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三阴性侵袭性乳腺癌病理及免疫组化特征预测:超声定量与定性特征分析的性能比较

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国际医学放射学杂志 2022年第3期 364-365页

作者： j.W.Li Y.C.Cao Z.j.zhao Z.T.Shi X.Q.Duan C.Chang 郭长旭

摘要目的三阴性乳腺癌(TNBC)的超声特征与病理及免疫组化特征有关。为了预测TNBC的生物学特性，将高通量超声定量特征分析与定性特征评估的性能进行比较。方法

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The OsBZR1-OsSPX1/2 module fine-tunes the growth-immunity trade-off in adaptation to phosphate availability in rice

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Molecular Plant 2024年第2期17卷 258-276页

作者： Yuqing He Yao zhao jitao Hu Lanlan Wang Linying Li Xueying Zhang Zhongjing Zhou Lili Chen Hua Wangl jiaoyu Wang Gaojie Hong State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products Key Laboratory of Biotechnology in Plant Protection of MOA of China and Zhejiang ProvinceInstitute of Virology and BiotechnologyZhejiang Academy of Agricultural SciencesHangzhou 310021P.R.China Key Laboratory of Traceability for Agricultural Genetically Modified Organisms Ministry of Agriculture and Rural AffairsHangzhou 310021P.R.China College of Life Sciences Zhejiang Sci-Tech UniversityHangzhou 310018P.R.China State Key Laboratory for Managing Biotic and Chemical Threats to the Qualty and Safety of Agro-products Zhejang Academy of Agricultural SciencesHangzhou 310021P.R.China State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products Key Labory of Biotechnology in Plant Protection of MOA of China and Zhejiang ProvinceInstitute of Plant Protection and MicrobiologyZhejiang Academy of Agricultural SciencesHangzhou 310021P.R.China

The growth-promoting hormones brassinosteroids(BRs)and their key signaling component BZR1 play a vital role in balancing normal growth and defense ***,we discovered that BRs and OsBZR1 up-regulated sakuranetin accumulation and conferred basal defense against Magnaporthe oryzae infection under normal *** shortages,including phosphate(Pi)deficiency,potentially disrupt this growth-defense ***1 and OsSPX2 have been reported to sense Pi concentration and interact with the Pi signal mediator OsPHR2,thus regulating Pi starvation *** this study,we discovered that OsSPX1/2 interacts with OsBZR1 in both Pi-sufficient and Pi-deficient conditions,inhibit-ing BR-responsive *** Pi is sufficient,OsSPX1/2 is captured by OsPHR2,enabling most of OsBzR1 to promote plant growth and maintain basal *** response to Pi starvation,more OsSPX1/2 is released from OsPHR2 to inhibit OsBZR1 activity,resulting in slower ***,our study reveals that the OsBZR1-SPX1/2 module balances the plant growth-immunity trade-off in *** Y.,zhao Y.,Hu j.,Wang L.,Li L.,Zhang X.,Zhou Z.,Chen L.,Wang H.,Wang j.,and Hong G.(2024).The OsBZR1-OsSPX1/2 module fine-tunes the growth-immunity trade-off in adaptation to phosphate availability in esponse to Pi availability.

关键词： immunity maintain adaptation

Single-cell transcriptomic Atlas of aging macaque ocular outflow tissues

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Protein & Cell 2024年第8期15卷 594-611页

作者： jian Wu Chaoye Wang Shuhui Sun Tianmin Ren Lijie Pan Hongyi Liu Simeng Hou Shen Wu Xuejing Yan jingxue Zhang Xiaofang zhao Weihai Liu Sirui Zhu Shuwen Wei Chi Zhang Xu jia Qi Zhang Ziyu Yu Yehong Zhuo Qi zhao Chenlong Yang Ningli Wang Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Key Laboratory of Ophthalmology and Visual SciencesBeijing 100730China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Department of Neurosurgery Peking University Third HospitalCenter for Precision Neurosurgery and Oncology of Peking University Health Science CenterBeijing 100191China Spencer Center for Vision Research Byers Eye InstituteSchool of MedicineStanford UniversityPalo AltoCA 94304USA

The progressive degradation in the trabecular meshwork(TM)is related to age-related ocular diseases like primary open-angle ***,the molecular basis and biological significance of the aging process in TM have not been fully ***,we established a dynamic single-cell transcriptomic landscape of aged macaque TM,wherein we classified the outflow tissue into 12 cell subtypes and identified mitochondrial dysfunction as a prominent feature of TM ***,we divided TM cells into 13 clusters and performed an in-depth analysis on cluster O,which had the highest aging score and the most significant changes in cell proportions between the two ***,we found that the APOE gene was an important differentially expressed gene in cluster O during the aging process,highlighting the close relationship between cell migration and extracellular matrix regulation,and TM *** work further demonstrated that silencing the APOE gene could increase migration and reduce apoptosis by releasing the inhibition on the PI3K-AKT pathway and downregulating the expression of extracellular matrix components,thereby increasing the aqueous outflow rate and maintaining intraocular pressure within the normal *** work provides valuable insights for future clinical diagnosis and treatment of glaucoma.

关键词： single-cell transcriptomic atlas macaque trabecular meshwork ocular outflow tissue aging

Improving iconic memory through contrast detection training with HOA-corrected vision

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Fundamental Research 2024年第1期4卷 95-102页

作者： Ling Gong junlei zhao Yun Dai Zili Wang Fang Hou Yudong Zhang Zhong-Lin Lu jiawei Zhou State Key Laboratory of Ophthalmology Optometry and Vision ScienceEye HospitalSchool of Ophthalmology and OptometryWenzhou Medical UniversityWenzhou 325027China Institute of Optics and Electronics Chinese Academy of SciencesChengdu 610209China The Key Laboratory of Adaptive Optics Chinese Academy of SciencesChengdu 610209China Chengdu University of Traditional Chinese Medicine Chengdu 610075China Division of Arts and Sciences New York University ShanghaiShanghai 200126China Center for Neural Science Department of PsychologyNew York UniversityNew York 10003United States NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai Shanghai 200062China

Iconic memory and short-term memory are not only crucial for perception and cognition,but also of great importance to mental ***,we first showed that both types of memory could be improved by improving limiting processes in visual processing through perceptual *** adults were trained in a contrast detection task for ten days,with their higher-order aberrations(HOA)corrected in *** found that the training improved not only their contrast sensitivity function(CSF),but also their iconic memory and baseline information maintenance for short-term memory,and the relationship between memory and CSF improvements could be well-predicted by an observer *** results suggest that training the limiting component of a cognitive task with visual perceptual learning could improve visual *** may also provide an empirical foundation for new therapies to treat people with poor sensory memory.

关键词： Perceptual learning Iconic memory Higher-order aberrations Contrast sensitivity Short-term memory

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结冰风洞小流量发动机进气部件防冰试验技术

航空动力学报 2024年第4期39卷 1-7页

作者：冉林熊建军赵照易贤中国空气动力研究与发展中心结冰与防除冰重点实验室四川绵阳621000 中国空气动力研究与发展中心空气动力学国家重点实验室四川绵阳621000

为满足国产航空发动机小流量进气防冰试验的需求,基于结冰风洞的发动机进气模拟系统,分析了典型小流量发动机进气部件的进气特征,开展了小流量发动机进气模拟方法研究。提出采用水环真空泵解决了大流阻进气导致吸气管道压力大幅度降低问... 详细信息

为满足国产航空发动机小流量进气防冰试验的需求,基于结冰风洞的发动机进气模拟系统,分析了典型小流量发动机进气部件的进气特征,开展了小流量发动机进气模拟方法研究。提出采用水环真空泵解决了大流阻进气导致吸气管道压力大幅度降低问题,在此基础上,优化了发动机进气模拟系统,建立了在结冰风洞开展小流量发动机进气部件防冰试验的流程,并应用于某型号小流量发动机进气部件防冰试验。结果表明:发动机进气模拟系统满足小流量发动机进气部件防冰试验要求,进气流量控制精度达到±0.05 kg/s(±0.33%FS),试验过程中的流量变化可用于辨别防冰效果。相关研究为发动机进气模拟系统设计、优化和小流量发动机进气部件的防冰特性考核提供了参考依据。

关键词：结冰风洞发动机进气模拟系统小流量发动机进气部件防冰试验进气流量

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大型结冰风洞热气供气防除冰试验技术

航空动力学报 2024年第5期39卷 11-17页

作者：赵照熊建军冉林易贤中国空气动力研究与发展中心结冰与防除冰重点实验室四川绵阳621000

在结冰风洞建立热气供气防除冰试验系统是开展热气防除冰试验的主要手段,为满足我国一系列国产飞机防除冰系统设计与结冰适航审定需求,中国空气动力研究与发展中心依托3 m×2 m大型结冰风洞开展了热气供气防除冰试验技术研究,自主研制... 详细信息

在结冰风洞建立热气供气防除冰试验系统是开展热气防除冰试验的主要手段,为满足我国一系列国产飞机防除冰系统设计与结冰适航审定需求,中国空气动力研究与发展中心依托3 m×2 m大型结冰风洞开展了热气供气防除冰试验技术研究,自主研制了热气供气防除冰试验系统。设计并研制了数字阀流量控制单元、电加热器单元、流量控制单元等试验子系统,建立了试验流程与方法,构建了完善的多路热气供气防除冰试验技术,并对某小型航空发动机进气道部件开展了双路防除冰试验验证,试验结果表明:热气供气防除冰试验系统可模拟真实压气机引出的热气,具备多路热气供气试验能力,温度控制精度可达±1℃,流量控制精度可达±1%,性能指标优异,为下一步我国飞行器防除冰试验系统设计与适航审定提供了有力支撑。

关键词：大型结冰风洞多路热气供气防除冰试验技术飞行器适航审定

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Epinephrine promotes tumor progression and M2 polarization of tumor-associated macrophages by regulating the TRIM2-NF-kB pathway in colorectal cancer cells

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Genes & Diseases 2024年第4期11卷 141-144页

作者： Zhengyi Liu Chenxing jian Wenzheng Yuan Guiqing jia Donghui cheng Yanzhuo Liu Yanling Zhang Bin Zhang Zili Zhou Gaoping zhao Department of Breast Surgery Henan Provincial People's HospitalThe People's Hospital of Zhengzhou UniversityThe People's Hospital of Henan UniversityZhengzhouHenan 450003China Microbiome Laboratory Henan Provincia People's Hospital Zhengzhou University People's HospitalZhengzhouHenan 450000China Department of Gastrointestinal Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Gastrointestinal Surgeryll Renmin Hospital of Wuhan UniversityWuhanHubei 430060China Department of Gastrointestinal Surgery Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Department of Hepatobiliary Surgery Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China

Tumor-associated inflammation is an important component of the tumor microenvironment,and an important factor affecting tumor *** the tumor microenvironment,tumor-associated macrophages(TAMs)receive different stimuli and can be polarized into classically activated M1 macrophages and alternatively activated M2 *** studies have indicated that the polarization of TAMs is closely related to tumor progression.

关键词： nephrin tumor inflammation

Genome-wide association study reveals that jASMONATE ZIM-DOMAIN 5 regulates seed germination in rice

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The Crop journal 2024年第4期12卷 1001-1009页

作者： Shan Sun Liling Peng Qianqian Huang Zhibo Huang Chengjing Wang jia zhao Zhoufei Wang Yongqi He The Laboratory of Seed Science and Technology Guangdong Key Laboratory of Plant Molecular BreedingKey Laboratory for Enhancing Resource Use Efficiency of Crops in South ChinaMinistry of Agriculture and Rural AffairsSouth China Agricultural UniversityGuangzhou 510642GuangdongChina

Seed germination is a complex trait regulated by multiple genes in ***,the regulators of rice seed germination have yet to be sufficiently ***,a quantitative trait locus(QTL)for rice seed germination was identified in a genome-wide association *** candidate gene jASMONATE ZIM-DOMAIN 5(OsjAZ5)of the QTL was verified that positively regulates seed ***5 regulation of seed germination involves an OsABI3-mediated abscisic acid *** of OsjAZ5 facilitated seed *** application of OsjAZ5 might be useful for increasing seed germination for rice direct seeding.

关键词： Abscisic acid jASMONATE ZIM-DOMAIN Oryza sativa Seed germination

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Taming heat with tiny pressure

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The Innovation 2024年第2期5卷 70-78页

作者： Kun Zhang Zhe Zhang Hailong Pan Haoyu Wang Xueting zhao ji Qi zhao Zhang Ruiqi Song Chenyang Yu Biaohong Huang Xujing Li Huaican Chen Wen Yin Changlong Tan Weijin Hu Michael Wüubbenhorst jiangshui Luo Dehong Yu Zhidong Zhang Bing Li Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Laboratory for Soft Matter and Biophysics Department of Physics and AstronomyKU Leuven3001 LeuvenBelgium Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China College of Materials Science and Engineering Sichuan UniversityChengdu 610064China School of Materials Science and Chemical Engineering Harbin University of Science and TechnologyHarbin 150080China Australian Nuclear Science and Technology Organisation Lucas HeightsNSW 2234Australia

Heat is almost *** electricity,which can be easily manipulated,the current ability to control heat is still highly limited owing to spontaneous thermal dissipation imposed by the second law of *** illumination and pressure have been used to switch endothermic/exothermic responses of materials via phase transitions;however,these strategies are less cost-effective and ***,we spectroscopically demonstrate the glassy crystal state of 2-amino-2-methyl-1,3-propanediol(AMP)to realize an affordable,easily manageable approach for thermal energy *** supercooled state of AMP is so sensitive to pressure that even several megapascals can induce crystallization to the ordered crystal,resulting in a substantial temperature increase of 48 K within 20 ***,we demonstrate a proof-of-concept device capable of programable heating with an extremely high work-to-heat conversion effi-ciency of*** delicate and efficient tuning of heat may remarkably facilitate rational utilization of waste heat.

关键词： illumination thermal rational