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The Expression of the IGF Family During Mouse Mammary Gland Development

Agricultural Sciences in China 2007年第9期6卷 1149-1156页

作者： zhao feng li Qing-zhang The Key Laboratory of Dairy Science Ministry of Education~Northeast Agricultural University Harbin 150030 P.R.China

This study was to determine the patterns and levels of IGF family members＇ expression during postnatal mammary gland development. The authors investigated the protein expression profile of the major components of the IGF axis in murine mammary glands. All the proteins examined, IGF- Ⅰ, IGF- Ⅱ, and IGF- Ⅰ receptor （IGF-Ⅰ R） were expressed at greatly different levels and displayed unique expression profiles. IGF- Ⅱ and IGF- ⅠR were always expressed at significantly higher levels than IGF- Ⅰ. IGF- Ⅰwas localized in adipocytes as well as the epithelial and stromal compartments, but just distinctly expressed where mammary cells aggregated to form ducts, in virgins. The IGF- Ⅱ was localized only on the basal layer epithelial cell membranes of ducts and alveoli, with a peak level on the initiation of lactation. The higher level of IGF- ⅠR compared with IGF- Ⅰ was also found in adipocytes as well as in the epithelial and stromal compartments, especially during pregnancy and late lactation. The IGF- Ⅰ R pathway was obviously significant for the development of the mammary parenchyma and stroma. Overall, the comparison of the expression profiles of these different proteins would strongly suggest that they were likely to have different functions throughout the mammary gland development, and it also highlighted the potential interactions and coregulation of the members of this axis. It seems that IGF- Ⅱ was the major local modulator rather than IGF- Ⅰ by an IGF- Ⅰ R-independent pathway, especially for initiation of lactation. This study has demonstrated the importance and complexity of the IGF axis during mammary gland development and provides a valuable resource for future research in this area.

关键词： mammary gland insulin-like growth factors receptor laser scanning confocal microscope (LSCM)

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Effects of body-resistance strengthening and tumor-suppressing granules on immune adhesion function of red blood cells and expression of metastasis protein CD44 in tumor cells of patients with esophageal carcinoma

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World Journal of Gastroenterology 2007年第32期13卷 4360-4364页

作者： Jian-Xiong zhao Xue-feng li Xue-Xi Wang Institute of Combined Western and Chinese Traditional Medicine Lanzhou University Medical School Lanzhou 730000 Gansu Province China

AIM： To investigate the effects of Fuzheng Yiliu granules （body-resistance strengthening and tumor-suppressing granules） in patients with esophageal carcinoma. METHODS： We compared the immune adherent properties of red blood cells （RBCs）, the expression of metastasis protein CD44, and the metastasis inhibition factor nm23, in esophageal carcinoma tumor cells of patients before and after radiotherapy in the presence and absence of orally administered Fuzheng Yiliu granules. Sixty-three hospitalized patients with esophageal carcinoma were treated with standard radiotherapy and randomly divided into treatment group （n = 30） treated with both radiotherapy and Fuzheng Yiliu granules and control group （n = 33） given radiotherapy only. Blood samples and tumor tissue were obtained before and after 21 d of treatment. The rosette rates for complement receptor type 3b （C3bRR） and immune complex receptor （ICRR） on RBCs were measured by erythrocyte immunological methods. Expression of CD44 and rim23 in tumor tissue sections was determined by immunohistochemical staining with monoclonal antibodies CD44v6 ad nm23H-1, respectively. RESULTS： The positivity of RBC-C3bRR before and after 21 d of treatment increased from 7.78% ± 1.59% to 10.03% ± 2.01% in the double treatment group, while it changed only slightly from 7.18% ± 1.29% to 7.46% ± 1.12% in the radiotherapy group. The positive rate for RBC-ICRR decreased from 37.68% ± 2.51% to 22.55% ± 1.65% after the double treatment, and from 37.28% ± 2.41% to 24.69% ± 1.91% in radiotherapy group at the same time points. The difference in erythrocyte immune adherent function between the two groups was significant （P 〈 0.01, t-test）. The CD44^± - cases were reduced from 21 （70.00%） to 12 （40.00%） after treatment with Fuzheng Yiliu granules, whereas the CD44^± -cases （69.70%） in the radiotherapy group remained unchanged. The difference between the treatment （40.00%） and control （69.70%） groups was significant （P 〈 0.05）. Although the nm23^±

关键词： Fuzheng Yiliu granule RBC immune function CD44 nm23 Esophageal carcinoma Metastasis protein CD44 controlled clinical trial

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Medical comorbidities at admission is predictive for 30-day in-hospital mortality in patients with acute myocardial infarction： analysis of 5161 cases

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Journal of Geriatric Cardiology 2011年第1期8卷 31-34页

作者： Xue-Dong Yang Yu-Sheng zhao Yu-feng li Xin-Hong Guo Institute of Geriatric Cardiology Chinese PLA General Hospital Beijing 100853 China

Background The present study investigated the prognostic value of medical comorbidities at admission for 30-day in-hospital mortality in patients with acute myocardial infarction （AMI）. Methods A total of 5161 patients with AMI were admitted in Chinese PLA General Hospital between January 1, 1993 and December 31, 2007. Medical comorbidities including hypertension, diabetes mellitus, previous myocardial infarction, valvular heart disease, chronic obstructive pulmonary disease （COPD）, renal insufficiency, previous stroke, atrial fibrillation and anemia, were identified at admission. The patients were divided into 4 groups based on the number of medical comorbidities at admission （0, 1, 2, and ≥3）. Cox regression analysis was used to calculate relative risk （RR） and 95% confidence intervals （CI）, with adjustment for age, sex, heart failure and percutaneous coronary intervention （PCI）. Results The mean age of the studied population was 63.9 ± 13.6 years, and 80.1% of the patients were male. In 74.6% of the patients at least one comorbidity were identified. Hypertension （50.7%）, diabetes mellitus （24.0%） and previous myocardial infarction （12%） were the leading common comorbidities at admission. The 30-day in-hospital mortality in patients with 0, 1, 2, and ≥3 comorbidities at admission （7.2%） was 4.9%, 7.2%, 11.1%, and 20.3%, respectively. The presence of 2 or more comorbidities was associated with higher 30-day in-hospital mortality compared with patients without comorbidity （RR： 1.41, 95% CI： 1.13-1.77, P = 0.003, and RR： 1.95, 95% CI： 1.59-2.39, P = 0.000, respectively）. Conclusions Medical comorbidities were frequently found in patients with AMI. AMI patients with more comorbidities had a higher 30-day in-hospital mortality might be predictive of early poor outcome in patients with AMI.

关键词： acute myocardial infarction comorbidity mortality

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Synthesis and characterization of novel polyimides based on thiazole-containing diamine

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Chinese Chemical Letters 2007年第10期18卷 1203-1204页

作者： Xin zhao Yan feng li Shu Jiang Zhang Xiao Long-Wang Yu Shao State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical EngineeringInstitute of Biochemical Engineering ＆ Environmental Technology Lanzhou University Lanzhou 730000 China

A new kind of aromatic diamine monomer containing thiazole unit, 2-amino-5-（4-aminophenyl）-thiazole （AAPT）, was synthesized in three steps, starting from 4-nitroacetophenone. A novel thiazole-containing polyimide was prepared via the polycondensation of AAPT with 6FDA by one-step method. The resulting polyimide exhibits excellent solubility, film-forming capability and high thermal resistance.

关键词： Thiazole Thiazole-containing monomer Synthesis Aromatic diamine

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Genome-wide analysis of the calcium-dependent protein kinase gene family in Gossypium raimondii

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Journal of Integrative Agriculture 2015年第1期14卷 29-41页

作者： li li-bei YU Ding-wei zhao feng-li PANG Chao-you SONG Mei-zhen WEI Heng-ling FAN Shu-li YU Shu-xun State Key Laboratory of Cotton Biology Institute of Cotton ResearchChinese Academy of Agricultural Sciences

Plant calcium-dependent protein kinases （CDPKs） play important roles in diverse physiological processes by regulating the downstream components of calcium signaling. To date, only a few species of the plant CDPK gene family have been functionally identified. In addition, there has been no systematic analysis of the CDPK family in cotton. Here, 41 putative cotton CDPK （GrCDPK） genes were identified via bioinformatics analysis of the entire genome of Gossypium raimondii and were classified into four groups based on evolutionary relatedness. Gene structure analysis indicated that most of these GrCDPK genes share a similar intron-exon structure （7 or 8 exons）, strongly supporting their close evolutionary relationships. Chromosomal distributions and phylogenetics analysis showed that 13 pairs of GrCDPK genes arose via segmental duplication events. Furthermore, using microarray data of upland cotton （G. hirsutum L.）, comparative profiles analysis of these GhCDPKs indicated that some of the encoding genes might be involved in the responses to multiple abiotic stresses and play important regulatory roles during cotton fiber development. This study is the first genome-wide analysis of the CDPK family in cotton, and it will provide valuable information for the further functional characterization of cotton CDPK genes.

关键词： GrCDPK cotton stress gene family expression

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Comparison of the autofluorescence bronchoscope and the white light bronchoscope in airway examination

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Chinese Journal of Cancer 2010年第12期29卷 1018-1022页

作者： Yun li Xiao li Xi-zhao Sui liang Bu Zu-li Zhou Fan Yang Yan-Guo liu Hui zhao Jian-feng li Jun liu Guan-Chao Jiang Jun Wang Department of Thoracic Surgery People's Hospital Peking University Beijing 100044 P. R. China

Background and Objective: The sensitivity and accuracy of white light bronchoscopy (WLB) in airway examination are low. Autofluorescence bronchoscope (AFB) can determine early lesions in bronchial mucosa more sensitively, but it has seldom performed in China. To assess the clinical value of the AFB in airway examination, we compared the sensitivity and specificity of the AFB and WLB in detecting cancer of the airway mucosa. Methods: Between September 2009 and May 2010, bronchoscope examinations using both the AFB and WLB were performed on 136 patients, 95 men and 41 women with a median age of 61.5 years (ranged from 25 to 84 years). There were 46 lesions located in the central airway, 84 in the peripheral lung parenchyma, and 6 in the mediastinal region. All patients received local and general anesthesia and were subsequently examined with the WLB and AFB in tandem. All procedures were completed safely. Abnormal visual findings were recorded, and biopsies of the affected regions were collected for pathologic examination. Results: Of 241 regions sampled for biopsy, 76 sites contained malignant lesions, whereas 165 sites contained benign lesions. The AFB detected 72 of the 76 malignant lesions, but the WLB detected only 50. The sensitivities of the AFB and WLB were 94.7% and 65.8%, respectively, and the specificities were 57.0% and 83.6%, respectively. The negative predictive values of the AFB and WLB were 95.9% and 84.1%, respectively. Conclusions: The AFB is more sensitive than the WLB in detecting cancerous lesions in the mucosa, and is an effective airway examination.

关键词：病理检查支气管气道萤光自体检测灵敏度空军基地色光

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Dietary Iodine Intake in the Chinese Population

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Biomedical and Environmental Sciences 2011年第6期24卷 617-623页

作者： SUI Hai Xia li Jian Wen MAO Wei feng ZHU Jiang Hui HE Yu Na SONG Xiao Yu MA Ning ZHANG Lei liU Sa Na liU zhao Ping li feng Qin National Institute of Nutrition and Food Safety China CDC Beijing 100021 China

Objective To evaluate dietary iodine intake and its potential risks among the Chinese population Methods Individual dietary iodine intake was calculated using food consumption data multiplying by iodine concentration in foods, table salt and drinking water, followed by summing, and then compared with the corresponding age-specific reference values, including Upper Intake Level （UL） and Recommended Nutrient Intake （RNI）. Results In areas with water iodine concentration （Wl） lower than 150 ug/L, 80.8% of residents had iodine intake between the RNI and UL, 5.8% higher than UL, and the remaining （13.4%） lower than RNI if iodized salt was consumed. However, in the uniodized salt consumption scenario, only 1.0% of residents between RNI and UL, 1.4% higher than UL, and a large part of residents （97.6%） lower than RNI. In areas with Wl higher than 150 ug/L ,all residents had iodine intake between RNI and UL if iodized salt was consumed, except 10.5% and 24.9% of residents higher than UL in areas with Wl at 150-300 ug/L and higher than 300 ug/L respectively. However, in the uniodized salt consumption scenario, only 1.5% and 1.7% of residents had higher iodine intake than UL respectively. Conclusion The findings suggested that in general, the dietary iodine intake by the Chinese population was appropriate and safe at the present stage. People in areas with WI lower than 150 ug/L were more likely to have iodine deficiency. While people in areas with WI higher than 150 ug/L were more likely to have excessive iodine intake if iodized salt was consumed.

关键词： Iodine Exposure assessment Drinking water Iodine Dietary Iodine Intake

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First total synthesis of two nematicidal prenylated flavanones

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Chinese Chemical Letters 2009年第9期20卷 1062-1064页

作者： Jin Hui Yang Shi Zhi Jiang Yan Min zhao Yun feng li Cong Bin Ji Wan Yi liu Key Laboratory of Energy Resources and Chemical Engineering of Ningxia Ningxia University Yinchuan 750021 China

The total synthesis of （＋）-8-（3-methylbut-2-enyl）-2-phenyl-2,3-dihydrochromen-4-one and （±）-2-（4-hydroxyphenyl）-8-（3- methylbut-2-enyl）-2,3-dihydrochromen-4-one was first achieved through C-prenylation, protection of phenolic hydroxyl group, aldol condensation, cyclization and deprotection starting from cheap benzaldehyde, 4-hydroxybenzaldehyde and 2-hydroxyace- tophenone, with total yield of 20 and 16.3%. All structures of new compounds were confirmed by IR, 1H NMR and MS. 2009 Jin Hui Yang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： Nematicidal Fiavanone Isoprenylflavanoids Total synthesis

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Analysis of resonance asymmetry phenomenon in resonator integrated optic gyro

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Chinese Physics B 2018年第8期27卷 297-300页

作者： Yao Fei Yu-Ming He Xiao-Dong Wang Fu-Hua Yang zhao-feng li Engineering Research Center for Semiconductor Integrated Technology Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China College of Materials Science and Opto-Electronic Technology University of Chinese Academy of ScienceBeijing 100049China School of Microelectronics University of Chinese Academy of SciencesBeijing 100049China

Resonator integrated optic gyro （RIOG） is a high-accuracy gyroscope based on the Sagnac effect. The waveguide- type ring resonator is a key rotation sensing element in the RIOG. An asymmetric resonance line shape is found in the optic resonator. These asymmetries will induce offset errors when the phase modulation spectroscopy technique （PMST） is applied to the RIOG. The polarization errors and the difference among normal mode losses are found to be the two main sources of resonance asymmetry in an experiment. These sources are fully investigated and their contributions to the offset errors are compared. The analysis shows that proper modulation frequencies in clockwise （CW） and counterclockwise （CCW） directions can reduce an RIOG bias error. A transmissive resonator is recommended to obtain a better resonance line shape.

关键词： gyroscopes optical sensing and sensors resonators

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Effects of Substitution of Sm for Bi in BiFeO3 Thin Films Prepared by the Sol-Gel Method

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Chinese Physics Letters 2010年第2期27卷 281-284页

作者：黄宁湘赵立峰许加阳陈吉利赵勇 Key Laboratory of Advanced Materials (Ministry of Education) Superconductivity R&D Center (SRDC) Southwest Jiaotong University Chengdu 610031 School of Materials Science and Engineering University of New South Wale Sydney 2052 NSW Australia

Bi1-xSmxFeO3 films with x= 0, 0.03, 0.05, 0.07 and 0.10 are prepared on LaNiO3/Si（100） substrates by the sol-gel method. X-ray diffraction patterns reveal that pure phase films with random orientations are fabricated. The results of SEM indicate that films with denser surfaces are obtained by Sm substitution. At the doping level of x=0.05, remnant polarization Pr increases to 3.19 μC/cm2 from 1.12 μC/cm2 of the un-substituted BiFeO3 film and shows enhanced ferroelectricity at room temperature. Because of the low leakage current density in the high electric field region, a polarization hysteresis loop with remanent polarization of 5.15 μC/cm2 is observed in the 0.10 Sm-substituted BiFeO3 films at the applied electric field of 226 kV/cm. Through the substitution of Sm, the leakage current density is reduced for the films with x= 0.07-0.10.

关键词： Packaging materials Films Electric field Density Fields Electricity Polarity Optical properties

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