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A Prediction Model for Detecting Dysthyroid Optic Neuropathy Based on Clinical Factors and Imaging Markers of the Optic Nerve and Cerebrospinal Fluid in the Optic Nerve Sheath

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Current Medical Science 2024年第4期44卷 827-832页

作者： Hong-yu WU Ban LUO Gang YUAN Qiu-xia WANG ping LIU ya-li zhao Lin-han ZHAI Wen-zhi LV Jing ZHANG Lang CHEN Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Ophthalmology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Endocrinology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Medical Imaging Guangdong Second Provincial General HospitalGuangzhou510317China Department of Radiology Sir Run Run Shaw Hospital Affiliated with the School of Medicine of Zhejiang UniversityHangzhou310000China Department of Artificial Intelligence Julei Technology CompanyWuhan430030China

Objective This study aimed to develop and test a model for predicting dysthyroid optic neuropathy(DON)based on clinical factors and imaging markers of the optic nerve and cerebrospinal fluid(CSF)in the optic nerve *** This retrospective study included patients with thyroid-associated ophthalmopathy(TAO)without DON and patients with TAO accompanied by DON at our *** imaging markers of the optic nerve and CSF in the optic nerve sheath were measured on the water-fat images of each patient and,together with clinical factors,were screened by Least absolute shrinkage and selection ***,we constructed a prediction model using multivariate logistic *** accuracy of the model was verified using receiver operating characteristic curve *** In total,80 orbits from 44 DON patients and 90 orbits from 45 TAO patients were included in our *** variables(optic nerve subarachnoid space and the volume of the CSF in the optic nerve sheath)were found to be independent predictive factors and were included in the prediction *** the development cohort,the mean area under the curve(AUC)was 0.994,with a sensitivity of 0.944,specificity of 0.967,and accuracy of ***,in the validation cohort,the AUC was 0.960,the sensitivity was 0.889,the specificity was 0.893,and the accuracy was *** A combined model was developed using imaging data of the optic nerve and CSF in the optic nerve sheath,serving as a noninvasive potential tool to predict DON.

关键词： dysthyroid optic neuropathy magnetic resonance imaging water-fat sequence optic nerve optic nerve subarachnoid space

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MicroRNA let-7 targets BmCDK1 to regulate cell proliferation and endomitosis of silk gland in the silkworm,Bombyx mori

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Insect Science 2024年第4期31卷 1026-1040页

作者： Wei Wang Linshengzhe Ji Xinyuan Jing ping zhao Qingyou Xia Integrative Science Center of Germplasm Creation in Western China(Chongqing)Science City Biological Science Research CenterSouthwest UniversityChina Key Laboratory for Germplasm Creation in Upper Reaches of the yangtze River Ministry of Agriculture and Rural AffairsChongqingChina Engineering Laboratory of Sericultural and Functional Genome and Biotechnology Development and Reform CommissionChongqingChina

MicroRNAs play critical roles in multiple developmental processes in *** previous study showed that CRISPR/Cas9-mediated knock down of the microRNA let-7 in silkworms increased the size of larvae and silk glands,thereby improving the silk production *** this study,we elucidate the molecular mechanism underlying of let-7 regulates *** of differentially expressed genes in response to let-7 knock down revealed enrichment of pathways associated with cell proliferation and DNA ***-7 dysregulation affected the cell cycle and proliferation of the Bombyx mori cell line ***-luciferase and target site mutation assays showed that BmCDK1 is a direct target gene of let-7,with only 1 binding site on its 3′-untranslated *** interference of BmCDK1 inhibited cell proliferation,but this effect was counteracted by co-transfection with let-7 ***,let-7 knock down induced BmCDK1 expression and promoted cell proliferation in multiple tissues,and further induced endomitosis in the silk gland in *** down of BmCDK1 resulted in abnormal formation of a new epidermis,and larval development was arrested at the 2nd or 3rd molt *** together,our results demonstrated that BmCDK1 is a novel target of let-7 in cell fate determination,possessing potential for improving silk yield in silkworm.

关键词： BmCDKI CRISPR/Cas9 cell proliferation let-7 silkworm

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A Disulfide-Based Poly(ether-b-amide)Copolymer with Rapid Self-healing Ability under Moderate Conditions

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Chinese Journal of Chemistry 2024年第9期42卷 943-950页

作者： Weijan Lu ping Zhu Ying zhao Dujin Wang Xia Dong Institute of Chemistry Chinese Academy of SciencesBeijing 100190China Schoolof Chemical Sciences University of Chinese Academy of SciencesBeijing 100049China

Comprehensive Summary A disulfide-based poly(ether-b-amide)copolymer with rapid self-healing capability under moderate conditions was synthesized from 4,4’-dithiodibutyric acid(DTDBA),isophorondiamine(IPDA)and poly(tetramethylene oxide)(PTMO)based on a two-step *** incorporation of IPDA with asymmetric structure and substantial steric hindrance not only effectively decreased the number of regular H-bonds,but also inhibited the crystallization of polyamide segments,imparting the synthesized poly(ether-b-amide)copolymer with an amorphous structural *** on the coordination of segmental diffusion and recombination of disulfide bonds and hydrogen bonds,the scratches and damaged mechanical properties of PEBADS-I611 could be completely self-healed after healing at 40°C for only 11 min and 3 h,respectively.

关键词： Poly(ether-b-amide)copolymer Disulfide bonds Hydrogen bonds Polycondensation Smart polymers Self-healing

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Analytical solution for the effective elastic properties of rocks with the tilted penny-shaped cracks in the transversely isotropic background

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Petroleum Science 2024年第1期21卷 221-243页

作者： Zheng-Qian Ma Xing-yao Yin zhao-Yun Zong Yuan-Yuan Tan ya-Ming yang National Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao266580ShandongChina School of Geosciences China University of Petroleum(East China)Qingdao 266580ShandongChina Pilot National Laboratory for Marine Science and Technology(Qingdao) Qingdao266200ShandongChina

Seismic prediction of cracks is of great significance in many disciplines,for which the rock physics model is ***,up to now,multitudinous analytical models focus primarily on the cracked rock with the isotropic background,while the explicit model for the cracked rock with the anisotropic background is rarely investigated in spite of such case being often encountered in the ***,we first studied dependences of the crack opening displacement tensors on the crack dip angle in the coordinate systems formed by symmetry planes of the crack and the background anisotropy,respectively,by forty groups of numerical *** on the conclusion from the experiments,the analytical solution was derived for the effective elastic properties of the rock with the inclined penny-shaped cracks in the transversely isotropic ***,we comprehensively analyzed,according to the developed model,effects of the crack dip angle,background anisotropy,filling fluid and crack density on the effective elastic properties of the cracked *** analysis results indicate that the dip angle and background anisotropy can significantly either enhance or weaken the anisotropy degrees of the P-and SH-wave velocities,whereas they have relatively small effects on the SV-wave velocity ***,the filling fluid can increase the stiffness coefficients related to the compressional modulus by reducing crack compliance parameters,while its effects on shear coefficients depend on the crack dip *** increasing crack density reduces velocities of the dry rock,and decreasing rates of the velocities are affected by the crack dip *** comparing with exact numerical results and experimental data,it was demonstrated that the proposed model can achieve high-precision estimations of stiffness ***,the assumption of the weakly anisotropic background results in the consistency between the proposed model and Hudson's published theory for the or

关键词： Effective elastic property Tilted crack Transverse isotropy Analytical solution Crack opening displacement

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Hourly land surface temperature retrieval over the Tibetan Plateau using Geo-LightGBM framework: Fusion of Himawari-8 satellite, ERA5 and site observations

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Advances in Climate Change Research 2024年第4期15卷 623-635页

作者： zhao-Hua LIU Shan-Shan WENG zhao-Liang ZENG Ming-Hu DING ya-Qiang WANG Zhehao LIANG Civil and Surveying&Mapping Engineering Jiangxi University of Science and TechnologyGanzhou 341000China State Key Laboratory of Severe Weather Chinese Academy of Meteoroogical Sciences Beijing 100081China Space Geodesy and Geoinformation Technical Unviersity of BerlinBerlin 10623Germany

The Tibetan Plateau(TP)is highly sensitive to even minor fluctuations in land surface temperature(LST),which can result in permafrost melting and degradation of alpine grasslands,leading to serious ecological ***,it is crucial to have high-temporal-resolution and seamless hourly estimating and monitoring of LST for a better understanding of climate change on the ***,we employed Himawari-8 satellite,Digital Elevation Model(DEM),ERA5 reanalysis and meteorological station observations data to develop a new LightGBM framework(called Geo-LightGBM)for estimating LST on the TP,and then analyzed the spatiotemporal variations of those ***-LightGBM demonstrated excellent LST estimation accuracy,with an R2(coefficient of determination)of 0.971,RMSE(root-mean-square error)of 2.479℃,and MAE(mean absolute error)of 1.510℃.The estimated LST values for the year 2020 agreed well with observed values,with remarkable differences in hourly LST ***,the estimated LST was more accurate than that from ***,there were two high LST centers,located in the yarlung Zangbo River Basin and the Qaidam Basin,and a low LST center located in the central *** SHAP(SHapley Additive exPlanations)and correlation analyses revealed DSCS(the mean ground downward shortwave radiation under clear-sky conditions)to be the most importantly input variable for estimating *** dummy variables(e.g.,longitude,latitude,DEM)were also found to be crucial for model accuracy *** findings indicate the potential for constructing a high-precision and seamless 24-h LST real-time retrieval and monitoring platform for the TP by combining satellite and China's independently developed CLDAS(China Land Data Assimilation System)data in future.

关键词： Tibetan Plateau Himawari-8 ERA5 Land surface temperature Geo-LightGBM

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凌云剑气太白诗

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辽宁大学学报（哲学社会科学版） 2007年第5期35卷 59-63页

作者：赵亚平沈阳大学新民师范学院辽宁沈阳110300

作为中国古代兵器的剑,我们的先祖在实现其使用价值的过程中逐渐赋予它以丰赡的文化内涵,使之成为了某种人文精神的象征,因而骚人韵士也便常将其作为固定的抒情意象摄入吟篇。太白诗中所透射出的"凌云剑气"是其全部歌吟之精魂,蕴聚着建... 详细信息

作为中国古代兵器的剑,我们的先祖在实现其使用价值的过程中逐渐赋予它以丰赡的文化内涵,使之成为了某种人文精神的象征,因而骚人韵士也便常将其作为固定的抒情意象摄入吟篇。太白诗中所透射出的"凌云剑气"是其全部歌吟之精魂,蕴聚着建功立业的英雄壮气,扶危济困的任侠豪气,同心急难的金兰义气,固穷守节的君子正气,傲世独立的隐者骨气,诛强恤弱的仁人怨气,全方位、多视角地展示了大唐王朝的勃然之气,华夏民族的浩然之气,能给读者以强烈的情感震撼和深刻的理智启迪。

关键词：太白诗凌云剑气意象剑

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跨国零售绿色经营推动我国产业绿色提升的路径及措施

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生态经济 2008年第6期24卷 140-143页

作者：赵亚平北京联合大学商务学院北京100025

本文从全球绿色消费发展、全球绿色壁垒加强、全球产业链中绿色竞争加剧的现实出发,提出了提升产业绿色水平已经成为我国当前面临的重要问题之一的观点;依据产业经济学原理,构建了跨国零售绿色经营推动东道国产业绿色提升的分析框架;在... 详细信息

本文从全球绿色消费发展、全球绿色壁垒加强、全球产业链中绿色竞争加剧的现实出发,提出了提升产业绿色水平已经成为我国当前面临的重要问题之一的观点;依据产业经济学原理,构建了跨国零售绿色经营推动东道国产业绿色提升的分析框架;在分析的基础上提出了总体思路,以及政府和行业协会推动企业绿色生产经营的具体措施与建议。

关键词：跨国零售绿色经营产业

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从杜甫与白居易的忧民歌吟看主体的“仁”格差异

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辽宁大学学报（哲学社会科学版） 2008年第3期36卷 50-54页

作者：赵亚平沈阳大学新民师范学院辽宁沈阳110300

在以外施人道、内修人格为特征的儒家"仁学"思想模式及以阐发礼乐为目的的儒家诗学观念占统治地位的封建时代文化语境下,唐朝的诗坛上升起了两颗现实主义巨星——杜甫与白居易,他们忧民歌吟所抵达的儒家人道主义精神境界的高度是整个封... 详细信息

在以外施人道、内修人格为特征的儒家"仁学"思想模式及以阐发礼乐为目的的儒家诗学观念占统治地位的封建时代文化语境下,唐朝的诗坛上升起了两颗现实主义巨星——杜甫与白居易,他们忧民歌吟所抵达的儒家人道主义精神境界的高度是整个封建时代的任何诗人都难与俦比的,他们生命的过程就是各自用忧民歌吟诠释主体道德人格的过程。但主客观条件的不同又使同样以仁善为怀的主体道德人格显示出了很大的差异性——"苦身利人"式的平民诗人与"推己及人"式的贵族诗人的差异,而这种差异即可以通过其忧民歌吟在生存方式、思维方式、情感方式、行为方式等层面上透视出来。

关键词：杜甫白居易儒家忧民歌吟 “仁”格差异

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Mutant rs189037 in ataxia-telangiectasia mutated gene had a negative association with metabolic syndrome but not cognitive decline in centenarians

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Genes & Diseases 2024年第3期11卷 106-108页

作者： Long Feng Hongqi Huo Qun Li Tao yang yali zhao Pei Zhang ping ping Shihui Fu Department of Anesthesiology Hainan Hospital of Chinese People's Liberation Army General HospitalSanyaHainan 572013China Nuclear Medicine Department Handan Central HospitalHandanHebei056001China Department of Neurosurgery Hainan Hospital of Chinese People's Liberation Army General HospitalSanyaHainan 572013China Department of Oncology Hainan Hospital of Chinese People's Liberation Army General HospitalSanyaHainan 572013China Central Laboratory Hainan Hospital of Chinese People's Liberation Army General HospitalSanyaHainan 572013China School of Life Science Beijing Institute of TechnologyBeijing 100081China General Station for Drug and Instrument Supervision and Control Joint Logistic Support Force of Chinese People's LiberationArmyBeijing 100071China Department of Cardiology Hainan Hospital of Chinese People's Liberation Army General HospitalSanyaHainan 572013China Department of Geriatric Cardiology Chinese People's Liberation Army General HospitalBeijing 100853China

Approximately 20%-25%of adults encounter metabolic syndrome(MetS)worldwide,and MetS is a riskfactorfor cognitive decline(CD)*** with MetS have an 11.48-fold increased incidence of CD compared with those without Mets.^(1) Ataxia-telangiectasia mutated(ATM)gene encodes ATM kinase,which belongs to the phosphatidylinositol 3-hydroxy kinase family.

关键词： ATM development cognitive

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A method for support stiffness failure identification in a steel spring floating slab track of urban railway: a case study in China

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第3期25卷 206-222页

作者： Junyuan ZHENG Caiyou zhao Duojia SHI ping WANG Jian WANG Bolong JIANG Xi SHENG Key Laboratoryof High-speed Railway Engineering Ministry of EducationSouthwest Jiaotong UniversityChengdu 60031China School of Civil Engineering Southwest Jiaotong UniversityChengdu 610031China 01 DYNA(Qingdao)Test&Data Co. Ltd.Qingdao 266000China Rail Transit Digital Construction and Measurement Technology National Engineering Research Center China Railway Design CorporationTianjin300308China Institute of Urban Smart Transportation&Safety Maintenance Shenzhen UniversityShenzhen 518060China

The extensive use of steel spring floating slab tracks has effectively addressed the challenge of alleviating the environmental vibrations induced by urban rail transit ***,under the combined action of train dynamic loads and complex environmental factors,problems,such as the fracture of steel spring vibration isolators and suspension vibrations induced by the uneven settlement of the base,often *** failure of isolator support stiffness is often hidden in its early stages and is challenging to identify by conventional detection *** the same time,it will aggravate the wheel-rail interaction,accelerate the deterioration of track structure,and even affect the driving *** study first establishes a detailed coupled train-floating slab track-foundation analytical *** the influence of the vibration isolator support stiffness failure on the dynamic indices of the floating slab track system response is analyzed.A set of defect identification methods that can detect the number of failed steel springs,severity of damage,and their location is ***,an intelligent monitoring system for support stiffness of floating slab track is built by combining the density-based spatial clustering of applications with noise algorithm and statistical data analysis and is applied to a rail line in southern *** a three-year monitoring campaign,a suspension failure and a fracture of a steel spring were each successfully detected and detailed failure information was *** investigation results were consistent with the damage identification *** repair,the track structure dynamic response returned to the average pre-damage level and further deterioration had been *** proposed damage identification methods and monitoring system provide an approach for intelligent identification of track structure support stiffness failures.

关键词： Floating slab track Support stiffness Detailed analytical model Failure identification Monitoring system

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