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Enhanced optical imaging and fluorescent labeling for visualizing drug molecules within living organisms

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2428-2446页

作者： Ting Sun huanxin zhao Luyao Hu Xintian Shao Zhiyuan Lu Yuli Wang Peixue Ling Yubo Li Kewu Zeng Qixin Chen School of Pharmaceutical Sciences National Key Laboratory of Advanced Drug Delivery SystemMedical Science and Technology Innovation CenterShandong First Medical University&Shandong Academy of Medical SciencesJinan 250062China Departments of Diagnostic Radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and College of Design and EngineeringNational University of SingaporeSingapore 119074Singapore Institute of Biochemical and Biotechnological Drugs School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China Key Laboratory of Biopharmaceuticals Postdoctoral Scientific Research WorkstationShandong Academy of Pharmaceutical ScienceJinan 250098China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China School of Life Sciences Science and Technology Innovation CenterShandong First Medical University&Shandong Academy of Medical SciencesJinan 250062China School of Chinese Materia Medica Tianjin University of Traditional Chinese MedicineTianjin 301617China Tianjin Pharmaceutical DA REN TANG Group Corporation Limited Traditional Chinese Pharmacy Research Institute Tianjin 300457China Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemistry Engineering and TechnologyTianjin UniversityTianjin 300072China

The visualization of drugs in living systems has become key techniques in modern *** advancements in optical imaging technologies and molecular design strategies have revolutionized drug *** the subcellular level,super-resolution microscopy has allowed exploration of the molecular landscape within individual cells and the cellular response to *** beyond subcellular imaging,researchers have integrated multiple modes,like optical near-infrared II imaging,to study the complex spatiotemporal interactions between drugs and their *** combining these visualization approaches,researchers gain supplementary information on physiological parameters,metabolic activity,and tissue composition,leading to a comprehensive understanding of drug *** review focuses on cutting-edge technologies in drug visualization,particularly fluorescence imaging,and the main types of fluorescent molecules ***,we discuss current challenges and prospects in targeted drug research,emphasizing the importance of multidisciplinary cooperation in advancing drug *** the integration of advanced imaging technology and molecular design,drug visualization has the potential to redefine our understanding of pharmacology,enabling the analysis of drug micro-dynamics in subcellular environments from new perspectives and deepening pharmacological research to the levels of the cell and organelles.

关键词： Optical imaging Drug visualization Fluorophore labeling Therapeutics

DNA Extraction Protocol for Biological Ingredient Analysis of Liuwei Dihuang Wan

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Genomics, Proteomics & Bioinformatics 2014年第3期12卷 137-143页

作者： Xinwei Cheng Xiaohua Chen Xiaoquan Su huanxin zhao Maozhen Han Cunpei Bo Jian Xu Hong Bai Kang Ning Institute of Materia Medica Shandong Academy of Medical Sciences School of Medicine and Life Sciences University of Jinan Shandong Academy of Medical Sciences Shandong Key Laboratory of Energy Genetics CAS Key Laboratory of Biofuels and Bioinformatics Group of Single Cell CenterQingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of Sciences

Traditional Chinese medicine （TCM） clinical practice. So far, the methods commonly preparations are widely used for healthcare and used for quality evaluation of TCM preparations mainly focused on chemical ingredients. The biological ingredient analysis of TCM preparations is also important because TCM preparations usually contain both plant and animal ingredients, which often include some mis-identified herbal materials, adulterants or even some biological contaminants. For biological ingredient analysis, the efficiency of DNA extraction is an important factor which might affect the accuracy and reliability of identification. The component complexity in TCM preparations is high, and DNA might be destroyed or degraded in different degrees after a series of processing procedures. Therefore, it is necessary to establish an effective protocol for DNA extraction from TCM preparations. In this study, we chose a classical TCM preparation, Liuwei Dihuang Wan （LDW）, as an example to develop a TCM-specific DNA extraction method. An optimized cetyl trimethyl ammonium bromide （CTAB） method （TCM-CTAB） and three commonly-used extraction kits were tested for extraction of DNA from LDW samples. Experimental results indicated that DNA with the highest purity and concentration was obtained by using TCM-CTAB. To further evaluate the different extraction methods, amplification of the second internal transcribed spacer （ITS2） and the chloroplast genome trnL intron was carried out.

关键词： DNA extraction Traditional Chinese medicinepreparation Biological ingredients Liuwei Dihuang Wan

Forward Steps in Trade Talks ’Encouraging’

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China Today 2019年第12期68卷 10-11页

作者： JING SHUIYU ZHONG NAN zhao huanxin 不详

THE preliminary agreement reached between China and the United States in the latest trade consultations is“encouraging”and will pave the way for both sides to end the long-running dispute,experts and business leader... 详细信息

关键词： Trade dispute Forward

Multifunctional Nacre‑Like Nanocomposite Papers for Electromagnetic Interference Shielding via Heterocyclic Aramid/MXene Template‑Assisted In‑Situ Polypyrrole Assembly

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Nano-Micro Letters 2025年第3期17卷 37-54页

作者： Jinhua Xiong Xu zhao Zonglin Liu He Chen Qian Yan huanxin Lian Yunxiang Chen Qingyu Peng Xiaodong He National Key Laboratory of Science and Technology On Advanced Composites in Special Environments Center for Composite Materials and StructuresHarbin Institute of TechnologyHarbin 150080People’s Republic of China

Robust, ultra-flexible, and multifunctional MXene-basedelectromagnetic interference (EMI) shielding nanocomposite filmsexhibit enormous potential for applications in artificial intelligence,wireless telecommunication, and portable/wearable electronic *** this work, a nacre-inspired multifunctional heterocyclic aramid(HA)/MXene@polypyrrole (PPy) (HMP) nanocomposite paper withlarge-scale, high strength, super toughness, and excellent tolerance tocomplex conditions is fabricated through the strategy of HA/MXenehydrogel template-assisted in-situ assembly of PPy. Benefiting from the"brick-and-mortar" layered structure and the strong hydrogen-bondinginteractions among MXene, HA, and PPy, the paper exhibits remarkable mechanical performances, including high tensile strength (309.7 MPa),outstanding toughness (57.6 MJ m−3), exceptional foldability, and structural stability against ultrasonication. By using the template effect ofHA/MXene to guide the assembly of conductive polymers, the synthesized paper obtains excellent electronic conductivity. More importantly,the highly continuous conductive path enables the nanocomposite paper to achieve a splendid EMI shielding effectiveness (EMI SE) of 54.1 dBat an ultra-thin thickness (25.4 μm) and a high specific EMI SE of 17,204.7 dB cm2g−1. In addition, the papers also have excellent applicationsin electromagnetic protection, electro-/photothermal de-icing, thermal therapy, and fire safety. These findings broaden the ideas for developinghigh-performance and multifunctional MXene-based films with enormous application potential in EMI shielding and thermal management.

关键词： MXene Remarkable mechanical properties Heterocyclic aramid Electromagnetic interference shielding Polypyrrole Multifunctionality

The mechanism and effect of baicalin on the proliferative ability and apoptosis of human bone marrow mesenchymal stem cells in the elderly

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解剖学杂志 2021年第S1期44卷 225-226页

作者： Zhai Xiaoyan Yang Rong zhao huanxin Yang Liwang Ji Xinyan Chu Kaibo Zhang Yumin Zhou Rukui Department of Basic Medicine Shanxi University of Chinese MedicineYuci 030619 Department of Biom edicine Shanxi University of Chinese Medicine

Human bone marrow mesenchymal stem cells(hBM-MSCs)in the elderly were isolated and cultured by whole bone marrow adherent *** hBM-MSCs were treated with different concentrations of baicalin(0,0.5,1,10,50,100,500,1000μmol/L)for 3 days,then cytotoxicity assay of baicalin on the elderly hBM-MSCs was detected with CCK-8 method,and the appropriate baicalin concentration was *** the appropriate concentration range(0.5,1,10μmol/L),the effect of baicalin on the proliferative ability of hBM-MSCs in the elderly was detected by cell counting method,and the optimal drug concentration was *** elderly hBM-MSCs were divided into control group and baicalin ***(1μmol/L)was added to the baicalin group.

关键词： proliferative marrow bone

Co-FeOOH/g-C3N4的制备及其在非均相光芬顿反应中的催化性能

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环境工程学报 2020年第12期14卷 3262-3269页

作者：宋思扬吴丹赵焕新曹宇王欣赵宇沈阳化工大学环境与安全工程学院沈阳110142 抚顺市环境科学研究院抚顺113006

通过化学浴沉淀法制备了Co掺杂的FeOOH与石墨相氮化碳复合材料(Co-FeOOH/g-C3N4),作为非均相光芬顿催化剂,以罗丹明B(RhB)为目标污染物,分别考察了Co掺杂量、pH、温度、H2O2浓度、催化剂剂量等因素对光催化效率的影响。在最佳反应条件下... 详细信息

通过化学浴沉淀法制备了Co掺杂的FeOOH与石墨相氮化碳复合材料(Co-FeOOH/g-C3N4),作为非均相光芬顿催化剂,以罗丹明B(RhB)为目标污染物,分别考察了Co掺杂量、pH、温度、H2O2浓度、催化剂剂量等因素对光催化效率的影响。在最佳反应条件下,Co-FeOOH、g-C3N4和Co-FeOOH/g-C3N4对RhB的去除率分别为23.7%、59.6%和91.5%。通过阿伦尼乌斯方程计算得到反应的活化能为12.8 kJ·mol^−1,通过自由基捕获实验证实·OH与h+均为起主要作用的活性物种。Co-FeOOH/g-C3N4经过5次循环使用后,对RhB的去除率没有明显下降,说明其具有良好的稳定性。最后,以天然日光作为驱动光源,考察了催化剂对高浓度染料废水的处理性能,反应6 h后,废水的脱色率达到100%,COD去除率为43.9%,延长反应时间至10 h,COD的去除率达到81.6%。在非均相芬顿反应中引进了可见光,在提高降解反应速率的同时降低了催化反应发生的成本,本研究结果可为非均相光芬顿体系的实际应用提供实验基础。

关键词：非均相光芬顿太阳光 Co-FeOOH/g-C3N4

The mechanism and effect of baicalin on the proliferative ability and apoptosis of human bone marrow mesenchymal stem cells in the elderly

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The mechanism and effect of baicalin on the proliferative ab...

POINT PATTERN MATCHING ALGORITHM BASED ON POINT PAIR TOPOLOGICAL CHARACTERISTICS AND SPECTRAL MATCHING

中国解剖学会2021年年会

作者： Zhai Xiaoyan Yang Rong zhao huanxin Yang Liwang Ji Xinyan Chu Kaibo Zhang Yumin Zhou Rukui Department of Basic Medicine Shanxi University of Chinese Medicine Department of Biomedicine Shanxi University of Chinese Medicine

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Journal of Electronics(China) 2012年第Z2期 279-285页

作者： Lu Chunyan Zou huanxin zhao Jian Zhou Shilin (Department of Information Engineering, College of Electronic Science and Engineering, National University of Defense Technology, Changsha 410073, China)

Most of the Point Pattern Matching (PPM) algorithm performs poorly when the noise of the point’s position and outliers exist. This paper presents a novel and robust PPM algorithm which combined Point Pair Topological Characteristics (PPTC) and Spectral Matching (SM) together to solve the afore mentioned issues. In which PPTC, a new shape descriptor, is firstly proposed. A new comparability measurement based on PPTC is defined as the matching probability. Finally, the correct matching results are achieved by the spectral matching method. The synthetic data experiments show its robustness by comparing with the other state-of-art algorithms and the real world data experiments show its effectiveness.

关键词： Point Pattern Matching (PPM) Point Pair Topological Characteristics (PPTC) Assign graph Spectral matching

纳米CuO在水体环境中的转化行为及其对大型溞的毒性效应

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环境科学学报 2020年第5期40卷 1858-1864页

作者：马增杰赵焕新张辉万斌沈阳化工大学环境与安全工程学院沈阳110142 中国科学院生态环境研究中心环境化学与生态毒理学国家重点实验室北京100085

为探究纳米CuO颗粒(CuO NP)在水体中的环境暴露风险,考察了腐殖酸(SRHA)和酸根离子对CuO NP转化行为的影响,探讨了CuO NP在不同条件下转化对大型溞的毒性效应差异.结果表明,与单独水体中CuO NP的转化行为相比,H2PO4^-显著促进了CuO NP释... 详细信息

为探究纳米CuO颗粒(CuO NP)在水体中的环境暴露风险,考察了腐殖酸(SRHA)和酸根离子对CuO NP转化行为的影响,探讨了CuO NP在不同条件下转化对大型溞的毒性效应差异.结果表明,与单独水体中CuO NP的转化行为相比,H2PO4^-显著促进了CuO NP释放Cu^2+,Cl^-、NO3^-、SO4^2-对CuO NP的转化行为没有显著影响,而CO3^2-、HCO3^-、PO4^3-、HPO4^2-抑制了CuO NP中Cu^2+的释放;SRHA显著促进了CuO NP释放Cu^2+,但HCO3^-、PO4^3-的存在可以明显抑制SRHA促进CuO NP中Cu^2+释放的进程.CuO NP在单独水体中,以及在Cl^-、PO4^3-和SRHA+PO4^3-存在的水体中转化后对大型溞的致死中浓度为16~32 mg·L^-1,而在SRHA与SRHA+Cl^-存在的水体中转化后对大型溞的致死中浓度分别降到0.8和2.5 mg·L^-1,说明SRHA促进了CuO NP释放Cu^2+,提高了CuO NP颗粒分散性,使其易于被大型溞体内细胞组织摄取,增加了CuO NP对大型溞的毒性效应,因此,环境转化对CuO NP的环境暴露风险有重要影响.

关键词： CuO NP 腐殖酸酸根离子环境转化生物毒性