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Modeling the Interaction between Vacancies and Grain Boundaries during Ductile Fracture

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 2019-2034页

作者： Mingjian Li ping yang Pengyang zhao Department of Engineering Mechanics School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China

The experimental results in previous studies have indicated that during the ductile fracture of pure metals,vacancies aggregate and form voids at grain ***,the physical mechanism underlying this phenomenon remains not fully *** study derives the equilibrium distribution of vacancies analytically by following thermodynamics and the micromechanics of crystal *** derivation suggests that vacancies cluster in regions under hydrostatic compression to minimize the elastic strain ***,a finite element model is developed for examining more general scenarios of interaction between vacancies and grain *** model is first verified and validated through comparison with some available analytical solutions,demonstrating consistency between finite element simulation results and analytical solutions within a specified numerical accuracy.A systematic numerical study is then conducted to investigate the mechanism that might govern the micromechanical interaction between grain boundaries and the profuse vacancies typically generated during plastic *** simulation results indicate that the reduction in total elastic strain energy can indeed drive vacancies toward grain boundaries,potentially facilitating void nucleation in ductile fracture.

关键词： Ductile fracture vacancy grain boundary micromechanical finite element method

Four-to Six-Year Periodic Variation of Arctic Sea-Ice Extent and Its Three Main Driving Factors

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Advances in Atmospheric Sciences 2024年第10期41卷 1999-2010页

作者： ping CHEN Jinping zhao Xiaoyu WANG Institute of Oceanographic Instrumentation Qilu University of Technology(Shandong Academy of Sciences)Qingdao 266000China College of Oceanic and Atmospheric Sciences Ocean University of ChinaQingdao 266000China Frontiers Science Center for Deep Ocean Multispheres and Earth SystemKey Laboratory of Physical OceanographyOcean University of ChinaQingdao 266000China

Besides the rapid retreating trend of Arctic sea-ice extent(SIE),this study found the most outstanding low-frequency variation of SIE to be a 4-6-year periodic *** a clustering analysis algorithm,the SIE in most ice-covered regions was clustered into two special regions:Region-1 around the Barents Sea and Region-2 around the Canadian Basin,which were located on either side of the Arctic Transpolar *** 4-6-year periodic variation in these two regions was identified using a novel method called“running linear fitting algorithm”.The rate of temporal variation of the Arctic SIE was related to three driving factors:the regional air temperature,the sea-ice areal flux across the Arctic Transpolar Drift,and the divergence of sea-ice *** 4-6-year periodic variation was found to have always been present since 1979,but the SIE responded to different factors under heavy and light ice conditions divided by the year *** joint contribution of the three factors to SIE variation exceeded 83%and 59%in the two regions,respectively,remarkably reflecting their dynamic *** is proven that the process of El Niño-Southern Oscillation(ENSO)is closely associated with the three factors,being the fundamental source of the 4-6-year periodic variations of Arctic SIE.

关键词： sea-ice extent periodic variation air temperature sea-ice areal flux Arctic Transpolar Drift ice-drift divergence ENSO

Targeting CD47-SIRPα axis for Hodgkin and non-Hodgkin lymphoma immunotherapy

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Genes & Diseases 2024年第1期11卷 205-217页

作者： Pengcheng zhao Longyan Xie Lei Yu ping Wang School of Life Sciences and Medicine Shandong University of TechnologyZiboShandong 255000China Tongji University Cancer Center Shanghai Tenth People's HospitalSchool of MedicineTongji UniversityShanghai 200092China

The interaction between cluster of differentiation 47(CD47)and signal regulatory proteinα(SiRPa)protects healthy cells from macrophage attack,which is crucial for maintain-ing immune *** of CD47 occurs widely across various tumor cell types and transmits the"don't eat me"signal to macrophages to avoid phagocytosis through binding to *** of the CD47-SIRPa axis is therefore a promising approach for cancer *** is the most common hematological malignancy and is an area of unmet clin-ical *** review mainly described the current strategies targeting the CD47-SIRPa axis,including antibodies,SiRPaFc fusion proteins,small molecule inhibitors,and peptides both in preclinical studies and clinical trials with Hodgkin lymphoma and non-Hodgkin lymphoma.

关键词： Cancer treatment CD47-SIRPαaxis Hodgkin lymphoma Immunotherapy Non-Hodgkin lymphoma

Encouraging Solution to the Problem of Synthesizing Protein α-Thioester

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Chinese Journal of Chemistry 2024年第10期42卷 1114-1120页

作者： Xinliang Liu Zijun Gao Jie zhao Farong Ye ping Huang ping Wang Center for Chemical Glycobiology Shanghai Key Laboratory for Molecular Engineering of Chiral DrugsFrontiers Science Center for Transformative MoleculesSchool of Chemistry and Chemical EngineeringZhangjiang Institute for Advanced StudyShanghai JiaoTongUniversityShanghai 200240China Shenzhen Research Institute of Shanghai Jiao Tong University ShenzhenGuangdong 518057China

Expressed protein ligation(EPL)provides a powerful tool to access large-size proteins with precise *** methods for constructing the critical protein thioester for EPL have predominantly relied on the recombinant intein fusion expressed in Escherichia coli(***).Despite its powerful applications,the expression of thioester derived from eukaryotic protein in *** inherently suffers from its limited solubility,the inactivity of intein,premature hydrolysis and low *** overcome these obstacles,we present herein the facile one-flask synthesis of inaccessible proteinα-thioester via a SUMO-protein-intein(SPI)sandwich *** utility of SUMO enhances the protein fusion yield and solubility,prevents premature hydrolysis and simplifies the purification *** inaccessible protein thioester with internal Cys residues can be readily produced and is compatible with the EPL-desulfurization protocol used to prepare complex proteins,which is otherwise difficult to obtain using traditional *** utility has been highlighted through the synthesis of human granulocyte colony-stimulating factor(G-CSF).

关键词： Desulfurization Glycoproteins Glycopeptides Protein expression Peptide thioester

Promoted monolithic perovskite/organic tandem solar cells through elaborate manipulation of light transmission and carrier tunneling in interconnect junction

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Science China Chemistry 2024年第9期67卷 3131-3139页

作者： Rongbo Wang Jiawei Zhang Juntao zhao ya Wang Yi Ding Ying zhao Xiaodan Zhang Guofu Hou Institute of Photoelectronic Thin Film Devices and Technology Renewable Energy Conversion and Storage CenterSolar Energy Conversion CenterNankai UniversityTianjin 300350China Key Laboratory of Photoelectronic Thin Film Devices and Technology of Tianjin Tianjin 300350China Engineering Research Center of Thin Film Photoelectronic Technology of Ministry of Education Tianjin 300350China State Key Laboratory of Photovoltaic Materials and Solar Cells Tianjin 300350China

Monolithic perovskite/organic tandem solar cells(TSCs)have emerged as promising thin film solar *** is recognized that interconnect junction plays a pivotal role in tandem ***,wide bandgap Cs_(0.25)FA_(0.75)Pb(I_(0.6)Br_(0.4))_(3)perovskite top-cell and narrow bandgap PM6:Y6:PC_(61)BM ternary organic bottom-cell were integrated in this study with several kinds of thin metal interconnect layers,which provides feasibility to elaborately manipulate light transmission and carrier tunneling process in interconnect *** is confirmed that,in comparison with Au,employing an Ag interconnect layer elevates integrated transmittance of light in longer wavelength regions,mainly because of the alleviated screening effect with a lower free electron concentration,which offers sufficient light harvest for the ***,established energy barriers with moderate height afford convenient extraction and recombination for both holes and ***,the performance of TSCs is promoted ***,an innovative Ag/Au double interconnect layer is proposed accordingly,which can preserve exceptional conductivity and light transmission and further reduce barrier height,especially for hole tunneling,by optimizing the band alignment between the interconnect layer and ***,the monolithic perovskite/organic TSC with a striking efficiency of 23.26% is *** a word,this study can pave a general approach toward high-performance TSCs integration.

关键词： tandem solar cells band alignment perovskite organic solar cells interconnect junction

Vibration transfer from underground train to multi-story building:Modelling and validation with in-situ test data

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Underground Space 2024年第6期19卷 301-316页

作者： Li Wang Xin Gao Caiyou zhao ping Wang Zili Li Section of Railway Engineering Delft University of TechnologyStevinweg 12628CN DelftThe Netherlands Key Laboratory of High-speed Railway Engineering(Southwest Jiaotong University) Ministry of EducationChengdu 610031China

Excessive underground train-induced vibration becomes a serious environmental problem in *** investigate the vibration transfer from an underground train to a building nearby,an explicit-integration time-domain,three-dimensional finite element model is *** underground train,track,tunnel,soil layers and a typical multi-story building nearby are all fully coupled in this *** complex geometries involving the track components and the building are all modelled in detail,which makes the simulation of vibration transfer more realistic from the underground train to the *** model is validated with in-situ tests data and good agreements have been achieved between the numerical results and the experimental results both in time domain and frequency *** proposed model is applied to investigate the vibration transfer along the floors in the building and the influences of the soil stiffness on the vibration characteristics of the track-tunnel-soil-building *** is found that the building vibration induced by an underground train is dominant at the frequency determined by the P2 resonance and influenced by the vibration modes of the *** vertical vibration in the building decreases in a fluctuant pattern from the foundation to the top floor due to loss of high frequency contents and local *** vibration levels in different rooms at a same floor can be different due to the different local stiffness.A room with larger space thus smaller local stiffness usually has higher vibration *** soil layers make the tunnel lining and the building have more low frequency *** influence of the soil stiffness on the amplification scale along the floors of the building is found to be nonlinear and frequency-dependent,which needs to be further investigated.

关键词： Railway vibration Underground train Multi-story building vibration Finite element model Dynamic interaction

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地方院所提升自主创新能力研究

地域研究与开发 2006年第3期25卷 10-12页

作者：赵亚平河南省科学院郑州450002

河南省科学院是全国地方科学院中综合实力比较强的单位之一,在材料科学、生物工程、化学化工、能源与环境技术、电子与自动化和软科学研究领域均拥有独特自主创新优势,在建设创新型河南中将发挥重要作用。为了贯彻落实全国科学技术大会... 详细信息

河南省科学院是全国地方科学院中综合实力比较强的单位之一,在材料科学、生物工程、化学化工、能源与环境技术、电子与自动化和软科学研究领域均拥有独特自主创新优势,在建设创新型河南中将发挥重要作用。为了贯彻落实全国科学技术大会精神,河南省科学院将采取多种措施,深化管理体制改革,努力打造一流的创新团队,力争在自然科学领域大幅度提升自主创新能力。

关键词：自主创新人才团队河南省科学院

残疾人就业的模式创新探索——以长春市有劳动能力的残疾人为例

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东北师大学报（哲学社会科学版） 2010年第1期 49-53页

作者：赵燕平长春工业大学人文学院吉林长春130012

创新是实现事业快速发展的不竭动力。残疾人事业和残疾人就业工作的快速发展同样需要从体制与模式的不断创新中获得动力。因此,在残疾人就业难的原因分析的基础上,探索具有特色的扩大残疾人就业的创新模式,对于开创我市残疾人事业的新局... 详细信息

创新是实现事业快速发展的不竭动力。残疾人事业和残疾人就业工作的快速发展同样需要从体制与模式的不断创新中获得动力。因此,在残疾人就业难的原因分析的基础上,探索具有特色的扩大残疾人就业的创新模式,对于开创我市残疾人事业的新局面,迅速提升我市残疾人的就业率和就业质量,都将起到积极的推动作用。

关键词：残疾人就业模式创新

Automatic detection of small bowel lesions with different bleeding risks based on deep learning models

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World Journal of Gastroenterology 2024年第2期30卷 170-183页

作者： Rui-ya Zhang Peng-Peng Qiang Ling-Jun Cai Tao Li yan Qin Yu Zhang Yi-Qing zhao Jun-ping Wang Department of Gastroenterology The Fifth Clinical Medical College of Shanxi Medical UniversityTaiyuan 030012Shanxi ProvinceChina School of Computer and Information Technology Shanxi UniversityTaiyuan 030006Shanxi ProvinceChina School of Life Sciences and Technology Mudanjiang Normal UniversityMudanjiang 157011Heilongjiang ProvinceChina

BACKGROUND Deep learning provides an efficient automatic image recognition method for small bowel(SB)capsule endoscopy(CE)that can assist physicians in ***,the existing deep learning models present some unresolved *** To propose a novel and effective classification and detection model to automatically identify various SB lesions and their bleeding risks,and label the lesions accurately so as to enhance the diagnostic efficiency of physicians and the ability to identify high-risk bleeding *** The proposed model represents a two-stage method that combined image classification with object ***,we utilized the improved ResNet-50 classification model to classify endoscopic images into SB lesion images,normal SB mucosa images,and invalid ***,the improved YOLO-V5 detection model was utilized to detect the type of lesion and its risk of bleeding,and the location of the lesion was *** constructed training and testing sets and compared model-assisted reading with physician *** The accuracy of the model constructed in this study reached 98.96%,which was higher than the accuracy of other systems using only a single *** sensitivity,specificity,and accuracy of the model-assisted reading detection of all images were 99.17%,99.92%,and 99.86%,which were significantly higher than those of the endoscopists’*** image processing time of the model was 48 ms/image,and the image processing time of the physicians was 0.40±0.24 s/image(P<0.001).CONCLUSION The deep learning model of image classification combined with object detection exhibits a satisfactory diagnostic effect on a variety of SB lesions and their bleeding risks in CE images,which enhances the diagnostic efficiency of physicians and improves the ability of physicians to identify high-risk bleeding groups.

关键词： Artificial intelligence Deep learning Capsule endoscopy Image classification Object detection Bleeding risk