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古近纪至新近纪青藏高原的气候演变及其驱动因素

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中国科学：地球科学 2022年第8期52卷 1562-1576页

作者：赵佳港李树峰 Alexander FARNSWORTH Paul j.VALDES Tammo REICHGELT 陈琳琳周浙昆苏涛中国科学院西双版纳热带植物园热带森林生态学重点实验室勐腊666303 中国科学院大学北京100049 中国科学院核心植物园勐腊666303 School of Geographical Sciences University of BristolBristol BS81SSUK Department of Geosciences University of ConnecticutStorrs CT 06269USA 中国科学院昆明植物研究所东亚植物多样性与植物地理重点实验室昆明650204 中国科学院青藏高原研究所青藏高原地球系统与资源环境国家重点实验室北京100101

新生代青藏高原持续生长,气候环境经历了剧烈变化,但是其气候演变缺乏综合性研究.文章整合了青藏高原地区古近纪和新近纪(66~2.58Ma)共48个化石点的植物大化石和孢粉数据,采用生物气候分析法和联合概率密度函数法定量重建了重要的古气... 详细信息

新生代青藏高原持续生长,气候环境经历了剧烈变化,但是其气候演变缺乏综合性研究.文章整合了青藏高原地区古近纪和新近纪(66~2.58Ma)共48个化石点的植物大化石和孢粉数据,采用生物气候分析法和联合概率密度函数法定量重建了重要的古气候参数,两者的结果均表明:从古近纪至新近纪,青藏高原的温度和降水呈现波动降低的趋势.利用HadCM3模型对青藏高原古近纪和新近纪不同时期进行古气候模拟,结果显示:自晚始新世,温度和降水量的分布规律主要受地形地貌的影响,温度由之前的纬度分布格局转变为由地形地貌主导的分布格局;随着青藏高原东北向生长,温度降低和降水减少的范围向高原的东北方向扩展.通过综合对比植物化石数据定量重建、模型模拟和其他代理指标恢复的古气候,结果表明:青藏高原隆升等地质构造运动和全球气候变冷是驱动该地区气候变化的主要因素.本研究可为深入探讨青藏高原的环境变迁和生态系统演化提供重要参考价值.

关键词：青藏高原新生代古气候植物化石气候模拟

Royal jelly modulates serum lipid metabolism and improves brain lipid profiles in natural aging mice

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Food Science and Human Wellness 2024年

作者： Lili Chen Li zhao Gaowei Zhang Zhuozhen Li Huihui Ming Liangliang Qu Fangjian Ning Liping Luo College of Food and Health Beijing Technology and Business University Key Laboratory of Geriatric Nutrition and Health Ministry of Education Beijing Technology and Business University School of Life Sciences Nanchang University School of Life Science jiangxi Science & Technology Normal University

Royal jelly (Rj) is rich in various nutrients with multiple health-promoting properties. This study aims to evaluate whether Rj can modulate related metabolite in the natural aging mice. Male C57BL/6j mice drank Rj solution daily for 9 months. Determination of serum lipids and pathological analysis exhibited that triglycerides (TG)， serum cholesterol (TC)， and low-density lipoprotein cholesterol (LDL-C) were decreased by 31.15%， 9.96%， and 22.58%， respectively， the morphology of brain nerve cells was also effectively recovered after Rj intervention. Lipidomic analysis showed that Rj could improve the levels of different kinds of lipids in aging mice brain， especially by increasing the content of antioxidant ether ester， and that the ratio of monounsaturated fatty acid (MUFA) to polyunsaturated fatty acid (PUFA) was up by 23.46%， which could alleviate oxidative stress. Moreover， the metabolism of glycerol phospholipids， glycerols， and fatty acids in aging mice could be regulated by Rj. Rj intervention can effectively improve lipid metabolism disorders caused by aging.

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一维动静组合加载下岩石冲击破坏试验研究

岩石力学与工程学报 2010年第2期29卷 251-260页

作者：李夕兵宫凤强高科尹土兵中南大学资源与安全工程学院瑞士洛桑联邦理工大学岩石力学实验室

利用研制的岩石动静组合加载SHPB试验装置,系统研究岩石在一维动静组合加载下的冲击破坏特性。首先按照一维应力波传播理论,对动静组合加载的试验原理进行理论论证。试验过程中预先在轴向施加不同载荷,按照静载强度的20%,30%,40%,70%,80... 详细信息

利用研制的岩石动静组合加载SHPB试验装置,系统研究岩石在一维动静组合加载下的冲击破坏特性。首先按照一维应力波传播理论,对动静组合加载的试验原理进行理论论证。试验过程中预先在轴向施加不同载荷,按照静载强度的20%,30%,40%,70%,80%和90%等6个系列进行,然后沿轴向进行冲击加载,考察岩石的临界破坏承载强度。研究结果表明:在临界破坏的情况下,动态冲击的应力–应变曲线(包括常规冲击和动静组合加载)最后都会出现总应变减小的现象,这是由于冲击过程中岩石内部储存弹性能释放所致。在轴向静压较小时,岩石的组合加载应力–应变曲线跟常规的冲击试验曲线类似;轴压较大时,岩石的组合加载应力–应变曲线没有初始的近似线弹性段,直接从非线性段开始。随着轴向静压的增大,岩石的抗冲击强度呈现出先增大后减小的趋势,大约在静载强度60%时,抗冲击强度达到最大值。在入射能较小时,岩石吸收的能量会缓慢增加,在入射能较高时,岩石吸能会快速增加。常规冲击下岩石的临界破坏模式为劈裂形式,动静组合加载下呈现压剪形式。

关键词：岩石力学岩石材料动静组合加载动态强度吸收能

Dual-functional microneedle with programmatic regulation of macrophage for autoimmune psoriasis treatment

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Nano Research 2024年第8期17卷 7436-7448页

作者： Ze Qiang zhao Bo Zhi Chen jia Li Gan Yun Hao Feng Ling Liang Lingyun Yu Zi Yi Wang Samin Abbaszadeh Mohammad-Ali Shahbazi Ruixing Yu Xin Dong Guo State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China Beijing Laboratory of Biomedical Materials College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China China-japan Friendship Hospital Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100029China Department of Dermatology China-Japan Friendship HospitalBeijing 100029China Department of Pharmaceutical Biomaterials School of PharmacyZanjan University of Medical SciencesZanjan 45139-56184Iran Department of Biomaterials and Biomedical Technology University Medical Center GroningenUniversity of GroningenAntonius Deusinglaan 19713 AV GroningenThe Netherlands W.j.Kolff Institute for Biomedical Engineering and Materials Science University of GroningenAntonius Deusinglaan 19713 AV GroningenThe Netherlands

Modulating the immune microenvironment to establish sustained positive feedback within immune pathways represents a promising avenue for the treatment of ***,the precise and efficient delivery of therapeutic systems to the subcutaneous basal layer to modulate immune disorders is a major challenge in the treatment of autoimmune *** this project,we introduce a dual-functional microneedle(DF-MN)designed to combine MNs with multiple release kinetics and immunotherapy,the programmed treatment is achieved through segmented design of the MN structure,realizing the unification of rapid and long-lasting treatment of autoimmune *** vivo imaging results showed that GelMA@M-CSF showed fluorescent signals after 5 days of delivery to subcutaneous tissues,whereas HA@IL-13 showed minimal fluorescent signals after 2 *** multistage release behavior of MNs and the diffusion mechanism of drugs were explained at the molecular level,in combination with coarse-grained molecular ***,DF-MN can successfully induce macrophage reprogramming in vitro and ameliorate overall symptoms in a psoriasis mice model,suggesting that it has the potential to be an effective strategy for the treatment of psoriasis and portends to be a transformative platform for the treatment of other autoimmune diseases.

关键词： microneedle psoriasis M2 macrophage immunoregulation

采动地表与输电线塔大板基础协同变形规律研究

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采矿与安全工程学报 2024年第3期41卷 472-480页

作者：赵兵朝赵阳冯杰王京滨冯欣怡西安科技大学能源学院陕西西安710054 西安科技大学西部矿井开采及灾害防治教育部重点实验室陕西西安710054

为保障矿区输电线塔在采动影响下安全运行,通过理论分析和数值模拟探究采动地表与输电线塔大板基础协同变形规律。以某工作面上覆输电线塔大板基础为研究对象,基于基础的破坏形式,建立了大板基础力学模型,结合概率积分法推导得出地表与... 详细信息

为保障矿区输电线塔在采动影响下安全运行,通过理论分析和数值模拟探究采动地表与输电线塔大板基础协同变形规律。以某工作面上覆输电线塔大板基础为研究对象,基于基础的破坏形式,建立了大板基础力学模型,结合概率积分法推导得出地表与拉伸区、压缩区及中性区基础的协同变形关系式。理论分析表明:采动基础变形的关键参数有基础弹性模量(E_(j))、土体泊松比(μ)、基础根开(b_(t))、土体弹性模量(E)、电塔自重(P)和基础截面惯性矩(I_(y));基础水平变形ε_(j)与E_(j)和μ呈负相关,与地表水平变形ε、b_(t)和E呈正相关;基础倾斜变形i_(j)与地表倾斜变形i、P和b_(t)呈正相关,与E_(j)和I_(y)呈负相关。数值模拟表明:拉伸区基础水平变形>压缩区基础水平变形>中性区基础水平变形。

关键词：采动地表变形输电线塔大板基础概率积分协同变形

MOF-derived Cu embedded into N-doped mesoporous carbon as a robust support of PdAu nanocatalysts for ethanol electrooxidation

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Rare Metals 2024年第3期43卷 1083-1094页

作者： Yu-Fu Huang Peng Wu jun-Ping Tang jian Yang jing Li Shuai Chen Xue-Ling zhao ChengChen Bin-Wei Zhang Yan-Yun Ma Wei-Heng Shi Dong-Hai Lin Shi-Gang Sun School of Energy and Materials Shanghai Engineering Research Center of Advanced Thermal Functional MaterialsShanghai Key Laboratory of Engineering Materials Application and EvaluationShanghai Polytechnic UniversityShanghai201209China State Key Laboratory of Physical Chemistry of Solid Surfaces Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen361005China School of Chemistry and Chemical Engineering Chongqing UniversityChongqing401331China Center of Advanced Energy Technology and Electrochemistry Institute of Advanced Interdisciplinary StudiesChongqing UniversityChongqing400044China Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou215123China Department of Materials Science and Engineering Drexel UniversityPhiladelphiaPA19104USA

Metal-organic frameworks(MOFs)h ave attracted widespread attention due to their large surface area and porous *** designing the nanostructures of MOFs to promote their application in ethanol electrooxidation is still a ***,a novel Cu-NCNs(Cu-nitrogen-doped carbon nanotubes)support was synthesized by pyrolysis of melamine(MEL)and Cu-ZIF-8 together,and then,Pd-Au nanoalloys were loaded by sodium borohydride reduction method to prepare PdAu@Cu-NCNs *** generating mesoporous carbon with high specific surface area and favorable electron and mass transport can be used as a potential excellent carrier for PdAu *** addition,the balance of catalyst composition and surface structure was tuned by controlling the content of Pd and ***,the best-performed Pd_(2)Au_(2)@Cu-NCN-1000-2(where 1000 means the carrier calcination temperature,and 2 means the calcination constant temperature time)catalyst exhibits better long-term stability and electrochemical activity for ethanol oxidation in alkaline media(4.80 A·mg^(-1)),which is 5.05 times higher than that of commercial Pd/C(0.95 A·mg^(-1)).Therefore,this work is beneficial to further promoting the application of MOFs in direct ethanol fuel cells(DEFCs)and can be used as inspiration for the design of more efficient catalyst support structures.

关键词： Metal-organic frameworks(MOFs) N-doped Mesoporous carbon PdAu Ethanol electrooxidation

Ecology and risks of the global plastisphere as a newly expanding microbial habitat

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The Innovation 2024年第1期5卷 49-58页

作者： Changchao Li Michael RGillings Chao Zhang Qinglin Chen Dong Zhu jie Wang Kankan zhao Qicheng Xu Polly Hangmei Leung Xiangdong Li jian Liu Ling jin Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityKowloonHong KongChina Environment Research Institute Shandong UniversityQingdao 266237China State Key Laboratory of Marine Pollution City University of Hong KongKowloon TongHong KongChina ARC Centre of Excellence in Synthetic Biology Faculty of Science and EngineeringMacquarie UniversitySydneyNSW 2109Australia Key Laboratory of Urban Environment and Health Ningbo Urban Environment Observation and Research StationInstitute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Beijing Key Laboratory of Farmland Soil Pollution Prevention and Remediation College of Resources and Environmental SciencesChina Agricultural UniversityBeijing 100193China Institute of Soil and Water Resources and Environmental Science College of Environmental and Resource SciencesZhejiang UniversityHangzhou 310058China jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization Nanjing Agricultural UniversityNanjing 210095China Department of Health Technology and Informatics and Research Institute for Future Food The Hong Kong Polytechnic UniversityKowloonHong KongChina Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China

Plastic offers a new niche for microorganisms,the *** everincreasing emission of plastic waste makes it critical to understand the microbial ecology of the plastisphere and associated ***,we present a global fingerprint of the plastisphere,analyzing samples collected from freshwater,seawater,and terrestrial *** plastisphere assembles a distinct microbial community that has a clearly higher heterogeneity and a more deterministically dominated assembly compared to natural *** coexistence patterns—loose and fragile networks with mostly specialist linkages among microorganisms that are rarely found in natural habitats—are seen in the *** microbiomes generally have a great potential to metabolize organic compounds,which could accelerate carbon *** involved in the nitrogen cycle are also altered in the plastisphere,especially in freshwater plastispheres,where a high abundance of denitrifiers may increase the release of nitrite(aquatic toxicant)and nitrous oxide(greenhouse gas).Enrichment of animal,plant,and human pathogens means that the plastisphere could become an increasingly mobile reservoir of harmful *** findings highlight that if the trajectory of plastic emissions is not reversed,the expanding plastisphere could pose critical planetary health challenges.

关键词： reservoir mostly habitat

Quasinormal modes and isospectrality of Bardeen(Anti-)de Sitter black holes

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Chinese Physics C 2024年第3期48卷 191-202页

作者：赵莹刘文韬张超房熊俊荆继良 Department of Physics Key Laboratory of Low Dimensional Quantum Structures and Quantum Control of Ministry of Educationand Synergetic Innovation Center for Quantum Effects and ApplicationsInstitute of Interdisciplinary StudiesHunan Normal UniversityChangsha 410081China Department of Physics Faculty of ScienceTokyo University of Science1-3KagurazakaShinjuku-kuTokyo 162-8601Japan

Black holes(BHs)exhibiting coordinate singularities but lacking essential singularities throughout the spacetime are referred to as regular black holes(RBHs).The initial formulation of RBHs was presented by Bardeen,who considered the Einstein equation coupled with a nonlinear electromagnetic *** this study,we investigate the gravitational perturbations,including the axial and polar sectors,of the Bardeen(Anti-)de Sitter black *** derive the master equations with source terms for both axial and polar perturbations and subsequently compute the quasinormal modes(QNMs)through numerical *** the Bardeen de Sitter black hole,we employ the 6thorder WKB *** numerical results reveal that the isospectrality is broken in this ***,the QNM frequencies are calculated using the HH method for the Bardeen Anti-de Sitter black hole.

关键词： Bardeen quasinormal modes master equation

Searching for the Highest Energy of Pulsation and Critical Luminosity of Swift j0243.6+6124 Observed by Insight-HXMT

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Research in Astronomy and Astrophysics 2024年第5期24卷 61-69页

作者： Qing-Xia zhao Xian Hou Ming-Yu Ge Shuang-Nan Zhang Yun-Xiang Xiao You-Li Tuo Zi-Xu Yang Ling-Da Kong jin-Lu Qu Shu Zhang jian-Cheng Wang Yunnan Observatories Chinese Academy of SciencesKunming 650216China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences ChineseAcademy of SciencesBeijing 100049China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650216China Institut fur Astronomic und Astrophysik Sand 1D-72076 TabingenGemany School of Physics and Optoelectronic Engineering Shandong University of TechnologyZibo 255000China

Owing to the broad energy coverage of Insight-HXMT in the hard X-ray band,we detected the highest energy of pulsation exceeding 200 keV around the 2017–2018 outburst peak of the first Galactic pulsating ultraluminous X-ray source (PULX) Swift j0243.6+6124,which is the highest energy detected from PULXs to *** also obtained the highest energy of pulsation of every exposure during the outburst in 2017–2018,and found the highest energy is roughly positively correlated with *** our newly developed method,we identified the critical luminosity being 4×10^(38)erg s^(-1) when the main peaks of the low and high energy pulse profiles became aligned,which separates the fan-beam dominated and pencil-beam dominated accretion *** the critical luminosity,the phase of the main peak shifted gradually from 0.5 to 0.8 until the outburst peak in al energy bands is reached,which is in agreement with the phase shift found previously at low *** result is consistent with what is derived from spectral analysis.

关键词： (stars:)pulsars-individual(Swift j0243.6+6124)-X-rays binaries–stars neutron