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Science China Chemistry 2024年第7期67卷 2306-2313页

作者： Dong-Yue Cai Weiming Shi zhao-hui jin Zhi-Xiang Yu jin-Xin zhao Jian-Min Yue State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Beijing National Laboratory for Molecular Sciences(BNLMS) Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of ChemistryPeking UniversityBeijing 100871China

Mimicking biosynthetic pathways of hongkonoids led to the development of a new Cu(Ⅰ)-catalyzed[3+2]cycloaddition ofα-hydroxyketone andβ-keto enol ethers,affording tetrahydrofuran acetals in a highly diastereoselective manner and 100%atom economy.Computational studies on the mechanism disclosed a concerted but asynchronous Michael addition/aldol reaction.Of the same importance,this methodology provides a practical biomimetic approach for one-step construction of the dibenzylbutyrolactol lignan backbone starting from two phenyl propane derivatives,opening up a powerful new approach for lignan synthesis,which is showcased by succinct total syntheses of two biologically important aryltetralin-type lignans,β-apopicropodophyllin and cycloolivil.Given the mild and operationally simple conditions,the developed chemistry might have a promising prospect in potential industrial applications.

关键词： [3+2]cycloaddition transition-metal catalysis tetrahydrofuran lignans natural products

Advances in quantum dot-mediated siRNA delivery

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Chinese Chemical Letters 2017年第9期28卷 1851-1856页

作者： Zhi-Yao He zhao-hui jin Mei Zhan Zhou Qin Zhi Li Ting Xu Department of Pharmacy and Cancer CenterWest China HospitalSichuan University and Collaborative Innovation Center of Biotherapy Department of Gastroenterology Hospital(T.C.M) Affiliated to Southwest Medical UniversitySouthwest Medical University

Nano-sized quantum dots（QDs） exhibit uniquely optical properties that are tunable with different sizes and shapes.QDs can emit narrow symmetric bands under a wide excitation range,possess antiphotobleaching stability,and be bio-functionalized on the large surface area.Therefore,QDs are attractive vectors for imaging-guided therapy.Small-interfering RNA（siRNAs）-based therapeutics hold great potential to target a large part of the currently undruggable genes,but overcoming the lipid bilayer to deliver siRNA into cells has remained a major challenge to solve for widespread development of siRNA therapeutics.In this mini-review,we focus on theranostic QD/siRNA assembles for enhancing delivery of siRNA and facilitating evaluation of therapeutic efficacy via imaging of QDs,with special attention to carbonaceous QDs for delivery of siRNA.

关键词： Quantum dot Carbon quantum dot Small-interfering RNA Theranostic Gene delivery Gene therapy

Efficacy of short-term multidisciplinary intensive rehabilitation in patients with different Parkinson's disease motor subtypes: a prospective pilot study with 3-month follow-up

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Neural Regeneration Research 2021年第7期16卷 1336-1343页

作者： Ke-Ke Chen zhao-hui jin Lei Gao Lin Qi Qiao-Xia Zhen Cui Liu Ping Wang Yong-Hong Liu Rui-Dan Wang Yan-Jun Liu jin-Ping Fang Yuan Su Xiao-Yan Yan Ai-Xian Liu Bo-Yan Fang Beijing Rehabilitation Medical College Capital Medical UniversityBeijingChina Parkinson Medical Center Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina Peking University Clinical Research Institute BeijingChina

Parkinson's disease(PD) can be classified into three motor-based subtypes: postural instability/gait difficulty(PIGD), tremor dominant(TD), and indeterminate.The neuropathophysiological mechanisms of the three motor subtypes are different, which may lead to different responses to therapy.Sixty-nine patients with idiopathic Parkinson's disease(Hoehn–Yahr stage ≤ 3) were screened from 436 patients with Parkinsonism recruited through outpatient services and the internet.According to the Movement Disorder Society Unified Parkinson's Disease Rating Scale(MDS-UPDRS) TD/PIGD ratio, the patients were divided into PIGD(TD/PIGD ≤ 0.09;n = 36), TD(TD/PIGD ≥1.15;n = 19), and indeterminate(TD/PIGD = 0.90–1.15;n = 14) groups.All patients received 2 weeks of multidisciplinary intensive rehabilitation treatment(MIRT) during hospitalization, as well as a remote home rehabilitation health education class.Compared with the scores at admission, all patients showed significant improvements in their MDS-UPDRS III score, walking ability, balance, and posture control at discharge.Moreover, the MDS-UPDRS III score improvement was greater in the PIGD group than in the TD group.The follow-up data, collected for 3 months after discharge, showed that overall symptom improvement in each group was maintained for 1–3 months.Furthermore, there were no significant differences in the duration or grade effects of symptom improvement among the three groups.These findings suggest that 2 weeks of MIRT is effective for improving motor performance in all three motor subtypes.Patients in the PIGD group had a better response after hospitalization than those in the TD group.This study was approved by the Institutional Ethics Committee of Beijing Rehabilitation Hospital of Capital Medical University of China(approval No.2018 bkky022) on May 7, 2018 and registered with the Chinese Clinical Trial Registry(registration No.Chi CTR1900020771) on January 19, 2019.

关键词： balance gait motor neurodegeneration Parkinson's disease posture rehabilitation tremor

Electromagnetic fields in ultra-peripheral relativistic heavy-ion collisions

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Nuclear Science and Techniques 2024年第2期35卷 103-109页

作者： Jie zhao jin-hui Chen Xu-Guang Huang Yu-Gang Ma Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Research Center for Theoretical Nuclear Physics NSFC and Fudan UniversityShanghai 200438China Physics Department and Center for Particle Physics and Field Theory Fudan UniversityShanghai 200438China

Ultra-peripheral heavy-ion collisions(UPCs)offer unique opportunities to study processes under strong electromagnetic fields.In these collisions,highly charged fast-moving ions carry strong electromagnetic fields that can be effectively treated as photon fluxes.The exchange of photons can induce photonuclear and two-photon interactions and excite ions.This excitation of the ions results in Coulomb dissociation with the emission of photons,neutrons,and other particles.Additionally,the electromagnetic fields generated by the ions can be sufficiently strong to enforce mutual interactions between the two colliding ions.Consequently,the two colliding ions experience an electromagnetic force that pushes them in opposite directions,causing a back-to-back correlation in the emitted neutrons.Using a Monte Carlo simulation,we qualitatively demonstrate that the above electromagnetic effect is large enough to be observed in UPCs,which would provide a clear means to study strong electromagnetic fields and their effects.

关键词： Electromagnetic fields Neutrons Ultra-peripheral relativistic heavy-ion collisions(UPC)

A phase Ⅳ study of homoharringtonine, cytarabine, aclacinomycin and G-CSF(HCAG) regimen compared with traditional IA regimen in the treatment of newly diagnosed elderly acute myeloid leukemia patients

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上海交通大学学报（医学版） 2017年第8期37卷 1100-1105页

作者：刘钊张赟翔王丽宁 XIA Zheng MAO Yuan-fei zhao hui-jin YOU Jian-hua YU Yang zhao Yu-bing REN Yu-hong LI Ya WANG Yan CHEN Qiu-sheng 李军民陈瑜 Shanghai Institute of Hematology Ruijin Hospital Shanghai Jiao Tong University School of Medicine

Objective · To compare the efficacy and prognostic factors of HCAG regimen with traditional IA regimen in the treatment of newly diagnosed elderly acute myeloid leukemia(AML) patients. Methods · Forty-one patients with AML(aged 55-71 years) were randomly divided into two groups(Group HCAG and Group IA) between 2014 and 2016 for induction and consolidation therapy. Multivariate analysis was applied to identify prognostic factors for relapse-free survival(RFS). Results · A total of 29 patients(70.7%) achieved complete remission(CR). The estimated 2-year overall survival(OS) was 66.8% in Group HCAG and 75.4% in Group IA(P=0.913). The estimated 2-year RFS was 61.8% in Group HCAG and 49.1% in Group IA(P=0.411). Age remained as the unfavorable prognostic factor, leading to significant differences in OS and RFS. In addition, RFS was influenced by cytogenetic/molecular risk stratification. Conclusion · Although HCAG seemed not to particularly benefit the group, the dose reduction of anthracyclines may be applied in elderly patients with comparable short-time outcome. Furthermore, the introduction of homoharringtonine resulted in an improvement of treatment response for more than 20% compared with CAG regimen.

关键词： homoharringtonine long-term survival risk factors acute myeloid leukemia elderly patient

Multiobjective Optimization for Controller Design

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自动化学报 2008年第4期34卷 472-477页

作者： HUANG Liang WANG Ning zhao jin-hui State Key Laboratory of Industrial Control Technology Institute of Systems and Control Zhejiang University Hangzhou 310027 P. R. China Intelligence and Communications for Robots Laboratory College of Information and Communications Hanyang University Seoul Korea

用 multiobjective 优化方法的控制器设计被考虑，在哪个为设计控制器的目的和限制被分析并且改善。以便同时地满足目的，一个新 multiobjective 优化算法被介绍进设计一个最佳的 PID 控制器，由织物 P 系统启发了。控制器的参数根据联... 详细信息

用 multiobjective 优化方法的控制器设计被考虑，在哪个为设计控制器的目的和限制被分析并且改善。以便同时地满足目的，一个新 multiobjective 优化算法被介绍进设计一个最佳的 PID 控制器，由织物 P 系统启发了。控制器的参数根据联系的膜的规则被编码并且演变。唯一的设计是结构的整个人口被划分成几 subpopulations 减少计算复杂性。模拟结果证明算法快收敛，答案形成精确前面并且一致地散布。P 系统的变体设计的控制器有令人满意的性能。而且，答案的分析证明新算法对学习在性能之间的关系并且调节参数合适。建议方法为设计并且评估不同控制器是有用的。

关键词：自动化系统控制器设计多目标最优化设计设计方案

Long-term tadalafil once daily in Chinese men witherectile dysfunction:a 2-year final analysis of apost-marketing,multicenter,randomized,open-labeltrial

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Asian Journal of Andrology 2024年第3期26卷 282-287页

作者： hui Jiang Lian-Ming zhao Su Yan Ji-Hong Liu zhao-hui Zhu jin-Dan Luo Yu-Tian Dai Fu-Biao Li Hao-Cheng Lin Zhi-Chao Zhang Department of Urology Peking University First HospitalBeijing 100000China Department of Urology Peking University Third HospitalBeijing 100191China Department of Urology Peking Union Medical College HospitalBeijing 100730China Department of Urology Tongji HospitalTongji Medical CollegeHuazhongUniversity of Science and TechnologyWuhan 430030China Department of Urology Union Hospital of Tongji Medical CollegeHuazhong University of Science andTechnologyWuhan 430022China Department of Urology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Departmentof Andrology Nanjing Drum Tower HospitalNanjing 210008China Department of Andrology The First Hospital of Jilin UniversityChangchun 130021China Andrology Center Department of UrologyPeking University First HospitalBeijing 100034China.

The long-term safety and effectiveness of once-daily tadalafil is crucial,but limited data are available in Chinese patients witherectile dysfunction(ED).In this post-marketing,multicenter,randomized,open-label trial with 2-year follow-up,635 ED caseswere randomized to receive daily oral tadalafil 2.5 mg or 5 mg for 3 months,of whom 580 continued once-daily tadalafil 5 mg for21 months.Treatment-emergent adverse events in the 12-month and 24-month period were similar,with the most common beingviral upper respiratory tract infection,upper respiratory tract infection,and headache.Significant improvement from baseline inthe International Index of Erectile Function-Erectile Function(IIEF-EF)score was detected at month 12(least squares mean[LSM]change:7.9,95%confidence interval[CI]:7.5–8.4,P<0.001)and was maintained to month 24(LSM change:8.6,95%CI:8.1–9.0,P<0.001).The proportions of patients regaining normal erectile function(IIEF-EF score≥26)were 43.7%and 48.0%at months 12 and 24,respectively.Global Assessment Questionnaire results showed improved erection function in 97.5%ofpatients and improved ability to engage in sexual activity in 95.9%of patients at month 12;these values were 96.1%and 95.0%at month 24,respectively.The quality of sexual life score based on the Sexual Life Quality Questionnaire(SLQQ)was increased by52.2%at month 12 and by 55.3%at month 24(both P<0.001).The treatment satisfaction score determined by SLQQ(mean±standard deviation)was 62.4±21.0 at month 12 versus 65.9±20.2 at month 24.Two-year daily application of tadalafil 5mg in Chinese men with ED showed a favorable safety profile and durable improvement in sexual performance and satisfaction.

关键词： clinical trial erectile dysfunction long-term safety once-daily dosing tadalafil

Analysis of the causes of primary revision after unicompartmental knee arthroplasty: A case series

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World Journal of Clinical Cases 2024年第9期12卷 1560-1568页

作者： jin-Long zhao Xiao jin He-Tao Huang Wei-Yi Yang Jia-hui Li Ming-hui Luo Jun Liu Jian-Ke Pan The Second Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou 510405Guangdong ProvinceChina Department of Chinese Medicine The First Affiliated HospitalJinan UniversityGuangzhou 510630Guangdong ProvinceChina The Second School of Clinical Medical Sciences Guangzhou University of Chinese MedicineGuangdong Academy of Traditional Chinese MedicineGuangzhou 510405Guangdong ProvinceChina The Second Affiliated Hospital Guangzhou University of Chinese Medicine(Guangdong Provincial Hospital of Chinese Medicine)Guangzhou 510120Guangdong ProvinceChina The Affiliated TCM Hospital Guangzhou Medical UniversityGuangzhou 510405Guangdong ProvinceChina The Research Team on Bone and Joint Degeneration and Injury Guangdong Provincial Academy of Chinese Medical SciencesGuangzhou 510405Guangdong ProvinceChina

BACKGROUND Unicompartmental knee arthroplasty(UKA)has great advantages in the treatment of unicompartmental knee osteoarthritis,but its revision rate is higher than that of total knee arthroplasty.AIM To summarize and analyse the causes of revision after UKA.METHODS This is a retrospective case series study in which the reasons for the first revision after UKA are summarized.We analysed the clinical symptoms,medical histories,laboratory test results,imaging examination results and treatment processes of the patients who underwent revision and summarized the reasons for primary revision after UKA.RESULTS A total of 13 patients,including 3 males and 10 females,underwent revision surgery after UKA.The average age of the included patients was 67.62 years.The prosthesis was used for 3 d to 72 months.The main reasons for revision after UKA were improper suturing of the surgical opening(1 patient),osteophytes(2 patients),intra-articular loose bodies(2 patients),tibial prosthesis loosening(2 patients),rheumatoid arthritis(1 patient),gasket dislocation(3 patients),anterior cruciate ligament injury(1 patient),and medial collateral ligament injury with residual bone cement(1 patient).CONCLUSION The causes of primary revision after UKA were gasket dislocation,osteophytes,intra-articular loose bodies and tibial prosthesis loosening.Avoidance of these factors may greatly reduce the rate of revision after UKA,improve patient satisfaction and reduce medical burden.

关键词： Unicompartmental knee arthroplasty Total knee arthroplasty Causes Revision Case series

A real-time intelligent lithology identification method based on a dynamic felling strategy weighted random forest algorithm

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Petroleum Science 2024年第2期21卷 1135-1148页

作者： Tie Yan Rui Xu Shi-hui Sun zhao-Kai Hou jin-Yu Feng School of Petroleum Engineering Northeast Petroleum UniversityDaqing163318HeilongjiangChina Sanya Offshore Oil&Gas Research Institute Northeast Petroleum UniversitySanya572025HainanChina

Real-time intelligent lithology identification while drilling is vital to realizing downhole closed-loop drilling. The complex and changeable geological environment in the drilling makes lithology identification face many challenges. This paper studies the problems of difficult feature information extraction,low precision of thin-layer identification and limited applicability of the model in intelligent lithologic identification. The author tries to improve the comprehensive performance of the lithology identification model from three aspects: data feature extraction, class balance, and model design. A new real-time intelligent lithology identification model of dynamic felling strategy weighted random forest algorithm(DFW-RF) is proposed. According to the feature selection results, gamma ray and 2 MHz phase resistivity are the logging while drilling(LWD) parameters that significantly influence lithology identification. The comprehensive performance of the DFW-RF lithology identification model has been verified in the application of 3 wells in different areas. By comparing the prediction results of five typical lithology identification algorithms, the DFW-RF model has a higher lithology identification accuracy rate and F1 score. This model improves the identification accuracy of thin-layer lithology and is effective and feasible in different geological environments. The DFW-RF model plays a truly efficient role in the realtime intelligent identification of lithologic information in closed-loop drilling and has greater applicability, which is worthy of being widely used in logging interpretation.

关键词： Intelligent drilling Closed-loop drilling Lithology identification Random forest algorithm Feature extraction

Flexible and multifunctional triboelectric nanogenerator based on liquid metal/polyvinyl alcohol hydrogel for energy harvesting and self-powered wearable human-machine interaction

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Rare Metals 2024年第3期43卷 1186-1196页

作者： Hou-Wang Zhou Cong zhao Ze-Yu zhao Jun-Chen Jiang hui-Le jin Shun Wang Shuang Pan Min-Yi Xu Yi-Huang Chen Hai-Ming jin Department of Orthopaedics The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou325027China College of Chemistry and Materials Engineering Wenzhou UniversityWenzhou325035China Dalian Key Laboratory of Marine Micro/Nano Energy and Self-Powered Systems Marine Engineering CollegeDalian Maritime UniversityDalian116026China

Hydrogel-based triboelectric nanoge nerator(TENG)has a promising applied prospect in wearable electronic devices.However,its low performance,poor stability,insufficient recyclability and inferior self-healing seriously hinder its development.Herein,we report a robust route to a liquid metal(LM)/polyvinyl alcohol(PVA)hydrogel-based TENG(LP-TENG).Owing to the intrinsically liquid feature of conductive LM within the flexible PVA hydrogel,the as-prepared LP-TENG exhibited comprehensiye advantages of adaptability,biocompatibility,outstanding electrical performance,superior stability,recyclability and diverse applications,which were unattainable by traditional systems.Concretely,the LP-TENG delivered appealing open circuit voltage of 250 V,short circuit current of 4μA and transferred charge of 120 nC with high stability,outperforming most advanced TENG systems.The LP-TENG was successfully employed for versatile applications with multifunctionality,including human motion detection,handwriting recognition,energy collection,message transmission and human-machine interaction.This work presents significant prospects for crafting advanced materials and devices in the fields of wearable electronics,flexible skin and smart robots.

关键词： Liquid metal Hydrogel Wearable TENG Multifunctionality Human-machine interaction