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Overview of the main biological mechanisms linked to changes in periodontal ligament stem cells and the inflammatory microenvironment

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第5期24卷 373-386页

作者： xuetao zhao Hongbing LIN Tong DING Yawei WANG Na LIU Yuqin SHEN Department of Periodontics Jilin Provincial Key Laboratory of Tooth Development and Bone RemodelingHospital of StomatologyJilin UniversityChangchun 130021China Department of Periodontics Affiliated Stomatology Hospital of Guangzhou Medical UniversityGuangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative MedicineGuangzhou 510182China

Periodontitis is a complex chronic inflammatory *** invasion of pathogens induces the inflammatory microenvironment in *** behavior changes in response to changes in the microenvironment,which in turn alters the local inflammatory microenvironment of the periodontium through factors secreted by *** has been confirmed that periodontal ligament stem cells(PDLSCs)are vital in the development of periodontal ***,PDLSCs are the most effective cell type to be used for periodontium *** review focuses on changes in PDLSCs,their basic biological behavior,osteogenic differentiation,and drug effects caused by the inflammatory microenvironment,to provide a better understanding of the influence of these factors on periodontal tissue *** addition,we discuss the underlying mechanism in detail behind the reciprocal responses of PDLSCs that affect the microenvironment.

关键词： Inflammatory microenvironment Inflammatory regulation Osteogenic differentiation Periodontal ligament stem cells Periodontitis

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人工湿地发展现状

林业科技情报 2024年第2期56卷 125-127页

作者：马晓龙赵雪涛杨海娇石坤冉善水博通(宁夏)环境科技有限公司银川750001

作为水环境保护体系的重要角色,人工湿地在我国发展迅速,被广泛应用于各种污水体系建设。该文系统总结了人工湿地研究的发展现状,梳理了近年来国内外人工湿地类型及优缺点现状。并且针对人工湿地的植物、基质等主要组成部分的成果做研... 详细信息

作为水环境保护体系的重要角色,人工湿地在我国发展迅速,被广泛应用于各种污水体系建设。该文系统总结了人工湿地研究的发展现状,梳理了近年来国内外人工湿地类型及优缺点现状。并且针对人工湿地的植物、基质等主要组成部分的成果做研究分析,旨为今后的人工湿地设计、建设和运维提供技术参考。

关键词：人工湿地现状类型植物选型基质

The RNA m^(6)A demethylase ALKBH5 drives emergency granulopoiesis and neutrophil mobilization by upregulating G-CSFR expression

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Cellular & Molecular Immunology 2024年第1期21卷 6-18页

作者： Yang Liu Renjie Song Zhike Lu Lu zhao Xinyi Zhan Yini Li xuetao Cao Department of Immunology Center for ImmunotherapyInstitute of Basic Medical SciencesPeking Union Medical CollegeChinese Academy of Medical SciencesBeijingChina Suzhou Institute of Systems Medicine Chinese Academy of Medical SciencesSuzhouChina Frontier Research Center for Cell Response Institute of ImmunologyCollege of Life SciencesNankai UniversityTianjinChina School of Life Sciences Westlake UniversityHangzhouChina

Emergency granulopoiesis and neutrophil mobilization that can be triggered by granulocyte colony-stimulating factor(G-CSF)through its receptor G-CSFR are essential for antibacterial innate ***,the epigenetic modifiers crucial for intrinsically regulating G-CSFR expression and the antibacterial response of neutrophils remain largely unclear.N6-methyladenosine(m^(6)A)RNA modification and the related demethylase alkB homolog 5(ALKBH5)are key epigenetic regulators of immunity and inflammation,but their roles in neutrophil production and mobilization are still *** used cecal ligation and puncture(CLP)-induced polymicrobial sepsis to model systemic bacterial infection,and we report that ALKBH5 is required for emergency granulopoiesis and neutrophil ***5 depletion significantly impaired the production of immature neutrophils in the bone marrow of septic *** addition,Alkbh5-deficient septic mice exhibited higher retention of mature neutrophils in the bone marrow and defective neutrophil release into the circulation,which led to fewer neutrophils at the infection site than in their wild-type *** bacterial infection,ALKBH5 imprinted production-and mobilization-promoting transcriptome signatures in both mouse and human ***,ALKBH5 erased m^(6)A methylation on the CSF3R mRNA to increase the mRNA stability and protein expression of G-CSFR,consequently upregulating cell surface G-CSFR expression and downstream STAT3 signaling in *** RIP-qPCR results confirmed the direct binding of ALKBH5 to the CSF3R mRNA,and the binding strength declined upon bacterial infection,accounting for the decrease in G-CSFR expression on bacteria-infected *** these results collectively,we define a new role of ALKBH5 in intrinsically driving neutrophil production and mobilization through m^(6)A demethylation-dependent posttranscriptional regulation,indicating that m^(6)A RNA modification in neutrop

关键词： Emergency granulopoiesis Neutrophil mobilization ALKBH5 m^(6)A RNA modification G-CSF receptor

Water-saving Technologies,Solar Green House and Ecological Rehabilitation in Minqin Oasis of Gansu Province,China

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Chinese Journal of Population,Resources and Environment 2008年第3期6卷 73-82页

作者： Tao Weichun Shi Minjun zhao xuetao Graduate University of Chinese Academy of Sciences CAS Beijing 100049 China Research Center on Fictitious Economy and Data Science CAS Beijing 100080 China

Land degradation and desertification have become severe environmental problems in arid areas due to excessive use of water resources. It is urgent to reduce agricultural water use for ecological rehabilitation, which may result in a decrease in agricultural production and farmer＇s welfare. This paper focused on the impacts of some main measures including extensions of watersaving irrigation, expanding solar green house and increasing off-farm employment, which are generally recognized to be important to alleviate water shortage and poverty. A bioconomic model is applied taking Minqin Oasis in Gansu Province as a case study site. Simulation results showed that the effect of expanding solar greenhouse was more positive than other ones so it drew more attention. On the view of the different effects between each irrigation zone, mixed policy patterns suitable for them are suggested. In Baqu, expanding solar greenhouse should be the most important, auxiliary with encouraging pipe irrigation. Inversely, with regard to Quanshan, the major attention should be paid to subsidy for pipe irrigation and it would be better to supply the off-farm employment opportunities to the households in Huqu, where the expanding of solar greenhouse should also be summoned. Finally, it should be noted that farmer＇s income would only resume to 90% of the current level in the short run by putting more effort into local policies. Thus, the ecological compensation is needed to ensure farmer＇s welfare.

关键词： water-saving technologies solar green house Minqin Oasis ecological rehabilitation

Restoring periodontal tissue homoeostasis prevents cognitive decline by reducing the number of Serpina3nhigh astrocytes in the hippocampus

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The Innovation 2024年第1期5卷 98-108页

作者： Zongshan Shen Shuhong Kuang Yong Zhang Jiayao Chen Shuting Wang Congfei Xu Yunjia Huang Min Zhang Shuheng Huang Jun Wang ChuanJiang zhao Zhengmei Lin xuetao Shi Bin Cheng Hospital of Stomatology Guangdong Provincial Key Laboratory of StomatologyGuanghua School of StomatologySun Yat-sen UniversityGuangzhou 510060China National Engineering Research Centre for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhou 510006China Key Laboratory of Biomedical Engineering of Guangdong Province South China University of TechnologyGuangzhou 510006China School of Biomedical Science and Engineering South China University of TechnologyGuangzhou 510650China The First Affiliated Hospital Sun Yat-sen UniversityGuangzhou 510080China

Cognitive decline has been linked to periodontitis through an undetermined pathophysiological *** study aimed to explore the mechanism underlying periodontitis-related cognitive decline and identify therapeutic strategies for this *** single-nucleus RNA sequencing we found that changes in astrocyte number,gene expression,and cell‒cell communication were associated with cognitive decline in mice with *** addition,activation of the NOD-like receptor family pyrin domain containing 3(NLRP3)inflammasome was observed to decrease the phagocytic capability of macrophages and reprogram macrophages to a more proinflammatory state in the gingiva,thus aggravating *** further investigate this finding,lipid-based nanoparticles carrying NLRP3 siRNA(NPsiNLRP3)were used to inhibit overactivation of the NLRP3 inflammasome in gingival macrophages,restoring the oral microbiome and reducing periodontal ***,gingival injection of NPsiNLRP3 reduced the number of Serpina3nhigh astrocytes in the hippocampus and prevented cognitive *** study provides a functional basis for the mechanism by which the destruction of periodontal tissues can worsen cognitive decline and identifies nanoparticle-mediated restoration of gingival macrophage function as a novel treatment for periodontitis-related cognitive decline.

关键词： NLRP3 periodontal number

A study of benef its compensation mechanism for agricultural water rights trading under the restriction of ecological reconstruction:a case study of Shiyang River basin

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Ecological Economy 2008年第4期4卷 454-461页

作者： zhao xuetao Shi Minjun Tao Weichun Graduate University Chinese Academy of Sciences Beijing 100049 P. R. China Research Center on Fictitious Economy and Data Sciences Chinese Academy of Sciences Beijing 100080 P R. China

Agricultural water allocation system based on priority rights has caused regional conflicts and downstream ecological degradation. It is the urgent need to introduce the concept of the initial water rights and establish benefits compensation mechanism to resolve such problems. This paper takes the Shiyang River basin as an example to calculate the opportunity cost of 0.97×10^8 m^3 of agricultural water encroached by the middle reach based on initial water right allocation system under which water is allocated in accordance with the ratio between agricultural population of two different regions concerning the downstream ecological reconstruction needs with Bio-economic model （BEM）. The results suggest that the total economic loss of Minqin County for ecological reconstruction amounts to 2.5 7×10^8 yuan, of which 1.68×10^8 yuan is ecological compensation, representing the economic loss Minqin suffered for ecological reconstruction which shouM burden beneficial groups of ecological reconstruction and 0.89 ×10^8 yuan is the economic loss Minqin suffered due to Liangzhou＇s encroachment behavior which should be compensated by Liangzhou.

关键词： Ecological reconstruction Water right trading, Benefit compensation Shiyang River basin

Automatic modeling algorithm of stochastic error for inertial sensors

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Control Theory and Technology 2024年第1期22卷 81-91页

作者： Luodi zhao Long zhao School of Automation Science and Electrical Engineering Beihang UniversityBeijing100191China Digital Navigation Center Beihang UniversityBeijing100191China Science and Technology on Aircraft Control Laboratory Beihang UniversityBeijing100191China

This paper proposes an automatic algorithm to determine the properties of stochastic processes and their parameters for inertial error. The proposed approach is based on a recently developed method called the generalized method of wavelet moments (GMWM), whose estimator was proven to be consistent and asymptotically normally distributed. This algorithm is suitable mainly (but not only) for the combination of several stochastic processes, where the model identification and parameter estimation are quite difficult for the traditional methods, such as the Allan variance and the power spectral density analysis. This algorithm further explores the complete stochastic error models and the candidate model ranking criterion to realize automatic model identification and determination. The best model is selected by making the trade-off between the model accuracy and the model complexity. The validation of this approach is verified by practical examples of model selection for MEMS-IMUs (micro-electro-mechanical system inertial measurement units) in varying dynamic conditions.

关键词： GMWM Stochastic process Inertial sensor Sensor calibration Error model Allan variance

Meeting the challenges of invasive alien species

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National Science Review 2024年第3期11卷 296-298页

作者： Weijie zhao NSR news

The Xinjiang Uygur Autonomous Region of China is famous for its tomato production. Abundant sunshine, large day–night temperature difference and the abundant irrigation by snowmelt from the Tianshan Mountains produce...

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Ling-Ling Chen: RNA has its own features;don't study it as a protein

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National Science Review 2024年第2期11卷 301-305页

作者： Weijie zhao NSR

Non-coding RNA(ncRNA) has been a very active research area over the past 30 years. From small nc RNA – the discovery of RNA interference won the lead researchers the Nobel Prize, to long ncRNA(lncRNA), which has attracted much attention in recent years, various nc RNAs participate in all kinds of biological processes and show a variety of biomedical application prospects.

关键词： RNA