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新时代高校思想政治教育与创新创业教育融合的四重维度

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湖北开放职业学院学报 2024年第8期37卷 21-23页

作者：赵建国扬州工业职业技术学院江苏扬州225127

“课程思政”与“五育并举”是培养社会主义事业建设者和接班人的必经之路,也是新时代全面深化教育改革的重要内容。其中,高校思想政治教育与创新创业教育融合是新时代高校创新型人才培养的主旋律之一。然而,在百年未有之大变局下,高校... 详细信息

“课程思政”与“五育并举”是培养社会主义事业建设者和接班人的必经之路,也是新时代全面深化教育改革的重要内容。其中,高校思想政治教育与创新创业教育融合是新时代高校创新型人才培养的主旋律之一。然而,在百年未有之大变局下,高校思想政治教育和创新创业教育都面临着新的挑战,需根据新形势、新任务和新要求下,对思想政治教育和创新创业教育提出更高的要求。当下,将两者有机融合,发挥思想政治教育的思想引领作用来“引航”创新创业教育,形成“同向同行”的育人合力。

关键词：高校思想政治教育创新创业教育融合

Multivariate analysis of surface water quality in the Three Gorges area of China and implications for water management

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Journal of Environmental Sciences 2011年第9期23卷 1460-1471页

作者： jian zhao guo Fu Kun Lei Yanwu Li Chinese Research Academy of Environmental Sciences Beijing 100012 China.

Multivariate statistical techniques,cluster analysis,non-parametric tests,and factor analysis were applied to analyze a water quality dataset including 13 parameters at 37 sites of the Three Gorges area,China,from 2003–2008 to investigate spatio-temporal variations and identify potential pollution *** cluster analysis,the twelve months of the year were classified into three periods of lowflow （LF）,normal-flow （NF）,and high-flow （HF）;and the 37 monitoring sites were divided into low pollution （LP）,moderate pollution （MP）,and high pollution （HP）.Dissolved oxygen （DO）,potassium permanganate index （COD Mn ）,and ammonia-nitrogen （NH 4 ＋-N） were identified as significant variables affecting temporal and spatial variations by non-parametric *** analysis identified that the major pollutants in the HP region were organic matters and nutrients during NF,heavy metals during LF,and petroleum during *** the MP region,the identified pollutants primarily included organic matter and heavy metals year-around,while in the LP region,organic pollution was significant during both NF and HF,and nutrient and heavy metal levels were high during both LF and *** main sources of pollution came from domestic wastewater and agricultural activities and runoff;however,they contributed differently to each region in regards to pollution *** the HP region,inputs from wastewater treatment plants were significant;but for MP and LP regions,water pollution was more likely from the combined effects of agriculture,domestic wastewater,and chemical *** results provide fundamental information for developing better water pollution control strategies for the Three Gorges area.

关键词： water quality spatial variations seasonal variations multivariate statistical techniques the Three Gorges

Gene engineering in swine for agriculture

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Journal of Integrative Agriculture 2017年第12期16卷 2792-2804页

作者： WANG Yan-fang HUANG Jiao-jiao zhao jian-guo Institute of Animal Science Chinese Academy of Agricultural Sciences Beijing 100193 P.R. China Institute of Zoology Chinese Academy of Sciences Beijing 100101 P.R.China University of Chinese Academy of Sciences Beijing 100049 P.R. China

Domestic pigs are the second most important source of meat world-wide, and the genetic improvement of economic traits, such as meat production, growth, and disease resistance, is a critical point for efficient production in pigs. Through conventional breeding and selection programs in pigs, which are painstakingly slow processes, some economic traits, such as growth and backfat, have been greatly improved over the past several decades. However, the improvement of many polygenetic traits is still very slow and challenging to be improved by conventional breeding strategies. The development of reproductive knowledge and a variety of techniques, including foreign gene transfer strategies, somatic cell nuclear transfer（SCNT） and particularly, recently developed nuclease-mediated genome editing tools, has provided efficient ways to produce genetically modified（GM） pigs for the dramatic improvement of economic traits. In this review, we briefly discuss the progress of genomic markers used in pig breeding program, trace the history of genetic engineering, mainly focusing on the progress of recently developed genome editing tools, and summarize the GM pigs which have been generated to aim at the agricultural purposes. We also discuss the specific challenges facing application of gene engineering in pig breeding, and future prospects.

关键词： gene engineering genome editing pig agricultural application

Polypropylene/poly(butyl methacrylate) blends prepared by diffusion and subsequent polymerization of butyl methacrylate in isotactic polypropylene pellets

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Chinese Chemical Letters 2012年第6期23卷 753-756页

作者： Xue Rong Yao Fang Chen zhao Xia guo jian Yu Key Laboratory of Advanced Materials （MOE） Department of Chemical Engineering Tsinghua University Beijing 100084 China

Polypropylene/poly（butyl methacrylate）（PP/PBMA） blends were prepared by diffusion and subseqtuent polymerization＇of butyl methacrylate （BMA） in commercial isotactic polypropylene （iPP） pellets. The diffusion kinetics, diametrical distribution of PBMA in a pellet and phase morphology of a typical PP/PBMA blend were investigated.

关键词： Polypropylene Poly(butyl methacrylate) Diffusion Blend

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钢筋混凝土桥面板弹性动力学特征研究

河南城建学院学报 2024年第2期33卷 35-42页

作者：赵建国徐浩李萌晓王辰宇武汉轻工大学土木工程与建筑学院湖北武汉430023 天津大学环境科学与工程学院天津300072 山东外事职业大学城市学院山东威海264504

为解决半无限地域钢筋混凝土结构无损检测及空腔与钢筋波场相互干扰的问题,提出了梳状检波点全方向特征分析的低频超声波定量无损检测方法。首先引入了无限元人工边界,探索了边界尺寸对脉冲信号的衰减影响,然后提取了低频超声波在钢混... 详细信息

为解决半无限地域钢筋混凝土结构无损检测及空腔与钢筋波场相互干扰的问题,提出了梳状检波点全方向特征分析的低频超声波定量无损检测方法。首先引入了无限元人工边界,探索了边界尺寸对脉冲信号的衰减影响,然后提取了低频超声波在钢混结构中的全方向波场特征,通过特征反射时长确定空腔位置与尺寸。结果显示,所提方法可以有效减少边界反射波场带来的不利影响,降低噪点分贝,有利于时域信号的波场特征分析。对空腔钢筋的混凝土板进行空腔位置及尺寸的判定,误差分别为0.75%和2.0%,表明该方法不仅可以消除在结构材料与缺陷堆叠情况下的信号盲区,同时避免了特殊情况下斜入射震源的激发不便,实现了准确高效的缺陷检测。

关键词：无损检测低频超声波钢筋混凝土桥面板波场特征全方向特征分析

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药师参与下的碘克沙醇不良反应监测与分析

海峡药学 2024年第7期36卷 98-101页

作者：马曾庆李素素吴连平赵欣赵建国陶洋南京市高淳人民医院药学部江苏南京211300

目的监测并分析碘克沙醇不良反应(Adverse Drug Reaction,ADR)的发生、特点和影响因素,为碘克沙醇安全用药提供保障。方法通过药学查房,对2022年1月至2023年8月在我院使用碘克沙醇的患者进行监测,收集患者的人口学和临床信息,结合患者的... 详细信息

目的监测并分析碘克沙醇不良反应(Adverse Drug Reaction,ADR)的发生、特点和影响因素,为碘克沙醇安全用药提供保障。方法通过药学查房,对2022年1月至2023年8月在我院使用碘克沙醇的患者进行监测,收集患者的人口学和临床信息,结合患者的ADR发生情况和用药情况等,对发生ADR的风险因素、ADR的分类和转归情况进行统计并分析。结果在1961例患者中,累计24例患者发生ADR,发生率为1.22%。ADR主要涉及消化系统、皮肤系统和体温调节系统,其中发生率最高的为恶心呕吐(14,0.71%)、发热(4,0.20%)和皮肤瘙痒(3,0.15%)。ADR的发生与患者年龄超过75岁有统计学差异(P<0.05),而和性别、给药途径、用量以及是否合并慢性病无关。结论药师主动参与碘克沙醇ADR监测,能够做到早期干预,保障患者安全用药。

关键词：碘克沙醇药物不良反应临床药师监测

NIR-Ⅱ responsive Janus nanoparticles amplify immunogenic cell death for enhanced cancer immunotherapy

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Science China(Technological Sciences) 2024年第1期67卷 321-329页

作者： CHEN BeiBei guo KangLi WANG HaoRan XU Fu-jian WANG JuLin zhao NaNa State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China Key Laboratory of Biomedical Materials of Natural Macromolecules(Beijing University of Chemical Technology) Beijing Laboratory of Biomedical MaterialsBeijing University of Chemical TechnologyBeijing 100029China College of Materials Sciences and Engineering Beijing University of Chemical TechnologyBeijing 100029China Beijing Key Laboratory of Electrochemical Process and Technology for Materials Beijing University of Chemical TechnologyBeijing 100029China

Immunotherapy brings new hope for tumor treatment by inducing immunogenic cell death(ICD)of tumor ***,insufficient immunogenicity and low immune response rate greatly limit antitumor ***,by optimizing the composition and morphology,the rational design of Janus nanoparticles composed of Fe_(3)O_(4) nanospheres and SiO_(2)nanorods was realized for enhanced cancer immunotherapy through amplified *** glucose oxidase(GOx)was loaded by the Janus nanoparticles,the resultant M-FS-GOx consumes glucose at tumor sites to generate gluconic acid and hydrogen peroxide(H_(2)O_(2))for starvation therapy while the H_(2)O_(2)supply promotes the production of highly toxic·OH to achieve effective chemodynamic therapy(CDT).Under a 1064 nm light irradiation,the photothermal effect of M-FS-GOx enhances the enzyme activity of GOx for improved starvation ***,both tumor-associated antigens released during the process of ICD and the intrinsic immunoadjuvant property of M-FS-GOx stimulate dendritic cell maturation to activate antitumor immune *** work provides a promising strategy for the construction of Janus nanoparticles to achieve enhanced cancer immunotherapy through combination therapy-amplified ICD.

关键词： Janus nanoparticles immunogenic cell death cancer immunotherapy

Suppression of low-frequency ultrasound broadband vibration using star-shaped single-phase metamaterials

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Defence Technology（防务技术） 2024年第4期34卷 217-224页

作者： Rui zhao jian Zheng Jin guo Yunbo Shi Hengzhen Feng Jun Tang Jun Liu Science and Technology on Electronic Test&Measurement Laboratory North University of ChinaTaiyuan 030051ShanxiChina School of Mechatronical Engineering Beijing Institute of TechnologyBeijing 100081China

In order to suppress the low-frequency ultrasound vibration in the broadband range of 20 k Hz—100 k Hz,this paper proposes and discusses an acoustic metamaterial with low-frequency ultrasound vibration attenuation properties,which is configured by hybrid arc and sharp-angle convergent star-shaped *** effect of the dispersion relation and the bandgap characteristic for the scatterers in star-shaped are simulated and *** target bandgap width is extended by optimizing the geometry parameters of arc and sharp-angle convergent *** proposed metamaterial configured by optimized hybrid lattices exhibits remarkable broad bandgap characteristics by bandgap complementarity,and the simulation results verify a 99%vibration attenuation amplitude can be obtained in the frequency of20 k Hz—100 k *** the fabrication of the proposed hybrid configurational star-shaped metamaterial by 3D printing technique,the transmission loss experiments are performed,and the experimental results indicate that the fabricated metamaterial has the characteristics of broadband vibration attenuation and an amplitude greater than 85%attenuation for the target *** results demonstrate that the hybrid configurational star-shaped metamaterials can effectively widen the bandgap and realize high efficiency attenuation,which has capability for the vibration attenuation in the application of highprecise equipment.

关键词： Star-shaped metamaterials Broadband Vibration attenuation Low-frequency ultrasound vibration Transmission loss

MADRL-based UAV swarm non-cooperative game under incomplete information

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Chinese Journal of Aeronautics 2024年第6期37卷 293-306页

作者： Ershen WANG Fan LIU Chen HONG Jing guo Lin zhao jian XUE Ning HE School of Electronic and Information Engineering Shenyang Aerospace UniversityShenyang 110136China College of Robotics Beijing Union UniversityBeijing 100101China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China College of Smart City Beijing Union UniversityBeijing 100101China

Unmanned Aerial Vehicles(UAVs)play increasing important role in modern *** this paper,considering the incomplete observation information of individual UAV in complex combat environment,we put forward an UAV swarm non-cooperative game model based on Multi-Agent Deep Reinforcement Learning(MADRL),where the state space and action space are constructed to adapt the real features of UAV swarm air-to-air *** multi-agent particle environment is employed to generate an UAV combat scene with continuous observation *** recently popular MADRL methods are compared extensively in the UAV swarm noncooperative game model,the results indicate that the performance of Multi-Agent Soft Actor-Critic(MASAC)is better than that of other MADRL methods by a large *** swarm employing MASAC can learn more effective policies,and obtain much higher hit rate and win *** under different swarm sizes and UAV physical parameters are also performed,which implies that MASAC owns a well generalization ***,the practicability and convergence of MASAC are addressed by investigating the loss value of Q-value networks with respect to individual UAV,the results demonstrate that MASAC is of good practicability and the Nash equilibrium of the UAV swarm non-cooperative game under incomplete information can be reached.

关键词： UAV swarm Reinforcement learning Deep learning Multi-agent Non-cooperative game Nash equilibrium