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Journal of Earth Science 1999年第1期18卷 25-28页

作者： Deng Jinfu Mo Xuanxue zhao Hailing Luo zhaohua zhao Guochun Department of Geology and Mineral Resources, China University of Geosciences, Beijing 100083 Department of Geology and Mineral Resources China University of GeosciencesBeijing 100083

Yanshanian igneous rocks in the East China, on an orogenic belt scale, are characterized by the continental marginal arc in petrology and geochemistry as Andes and West USA, except for the Hercyn type biotite two mica muscovite granite belt in the Nanling region. Three segments of the Yanshanian igneous rocks along the belt are recognized. In terms of magma tectonic event sequence, the north, middle and south segments have counter clockwise (ccw), clockwise (cw) and ccw+cw pTt paths of the orogenic process, respectively. A genetic model of the lithospheric delamination (loss of the lithospheric root in about 120 km) in combination with the oceanic subduction for the Yanshanian Andes like orogenic belt and both the crust and lithosphere thickening for the Yanshanian Hercyn type Nanling orogenic belt in the East China is suggested.

关键词： Yanshanian igneous rocks orogenic processes ccw/cw pTt path East China.

The Sequence of Magmatic-Tectonic Events and Orogenic Processes of the Yanshan Belt, North China

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Acta Geologica Sinica(English Edition) 2004年第1期78卷 260-266页

作者： DENG Jinfu, SU Shangguo, MO Xuanxue, zhao Guochun, XIAO Qinghiu, JI Guangyi,QIU Ruizhao, zhao Hailing, LUO zhaohua, WANG Yang and LIU Cui China University of Geosciences, Beijing 100083 and Key Laboratory of Lithospheric Tectonics and Lithoprobe Techniques, Ministry of Education of China China Univ Geosci Beijing 100083 Peoples R China Minist Educ China Key Lab Lithospher Tecton & Lithoprobe Tech Beijing 100083 Peoples R China

This paper emphasizes that the interactive constraints of geology and isotopic dating is the best approach to construct the geological event sequence, and has compiled 106 data of reasonable isotopic ages for the igneous rocks of the Yanshan belt. We propose a sequence of mgmatic-tectonic events in the Jurassic-Cretaceous Yanshan orogen of North China. Five orogenic episodes are divided, (1) pre-and initial orogenic episode (Early Jurassic); (2) early orogenic episode (Middle Jurassic); (3) peak orogenic episode (Late Jurassic); (4) late orogenic episode (early Early Cretaceous), and (5) post-orogenic episode. Each episode is a short cycle, all of the orogenic processes construct a longer cycle, and they, in general, followed a counter-clockwise (ccw) PTt path. Finally, it is suggested that the Yanshanian movement was so intensive that the magmatism and tectonic deformation had involved all the lithosphere thickness and the late-Achaean-formed cratonic lithosphere had been significantly reworked.

关键词： magmatic-tectomc event sequence Yanshan belt orogenic episodes and processes

Yanshanian Magma-Tectonic-Metallogenic Belt in East China of Circum-Pacific Domain(Ⅱ): Lithosphere-Asthenosphere System and Metallogenic Environment

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Journal of Earth Science 1999年第1期18卷 29-33页

作者： Deng Jinfu Mo Xuanxue zhao Hailing Luo zhaohua Dai Shengqian Department of Geology and Mineral Resources, China University of Geosciences, Beijing 100083

This paper shows that the catastrophe of lithosphere asthenosphere system (LAS) is developed for the Yanshanian metallogenic belt in the East China. Two types of Yanshanian disturbed LAS and metallogenesis in the East China are recognized: great lithosphere thinning and thickening in the compressional orogenic environment, and the related Andes type and Hercyn type metallogenesis, respectively. Great amount of the juvenile and hot mantle materials and the reactivated hot lower crustal materials replaced, heated and injected into the cold lithosphere and crust are believed to be a fundamental source and a basic deep environment for the Yanshanian metallogenic explosion. Reactivated and active discontinuities on the lithosphere scale are considered to be the main ore storing space of the metallogenic zone. Large magma tectonic metallogenic system is necessary for the formation of large cluster area of ore deposit. The eastern China is believed to have large potential for prospecting of ore deposits in terms of the metallogenic environment.

关键词： lithosphere asthenosphere system metallogenic environment catastrophe and explosion discontinuity on the lithosphere scale magma fluid metallogenic system and subsystem.

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饲料企业智慧物流服务体系构建研究

中国饲料 2021年第18期 121-124页

作者：赵召华商丘学院河南商丘476000

随着信息化技术的不断发展,将人工智能、物联网及云计算等先进技术运用于物流行业,可带来了巨大的行业发展机遇,智慧物流成为当前物流行业的发展趋势,是物流行业深度改革、提质增效的关键。当前我国饲料竞争激烈,企业竞争不在局限于产... 详细信息

随着信息化技术的不断发展,将人工智能、物联网及云计算等先进技术运用于物流行业,可带来了巨大的行业发展机遇,智慧物流成为当前物流行业的发展趋势,是物流行业深度改革、提质增效的关键。当前我国饲料竞争激烈,企业竞争不在局限于产品价格,高质量的服务、优质的品牌口碑、先进的管理经验等方面成为饲料企业提升竞争力的重要方向之一。我国饲料行业也正在向物流服务一体化、电子商务营销等方向转型,智慧物流能有效提升饲料企业的运输效率。优化原材料、产成品、半成品、存货的管理过程能降低企业的物流成本和人力资源管理成本,加强风险控制水平。因此,饲料行业大力发展智慧物流服务体系建设具有十分重要的意义。本文以饲料企业为研究对象,通过论述当前饲料行业智慧物流的发展现状,并基于饲料企业智慧物流服务体系建设过程中存在的行业标准规范不完善、基础设施建设落后及相关人才缺失等问题提出解决对策,希望对构建我国饲料企业智慧物流服务体系提供参考。

关键词：饲料企业智慧物流服务体系对策

民办应用型大学物流管理专业人才培养模式研究

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物流科技 2022年第1期45卷 171-173页

作者：赵召华韩丹丹商丘学院河南商丘476000

国家越来越重视普通本科高校的转型发展问题。作为高等教育之中重要组成部分的民办大学,更应该以应用型人才培养为主要目标,提升服务地方经济的能力。文章通过对部分民办应用型大学物流管理人才培养模式进行调研的基础上,对当前民办应... 详细信息

国家越来越重视普通本科高校的转型发展问题。作为高等教育之中重要组成部分的民办大学,更应该以应用型人才培养为主要目标,提升服务地方经济的能力。文章通过对部分民办应用型大学物流管理人才培养模式进行调研的基础上,对当前民办应用型大学物流管理人才培养的现状从人才需求的特点、人才培养现状两方面开展论述,并深入剖析其中存在的诸多问题,最后提出调整特色专业方向、加强产教融合、校企共育等应用型人才培养模式、搭建多样化的实践教学平台等有针对性的对策建议。

关键词：民办应用型大学物流管理专业人才培养模式

microRNA-770 regulates proliferation in glioma through CDK8 mediated signaling pathway

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解剖学杂志 2021年第S1期44卷 203-204页

作者： Zhang Junfeng Xu Hao Shi Lili Zhang Li zhao zhaohua Pang Long Chai Xuejun Qi Cunfang Xu Xi Department of Human Anatomy Xi'an Medical UniversityXi'an 710021

microRNAs(miRNAs)play crucial roles in tumorigenesis and tumor ***-770 has been reported to be downregulated in several cancers and it affects cancer cell proliferation,apoptosis,metastasis and drug ***,the role and underlying molecular mechanism of miR-770 in human glioma remain *** of miR 770 in glioma tissues and cell lines were measured by quantitative real-time PCR(qRT-PCR)to explore the association of miR-770 expression and clinicopathological *** expression of CDK8 was detected by qRT-PCR and Western blot in glioma *** prediction program(RegRNA)and dual-luciferase reporter assay were:conducted to confirm the target gene CDK8 of *** and cell counting assays were used to assess the effect of miR-770 on glioma cell *** cell cycle distribution and apoptosis were examined by flow ***8 siRNA and overexpression were used to further confirm the function of the target gene.

关键词： glioma metastasis apoptosis

microRNA-770 regulates proliferation in glioma through CDK8 mediated signaling pathway

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microRNA-770 regulates proliferation in glioma through CDK8 ...

血清自身免疫性抗体联合检测在1型糖尿病诊断中的价值研究

中国解剖学会2021年年会

作者： Zhang Junfeng Xu Hao Shi Lili Zhang Li zhao zhaohua Pang Long Chai Xuejun Qi Cunfang Xu Xi Department of Human Anatomy Xi’an Medical University

关键词：

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糖尿病新世界 2024年第6期27卷 51-53,71页

作者：田静苏兆花赵艳烟台市莱阳中心医院检验科山东莱阳265200 日照市人民医院检验科山东日照276826

目的研究血清谷氨酸脱羧酶抗体(Glutamate Decarboxylase Antibodies,GAD-Ab)、胰岛素自身抗体(Insulin Autoantibodies,IAA)、胰岛细胞抗体(Islet cell antibodies,ICA)联合检测在1型糖尿病(Type 1 Diabetes Mellitus,T1DM)诊断中的价值。方法回顾性选取2022年1月—2023年6月烟台市莱阳中心医院诊疗的40例T1DM患者及40名同期来医院体检的健康人群的临床资料,分别设为T1DM组和正常对照组,两组均进行血清GAD-Ab、IAA、ICA检查,研究血清GAD-Ab、IAA、ICA三项联合检测在1型糖尿病诊断中的价值。结果T1DM组血清GAD-Ab、IAA、ICA水平与正常对照组比较明显增高,差异有统计学意义(P均<0.05);三项抗体联合检测诊断T1DM的敏感性(95.00%)、准确性(93.75%)及阴性预测值(94.87)较单项检测明显提高,差异有统计学意义(χ^(2)=24.126,13.628,12.543,P均<0.05)。结论血清GAD-Ab、IAA、ICA三项联合检测明显提高1型糖尿病诊断价值。

关键词： 1型糖尿病血清谷氨酸脱羧酶抗体、胰岛素自身抗体、胰岛细胞抗体诊断

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临床ⅠA期肺腺癌的基因突变特征及其与患者长期预后的关系

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中华肿瘤杂志 2024年第8期46卷 755-763页

作者：张丽刘梦雯李琳赵爽吴丽虹尹朝华李蒙高燕宁吴宁国家癌症中心、国家肿瘤临床医学研究、中心中国医学科学院北京协和医学院肿瘤医院影像诊断科北京100021 国家癌症中心、国家肿瘤临床医学研究中心、中国医学科学院北京协和医学院肿瘤医院病理科北京100021 上海交通大学医学院附属上海儿童医学中心儿科转化医学研究所上海200127 嘉华药锐科技(北京)有限公司北京102206 国家癌症中心、国家肿瘤临床医学研究中心、中国医学科学院北京协和医学院肿瘤医院分子肿瘤学国家重点实验室病因及癌变研究室北京100021

目的探讨临床ⅠA期肺腺癌的基因突变特征及其与患者预后的关系,为早期肺腺癌患者的个体化治疗提供依据。方法收集2007年1月至2012年10月在中国医学科学院肿瘤医院接受手术切除且随访达10年以上或随访期间出现复发或转移的临床ⅠA期肺腺... 详细信息

目的探讨临床ⅠA期肺腺癌的基因突变特征及其与患者预后的关系,为早期肺腺癌患者的个体化治疗提供依据。方法收集2007年1月至2012年10月在中国医学科学院肿瘤医院接受手术切除且随访达10年以上或随访期间出现复发或转移的临床ⅠA期肺腺癌患者63例,采用全外显子组测序(WES)技术分析肺癌组织的基因突变谱,采用单因素和多因素Cox回归分析明确患者预后影响因素。结果在随访期间,63例患者中13例(20.6%)出现复发或转移。WES技术分析显示,肺癌组织中表皮生长因子受体突变频率最高,达65.1%(41/63),其次为肿瘤蛋白p53、异常类脂肪酸1、低密度脂蛋白受体相关蛋白1B、雷帕霉素机械靶点、磷脂酰肌醇4,5-双磷酸3-激酶催化亚单位γ(PIK3CG)及与SWI/SNF相关基质相关的依赖于肌动蛋白的染色质调节因子亚家族A成员4,突变频率分别为30.2%(19/63)、20.6%(13/63)、15.9%(10/63)、15.9%(10/63)、15.9%(10/63)和15.9%(10/63)。多因素Cox回归分析显示,PIK3CG突变(HR=21.52,95%CI:3.19~145.01)、平滑蛋白(SMO)突变(HR=35.28,95%CI:3.12~398.39)、β-连环蛋白1(CTNNB1)突变(HR=332.86,95%CI:15.76~7029.05)、集落刺激因子1受体(CSF1R)突变(HR=8109.60,95%CI:114.19~575955.17)、v-Raf小鼠肉瘤病毒癌基因同源B(BRAF)突变(HR=23.65,95%CI:1.86~300.43)为临床ⅠA期肺腺癌患者预后的独立危险因素。结论PIK3CG、SMO、CTNNB1、CSF1R、BRAF基因突变与临床ⅠA期肺腺癌的远期复发和转移密切相关,应给予具有这些基因突变的肺腺癌患者更为密切的临床关注。

关键词：肺肿瘤腺癌基因突变预后

A mechanically durable,excellent recyclable 3D hierarchical Ni_(3)S_(2)@Ni foam photothermal membrane

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Green Energy & Environment 2022年第3期7卷 492-499页

作者： Zhongping Yao Kailun Yu Mengyao Pan Hongbo Xu Tianqi zhao zhaohua Jiang School of Chemistry and Chemical Engineering State Key Laboratory of Urban Water Resource and EnvironmentHarbin Institute of TechnologyHarbin150001China

Solar-driven water evaporation is considered to be a viable and very efficient technology for fresh water ***,the photothermal membrane has a low absorptivity,low photothermal conversion and poor recyclability,which are difficult to meet the demands of self-floating solar driven evaporators in practical ***,a hierarchical nanostructure Ni_(3)S_(2) has been prepared by in-situ growing method on Ni foam(NF),which shows excellent absorptivity,outstanding recyclable and high mechanically durable *** photothermal membrane was composed of hierarchical nanostructure Ni_(3)S_(2)@NF,which exhibited excellent solar absorption(93.13%) in the wavelength range of 250–2500 nm and sustained anti-corrosion capacity for one *** addition,the hierarchical nanostructure Ni_(3)S_(2)@NF has good hydrophilicity and strong binding force,indicating this photothermal membrane exhibits good stability and outstanding photothermal conversion *** evaporation system based on 3D Ni_(3)S_(2)@NF membrane exhibited excellent water evaporation ability,the highest water evaporation rate(1.53 kg m^(-2)h^(-1)) and the photothermal conversion efficiency(84.7%) under 1 sun *** the desalination experiment,the water evaporation rate and photothermal conversion efficiency almost keep constant over 5 cycles tests and do not decrease compared with the experiment in pure *** result demonstrated that the Ni_(3)S_(2)@NF membrane has shown good corrosion resistance and outstanding *** to the simple preparation method,low cost,outstanding recyclability and high mechanical durability in the sea water,this Ni_(3)S_(2)@NF membrane have great potential for long-term solar distillation applications.

关键词： corrosion durability illumination