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Endovascular therapy for Acute ischemic Stroke Trial (EAST): study protocol for a prospective, multicentre control trial in china

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Stroke & Vascular Neurology 2016年第2期1卷 44-51页

作者： Zhongrong Miao Xiaochuan Huo Feng Gao Xiaoling Liao Chunjuan Wang Ya Peng Yibin Cao shengli Chen Meng Zhang Changchun Jiang Xiaoxiang Peng Cunfeng Song Liping Wei Qiyi Zhu Zaiyu guo Li Liu Hang Lin Hua Yang Wei wu Hui Liang Anding Xu Kangning Chen Xingquan {{3. Yuesong Pan Hao Li Liping Liu Yilong Wang Yongjun Wang EAST investigators Department of Interventional Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina china National Clinical Research Center for Neurological Diseases BeijingChina Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Tiantan Clinical Trial and Research Center for StrokeBeijing Tiantan HospitalCapital Medical UniversityBeijingChina Center of Stroke Beijing Institute for Brain DisordersBeijingChina Department of Neurosurgery Changzhou No 1 People’s HospitalChangzhouChina Department of Neurology Tangshan Gongren HospitalTangshanChina Department of Neurology Chongqing Sanxia Central HospitalChongqingChina Department of Neurology Daping HospitalChongqingChina Department of Neurology Baotou Central HospitalBaotouChina Department of Neurology Hubei Zhongshan HospitalWuhanChina Department of Neurology Liaocheng Third People’s HospitalLiaochengChina Department of Neurology Luoyang Central Hospital affiliated to Zhengzhou UniversityChina Department of Neurology People’s Hospital of Linyi CityChina Department of Neurology Tianjin TEDA HospitalChina Department of Neurology Chifeng Municipal HospitalChina Department of Neurology Fuzhou PLA General HospitalChina Department of Neurology Affiliated Hospital of Guiyang Medical CollegeChina Department of Neurology Qilu Hospital of Shandong UniversityChina Department of Neurology Yantai Hill HospitalChina Department of Neurology The First Affiliated Hospital of Jinan UniversityChina Department of Neurology Xinan HospitalChina Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease BeijingChina Neuro-intensive Care Unit Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina 不详

Background and purpose:5 recent trials have shown the benefit of endovascular treatment for acute ischaemic stroke(AIS)due to large vessel occlusion of the anterior *** study aims to evaluate the safety and efficacy of Solitaire thrombectomy in patients with moderate-to-severe stroke in the Chinese population,which has a high prevalence of intracranial *** and analysis:This multicentre prospective control study will involve 17 stroke centres in china,and plans to recruit 150 patients in the intervention group,and 150 patients in the medical group,in which patients meet enrolment criteria but refuse *** with AIS due to large vessel occlusion indicated for treatment with Solitaire stent retriever within 12.hours of symptom onset,and who meet the inclusion and exclusion criteria,will be enrolled in this *** primary efficacy endpoint is functional independence as defined by a modified Rankin Scale(mRS)score≤2.at 90 days or by functional improvement as defined by mRS,using shift *** procedural efficacy endpoint is arterial recanalisation of the occluded target vessel measured by a modified Thrombolysis in Cerebral Infarction(mTICI)score equal or superior to 2. right following the use of the study *** primary safety endpoint is symptomatic intracranial haemorrhage(sICH)within 2.±3.hours *** and dissemination:The protocol was approved by the Ethics Committee at the coordinating centre and by the local Institutional Review Board of each participating *** registration number:NCT02.502.3.

关键词： prospective centre occlusion

鄂尔多斯盆地奥陶系盐下马四段天然气成藏新认识及勘探重大突破

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石油勘探与开发 2022年第3期49卷 429-439页

作者：何海清郭绪杰赵振宇席胜利王居峰宋微任军峰吴兴宁毕赫中国石油勘探与生产分公司北京100007 中国石油勘探开发研究院北京100083 中国石油长庆油田公司西安710018

基于大量钻井、测井和地震资料分析,对鄂尔多斯盆地奥陶系盐下马家沟组四段天然气地质条件与成藏主控因素开展研究,提出古隆起控相、控储、控藏新认识:①马家沟组沉积期,中央古隆起分隔盆地中东部华北海与西南缘秦祁海两大沉积体系,在... 详细信息

基于大量钻井、测井和地震资料分析,对鄂尔多斯盆地奥陶系盐下马家沟组四段天然气地质条件与成藏主控因素开展研究,提出古隆起控相、控储、控藏新认识:①马家沟组沉积期,中央古隆起分隔盆地中东部华北海与西南缘秦祁海两大沉积体系,在马四段台缘带发育巨厚丘状颗粒滩相白云岩,同时控制盆地中东部形成“两隆两凹”古地理格局,其中水下低隆带发育台内滩相白云岩,隆间低洼区发育泥灰岩。②由中央古隆起至盆地东缘,马四段白云岩逐渐减薄并相变为灰岩,灰岩致密带侧向封挡形成大面积白云岩岩性圈闭。③加里东末期中央古隆起遭受不同程度剥蚀,面积达6×10^(4) km^(2.,上古生界石炭系—二叠系煤系优质烃源岩大面积披覆沉积,成为下伏奥陶系盐下白云岩岩性圈闭规模供烃主体。④印支期—燕山期盆地西倾掀斜,中央古隆起下拗转变为高效供烃窗,上古生界煤系烃源岩通过中央古隆起高孔渗白云岩体向上倾高部位侧向供烃,盐下海相烃源岩作为重要的气源补充,通过加里东期断裂、微裂缝输导供烃。以新认识为指导,转变勘探思路,综合评价优选盆地中东部马四段两大有利勘探区,部署实施两口风险探井均钻遇较厚马四段(含)气层,其中1口井获高产工业气流。该研究推动了奥陶系盐下马四段天然气勘探的历史性突破,开辟了鄂尔多斯盆地天然气勘探的重要新领域。

关键词：鄂尔多斯盆地奥陶系盐下马家沟组四段中央古隆起岩性相变带天然气成藏米探1井

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A Mucin-Like Protein of Planthopper Is Required for Feeding and Induces Immunity Response in Plants

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A Mucin-Like Protein of Planthopper Is Required for Feeding ...

Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)

2.18全国植物生物学大会

作者： Xinxin Shangguan Jing Zhang Bingfang Liu Yan zhao Huiying Wang Zhizheng Wang Jianping guo Weiwei Rao {2. Jing Wei Guan Yinhua Ma Yan {3. Liang Hu Rongzhi Chen Bo Du Lili Zhu Dazhao Yu Guangcun He State Key Laboratory of Hybrid Rice College of Life SciencesWuhan University Institute for Plant Protection and Soil sciences Hubei Academy of Agricultural Sciences

The brown planthopper,Nilaparvata lugens,is a pest that threatens rice(Oryza sativa)production *** feeding on rice plants,planthoppers secrete saliva,which plays crucial roles in nutrient ingestion and modulating plant defense responses,although the specific functions of salivary proteins remain largely *** identified a ***-secreted mucin-like protein(N1 MLP) by transcriptome and proteome analyses and characterized its function,both in brown planthopper and in *** is highly expressed in salivary glands and is secreted into rice during ***,of NlMLP expression in planthoppers disturbs the formation of salivary sheaths,thereby reducing their *** plants,NIMLP induces cell death,the expression of defense-related genes,and callose *** defense responses are related to Ca mobilization and the MEK2.MAP kinase and JA signaling *** active region of NIMLP that elicits plant responses is located in its *** work provides a detailed characterization of a salivary protein from a piercing-sucking insect other than *** finding that the protein that functions in plant immune responses offers new insights into the mechanismunderlying interactions between plants and herbivorous insects.

关键词： brown planthopper salivary protein insect-plantinteraction plantdefense response

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1198-1207页

作者： Hai-Dong Zhu Hai-Liang Li Ming-Sheng Huang Wei-Zhu Yang guo-Wen Yin Bin-Yan Zhong Jun-Hui Sun Zhi-Cheng Jin Jian-Jian Chen Nai-Jian Ge Wen-Bin Ding Wen-Hui Li Jin-Hua Huang Wei Mu Shan-Zhi Gu Jia-Ping Li Hui zhao Shu-Wei Wen Yan-Ming Lei Yu-Sheng Song Chun-Wang Yuan Wei-Dong Wang Ming Huang Wei zhao Jian-Bing {3. Song Wang Xu Zhu Jian-Jun Han Wei-Xin Ren Zai-Ming Lu Wen-Ge Xing Yong Fan Hai-Lan Lin Zi-Shu Zhang guo-Hui Xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng Zheng Yong Chen Xu-Ya zhao Zhu-Ting Fang Qi Wang Jin-Wei zhao Ai-Bing Xu Jian Xu Qing-Hua {3. Huan-Zhang Niu Jian Wang Feng Dai Dui-Ping Feng Qing-Dong Li Rong-Shu Shi Jia-Rui Li Guang Yang Hai-Bin Shi Jian-Song Ji Yu-E Liu Zheng Cai Po Yang Yang zhao Xiao-Li Zhu Li-Gong Lu Gao-Jun Teng Center of Interventional Radiology&Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjing 210009China Department of Minimally invasive Intervention The Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450008China Department of Interventional Radiology the Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510630China Department of Interventional Radiology Union Hospital of Fujian Medical UniversityFuzhou 350001China Department of Interventional Radiology Jiangsu Cancer Hospital&Jiangsu Institute of Cancer Research&The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009China Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Hepatobiliary and Pancreatic Interventional Treatment Center Division of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Interventional Radiology Eastern Hospital of Hepatobiliary SurgeryNavy Medical University(Second Military Medical University)Shanghai 200438China Department of Interventional Radiology Nantong First People’s HospitalNantong 226001China Department of Interventional Radiology Yancheng Third People’s HospitalYancheng 224008China Department of Minimally Invasive Interventional Therapy Sun YatSen University Cancer CenterGuangzhou 510060China Department of Vascular Surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China. Department of Interventional Radiology Hunan Cancer HospitalChangsha 410031China Department of Interventional Oncology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Interventional Radiology The Hospital of Nantong UniversityNantong 226001China Department of Interventional Therapy Shanxi Tumor HospitalTaiyuan 030001China Department of Interventional Radiology Tibet Autonomous Region People’s

There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world *** this nationwide,retrospective,cohort study,82. HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=3.6)or TACE monotherapy(monotherapy group,n=450)were included from January 2.18 to May *** primary endpoint was progression-free survival(PFS)according to modified *** secondary outcomes included overall survival(OS),objective response rate(ORR),and *** performed propensity score matching approaches to reduce bias between two *** matching,2.8 pairs were included with a predominantly advanced disease *** PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002..OS and ORR were also significantly higher in combination group(median OS,19.2.16.1-2..3.vs.15.7 months[13.0-2..2.;adjusted HR,0.63.P=0.001;ORR,60.1%vs.3.0}0%;P3.4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,*** results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile.

关键词： hepatocellular targeted matching

中硬低渗煤层定向长钻孔水力压裂瓦斯高效抽采技术与应用

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煤田地质与勘探 2020年第6期48卷 103-108,115页

作者：郭超奇赵继展李小建张静非仵胜利陈冬冬黄兴利李宝军陕西黄陵二号煤矿有限公司陕西黄陵727307 中煤科工集团西安研究院有限公司陕西西安710077

针对黄陇侏罗纪煤田中硬煤层渗透性差、瓦斯抽采浓度及流量衰减速度快等问题,利用自主研发的水力压裂成套工艺设备,提出煤层定向长钻孔水力压裂瓦斯高效抽采技术,并在黄陇煤田黄陵二号煤矿进行工程应用试验。现场共完成5个定向长钻孔钻... 详细信息

针对黄陇侏罗纪煤田中硬煤层渗透性差、瓦斯抽采浓度及流量衰减速度快等问题,利用自主研发的水力压裂成套工艺设备,提出煤层定向长钻孔水力压裂瓦斯高效抽采技术,并在黄陇煤田黄陵二号煤矿进行工程应用试验。现场共完成5个定向长钻孔钻探施工,单孔孔深2.0-2.5 m,总进尺1 3.0} m;采用整体压裂工艺对5个本煤层钻孔进行压裂施工,累计压裂液用量1 557.5 m3.单孔最大泵注压力19 MPa;压裂后单孔瓦斯抽采浓度及百米抽采纯量分别提升0.7-2..5倍、1.7~9.8倍;相比于普通钻孔,压裂孔瓦斯初始涌出强度提升2.1倍,钻孔瓦斯流量衰减系数降低3..6%。试验结果表明:采取水力压裂增透措施后,瓦斯抽采效果得到显著提升,煤层瓦斯可抽采性增加,为类似矿区低渗煤层瓦斯高效抽采提供了技术支撑。

关键词：黄陵矿区定向长钻孔裸眼坐封水力压裂瓦斯抽采

肝癌组织中miR-43.表达及其对多西他赛化疗耐药的机制研究

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中国临床药理学杂志 2020年第11期36卷 1507-1510页

作者：隋守光赵素伟路建宽吴淦春郭磊郭玉岩胜利油田中心医院血管介入科山东东营257034 青岛市第八人民医院急诊医学科山东青岛257034

目的研究肝癌组织中miR-43.表达及其对多西他赛(DOC)化疗耐药机制。方法常规培养人肝癌细胞株(HepG2.的DOC耐药的肝癌细胞(HepG2.DOC)。将实验分为3.:正常组、对照组(miR43.-NC2.和实验组(miR-43.-mimics)。以实时定量聚合酶链反应法测... 详细信息

目的研究肝癌组织中miR-43.表达及其对多西他赛(DOC)化疗耐药机制。方法常规培养人肝癌细胞株(HepG2.的DOC耐药的肝癌细胞(HepG2.DOC)。将实验分为3.:正常组、对照组(miR43.-NC2.和实验组(miR-43.-mimics)。以实时定量聚合酶链反应法测定miR-43.基因在肝癌和癌周组织的表达,用Hoechst3.3.2.PI染色法测定细胞凋亡率,用蛋白质印迹法检测cAMP反应元件结合蛋白(CREB1)表达;用荧光素酶报告基因分析miR-43.和CREB1的关系。结果 miR-43.基因在癌旁组织、肝癌组织中的表达分别为0.98±0.03.0.3.±0.14,miR-43.与CREB1具有靶向调控关系。正常组、对照组和实验组的细胞的凋亡率分别为(45±8)%,(43.11)%和(78±15)%;这3.的CREB1表达量分别为0.99±0.08,0.95±1.01和4.78±0.57。上述指标:实验组与正常组和对照组相比,差异均有统计学意义(均P3.能够明显抑制HepG2.DOC增殖,并通过调控CREB1的表达来增强细胞对DOC的敏感性。

关键词：多西他赛耐药HepG2.胞化疗耐药微小RNA43. 多西他赛

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不同原油界面活性组分的分离及表征

精细化工 2007年第5期24卷 457-461页

作者：郭继香李明远林梅钦吴肇亮中国石油大学(北京)提高采收率研究中心北京102249

用极性分离法将胜利油田孤东1#、孤东4#原油和大庆原油分离为饱和分、芳香分、胶质、沥青质组分(S、Ar、R、As)。孤东1#和孤东4#沥青质组分质量分数(14.43.、11.3.%)明显高于大庆原油沥青质组分质量分数(0.09%),而饱和分组分质量分数(47... 详细信息

用极性分离法将胜利油田孤东1#、孤东4#原油和大庆原油分离为饱和分、芳香分、胶质、沥青质组分(S、Ar、R、As)。孤东1#和孤东4#沥青质组分质量分数(14.43.、11.3.%)明显高于大庆原油沥青质组分质量分数(0.09%),而饱和分组分质量分数(47.08%、46.54%)低于大庆原油饱和分质量分数(68.08%)。孤东1#和孤东4#原油的原油组分(S、Ar、R、As)氧的质量分数、酸值由大到小的排序为:沥青质>胶质Ⅰ>芳香分>饱和分。而大庆原油的原油组分酸值由大到小的排序为:胶质Ⅰ>沥青质>芳香分>饱和分;大庆原油的饱和分组分中氧质量分数较低,饱和分中氧质量分数在原油氧中所占比例最高(0.3.5%),饱和分中的氧化物对大庆原油的界面活性影响不可忽视。在3.原油所有原油组分中,孤东1#原油沥青质的酸值最大(16.45 mg KOH/g沥青质),说明孤东1#原油沥青质组分含有较多酸性基团,反应活性较强。色-质分析结果表明,孤东原油饱和分正构烷烃在C10-C3.呈双正态分布,大庆原油饱和分正构烷烃主要分布在C10-C3.,基本呈正态分布。

关键词：原油分离酸值沥青质表面活性剂

基于人工智能的地球物理参数反演范式理论及判定条件

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智慧农业（中英文） 2023年第2期5卷 161-171页

作者：毛克彪张晨阳施建成王旭明郭中华李春树董立新吴门新孙瑞静武胜利姬大彬蒋玲梅赵天杰邱玉宝杜永明徐同仁中国农业科学院农业资源与农业区划研究所北方干旱半干旱耕地高效利用全国重点实验室北京100081 宁夏大学物理与电子电气工程学院宁夏银川750021 中国科学院空天信息创新研究院遥感科学国家重点实验室北京100094 北京大学环境科学与工程学院北京100871 中国科学院国家空间科学中心北京100190 国家卫星气象中心北京100081 国家气象中心北京100081 北京师范大学地理科学部北京100875

[目的/意义]人工智能(Artificial Intelligence,AI)技术已在学术和工程应用领域掀起了研究高潮,在地球物理参数和农业气象遥感参数反演方面也表现出了强大的应用潜力。目前大部分AI技术在地学和农学的应用还是“黑箱”,没有物理意义或... 详细信息

[目的/意义]人工智能(Artificial Intelligence,AI)技术已在学术和工程应用领域掀起了研究高潮,在地球物理参数和农业气象遥感参数反演方面也表现出了强大的应用潜力。目前大部分AI技术在地学和农学的应用还是“黑箱”,没有物理意义或缺乏可解释性及通用性。为了促进AI在地学和农学的应用和培养交叉学科的人才,本研究提出基于AI耦合物理和统计方法的地球物理参数反演范式理论。[方法]首先基于物理能量平衡方程进行物理逻辑推理,从理论上构造反演方程组,然后基于物理推导构建泛化的统计方法。通过物理模型模拟获得物理方法的代表性解以及利用多源数据获得统计方法代表性的解作为深度学习的训练和测试数据库,最后利用深度学习进行优化求解。[结果和讨论]判定形成具有通用性和物理可解释的范式条件包括:(1)输入与输出变量(参数)之间必须存在因果关系;(2.输入和输出变量(参数)之间理论上可以构建闭合的方程组(未知数个数少于或等于方程组个数),也就是说输出参数可以被输入参数唯一确定。如果输入参数(变量)和输出参数(变量)之间存在很强的因果关系,则可以直接使用深度学习进行反演。如果输入参数和输出参数之间存在弱相关性,则需要添加先验知识来提高输出参数的反演精度。此外,本研究以农业气象遥感中的关键参数地表温度、发射率、近地表空气温度和大气水汽含量联合反演作为案例对理论进行了证明,分析结果表明本理论是可行的,并且可以辅助优化设计卫星传感器波段组合。[结论]本理论和判定条件的提出在地球物理参数反演史上具有里程碑意义。

关键词：人工智能深度学习反演范式物理逻辑推导可解释农业气象遥感

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爱因斯坦探针：探索变幻多姿的X射线宇宙

中国科学：物理学、力学、天文学 2018年第3期48卷 2-21页

作者：袁为民张臣陈勇孙胜利张永合崔伟凌志兴黄茂海赵冬华王文昕裘予雷刘柱潘海武蔡洪波邓劲松贾振卿金驰川孙惠胡海波刘飞飞张墨宋黎明卢方军贾淑梅李承奎赵海升葛明玉张娟崔苇苇王于仨王娟孙小进金戈黎龙辉陈凡胜蔡志鸣郭彤刘国华刘华秋冯骅张双南张冰戴子高吴雪峰苟利军中国科学院国家天文台中国科学院空间天文与技术重点实验室北京100012 中国科学院大学天文与空间科学学院北京100049 中国科学院高能物理研究所北京100049 中国科学院上海技术物理研究所上海200083 中国科学院微小卫星创新研究院上海201203 清华大学天体物理中心北京100084 北方夜视技术股份有限公司南京211106 Department of Physics and Astronomy University of Nevada Las VegasNV 89154USA 北京大学科维理天文与天体物理研究所和天文系北京100871 南京大学天文与空间科学学院南京210093 中国科学院紫金山天文台南京210034

爱因斯坦探针(Einstein Probe,EP)是一颗面向时域天文学的、发现型的X射线天文探测卫星,是中国科学院空间科学战略性先导专项十三五规划的空间科学卫星系列任务之一.展望未来十年,时域天文学将进入一个前所未有的、多波段和多信使的大... 详细信息

爱因斯坦探针(Einstein Probe,EP)是一颗面向时域天文学的、发现型的X射线天文探测卫星,是中国科学院空间科学战略性先导专项十三五规划的空间科学卫星系列任务之一.展望未来十年,时域天文学将进入一个前所未有的、多波段和多信使的大视场监测的黄金时代.在软X射线窗口,灵敏且快速的全天监测为我们提供了一个难得的科学机遇.EP卫星将在这一能段窗口开展时域巡天监测,旨在发现和探索宇宙中的X射线暂现源和爆发天体,并发布预警以引导其他天文设备进行后随跟踪观测.EP的科学载荷包括一台宽视场软X射线监视器(3.00平方度,0.5–4 keV)和一台后随观测X射线望远镜(0.3.8 keV).卫星具有快速机动反应能力以及暂现源警报的快速下传功能.由于采用了新颖的微孔龙虾眼X射线聚焦成像技术,其探测灵敏度和空间分辨率比目前在轨运行设备提高了1个数量级,将能监测更远、更大的宇宙空间范围.预期EP将在以下三方面做出贡献:高能暂现天体的系统性巡天监测,发现隐身的沉寂黑洞并测绘宇宙黑洞的分布、研究其形成演化和物质吸积过程,搜寻来自引力波事件的X射线信号并精确定位等.此外,EP的探测目标还将包括从中子星、白矮星、超新星、宇宙早期伽玛暴、X射线闪到恒星耀发等众多的天体和现象,涉及广泛的天体物理学分支.卫星计划于2.2.年底左右发射.运行寿命为3.,目标5年.

关键词： X射线:空间科学 X射线:时域天文学空间科学卫星:爱因斯坦探针