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Journal of Earth Science 1999年第1期18卷 25-28页

作者： Deng Jinfu Mo Xuanxue zhao Hailing Luo zhaohua zhao Guochun Department of Geology and Mineral Resources, China University of Geosciences, Beijing 100083 Department of Geology and Mineral Resources China University of GeosciencesBeijing 100083

Yanshanian igneous rocks in the East China, on an orogenic belt scale, are characterized by the continental marginal arc in petrology and geochemistry as Andes and West USA, except for the Hercyn type biotite two mica muscovite granite belt in the Nanling region. Three segments of the Yanshanian igneous rocks along the belt are recognized. In terms of magma tectonic event sequence, the north, middle and south segments have counter clockwise (ccw), clockwise (cw) and ccw+cw pTt paths of the orogenic process, respectively. A genetic model of the lithospheric delamination (loss of the lithospheric root in about 120 km) in combination with the oceanic subduction for the Yanshanian Andes like orogenic belt and both the crust and lithosphere thickening for the Yanshanian Hercyn type Nanling orogenic belt in the East China is suggested.

关键词： Yanshanian igneous rocks orogenic processes ccw/cw pTt path East China.

The Sequence of Magmatic-Tectonic Events and Orogenic Processes of the Yanshan Belt, North China

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Acta Geologica Sinica(English Edition) 2004年第1期78卷 260-266页

作者： DENG Jinfu, SU Shangguo, MO Xuanxue, zhao Guochun, XIAO Qinghiu, JI Guangyi,QIU Ruizhao, zhao Hailing, LUO zhaohua, WANG Yang and LIU Cui China University of Geosciences, Beijing 100083 and Key Laboratory of Lithospheric Tectonics and Lithoprobe Techniques, Ministry of Education of China China Univ Geosci Beijing 100083 Peoples R China Minist Educ China Key Lab Lithospher Tecton & Lithoprobe Tech Beijing 100083 Peoples R China

This paper emphasizes that the interactive constraints of geology and isotopic dating is the best approach to construct the geological event sequence, and has compiled 106 data of reasonable isotopic ages for the igneous rocks of the Yanshan belt. We propose a sequence of mgmatic-tectonic events in the Jurassic-Cretaceous Yanshan orogen of North China. Five orogenic episodes are divided, (1) pre-and initial orogenic episode (Early Jurassic); (2) early orogenic episode (Middle Jurassic); (3) peak orogenic episode (Late Jurassic); (4) late orogenic episode (early Early Cretaceous), and (5) post-orogenic episode. Each episode is a short cycle, all of the orogenic processes construct a longer cycle, and they, in general, followed a counter-clockwise (ccw) PTt path. Finally, it is suggested that the Yanshanian movement was so intensive that the magmatism and tectonic deformation had involved all the lithosphere thickness and the late-Achaean-formed cratonic lithosphere had been significantly reworked.

关键词： magmatic-tectomc event sequence Yanshan belt orogenic episodes and processes

Yanshanian Magma-Tectonic-Metallogenic Belt in East China of Circum-Pacific Domain(Ⅱ): Lithosphere-Asthenosphere System and Metallogenic Environment

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Journal of Earth Science 1999年第1期18卷 29-33页

作者： Deng Jinfu Mo Xuanxue zhao Hailing Luo zhaohua Dai Shengqian Department of Geology and Mineral Resources, China University of Geosciences, Beijing 100083

This paper shows that the catastrophe of lithosphere asthenosphere system (LAS) is developed for the Yanshanian metallogenic belt in the East China. Two types of Yanshanian disturbed LAS and metallogenesis in the East China are recognized: great lithosphere thinning and thickening in the compressional orogenic environment, and the related Andes type and Hercyn type metallogenesis, respectively. Great amount of the juvenile and hot mantle materials and the reactivated hot lower crustal materials replaced, heated and injected into the cold lithosphere and crust are believed to be a fundamental source and a basic deep environment for the Yanshanian metallogenic explosion. Reactivated and active discontinuities on the lithosphere scale are considered to be the main ore storing space of the metallogenic zone. Large magma tectonic metallogenic system is necessary for the formation of large cluster area of ore deposit. The eastern China is believed to have large potential for prospecting of ore deposits in terms of the metallogenic environment.

关键词： lithosphere asthenosphere system metallogenic environment catastrophe and explosion discontinuity on the lithosphere scale magma fluid metallogenic system and subsystem.

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饲料企业智慧物流服务体系构建研究

中国饲料 2021年第18期 121-124页

作者：赵召华商丘学院河南商丘476000

随着信息化技术的不断发展,将人工智能、物联网及云计算等先进技术运用于物流行业,可带来了巨大的行业发展机遇,智慧物流成为当前物流行业的发展趋势,是物流行业深度改革、提质增效的关键。当前我国饲料竞争激烈,企业竞争不在局限于产... 详细信息

随着信息化技术的不断发展,将人工智能、物联网及云计算等先进技术运用于物流行业,可带来了巨大的行业发展机遇,智慧物流成为当前物流行业的发展趋势,是物流行业深度改革、提质增效的关键。当前我国饲料竞争激烈,企业竞争不在局限于产品价格,高质量的服务、优质的品牌口碑、先进的管理经验等方面成为饲料企业提升竞争力的重要方向之一。我国饲料行业也正在向物流服务一体化、电子商务营销等方向转型,智慧物流能有效提升饲料企业的运输效率。优化原材料、产成品、半成品、存货的管理过程能降低企业的物流成本和人力资源管理成本,加强风险控制水平。因此,饲料行业大力发展智慧物流服务体系建设具有十分重要的意义。本文以饲料企业为研究对象,通过论述当前饲料行业智慧物流的发展现状,并基于饲料企业智慧物流服务体系建设过程中存在的行业标准规范不完善、基础设施建设落后及相关人才缺失等问题提出解决对策,希望对构建我国饲料企业智慧物流服务体系提供参考。

关键词：饲料企业智慧物流服务体系对策

Mechanism of action of Wuzi Yanzong pill in the treatment of oligoasthenozoospermia in rats determined via serum metabolomics

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Journal of Traditional Chinese Medical Sciences 2024年第2期11卷 180-190页

作者： Zhenru Shen zhaohua Zhang Kejin Tong Chunrui Wang Shuaiqiang Wang Ping zhao Meng Gu Jingjing Hu Yibo Tang Zhenquan Liu School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing102488China Beijing Tong Ren Tang Company Limited Beijing100062China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing102488China China Beijing Tong Ren Tang Group Co. Ltd.Beijing100075China Faculty of Chinese Medicine Macao University of Science and TechnologyMacao999078China Department of Pathology University of California San DiegoLa JollaCA92093USA

Objective:To investigate the mechanism of action of Wuzi Yanzong pill(WYP)in rats with oligoasthenozoospermia(OAZ)via metabolomics and to provide a possible basis for improving this WYP-based ***:A rat model of OAZ was established by treating male SpragueeDawley rats with glucosides from Tripterygium wilfordii ***-two rats were randomly divided into six groups:control,L-carnitine(positive control),model,and low-,medium-,and high-dose WYP *** in the experimental groups were treated with WYP for 4 *** the end of the treatment period,sperm cell quality(density,motility,and viability)was assessed using a semen analysis system,mitochondrial membrane potential(MMP)was assessed using flow cytometry,and testicular injury was assessed using hematoxylin and eosin staining to validate the therapeutic effect of WYP in ***,serum metabolomics-based analysis was performed using high-performance liquid chromatography-mass spectrometry to identify differential metabolic pathways and possible mechanisms of action of WYP in OAZ ***:A rat model of OAZ was considered successfully-established after comparing the quality of spermatozoa in the model group to that in the control ***-M and WYP-H treatments significantly improved sperm cell density,motility,and viability compared with those in the model group(all P<.05).Compared with the model group,both WYP-M and WYP-H treatments increased MMP values(P=.006 and P=.021 respectively),while there was no significant difference in the L-carnitine group.L-carnitine and WYP administration reversed damage to the testes to varying degrees compared with that in the model ***,44 differential metabolites and four metabolic pathways,especially autophagy pathway,related to OAZ were identified via ***:WYP improves sperm cell quality and MMP in OAZ primarily via autophagy *** findings can be employed to improve the efficacy of WYP in humans.

关键词： Wuzi Yanzong pill Oligoasthenozoospermia Sperm cell quality Metabolomics Autophagy Male infertility

Baicalein suppresses Coxsackievirus B3 replication by inhibiting caspase-1 and viral protease 2A

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Virologica Sinica 2024年第4期39卷 685-693页

作者： Yanyan Dong Enze Shao Siwei Li Ruiqi Wang Dan Wang Lixin Wang Hong Yang Yingxia He Tian Luan Yang Chen Yao Wang Lexun Lin Yan Wang zhaohua Zhong Wenran zhao Department of Cell Biology Harbin Medical UniversityHarbin 150081China Department of Microbiology Harbin Medical UniversityHarbin 150081China

Myocarditis is an inflammatory disease of the cardiac muscle and one of the primary causes of dilated *** B coxsackievirus(CVB)is one of the leading causative pathogens of viral myocarditis,which primarily affects children and young *** to the lack of vaccines,the development of antiviral medicines is crucial to controlling CVB infection and the progression of *** this study,we investigated the antiviral effect of baicalein,a flavonoid extracted from Scutellaria *** results demonstrated that baicalein treatment significantly reduced cytopathic effect and increased cell viability in CVB3-infected *** addition,significant reductions in viral protein 3D,viral RNA,and viral particles were observed in CVB3-infected cells treated with *** found that baicalein exerted its inhibitory effect in the early stages of CVB3 *** also suppressed viral replication in the myocardium and effectively alleviated myocarditis induced by CVB3 *** study revealed that baicalein exerts its antiviral effect by inhibiting the activity of caspase-1 and viral protease *** together,our findings demonstrate that baicalein has antiviral activity against CVB3 infection and may serve as a potential therapeutic option for the myocarditis caused by enterovirus infection.

关键词： Baicalein Coxsackievirus B(CVB) Myocarditis 2A protease Caspase-1

microRNA-770 regulates proliferation in glioma through CDK8 mediated signaling pathway

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解剖学杂志 2021年第S1期44卷 203-204页

作者： Zhang Junfeng Xu Hao Shi Lili Zhang Li zhao zhaohua Pang Long Chai Xuejun Qi Cunfang Xu Xi Department of Human Anatomy Xi'an Medical UniversityXi'an 710021

microRNAs(miRNAs)play crucial roles in tumorigenesis and tumor ***-770 has been reported to be downregulated in several cancers and it affects cancer cell proliferation,apoptosis,metastasis and drug ***,the role and underlying molecular mechanism of miR-770 in human glioma remain *** of miR 770 in glioma tissues and cell lines were measured by quantitative real-time PCR(qRT-PCR)to explore the association of miR-770 expression and clinicopathological *** expression of CDK8 was detected by qRT-PCR and Western blot in glioma *** prediction program(RegRNA)and dual-luciferase reporter assay were:conducted to confirm the target gene CDK8 of *** and cell counting assays were used to assess the effect of miR-770 on glioma cell *** cell cycle distribution and apoptosis were examined by flow ***8 siRNA and overexpression were used to further confirm the function of the target gene.

关键词： glioma metastasis apoptosis

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无损检测用换能器灵敏度的测量

声学学报 1989年第6期14卷 460-465页

作者：赵其昌陈兆华南京大学声学研究所

在无损检测领域中换能器的灵敏度应该是一个重要的特性,但对于超声探伤用的换能器的灵敏度至今还没有一个有效的方法来进行测量。本文把换能器看成是平面源,推得了它在远场条件下的互易参量。并采用互易技术在固体样品中校准了超声换能... 详细信息

在无损检测领域中换能器的灵敏度应该是一个重要的特性,但对于超声探伤用的换能器的灵敏度至今还没有一个有效的方法来进行测量。本文把换能器看成是平面源,推得了它在远场条件下的互易参量。并采用互易技术在固体样品中校准了超声换能器的灵敏度,实验表明超声探伤用的换能器的发送和接收灵敏度是能够精确测量的,在一定的耦合条件下,测试总精确度在±1dB以内。

关键词：无损检测换能器灵敏度测量

microRNA-770 regulates proliferation in glioma through CDK8 mediated signaling pathway

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microRNA-770 regulates proliferation in glioma through CDK8 ...

HETEROGENEITY OF THE LITHOSPHERE IN TIBETAN PLATEAU ON THE CONSTRAINTS OF MAGMATISM

中国解剖学会2021年年会

作者： Zhang Junfeng Xu Hao Shi Lili Zhang Li zhao zhaohua Pang Long Chai Xuejun Qi Cunfang Xu Xi Department of Human Anatomy Xi’an Medical University

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地学前缘 2000年第S1期7卷 322-322页

作者： Mo Xuanxue,Guo Tieying, zhao Zhidan, Luo zhaohua [WT5,5”BX](China University of Geosciences, Beijing 100083, China)

Many evidences including those from magmatism and igneous rocks strongly support the heterogeneity of lithosphere in Tibetan *** estimation, volcanic and plutonic rocks occupy an area of 300000km\+2, equaling to 10% of total area of the Tibetan Plateau. Temporal and spatial distribution of igneous rocks in the Tibetan Plateau is very inhomogeneous (Mo et al., 1998). Temporarily, most of plutonic and volcanic rocks, which occurred in 60% of total area of igneous rocks in the plateau, formed in the period of 65～45Ma. Spatially, 80% of igneous rocks in the plateau concentrated in the Gangdise—Nyainqentanglha region formed a huge complex granite\|volcanic belt. Petrotectonic assemblage and type of igneous rocks also vary from district to district. While Himalayas (especially High\|Himalayan region) were characterized by well development of muscovite\|bearing granites with no high\|potassium volcanic rocks and other volcanic contemporaries, North Tibet (Qiangtang region) by highly potassic volcanic rock series without muscovite\|bearing granites. Besides wide\|spreading calc\|alkaline igneous rocks, however, both highly potassic volcanic rocks and muscovite\|bearing granites developed in the central portion of Gangdise\|Nyainqentanglha region. It was lack of igneous activities in the Pamirs. Mantle\|derived nodules and their hosted rocks have been found only on northern and eastern margins of the plateau so far. All mentioned above, combined with other evidences from geophysics, geochemistry and structural geology, give us a hint to understand the heterogeneity of the lithosphere in its structure, thermal state and evolution processes underneath Tibetan plateau.

关键词： heterogeneity lithosphere Tibet plateau