on the reaction network constructed,the reaction kinetics was established,and the kinetic parameters were then *** findings provide valuable insights into a controllable cyanoethylation reaction,which would be helpful for the design of efficient processes and optimization of reactors.

关键词： Cyanoethylation Microreactor Kinetics N,N-dicyanoethylaniline Optimization Safety

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Essential oils improve nursery pigs'performance and appetite via modulation of intestinal health and microbiota

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Animal Nutrition 2024年第1期16卷 174-188页

作者： Bi-Chen zhao Tian-Hao Wang Jian Chen Bai-Hao Qiu Ya-Ru Xu jin-Long Li College of Veterinary Medicine Northeast Agricultural UniversityHarbin150030China Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine Northeast Agricultural UniversityHarbin150030China Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment Northeast Agricultural UniversityHarbin150030China

Optimal intestinal health and functionality are essential for animal health and performance,and simultaneously intestinal nutrient transporters and intestinal peptides are also involved in appetite and feed intake control *** the potential of essential oil(EO)in improving animal performance and improving feed palatability,we hypothesized that dietary supplementation of cinnamaldehyde and carvacrol could improve performance and appetite of nursery pigs by modulating intestinal health and ***(100 mg/kg),carvacrol(100 mg/kg),and their mixtures(including 50 mg/kg cinnamaldehyde and 50 mg/kg carvacrol)were supplemented into the diets of 240 nursery pigs for 42 d,and data related to performance were ***,the influence of EO on intestinal health,appetite and gut microbiota and their correlations were *** supplementation increased(P<0.05)the body weight,average daily gain(ADG)and average daily feed intake(ADFI)of piglets,and reduced(P<0.05)diarrhea rates in nursery ***,EO increased(P<0.05)the intestinal absorption area and the abundance of tight junction proteins,and decreased(P<0.05)intestinal permeability and local *** terms of intestinal development and the mucus barrier,EO promoted intestinal development and increased(P<0.05)the number of goblet ***,we found that piglets in the EO-supplemented group had upregulated(P<0.05)levels of transporters and digestive enzymes in the intestine,which were significantly associated with daily gain and feed *** addition,EO supplementation somewhat improved appetite in nursery pigs,increased the diversity of the gut microbiome and the abundance of beneficial bacteria,and there was a correlation between altered bacterial structure and appetite-related *** findings indicate that EO is effective in promoting growth performance and nutrient absorption as well as in regulating appetite by improving intestinal health and ba

关键词： Nursery pig Essential oil Intestinal health Appetite Microbiota

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A Composite Elastomer with Photo-responsive Shape Memory and Programmable Hygroscopic Actuation Functionalities

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Chinese Journal of Polymer Science 2024年第10期42卷 1470-1478,I0009页

作者： Xiang-Xi Cui Li Shang Zhong-Wen Liu zhao-Tie Liu jin-Qiang Jiang Guo Li Key Laboratory of Syngas Conversion of Shaanxi Province School of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi’an710062China

Developing hydroscopic actuators with simultaneous high elasticity,shape programmability and tunable actuating behaviors are highly desired but still *** this study,we propose an orthogonal composite design to develop such a *** developed composite elastomer comprises carboxyl group-grafted polystyrene-block-poly(ethylene-co-butylene)-block-polystyrene(SEBS-g-COOH)as the elastic substrate,and a synthesized azobenzene derivative as the functional filler(Azo12).By surface treatment using acidic and base solutions,the carboxyl groups on the surface can reversibly transform into carboxylate groups,which render the composite tunable hygroscopic actuating *** another aspect,the added filler undergoes trans-to-cis isomerization when exposed to UV light irradiation,leading to liquefaction of the crystalline aggregates formed by Azo12 *** liquefied Azo12 molecules can autonomously resotre their trans form and reform the crystalline *** reversible change in crystralline structure is utilized to realize the shape memory property,and 5 wt%of Azo12addition is adequate for the composite to exhibit photo-responsive shape memory behavior without compromising much of the *** regualtion of external geometry by shape memory effect is effective in altering the actuating *** proposed method can be extend to designing different composites with the demonstrated functionalities.

关键词： Actuator Shape memory Photo-responsive Hygroscopic responsive Azobenzene

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Arthroscopic M-shaped suture fixation for tibia avulsion fracture of posterior cruciate ligament:A modified technique and case series

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World Journal of Orthopedics 2024年第7期15卷 642-649页

作者： Xiao-hui Zhang Jian Yu Meng-Yao zhao jin-hui Cao Bing Wu Dan-Feng Xu Department of Orthopaedic Surgery Shaoxing Central HospitalShaoxing 312000Zhejiang ProvinceChina Department of Orthopaedic Surgery The Central Hospital of Shaoxing UniversityShaoxing 312000Zhejiang ProvinceChina Central Laboratory Shaoxing Central HospitalShaoxing 312000Zhejiang ProvinceChina

BACKGROUND Tibial avulsion fractures of the posterior cruciate ligament(PCL)are challenging to treat and compromise knee stability and *** open surgery often requires extensive soft tissue dissection,which may increase the risk of *** response to these concerns,arthroscopic techniques have been *** aim of this study was to introduce a modified arthroscopic tech-nique utilizing an M-shaped suture fixation method for the treatment of tibial avulsion fractures of the PCL and to evaluate its outcomes through a case *** To evaluate the effects of arthroscopic M-shaped suture fixation on treating tibia avulsion fractures of the *** We developed a modified arthroscopic M-shaped suture fixation technique for tibia avulsion fractures of the *** case series included 18 patients who underwent the procedure between January 2021 and December *** patients were assessed for range of motion(ROM),Lysholm score and International knee documentation committee(IKDC)*** complications were also *** The patients were followed for a mean of 13.83±2.33 *** patients showed radiographic *** the final follow-up,all patients had full ROM and a negative posterior drawer *** mean Lysholm score significantly improved from 45.28±8.92 preoperatively to 91.83±4.18 at the final follow-up(P<0.001),and the mean IKDC score improved from 41.98±6.06 preoperatively to 90.89±5.32 at the final follow-up(P<0.001).CONCLUSION The modified arthroscopic M-shaped suture fixation technique is a reliable and effective treatment for tibia avulsion fractures of the PCL,with excellent fracture healing and functional recovery.

关键词： Posterior cruciate ligament Avulsion fracture Arthroscopic Case series Suture fixation

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SnO_(2)/metal organic complex composite derived from low-temperature activated metal organic complex for advanced lithium storage

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Rare Metals 2024年第7期43卷 3032-3043页

作者： Gui-Long Liu Zi-Han zhao jin-Ke Shen Zi-Bo zhao Nai-Teng Wu Dong-Lei Guo Wei-Wei Yuan Yong Liu Ye-Hua Su Xian-Ming Liu Luoyang Key Laboratory of Green Energy Materials College of Chemistry and Chemical EngineeringLuoyang Normal UniversityLuoyang 471934China School of Materials Science and Engineering Henan University of Science and TechnologyLuoyang 471023China Inner Mongolia Shijie Chemical Co. Ltd.Alxa League 737300

Sn-based metal organic complexes with coordination bonds,multi-active sites,and high theoretical capacity have attracted much attention as promising anodes for lithium ion ***,the low electrical conductivity and huge volume changes restricted their electrochemical stability and practical ***,Snbased anode with superior electrochemical performance,including a high reversible capacity of 1050.1 mAh·g^(-1)at 2 A·g^(-1)and a stable capacity of 1105.5 mAh·g^(-1)after 500 cycles at 1 A·g^(-1),was fabricated via a low-temperature calcination strategy from Sn metal organic *** low-temperature calcination process regulates Sn-O bond and prevents the agglomeration of SnO_(2),generating highly dispersed SnO_(2) decorated metal organic complexes and providing sufficient active sites for ion *** situ characterizations expound that the undecomposed Sn-based metal organic complexes could be transformed into SnO_(2) during lithiation and delithiation,which enhances the electrical conductivity and induces a strong pseudo-capacitive behavior,accelerating the electrochemical kinetics;the multiple solid electrolyte interface with inflexible LiF and flexible ROCO_(2)Li buffers the volume variation of the electrode,resulting in its high electrochemical *** work provides a simple strategy for preparing excellent Sn-based anodes from metal organic complexes and reveals the lithium storage mechanism of the prepared Snbased anode.

关键词： Metal organic complex Lithium ion battery Electrochemical activation Low-temperature activation Partial decomposition

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Research on Bast Fiber Extracted from the White Bark of Three Species in the Genus Broussonetia

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Chinese Journal of Polymer Science 2024年第6期42卷 729-738页

作者： Shan-Shan jin Si-Nong Wang Yan-Yan Huang jing-Yu Zhang Peng Liu hui Yu Hong-Dong Zhang Yu-Liang Yang Institute for Preservation and Conservation of Chinese Ancient Books Fudan University LibraryFudan UniversityShanghai200433China State key laboratory of Molecular Engineering of polymers Department of Macromolecular ScienceFudan UniversityShanghai200433China

Against the backdrop of a global paper resource shortage,there is a growing need to identify fast-growing tree species capable of producing long-lasting *** plant species namely Broussonetia kazinoki,Broussonetia papyrifera and hybrid paper mulberry,belong to the Broussonetia genus,were collected from China to study their white bark suitability for pulp and *** chemical composition revealed that the holocellulose content in Broussonetia kazinoki and Broussonetia papyrifera was more than 80%.The molecular weight distribution of several holocellulose/α-cellulose is observed by GPC,which allows us to better observe the changes of various components on the molecular *** yield,lignin,whiteness,and molecular weight of the pulps obtained by NaOH treatment were *** microscope was used to characterize the fiber length-width ratio and ***,the improvement of the fiber rigidity method based on the Kratky-Porod chain model makes it more theoretical and further reveals the influencing factors of fiber *** study demonstrates the high potentiality of these three species for papermaking applications.

关键词： Broussonetia genus Cellulose Alkaline pulping Kratky-Porod chain model Fiber rigidity

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Application of UiO-66 and its composites for remediation and resource recovery of typical environmental contaminants:a review

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Rare Metals 2024年第6期43卷 2498-2526页

作者： hui-Min Zhang Yun-Long Wang Xin-Feng Zhu Zhen-Zhen Huang Dan-Dan Pang Kai Wang Chao-Hai Wang Zhong-Xian Song Shi-Qiang Yin Lin-Lin Chang jin-hui Zhang School Infirmary Henan University of Urban ConstructionPingdingshan 467036China Faculty of Environmental and Municipal Engineering Henan Key Laboratory of Water Pollution Control and Rehabilitation TechnologyKey Laboratory of Carbon Emission Reduction and Combined Air Pollution Control TechnologyHenan University of Urban ConstructionPingdingshan 467036China School of Resources&Environment Collaborative Innovation Center of Coalbed Methane and Shale Gas for Central Plains Economic RegionHenan Polytechnic UniversityJiaozuo 454003China The Key Lab of Pollution Control and Ecosystem Restoration in Industry Clusters Ministry of EducationGuangzhou Higher Education Mega CentreSouth China University of TechnologyGuangzhou 510006China

UiO-66 series metal-organic framework materials(MOFs)are typical porous materials assembled by Zr^(4+) with a large mass-to-nucleus ratio and terephthalic acid ligands,which form tetrahedral and octahedral cages arranged in a periodic triangular window *** to the strong interaction between Zr and O,UiO-66 series MOFs exhibit high thermal stability,structural stability,and chemical *** article mainly reviews the applications of UiO-66 and its composites in adsorption,photocatalysis,and resource utilization,while exploring the harm of pollutants to human health and the *** the first part,the differences in adsorption and removal mechanisms of liquid organic pollutants,heavy metals,and volatile organic compounds(VOCs)are *** results show that organic pollutants are mainly removed by physical adsorption,electrostatic interactions,hydrogen bonding,andπ-πinteractions,while heavy metals are mainly removed by chemical adsorption,electrostatic interactions,reduction,and *** are mainly removed by the pore volume and pore size structure of the *** catalysis can achieve non-toxic treatment of pollutants,and this study mainly focuses on UiO-based composite materials constructed by strategies such as semiconductor composites,ion doping,and metal/dye *** the second part,the synergistic effect between the components of UiO-based composite materials promotes the oriented and rapid separation and transfer of earriers at the material interface,thereby promoting the generation of active species such as h^(+),·O_(2)^(-) and·OH,and achieving rapid degradation of pollutants and detoxification of heavy *** the third part,heterojunctions can realize the resource utilization of pollutants in water and air,producing energy-type substances such as hydrogen and methanol while solving environmental *** addition,this article also summarizes the harm of common typical pollutants to the environment

关键词： UiO Adsorption Photocatalysis Environmental pollution Resource recovery

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超音速火焰喷涂Cr_3C_2-NiCr与WC-Co涂层高温结合性能研究

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人工晶体学报 2015年第7期44卷 2005-2010页

作者：门向东陶凤和甘霖赵金辉军械工程学院石家庄050003 中国人民解放军理工大学南京210007

采用超音速火焰喷涂在PCr Ni3Mo VA钢基体上分别制备了Cr3C2-Ni Cr与WC-Co涂层,并对涂层进行了800℃高温后续处理。用扫描电镜(SEM)观察分析两种涂层表面及涂层截面组织,分析涂层界面结合状态。用SANS CMT5305型拉伸试验机分别测试两种... 详细信息

采用超音速火焰喷涂在PCr Ni3Mo VA钢基体上分别制备了Cr3C2-Ni Cr与WC-Co涂层,并对涂层进行了800℃高温后续处理。用扫描电镜(SEM)观察分析两种涂层表面及涂层截面组织,分析涂层界面结合状态。用SANS CMT5305型拉伸试验机分别测试两种涂层在常温和高温处理后的结合强度。结果表明,常温下Cr3C2-Ni Cr与WC-Co涂层与基体的结合能力相似,高温下Cr3C2-Ni Cr涂层与基体的结合能力基本保持不变,而WC-Co涂层发生剥落。

关键词：超音速火焰喷涂 Cr3C2-NiCr WC-Co 涂层结合强度

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Enhanced degradation of florfenicol by microscale SiC/Fe:Dechlorination via hydrogenolysis

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Chinese Chemical Letters 2024年第7期35卷 218-221页

作者： Yun-Fei Zhang Chun-hui Zhang Jian-hui Xu Lei Li Dan Li jin-Hong Fan Jiale Gao Xin Quan Qi Wu Yue Zou Yan-Ling Liu Dongguan University of Technology School of Environment and Civil EngineeringDongguan 523830China State Key Laboratory of Pollution Control and Resource Reuse School of Environmental Science and EngineeringTongji UniversityShanghai 200092China

Herein,the degradation of florfenicol(FLO)over zero-valent iron(ZVI)enhanced by SiC was systematically *** was found that 5 g/L of ZVI/SiC(1:3)at pH 3.0 could completely degrade 20 mg/L of FLO within 1 h,with a Kobsvalue of 0.0873 min^(-1),12.5 times greater than that of pure ZVI(0.0069 min^(-1)).Vibrating sample magnetometer(VSM)characterizations revealed that the use of SiC supporter reduces the magnetic intensity of ZVI,which mitigates iron particle agglomeration,increases Brunauer-Emmett-Teller(BET)surface area,and enhances FLO degradation ***,ZVI/SiC exhibits a much lower hydrogen evolution potential(HEP)and significantly higher corrosion currents compared to pure *** was proposed to undergo degradation via reductive dechlorination,involving a hydrogenolysis mechanism that entails the cleavage of theσ*** study provides new insights into the reduction hydrogenation mechanism of ZVI.

关键词： Zero-valent iron Silicon carbide Reductive dechlorination Hydrogenolysis Florfenicol

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