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羟基丁酸与羟基辛酸共聚体骨组织工程支架的初步研究

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功能材料 2009年第3期40卷 459-462,466页

作者：郭羽董岳峰陈璋赵良启山西大学化学生物学与分子工程教育部重点实验室山西太原030006 山西省医药与生命科学研究院山西太原030006

采用粒子滤出／冷冻干燥复合法制备羟基丁酸与羟基辛酸共聚体[P（HB-HO）]多孔支架，并进行扫描电镜观察、孔隙率和力学性能检测以及体外降解和细胞相容性实验。结果表明，P（HB-HO）多孔支架孔隙分布均匀，连通性好，孔隙率为50％～90... 详细信息

采用粒子滤出／冷冻干燥复合法制备羟基丁酸与羟基辛酸共聚体[P（HB-HO）]多孔支架，并进行扫描电镜观察、孔隙率和力学性能检测以及体外降解和细胞相容性实验。结果表明，P（HB-HO）多孔支架孔隙分布均匀，连通性好，孔隙率为50％～90％时，抗压强度在1．7～6．2MPa之间，十二周体外降解率约为20％；与P（HB-HO）复合培养的小鼠成骨样细胞MC3T3-E1黏附率高，生长状态良好。证明P（HB-HO）具有良好的理化性能和细胞相容性，有望成为一种具有临床应用价值的骨组织工程支架材料。

关键词：羟基丁酸与羟基辛酸共聚体骨组织工程支架理化性能细胞相容性

Asymptotic analysis of mode Ⅰ propagating crack-tip field in a creeping material

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Journal of Marine Science and Application 2003年第1期2卷 76-80,86页

作者： WANG Zhen-qing, zhao qi-cheng, liang Wen-yan, FU Zhang-jian School of Civil Engineering,Harbin Engineering University,Harbin 150001, China School of Civil Engineering Harbin Engineering UniversityHarbin 150001 China

Adopting an elastic-viscoplastic, the asymptotic problem of mode I propagat ing crack-tip field is investigated. Various asymptotic solutions resulting from the analysis of crack growing programs are presented. The analysis results show that the quasi-statically growing crack solutions are the special case of the dynamic propagating solutions. Therefore these two asymptotic solutions can be unified.

关键词： elastic-viscoplastic material viscosity coefficient quasi-static growth dynamic propagating

Flexible molecules dedicate to release strain of inverted inorganic perovskite solar cell

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Journal of Energy Chemistry 2025年第1期100卷 87-93页

作者： Hongrui Sun Sanlong Wang Pengyang Wang Yali Liu Shanshan qi Biao Shi Ying zhao Xiaodan Zhang Institute of Photoelectronic Thin Film Devices and Technology Renewable Energy Conversion and Storage Center State Key Laboratory of Photovoltaic Materials and CellsNankai University Key Laboratory of Photoelectronic Thin Film Devices and Technology of Tianjin Haihe Laboratory of Sustainable Chemical Transformations Engineering Research Center of Thin Film Photoelectronic Technology of Ministry of Education Collaborative Innovation Center of Chemical Science and Engineering (Tianjin)

The tensile strain in inorganic perovskite films induced by thermal annealing is one of the primary factors contributing to the inefficiency and instability of inorganic perovskite solar cells （IPSCs）,which reduces the defect formation ***,a flexible molecule 5-maleimidovaleric acid （5-MVA） was introduced as a strain buffer to release the residual strain of *** anhydride and carboxyl groups in 5-MVA interact strongly with the uncoordinated Pb2+through Lewis acid-base reaction,thus tightly“pull”the perovskite *** in-between soft carbon chain increased the structural flexibility of CsPbI2.85Br0.15perovskite materials,which effectively relieved the intrinsic internal strain of CsPbI2.85Br0.15,resisted the corrosion of external strain,and also reduced the formation of defects such as VIand *** addition,the introduction of 5-MVA improved crystal quality,passivated residual defects,and narrowed energy level ***,power conversion efficiency （PCE） of NiOxbased inverted IPSCs increased from 19.25% to 20.82% with the open-circuit voltage enhanced from 1.164 V to 1.230 *** release of strain also improved the stability of CsPbI2.85Br0.15perovskite films and devices.

关键词： Inverted inorganic perovskite solar cells Flexible molecules Strain release Crystallization Energy barrier High PCE

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山西老陈醋中有机酸的HPLC测定分析

食品科学 2007年第11期28卷 456-459页

作者：吕利华梁丽绒赵良启山西大学化学生物学与分子工程教育部重点实验室山西太原030006 太原市疾病预防控制中心山西太原030001

本实验建立了采用离子排斥色谱法快速测定山西老陈醋中的8种主要有机酸的方法。选用PRP-X300离子排斥色谱柱,确定最佳色谱分离条件为:0.05mmol/LH2SO4为流动相,流速1ml/min,柱温为室温,紫外检测器,检测波长为210nm,进样量5μl。各有机... 详细信息

本实验建立了采用离子排斥色谱法快速测定山西老陈醋中的8种主要有机酸的方法。选用PRP-X300离子排斥色谱柱,确定最佳色谱分离条件为:0.05mmol/LH2SO4为流动相,流速1ml/min,柱温为室温,紫外检测器,检测波长为210nm,进样量5μl。各有机酸的相对标准偏差为0.72%～5.47%,回收率达到95.1%～105%。该方法具有简便快速、选择性好、准确度高的特点。

关键词：离子排斥山西老陈醋有机酸高效液相色谱

Rhizobium sp．N613胞外多糖分离纯化及抗S180肉瘤的研究

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中国药学杂志 2008年第4期43卷 268-272页

作者：程红兵韩勇任盛梁丽绒赵良启山西大学化学生物学与分子工程教育部重点实验室太原030006 山西生物应用职业技术学院太原030031 太原市疾病预防控制中心太原030001

目的研究Rhizobiumsp.N613胞外多糖(REPS)的分离纯化条件和抑瘤活性。方法用酸化、加热、凝聚剂和絮凝剂进行发酵液预处理实验,经正交试验优化REPS醇沉制取条件。用凝胶柱色谱,紫外光谱扫描检测经Sevag法脱蛋白质所得REPS的纯度。采用... 详细信息

目的研究Rhizobiumsp.N613胞外多糖(REPS)的分离纯化条件和抑瘤活性。方法用酸化、加热、凝聚剂和絮凝剂进行发酵液预处理实验,经正交试验优化REPS醇沉制取条件。用凝胶柱色谱,紫外光谱扫描检测经Sevag法脱蛋白质所得REPS的纯度。采用动物移植性实体瘤的瘤重实验法研究REPS对小鼠S180肉瘤的抑瘤作用,并对荷瘤小鼠眼眶取血进行白细胞及淋巴细胞计数。结果发酵液预处理参数为:盐酸调节pH5.0,70℃加热20min,依次加入5g.L-1Al2(SO4)3.18H2O和0.2g.L-1海藻酸钠。优化的醇沉制取条件为:调节溶液pH7.0,乙醇浓度65%,醇沉时间8h。REPS经检测为均一多糖。抑瘤实验结果表明,REPS各剂量组对小鼠S180肉瘤均有抑制作用,其中REPS纯多糖剂量为***-1的抑瘤率达44.17%。与荷瘤对照组相比,REPS能够显著促进白细胞和淋巴细胞的增生。结论初步摸索到了发酵液预处理操作的技术参数与醇沉制取的条件。所得REPS对小鼠S180肉瘤有显著的抑制作用。

关键词：根瘤菌胞外多糖分离抑瘤

Lipid droplets in the nervous system:involvement in cell metabolic homeostasis

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Neural Regeneration Research 2025年第3期20卷 740-750页

作者： Yuchen Zhang Yiqing Chen Cheng Zhuang Jingxuan qi Robert Chunhua zhao Jiao Wang School of Life Sciences Shanghai UniversityShanghaiChina School of Medicine Shanghai UniversityShanghaiChina Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic MedicinePeking Union Medical CollegeBeijingChina Center of Excellence in Tissue Engineering Chinese Academy of Medical SciencesBeijingChina Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Therapy BeijingChina

Lipid droplets serve as primary storage organelles for neutral lipids in neurons,glial cells,and other cells in the nervous *** droplet formation begins with the synthesis of neutral lipids in the endoplasmic ***,lipid droplets were recognized for their role in maintaining lipid metabolism and energy homeostasis;however,recent research has shown that lipid droplets are highly adaptive organelles with diverse functions in the nervous *** addition to their role in regulating cell metabolism,lipid droplets play a protective role in various cellular stress ***,lipid droplets exhibit specific functions in neurons and glial *** of lipid droplet formation leads to cellular dysfunction,metabolic abnormalities,and nervous system *** review aims to provide an overview of the role of lipid droplets in the nervous system,covering topics such as biogenesis,cellular specificity,and ***,it will explore the association between lipid droplets and neurodegenerative *** the involvement of lipid droplets in cell metabolic homeostasis related to the nervous system is crucial to determine the underlying causes and in exploring potential therapeutic approaches for these diseases.

关键词： Alzheimer's disease lipid droplet biogenesis lipid droplets lipid metabolism nervous system neurodegenerative disorders oxidative stress Parkinson's disease

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封闭负压引流治疗骨科创伤感染临床疗效探讨

中外医疗 2015年第13期34卷 46-47页

作者：赵启亮黑龙江省农垦红兴隆管理局中心医院骨科黑龙江双鸭山155100

目的对封闭负压引流治疗骨科创伤感染的临床效果进行观察和探讨。方法整群选择2012年4月—2013年5月该院收治的72例骨科外伤感染患者作为研究对象,随机将其分成实验组和对照组,每组36例,实验组患者采取封闭负压引流的治疗方式治疗骨科... 详细信息

目的对封闭负压引流治疗骨科创伤感染的临床效果进行观察和探讨。方法整群选择2012年4月—2013年5月该院收治的72例骨科外伤感染患者作为研究对象,随机将其分成实验组和对照组,每组36例,实验组患者采取封闭负压引流的治疗方式治疗骨科创伤感染,对照组患者采取常规的治疗方式治疗骨科创伤感染,最终分析两组患者的治疗效果。结果实验组患者的治疗效果优于对照组患者,在住院天数方面,实验组患者的住院天数为(19.55±6.53)d,对照组患者的住院天数为(31.53±8.52)d;在换药次数方面,实验组患者的换药次数为(1.51±0.52)次,对照组患者的换药次数为(9.52±2.54)次;在住院费用方面,实验组患者的住院费用为(5211.00±30.53)元,对照组患者的住院费用为(5751.00±45.51)元,差异有统计学意义(P<0.05)。结论封闭负压引流治疗骨科创伤感染的临床效果显著,值得在临床实践中大力推广和实践。

关键词：封闭负压引流骨科创伤感染感染

Establishing a new testing protocol of the electrochemical stability window for electric double-layer capacitors

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Science China Chemistry 2025年第01期 217-225页

作者： Ruilin Hou Xiaoxi zhao Tingting liang qingyun Dou Shan Xu Xingbin Yan School of Materials Science and Engineering Sun Yat-sen University Laboratory of Clean Energy Chemistry and Materials Lanzhou Institute of Chemical Physics Chinese Academy of Sciences College of Engineering and Applied Sciences Nanjing University Center of Industrial Analysis and Testing Guangdong Academy of Science

The electrochemical stability window(ESW) is crucial for determining the energy density of electric double-layer capacitors(EDLCs). However, current ESW testing protocols of EDLCs are strongly affected by artificial factors, thereby leading to unreliable result. To solve this problem, we first identify the key shortcomings of the traditional protocols by analyzing their test principles. Subsequently, taking an aqueous carbon-based EDLC as an example, we design a side reaction descriptor to represent the response difference in the charging capacitance to side reactions between the cyclic voltammetry and galvanostatic chargedischarge methods. With the aid of this descriptor, we propose a new ESW testing protocol, which is not only able to completely avoid the adverse influence of subjective factors but also fully consider the operating condition limitations. The protocol can be extended from the single electrode to the full device. This work proposes a more rigorous definition of ESW and provides a reliable protocol for evaluating the ESW of EDLCs.

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羟基丁酸-羟基辛酸共聚体/脱细胞软骨基质支架的细胞黏附性

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中国组织工程研究与临床康复 2010年第25期14卷 4585-4588页

作者：张永红许钰林汲赵良启山西医科大学第二医院骨科山西省太原市030001 山西大学生物技术研究所化学生物学与分子工程教育部重点实验室山西省太原市030006

背景:羟基丁酸-羟基辛酸共聚体[poly(hydroxybutyrate-co-hydroxyoctanoate),PHBHOx]是一种新型的多聚羟基烷酸类材料,具有优良的可塑性、生物相容性、生物可降解性等性能,但同其他酯类材料相似,PHBHOx亲水性能较差,单纯PHBHOx材料支架... 详细信息

背景:羟基丁酸-羟基辛酸共聚体[poly(hydroxybutyrate-co-hydroxyoctanoate),PHBHOx]是一种新型的多聚羟基烷酸类材料,具有优良的可塑性、生物相容性、生物可降解性等性能,但同其他酯类材料相似,PHBHOx亲水性能较差,单纯PHBHOx材料支架细胞黏附性能明显不足。目的:观察羟基丁酸-羟基辛酸共聚体/脱细胞软骨基质支架的细胞黏附性。方法:取新鲜猪膝关节表面透明软骨,采用非离子型去污剂TritonX-100、低渗Tris-HCl以及Dna酶和Rna酶等进行脱细胞处理。低温粉碎后与PHBHOx以不同比例复合,采用溶剂浇铸-颗粒沥滤技术制备支架。分离培养猪关节软骨细胞,进行细胞-支架黏附实验并通过MTT比色法和扫描电镜观察软骨细胞在支架上的黏附存活情况。结果与结论:PHBHOx/脱细胞软骨基质支架的细胞黏附率较对照组显著提高,软骨细胞在支架上黏附紧密,生长良好。提示复合脱细胞软骨基质可以明显提高单纯PHBHOx支架的细胞黏附性能。

关键词：羟基丁酸-羟基辛酸共聚体脱细胞软骨基质支架材料细胞黏附性