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LiDAR-Visual SLAM with Integrated Semantic and Texture Information for Enhanced Ecological Monitoring Vehicle Localization

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Computers, Materials & Continua 2025年第1期82卷 1401-1416页

作者： Yiqing Lu Liutao zhao qiankun zhao Foreign Environmental Cooperation Center Ministry of Ecology and Environment of PRCBeijing100035China Beijing Computing Center Co. Ltd.Beijing Academy of Science and TechnologyBeijing100083China Beijing Guyu Interactive Artificial Intelligence Application Co. Ltd.Beijing100024China

Ecological monitoring vehicles are equipped with a range of sensors and monitoring devices designed to gather data on ecological and environmental *** vehicles are crucial in various fields,including environmental science research,ecological and environmental monitoring projects,disaster response,and emergency management.A key method employed in these vehicles for achieving high-precision positioning is LiDAR(lightlaser detection and ranging)-Visual Simultaneous Localization and Mapping(SLAM).However,maintaining highprecision localization in complex scenarios,such as degraded environments or when dynamic objects are present,remains a significant *** address this issue,we integrate both semantic and texture information from LiDAR and cameras to enhance the robustness and efficiency of data ***,semantic information simplifies the modeling of scene elements,reducing the reliance on dense point clouds,which can be less ***,visual texture information complements LiDAR-Visual localization by providing additional contextual *** incorporating semantic and texture details frompaired images and point clouds,we significantly improve the quality of data association,thereby increasing the success rate of *** approach not only enhances the operational capabilities of ecological monitoring vehicles in complex environments but also contributes to improving the overall efficiency and effectiveness of ecological monitoring and environmental protection efforts.

关键词： LiDAR-Visual simultaneous localization and mapping integrated semantic texture information

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细菌胞外多糖提取优化及毒性试验研究

中国生物工程杂志 2008年第3期28卷 74-78页

作者：程红兵任盛谢红赵良启山西大学化学生物学与分子工程教育部重点实验室太原030006 山西省食品药品监督管理局太原030012

优化了提取Rhizobium sp.N613胞外多糖(REPS)的工艺条件,以发酵液pH值、乙醇浓度以及醇沉时间为因子,采用响应面法试验获得了REPS的最佳提取条件,即pH5.9,乙醇浓度74%,醇沉时间16.5h。在该条件下,胞外多糖提取率为9.28±0.06g/L,其纯度... 详细信息

优化了提取Rhizobium sp.N613胞外多糖(REPS)的工艺条件,以发酵液pH值、乙醇浓度以及醇沉时间为因子,采用响应面法试验获得了REPS的最佳提取条件,即pH5.9,乙醇浓度74%,醇沉时间16.5h。在该条件下,胞外多糖提取率为9.28±0.06g/L,其纯度达97%,收率达93.6%。此外,还进行了REPS的特性粘度、急性毒性测试和蓄积毒性实验,结果表明该多糖具有粘度高、无毒性的特点,在食品医药领域有着广泛的应用前景。

关键词：胞外多糖响应面法提取急性毒性蓄积毒性

Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： Jie Jin Huajing Zhang qianying Lu Linqiang Tian Sanqiao Yao Feng Lai Yangfan liang Chuanchuan Liu Yujia Lu Sijia Tian Yanmei zhao Wenjie Ren Institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine Technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

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发酵生产L-乳酸的现状与展望

山西化工 2005年第1期25卷 15-19页

作者：赵鑫赵良启谢红山西大学化学生物学与分子工程教育部重点实验室山西太原030006 山西省生物研究所山西太原030006

L -乳酸是一种有多种用途的重要的有机酸。概述了生产制备 L -乳酸的方法及其优缺点 ,着重综述了微生物发酵法生产 L -乳酸的研究现状 ,并展望了其发展前景。

关键词： L-乳酸发酵工艺米根霉乳酸菌化学合成法发酵法微生物

Human neural stem cell-derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway

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Neural Regeneration Research 2025年第11期20卷 3245-3258页

作者： Jiayi Wang Mengke zhao Dong Fu Meina Wang Chao Han Zhongyue Lv liang Wang Jing Liu Stem Cell Clinical Research Center The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina Dalian Innovation Institute of Stem Cell and Precision Medicine DalianLiaoning ProvinceChina Institute(College)of Integrative Medicine Dalian Medical UniversityDalianLiaoning ProvinceChina

Human neural stem cell-derived extracellular vesicles exhibit analogous functions to their parental cells,and can thus be used as substitutes for stem cells in stem cell therapy,thereby mitigating the risks of stem cell therapy and advancing the frontiers of stem cell-derived *** lays a foundation for the development of potentially potent new treatment modalities for ischemic ***,the precise mechanisms underlying the efficacy and safety of human neural stem cell-derived extracellular vesicles remain unclear,presenting challenges for clinical *** promote the translation of therapy based on human neural stem cell-derived extracellular vesicles from the bench to the bedside,we conducted a comprehensive preclinical study to evaluate the efficacy and safety of human neural stem cell-derived extracellular vesicles in the treatment of ischemic *** found that administration of human neural stem cell-derived extracellular vesicles to an ischemic stroke rat model reduced the volume of cerebral infarction and promoted functional recovery by alleviating neuronal *** human neural stem cell-derived extracellular vesicles reduced neuronal apoptosis by enhancing phosphorylation of phosphoinositide 3-kinase,mammalian target of rapamycin,and protein kinase B,and these effects were reversed by treatment with a phosphoinositide 3-kinase *** findings suggest that human neural stem cell-derived extracellular vesicles play a neuroprotective role in ischemic stroke through activation of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling ***,we showed that human neural stem cell-derived extracellular vesicles have a good in vivo safety ***,human neural stem cell-derived extracellular vesicles are a promising potential agent for the treatment of ischemic stroke.

关键词： behavior exosome extracellular vesicles ischemic stroke mammalian target of rapamycin(mTOR) middle cerebral artery occlusion neural stem cells neuronal apoptosis phosphoinositide 3-kinase(PI3K) protein kinase B(AKT)

费氏中华根瘤菌合成羟基丁酸和羟基己酸共聚体的研究

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微生物学通报 2007年第6期34卷 1077-1081页

作者：张婵董岳峰王海宾赵良启山西大学化学生物学与分子工程教育部重点实验室太原030006

进行了费氏中华根瘤菌(Sinorhizobium fredii)合成羟基丁酸和羟基己酸共聚体[P(HB-HH)]的研究,通过摇瓶正交试验优化了培养基成分、培养条件和癸酸盐调控条件,采用发酵罐分批发酵和两阶段补料分批发酵方式及两步加盐法研究了P(HB-HH)的... 详细信息

进行了费氏中华根瘤菌(Sinorhizobium fredii)合成羟基丁酸和羟基己酸共聚体[P(HB-HH)]的研究,通过摇瓶正交试验优化了培养基成分、培养条件和癸酸盐调控条件,采用发酵罐分批发酵和两阶段补料分批发酵方式及两步加盐法研究了P(HB-HH)的高密度发酵技术参数。经55h发酵,P(HB-HH)产量可以达到17.55g/L,其中HH单体含量占共聚体的20.6%,该共聚体的分子量约为1.4×105D。结果表明***的生产性状优良,有可能通过该菌株的高密度发酵与代谢调控实现P(HB-HH)的工业化生产。

关键词：费氏中华根瘤菌癸酸盐聚羟基丁酸和羟基己酸共聚体补料分批发酵

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单颗磨粒磨削的分子动力学模拟

青岛理工大学学报 2020年第6期41卷 88-95,150页

作者：赵齐亮王德祥青岛理工大学机械与汽车工程学院青岛266525

为研究磨削加工过程中工件材料的去除机理,采用分子动力学方法模拟单颗磨粒磨削镍基合金的加工过程.利用多面体模板匹配的方法分析了单颗磨粒磨削过程中工件材料晶体结构的演变;研究了磨粒的磨削深度和速度对力、力比(切向力/法向力)和... 详细信息

为研究磨削加工过程中工件材料的去除机理,采用分子动力学方法模拟单颗磨粒磨削镍基合金的加工过程.利用多面体模板匹配的方法分析了单颗磨粒磨削过程中工件材料晶体结构的演变;研究了磨粒的磨削深度和速度对力、力比(切向力/法向力)和温度的影响规律及磨削力产生持续波动的原因;分析了磨削温度形成的内在机制,揭示了磨削界面热量产生的机理.结果表明:在磨削过程中,工件材料的初始面心立方结构主要转变为非晶结构和密排六方结构,少部分转变为体心立方结构;磨削力和力比随磨削深度的增加而增大,磨削速度对力和力比的影响较小,磨削温度随磨削深度和速度的增大而增大;在单颗磨粒磨削过程中,磨削热的主要来源是工件材料所发生的剧烈晶格变形,其次是磨粒与工件材料之间的摩擦.

关键词：磨削单颗磨粒分子动力学模拟晶体结构磨削力磨削温度

新型支架材料羟基丁酸与羟基辛酸共聚体的生物相容性

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中国组织工程研究与临床康复 2008年第10期12卷 1870-1872页

作者：董岳峰谢红郭羽张婵马绍英赵亚平赵良启山西大学生物技术研究所化学生物学与分子工程教育部重点实验室山西省太原市030006 山西省药品食品监督管理局山西省太原市030012 中国辐射防护研究院山西省太原市030006

文章选用细胞毒性实验、急性全身毒性实验、溶血实验、热源实验、皮内刺激实验、遗传毒性实验和皮下植入实验等7个生物相容性实验对生物可降解支架材料羟基丁酸与羟基辛酸共聚体的生物相容性进行评价。结果发现羟基丁酸与羟基辛酸共聚... 详细信息

文章选用细胞毒性实验、急性全身毒性实验、溶血实验、热源实验、皮内刺激实验、遗传毒性实验和皮下植入实验等7个生物相容性实验对生物可降解支架材料羟基丁酸与羟基辛酸共聚体的生物相容性进行评价。结果发现羟基丁酸与羟基辛酸共聚体及其浸提液与小鼠成骨细胞共培养时,细胞生长形态均良好,数量逐渐增加,无细胞毒性;羟基丁酸与羟基辛酸共聚体浸提液无急性毒性反应;其溶血率为1.67%,符合ISO规定的溶血率<5%的标准;将其注入家兔耳缘静脉后未引起发热反应;注入家兔皮内未引起皮肤刺激反应;注入小鼠尾静脉未引起遗传毒性反应;将羟基丁酸与羟基辛酸共聚体膜植入皮下12周,尚未发现明显的炎症反应。提示羟基丁酸与羟基辛酸共聚体具有良好的生物相容性。

关键词：羟基丁酸与羟基辛酸共聚体支架材料生物相容性

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一种根瘤菌胞外多糖对小鼠免疫功能的影响

免疫学杂志 2006年第z1期22卷 149-150,154页

作者：黄晓波张建国韩勇赵良启山西大学化学生物学与分子工程教育部重点实验室太原030006

目的研究一种根瘤菌胞外多糖(REPS)对正常小鼠免疫功能的影响。方法将该多糖以大、中、小3个剂量[(40、20、10 mg/(Kg.d)]给小鼠连续腹腔注射(ip)10 d,测定胸腺质量、脾脏质量、碳粒廓清指数、血清抗绵羊红细胞(SRBC)抗体凝集效价和淋... 详细信息

目的研究一种根瘤菌胞外多糖(REPS)对正常小鼠免疫功能的影响。方法将该多糖以大、中、小3个剂量[(40、20、10 mg/(Kg.d)]给小鼠连续腹腔注射(ip)10 d,测定胸腺质量、脾脏质量、碳粒廓清指数、血清抗绵羊红细胞(SRBC)抗体凝集效价和淋巴细胞转化值。结果与对照组比较,该多糖使小鼠脾脏质量明显增加,单核吞噬细胞的吞噬能力显著增强,提高了血清抗SRBC抗体凝集效价,增强了小鼠脾淋巴细胞转化功能。结论此根瘤菌胞外多糖对小鼠的非特异性和特异性免疫功能均有明显的增强作用。

关键词：根瘤菌胞外多糖免疫