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Piezoresistive pressure sensor with high sensitivity for medical application using peninsula-island structure

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Frontiers of Mechanical Engineering 2017年第4期12卷 546-553页

作者： Tingzhong XU Hongyan WANG Yong XIA Zhiming zhao Mimi HUANG Jiuhong WANG libo zhao Yulong zhao Zhuangde JIANG State Key Laboratory for Manufacmring Systems Engineering Interna-tional Joint Laboratory for Micro/Nano Manufacturing and Measure-ment Technologies Collaborative Innovation Center of Suzhou NanoScience and Technology School of Mechanical Engineering Xi'an Jiaotong University Xi'an 710049 China School of Mechanical and Manufacturing Engineering University ofNew South Wales Sydney NSW 2052 Australia Shaanxi Institute of Metrology Science Xi'an 710065 China

Abstract A novel micro-electromechanical systems piezoresistive pressure sensor with a diagonally positioned peninsula-island structure has high sensitivity for ultra- low-pressure measurement. The pressure sensor was designed with a working range of 0-500 Pa and had a high sensitivity of 0.06 mV-V^-1-Pa-1. The trade-off between high sensitivity and linearity was alleviated. Moreover, the influence of the installation angle on the sensing chip output was analyzed, and an application experiment of the sensor was conducted using the built pipettor test platform. Findings indicated that the proposed pressure sensor had sufficient resolution ability and accuracy to detect the pressure variation in the pipettor chamber. Therefore, the proposed pressure sensor has strong potential for medical equipment application.

关键词： MEMS low pressure sensor peninsula-island ultra-high sensitivity medical application

Finite p-Groups with Large or Small Normal Closures of Non-Normal Cyclic Subgroups

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Journal of Mathematical Research with Applications 2017年第2期37卷 209-213页

作者： libo zhao Lü GONG Department of Mathematics Guangdong University of Education School of Sciences Nantong University

A p-group G is called a JC-group if the normal closure H;of every cyclic subgroup H satisfies |G:H;| ≤ p or |H;:H| ≤ p. In this paper, we classify the non-Dedekindian JC-groups for p>2.

关键词： JC-group non-Dedekindian p-group regular p-group

An ultrasensitive and stretchable strain sensor based on a microcrack structure for motion monitoring

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Microsystems & Nanoengineering 2022年第5期8卷 105-114页

作者： Hao Sun Xudong Fang Ziyan Fang libo zhao Bian Tian Prateek Verma Ryutaro Maeda Zhuangde Jiang State Key Laboratory for Manufacturing Systems Engineering International Joint Laboratory for Micro/Nano Manufacturing and Measurement TechnologiesCollaborative Innovation Center of Suzhou Nano Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710049China Overseas Expertise Introduction Center for Micro/Nano Manufacturing and Nano Measurement Technologies Discipline Innovation and Xi’an Jiaotong University(Yantai)Research Institute for Intelligent Sensing Technology and SystemXi’anChina School of Chemical Engineering University of ArkansasFayettevilleAR 72701USA

Flexible strain sensors are promising candidates for intelligent wearable *** previous studies,although crack-based sensors have attracted a lot of attention due to their ultrahigh sensitivity,large strain usually causes fractures in the conductive *** of the unstable crack structure,the tradeoff between sensitivity and workable strain range is still a *** carbon nanotubes(CNTs)and silver nanowires(AgNWs)can form a strong interface with the thermoplastic substrate and strengthen the conductive network by capillary force during water evaporation,CNTs and AgNWs were deposited on electrospun TPU fiber mats via vacuum-assisted filtration in this *** prestretching treatment constructed a microcrack structure that endowed the sensor with the combined characteristics of a wide working range(0~171%strain),ultrahigh sensitivity(a gauge factor of 691 within 0~102%strain,~2×10^(4) within 102~135%strain,and>11×10^(4) within 135~171%strain),a fast response time(~65 ms),small hysteresis,and superior durability(>2000 cycles).Subsequently,the sensing mechanism of the sensor was *** microcrack propagation based on the“island-bridge”structure was explained in detail,and its influence on the strain-sensing behavior of the sensor was ***,the sensor was assembled to monitor various vibration signals and human motions,demonstrating its potential applications in the fields of electronic skin and human health monitoring.

关键词： strain structure crack

A flexible and wearable NO_(2)gas detection and early warning device based on a spraying process and an interdigital electrode at room temperature

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Microsystems & Nanoengineering 2022年第2期8卷 97-106页

作者： Fuzheng Zhang Qijing Lin Feng Flan Zuowei Wang Bian Tian libo zhao Tao Dong Zhuangde Jiang State Key Laboratory for Mechanical Manufacturing Systems Engineering Xi'an Jiaotong University710049 Xi'anChina Chongqing Key Laboratory of Micro-Nano Systems and Intelligent Sensing Chongqing Academician WorkstationChongqing 2011 Collaborative Innovation Center of Micro/Nano Sensing and Intelligent Ecological Internet of ThingsChongqing Technology and Business University400067 ChongqingChina Department of Microsystems Faculty of TechnologyNatural Sciences and Maritime SciencesUniversity of South-Eastern Norway(USN)Raveien 2153184 BorreNorway

Flexible sensors used to detect NO_(2) gas generally have problems such as poor repeatability,high operating temperature,poor selectivity,and small detection *** this work,a new spraying platform with a simple structure,low cost,and good film-forming consistency was designed and built to make a sensitive film(rGO/SnO_(2))for NO_(2) gas *** relationship between the solid content of rGO and SnO_(2)nanoparticles,annealing temperature,and sensor performance was *** results show that the interdigital electrode-sensitive film formed by spraying 0.25 ml of a 0.4 wt%rGO/SnO_(2)mixture and annealing at 250℃exhibited the best comprehensive performance for NO_(2) *** sensor's response value for 100 ppm NO_(2) gas was 0.2640 at room temperature(25℃),and the response time and recovery time were 412.4 s and 587.3 s,*** the range of 20-100 ppm,the relationship between the response and NO_(2) concentration was linear,and the correlation coefficient was *** addition,a soft-monitoring node module with an overlimit warning function for NO_(2) gas was designed and manufactured based on flexible ***,the flexible sensor and node module were embedded into woven fabric that could be used to make a mask or a watch that could detect NO_(2) gas,realizing the practical application of flexible NO_(2) gas sensors in the field of wearable electronics.

关键词： wear electrode spraying

CDK6 inhibits lymphoid cell infiltration and represents a prognostic marker in HPV+ squamous cell carcinoma of head and neck

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Chinese Journal of Cancer Research 2019年第6期31卷 901-909页

作者： Chuanhao Tang Li Lin Wei Zhou Xiang Liu Yali Fu Lingling Zhang Li Li Xiangyi Wang libo zhao Jun Liang libo zhao Jun Liang Department of Medical Oncology Peking University International Hospital

Objective:We investigated the correlations between cyclin-dependent kinase 4/6(CDK4/6)levels and human papillomavirus(HPV)infection state in head and neck squamous cell cancer(HNSCC).The aim was to explore the potential value of CDK4/6 inhibitors in the treatment of ***:Multiomic sequencing data for HNSCC were obtained from The Cancer Genome Atlas(TCGA),and the mRNA levels and copy number variations(CNVs)of CDK4 and CDK6 were strictly *** survival(OS)curves were produced using the Kaplan-Meier method,and survival differences between groups were assessed by the log-rank ***,gene set enrichment analysis(GSEA)was applied to interrogate CDK4/6-associated molecular pathways in HPV-positive(HPV+)and HPV-negative(HPV-)***,lymphoid cell infiltrates in each type of HNSCC were explored,and the correlations between CDK4/6 expression and lymphoid infiltrates were explored by Tumor Immune Estimation Resource(TIMER)***:Overexpression of either CDK6 or CDK4 was not a relevant factor for OS in HPV-HNSCC(CDK6:top 40%*** 40%,P=0.885;CDK4:top 40%*** 40%,P=0.267).In HPV+HNSCC,CDK6 but not CDK4 was a relevant factor for OS(CDK6:top 40%*** 40%,P=0.002;CDK4:top 40%*** 40%,P=0.452).GSEA found that overexpressed CDK6 in HPV+HNSCC inhibited pathways involved in the tumor immune response,suggesting its roles in antitumor *** analysis results revealed that CDK6 but not CDK4 accumulation was negatively correlated with the number of tumor-infiltrating lymphocytes specific for HPV+HNSCC,which led to tumor response ***:CDK6,but not CDK4,is a poor prognostic marker specific in HPV+HNSCC *** CDK6 might stimulate tumor progression by suppressing lymphocytes infiltration independent of its kinase *** abrogating its kinase activity using current CDK4/6 inhibitors was not enough to block its tumor promotion function.

关键词： HNSCC HPV CDK4/6 immune infiltration

Super-resolution imaging and tracking of TGF-β receptor II on living cells

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Science Bulletin 2016年第8期61卷 632-638页

作者： Zi Ye Nan Li libo zhao Yahong Sun Hefei Ruan Mingliang Zhang Jinghe Yuan Xiaohong Fang Key Laboratory of Molecular Nanostructure and Nanotechnology Beijing National Laboratory for Molecular Sciences Institute of Chemistry Chinese Academy of Sciences

Single-particle tracking photoactivated local- ization microscopy （sptPALM） has recently emerged as a powerful tool for high-density imaging and tracking of individual molecules in living cells. In this work, we have monitored and compared the diffusion dynamics of TGF-β type II receptor （TβRII） at high expression level using both traditional single-particle tracking （SPT） and sptPALM. The ligand-induced aggregation of TβRII oligomers was further indicated by sptPALM. Due to the capacity of distinguishing and tracking single molecules within diffraction limit, sptPALM outperforms traditional SPT by providing more accurate biophysical information,

关键词： Single-particle tracking Photoactivatedlocalization microscopy - Single-moleculefluorescence imaging TGF-β receptor II Membranediffusion

Finite p-Groups all of Whose Subgroups of Index p^(3) are Abelian

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Communications in Mathematics and Statistics 2015年第1期3卷 69-162页

作者： Qinhai Zhang libo zhao Miaomiao Li Yiqun Shen Department of Mathematics Shanxi Normal UniversityLinfen 041004ShanxiPeople’sRepublic of China

Suppose that G is a finite *** all subgroups of index p^(t)of G are abelian and at least one subgroup of index p^(t−1)of G is not abelian,then G is called an A_(t)-*** useA0-group to denote an abelian *** the definition,we know every finite non-abelian p-group can be regarded as an A_(t)-group for some positive integer t.A_(1)-groups and A_(2)-groups have been *** A_(3)-groups is an old *** this paper,some general properties about A_(t)-groups are given.A_(3)-groups are completely classified up to ***,we determine the Frattini subgroup,the derived subgroup and the center of every A_(3)-group,and give the number of A_(1)-subgroups and the triple(μ_(0),μ_(1),μ_(2))of every A_(3)-group,whereμi denotes the number of A_(i)-subgroups of index p of A_(3)-groups.

关键词： Finite p-groups Minimal non-abelian p-groups A_(t)-groups

Piezoelectric-AIN resonators at two-dimensional flexural modes for the density and viscosity decoupled determination of liquids

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Microsystems & Nanoengineering 2022年第2期8卷 23-34页

作者： Linya Huang Wei Li Guoxi Luo Dejiang Lu libo zhao Ping Yang Xiaozhang Wang Jiuhong Wang Qijing Lin Zhuangde Jiang State Key Laboratory for Manufacturing Systems Engineering International Joint Laboratory for Micro/Nano Manufacturing and Measurement TechnologiesOverseas Expertise Introduction Center for Micro/Nano Manufacturing and Nano Measurement Technologies Discipline InnovationXi'an Jiaotong University(Yantai)Research Institute for Intelligent Sensing Technology and SystemXi'an Jiaotong UniversityXi'an 710049China School of Mechanical Engineering Xi'an Jiaotong UniversityXi'an 710049China The Eleventh Research Institute of The Sixth Academy of CASC Xi'an 710100China

A micromachined resonator immersed in liquid provides valuable resonance parameters for determining the fluidic ***,the liquid operating environment poses a challenge to maintaining a fine sensing performance,particularly through electrical *** paper presents a piezoelectric micromachined cantilever with a stepped shape for liquid monitoring *** modes of the proposed cantilever are available with full electrical characterization for realizing self-actuated and seif-sensing *** focus is on higher flexural resonances,which nonconventionally feature two-dimensional vibration *** analyses are conducted for the developed cantilever under flexural vibrations at different *** explains not only the basic length-dominant mode but also higher modes that simultaneously depend on the length and width of the *** study determines that the analytical predictions for resonant frequency in liquid media exhibit good agreement with the experimental ***,the experiments on cantilever resonators are performed in various test liquids,demonstrating that higher-order flexural modes allow for the decoupled measurements of density and *** measurement differences achieve 0.39%in density and 3.50%in viscosity,and the frequency instability is below 0.05%*** the basis of these results,design guidelines for piezoelectric higher-mode resonators are proposed for liquid sensing.

关键词： flexural cantilever viscosity

Highly sensitive piezoresistive and thermally responsive fibrous networks from the in situ growth of PEDOT on MWCNT-decorated electrospun PU fibers for pressure and temperature sensing

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Microsystems & Nanoengineering 2023年第5期9卷 73-85页

作者： Yunyun Luo libo zhao Guoxi Luo Linxi Dong Yong Xia Min Li Ziping Li Kaifei Wang Ryutaro Maeda Zhuangde Jiang State Key Laboratory for Manufacturing Systems Engineering International Joint Laboratory for Micro/Nano Manufacturing and Measurement TechnologiesXi’an Jiaotong University(Yantai)Research Institute for Intelligent Sensing Technology and SystemXi’an Jiaotong UniversityXi’anChina School of Mechanical Engineering Xi’an Jiaotong UniversityXi’anChina Shandong Laboratory of Yantai Advanced Materials and Green Manufacturing YantaiChina Ministry of Education Engineering Research Center of Smart Microsensors and Microsystems College of Electronics and InformationHangzhou Dianzi UniversityHangzhouChina Department of Emergency The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anChina

Flexible electronics have demonstrated various strategies to enhance the sensory ability for tactile perception and wearable physiological *** microstructures have attracted much interest because of their excellent mechanical properties and ***,a structurally robust fibrous mat was first fabricated by electrospinning,followed by a sequential process of functionalization utilizing ultrasonication treatment and in situ polymerization *** polyurethane(PU)microfibers were anchored with multi-walled carbon nanotubes(MWCNTs)to form conductive paths along each fiber by a scalable ultrasonic cavitation treatment in an MWCNT ***,a layer of poly(3,4-ethylene dioxythiophene)(PEDOT)was grown on the surface of PU fibers decorated with MWCNTs to enhance the conductive conjunctions of *** to the superior electromechanical behaviors and mechanical reinforcement of PEDOT,the PEDOT/MWCNT@PU mat-based device exhibits a wide working range(0–70 kPa),high sensitivity(1.6 kPa−1),and good mechanical robustness(over 18,000 cycles).The PEDOT/MWCNT@PU mat-based sensor also demonstrates a good linear response to different temperature variations because of the thermoelectricity of the PEDOT/MWCNT *** novel strategy for the fabrication of multifunctional fibrous mats provides a promising opportunity for future applications for high-performance wearable devices.

关键词： fibers PEDOT conductive