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汉麻籽多肽靶向抑制胰脂肪酶/胆固醇酯酶的分子作用机制

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食品科学 2025年第2期46卷 38-49页

作者：尹浩朱将雄赵海云钟宇王丹凤邓云上海交通大学农业与生物学院上海200240 上海交通大学云南(大理)研究院云南大理671000 云南省大理白族自治州检验检测院云南大理671000

采用酶活动力学、联合抑制、荧光光谱、等温滴定量热法和分子对接等技术系统探究两种多肽(APAM和RLPA)对胰脂肪酶(pancreatic lipase,PL)和胆固醇酯酶(cholesterol esterase,CE)活性调控效果及分子结合机制。结果表明,RLPA对PL和CE具有... 详细信息

采用酶活动力学、联合抑制、荧光光谱、等温滴定量热法和分子对接等技术系统探究两种多肽(APAM和RLPA)对胰脂肪酶(pancreatic lipase,PL)和胆固醇酯酶(cholesterol esterase,CE)活性调控效果及分子结合机制。结果表明,RLPA对PL和CE具有更强的抑制活性,其半抑制浓度分别为(79.62±3.20)μmol/L和(301.27±14.40)μmol/L。抑制动力学分析表明APAM对两种酶的抑制机制为竞争性抑制,而RLPA则为混合性抑制。联合抑制表明APAM和RLPA在低浓度下均可与奥利司他协同抑制PL和CE,但在高浓度下协同作用减弱,甚至出现拮抗现象。荧光光谱结果表明两种多肽可以通过与PL和CE发生结合产生静态猝灭,改变了酶中脂肪族氨基酸的疏水环境。等温滴定量热法证明多肽与酶的结合过程是自发且放热,主要通过氢键和静电相互作用实现。分子对接模拟进一步分析表明氢键、盐桥和阳离子-π相互作用在多肽与酶的结合中起着至关重要的作用。这项研究丰富了对多肽与PL和CE的相互作用机制的认识,为开发基于汉麻籽蛋白的功能性食品提供了科学依据。

关键词：脂质消化酶抑制机制荧光光谱等温滴定量热法分子模拟

Second Harmonic Generation in Nanowires

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Chinese Physics Letters 2024年第10期41卷 43-60页

作者： bi-Jun zhao Jian-Lin zhao Xue-Tao Gan Microelectronics and Nanoelectronics Department School of MicroelectronicsNorthwestern Polytechnical UniversityXi’an 710072China Key Laboratory of Light Field Manipulation and Information Acquisition Ministry of Industry and Information Technologyand Shaanxi Key Laboratory of Optical Information TechnologySchool of Physical Science and TechnologyNorthwestern Polytechnical UniversityXi’an 710072China

Second harmonic generation(SHG)in optical materials serves as important techniques for laser source generations in awkward spectral ranges,physical identities of materials in crystalline symmetry and interfacial ***,we present a comprehensive review on SHGs in nanowires(NWs),which have been recognized as an important element in constructing photonic and optoelectronic devices with compact footprint and high quantum *** on NW’s one-dimensional geometry,its SHG could be employed as a sophisticated spectroscopy to determine the crystal phase and orientation,as well as the internal *** enhancements of SHG efficiency in NWs are discussed then,which were realized by hybrid integrating them with two-dimensional materials,nanophotonic and plasmonic ***,the potential applications of NW SHGs are concluded,including the areas of optical correlators and constructions of on-chip nano-laser sources.

关键词： nanowires integrating constructing

A symplectic finite element method based on Galerkin discretization for solving linear systems

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Applied Mathematics and Mechanics(English Edition) 2023年第8期44卷 1305-1316页

作者： Zhiping QIU zhao WANG Bo zhu Institute of Solid Mechanics School of Aeronautic Science and EngineeringBeihang UniversityBeijing 100083China

We propose a novel symplectic finite element method to solve the structural dynamic responses of linear elastic *** the dynamic responses of continuous medium structures,the traditional numerical algorithm is the dissipative algorithm and cannot maintain long-term energy ***,a symplectic finite element method with energy conservation is constructed in this paper.A linear elastic system can be discretized into multiple elements,and a Hamiltonian system of each element can be *** single element is discretized by the Galerkin method,and then the Hamiltonian system is constructed into the birkhoffian ***,all the elements are combined to obtain the vibration equation of the continuous system and solved by the symplectic difference *** the numerical experiments of the vibration response of the Bernoulli-Euler beam and composite plate,it is found that the vibration response solution and energy obtained with the algorithm are superior to those of the Runge-Kutta *** results show that the symplectic finite element method can keep energy conservation for a long time and has higher stability in solving the dynamic responses of linear elastic systems.

关键词： Galerkin finite element method linear system structural dynamic response symplectic difference scheme

Fabrication of high-quality silver nanowire conductive film and its application for transparent film heaters

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Journal of Materials Science & Technology 2021年第12期71卷 221-227页

作者： Boda Zheng Qingsheng zhu Yang zhao Institute of Metal Research Chinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China

Here,we report a facile method to produce pure silver nanowires(Ag NWs)with high yield.A highly conductive dispersant was used to ensure uniform dispersion of the Ag *** any posttreatment,the Ag NW networks,deposited on flexible substrates,showed excellent optoelectrical performance owing to minimal junction resistance between the Ag *** explore their potential in flexible optoelectronic devices,a transparent film heater was constructed based on the present Ag NW *** heater could achieve rapid response at low input voltage and reach a relatively high temperature in a short response *** this high-quality Ag NW film exhibits relatively low production costs and fast production time,it may have value for future electronic industry applications.

关键词： Silver nanowire Optoelectrical performance Conductive film Transparent film heater Optoelectronic device

Microstructures and soft magnetic properties of Fe_(73.5)Cu_(1)Nb_(3-x)Si_(13.5)B_(9)Yx(x=0-1.5)alloys

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Journal of Rare Earths 2021年第11期39卷 1402-1408,I0004页

作者： Yuchen Mao Zhenghou zhu Hui zhao College of Materials Science and Engineering Nanchang UniversityNanchang 330031China Dayou Technology Co. Ltd.Yichun 336000China Institute of Space Science and Technology Nanchang UniversityNanchang 330031China

Based on composition of Finemet alloy,structures and soft magnetic properties of Fe_(73.5)Cu_(1)Nb_(3-x)Si_(13.5)B_(9)Yx(x=0,0.5,1.0,1.5)alloys formed by replacing Nb(niobium)by Y(yttrium)were studied in this *** research results show that when x=0 or 0.5,rapidly solidified as-cast alloy is Fe amorphous single-phase structure,and Y atoms are dispersed in matrix;when x=1.0 or 1.5,crystalline phase ***_(73.5)Cu_(1)Nb_(3-x)Si_(13.5)B_(9)Yx(x=0,0.5,1.0,1.5)alloys begin to precipitateα-Fe(Si)solid solution phase after crystallization annealing above 480℃,when x=0.5,grain size is 12.6 nm,which shows that Y can replace Nb in small amount and refine grain ***_(73.5)Cu_(1)Nb_(2.5)Si_(13.5)B_(9)Y_(0.5)alloy has excellent soft magnetic properties:μm value is 813.1×10^(3),which is 36%higher than that of Finemet alloy;μi value is 154.6×10^(3),close to that of Finemet alloy,and BS and Hc values are 1.24 T and 0.56 A/m,respectively,better than those of Finemet *** addition,Fe_(73.5)Cu_(1)Nb_(2.5)Si_(13.5)B_(9)Y_(0.5)alloy has excellent soft magnetic properties at high temperature,μe value only reduces by 8.8%at 1 kHz with ambient temperature increased from 30 to150℃,andμe value is 128.02×10^(3)in 150℃,which is 15.74%higher than that of Finemet alloy.

关键词： Iron-based amorphous alloys Soft magnetic properties Rare earth Yttrium

Possible Streams of the Globular Clusters in the Galaxy

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Chinese Journal of Astronomy and Astrophysics 2007年第1期7卷 111-119页

作者： Shuang Gao bi-Wei Jiang Yong-Heng zhao Department of Astronomy Beijing Normal University Beijing 100875 National Astronomical Observatories Chinese Academy of Sciences Beijing 100012

We aim to retrieve ghost streams under the assumption that all the globular clusters in our Galaxy were formed in very early merge events. Our results are based on two speculations： that the specific energy and angular momentum of the globular clusters after merge are not changed in the course of evolution and that the globular clusters with a common origin would stay in the same orbit plane as the parent galaxy. After taking into account the apogalacticum distance of the orbits, we suggest with some Confidence five possible streams. The number of streams is consistent with the previous results. Three of the four well established members of the Sagittadus stream were found to be in one of our streams. Several other globular clusters in our result were also thought to come from accretion by previous researchers. The orbital parameters of the streams are derived, which provide a way to test whether these streams are true with the help of more accurate measurement of proper motions of the globular clusters.

关键词： globular clusters general-Galaxy formation-Galaxy halo

Dechloranes exhibit binding potency and activity to thyroid hormone receptors

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Journal of Environmental Sciences 2022年第2期34卷 16-24页

作者： Jianqiao zhu Lixia zhao Lianghong Guo State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-environmental SciencesChinese Academy of SciencesBeijing 100085China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China Institute of Environmental and Health Sciences China Jiliang UniversityHangzhou 310018China Institute of Environment and Health Jianghan UniversityWuhan 430056China

Dechloranes are a group of halogenated flame retardants with a basic bicyclo[2.2.1]heptene,including Dechlorane Plus(DP),Dechlorane 602(Dec 602),Dechlorane 603(Dec 603)and Dechlorane 604(Dec 604).A few epidemiological investigations and animal experiments have shown that DP exhibited thyroid-interfering *** the present study,we investigated whether DP and three other dechloranes could interfere the thyroid function through thyroid hormone receptors(TRs,TRαand TRβ)signaling *** binding affinities of the four dechloranes to the two TRs were determined by fluorescence competitive binding *** was found that all the four dechloranes could bind with the two *** relative potency(RP)values ranged from nd(not detectable)to *** the two TRs,dechloranes were more inclined to bind with TRβ,which implies that the thyroid interference effect of dechloranes may have selectivity in different tissues and ***-mediated luciferase reporter gene assay and T-screen assay showed that all the four dechloranes exhibited antagonistic activity to TRs in the *** together,our results demonstrated that dechloranes might interfere with thyroid function by binding with TRs and acting as TR *** health risk of highly exposed human populations should be of serious concern because of the high hazard quotient calculated from our cell assay results.

关键词： Antagonists Dechloranes Health risk Thyroid hormone receptors

A bi-metric autoscaling approach for n-tier web applications on kubernetes

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Frontiers of Computer Science 2022年第3期16卷 9-20页

作者： Changpeng zhu Bo HAN Yinliang zhao School of Artificial Intelligence Chongqing University of TechnologyChongqing 401135 School of Computer Science and Engineering Chongqing University of TechnologyChongqing 400054China School of Journalism and New Media Xi’an Jiaotong UniversityXi’an 710049China School of Computer Science and Technology Xi’an Jiaotong UniversityXi’an 710049China

Container-based virtualization techniques are becoming an alternative to traditional virtual machines,due to less overhead and better *** one of the most widely used open-source container orchestration systems,Kubernetes provides a built-in mechanism,that is,horizontal pod autoscaler(HPA),for dynamic resource *** default,scaling pods only based on CPU utilization,a single performance metric,HPA may create more pods than actually *** extensive measurements of a containerized n-tier application benchmark,RUBBoS,we find that excessive pods consume more CPU and memory and even deteriorate response times of applications,due to ***,a Kubernetes service does not balance incoming requests among old pods and new pods created by HPA,due to stateful *** this paper,we propose a bi-metric approach to scaling pods by taking into account both CPU utilization and utilization of a thread pool,which is a kind of important soft resource in Httpd and *** approach collects the utilization of CPU and memory of ***,it makes use of ELBA,a milli-bottleneck detector,to calculate queue lengths of Httpd and Tomcat pods and then evaluate the utilization of their thread *** on the utilization of both CPU and thread pools,our approach could scale up less replicas of Httpd and Tomcat pods,contributing to a reduction of hardware resource *** the same time,our approach leverages preStop hook along with liveness and readiness probes to relieve load imbalance among old Tomcat pods and new *** on the containerized RUBBoS,our experimental results show that the proposed approach could not only reduce the usage of CPU and memory by as much as 14%and 24%when compared with HPA,but also relieve the load imbalance to reduce average response time of requests by as much as 80%.Our approach also demonstrates that it is better to scale pods by multiple metrics rather than a single one.

关键词： autoscaling container kubernetes n-tier web application ELBA

Disinfection byproduct precursor removal by enhanced coagulation and their distribution in chemical fractions

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Journal of Environmental Sciences 2013年第11期25卷 2207-2213页

作者： Yanmei zhao Feng Xiao Dongsheng Wang Mingquan Yan Zhe bi Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Department of Environmental Engineering Peking University

Raw water from the Songhua River was treated by four types of coagulants, ferric chloride （FeC13）, aluminum sulfate （A12（504）3）, polyaluminum chloride （PACl） and composite polyaluminum （HPAC）, in order to remove dissolved organic matter （DOM）. Considering the disinfection byproduct （DBP） precursor treatability, DOM was divided into five chemical fractions based on resin adsorption. Trihalomethane formation potential （THMFP） and haloacetic acid formation potential （HAAFP） were measured for each fraction. The results showed that hydrophobic acids （HoA）, hydrophilic matter （HIM） and hydrophobic neutral （HoN） were the dominant fractions. Although both HoN and HoA were the main THM precursors, the contribution for THMFP changed after coagulation. Additionally, HoA and HiM were the main HAA precursors, while the contribution of HoN to HAAFP significantly increased after coagulation. HoM was more easily removed than HiM, no matter which coagulant was used, especially under enhanced coagulation conditions. DOC removal was highest for enhanced coagulation using FeCl3 while DBPFP was lowest using PAC1. This could indicate that not all DOC fractions contained the precursors of DBPs. Reduction of THMFP and HAAFP by PAC1 under enhanced coagulation could reach 51% and 59% respectively.

关键词： trihalomethanes haloacetic acids dissolved organic matter chemical fractionation enhanced coagulation