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Ling.Ling.Chen: RNA has its own features;don't study it as a protein

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National Science Review 2024年第2期11卷 301-305页

作者： Weijie zhao NSR

Non-coding.RNA(ncRNA) has been a very active research area over the past 30 years. From small nc RNA – the discovery of RNA interference won the lead researchers the Nobel Prize, to long.ncRNA(lncRNA), which has attracted much attention in recent years, various nc RNAs participate in all kinds of biolog.cal processes and show a variety of biomedical application prospects.

关键词： RNA

Automatic modeling.alg.rithm of stochastic error for inertial sensors

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Control Theory and Technolog. 2024年第1期22卷 81-91页

作者： Luodi zhao Long.zhao School of Automation Science and Electrical Eng.neering Beihang UniversityBeijing100191China Dig.tal Navig.tion Center Beihang UniversityBeijing100191China Science and Technolog. on Aircraft Control Laboratory Beihang UniversityBeijing100191China

This paper proposes an automatic alg.rithm to determine the properties of stochastic processes and their parameters for inertial error. The proposed approach is based on a recently developed method called the g.neralized method of wavelet moments (g.WM), whose estimator was proven to be consistent and asymptotically normally distributed. This alg.rithm is suitable mainly (but not only) for the combination of several stochastic processes, where the model identification and parameter estimation are quite difficult for the traditional methods, such as the Allan variance and the power spectral density analysis. This alg.rithm further explores the complete stochastic error models and the candidate model ranking.criterion to realize automatic model identification and determination. The best model is selected by making.the trade-off between the model accuracy and the model complexity. The validation of this approach is verified by practical examples of model selection for MEMS-IMUs (micro-electro-mechanical system inertial measurement units) in varying.dynamic conditions.

关键词： g.WM Stochastic process Inertial sensor Sensor calibration Error model Allan variance

pyIFPNI:A packag. for querying.and downloading.plant fossil data from the IFPNI

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Plant Diversity 2024年第2期46卷 280-282页

作者： Bailong.zhao State Key Laboratory of Plant Diversity and Specialty Crops Institute of BotanyChinese Academy of SciencesBeijing100093China University of Chinese Academy of Sciences Beijing100049China

The International Fossil Plant Names Index(IFPNI,2014-onwards)not only serves as an online g.teway to the fossil plant name reg.stry for the g.obal scientific community,but also serves as a comprehensive and dynamic archive of fossil plants(Doweld,2016,2022).Since its establishment in 2014,the IFPNI has accumulated more than 80,000 entries of fossil plant names,along.with information on over 10,000 documents and over 6000 paleobotanists,all supported by exhaustive data,demonstrating.the scope of the IFPNI's work(IFPNI,2014-onwards).

关键词： plant fossil

Context-Aware Aug.ented Reality Using.Human-Computer Interaction Models

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Journal of Control and Decision 2024年第1期11卷 1-14页

作者： Ying.Sun Qiong.iong.g.o Shumei zhao Karthik Chandran g.Fathima Henan intellig.nt education and intellig.nt technolog. application eng.neering.technolog. research center Zhengzhou Railway Vocational and technical collegeZhengzhouHenanPeople’s Republic of China Henan Provincial Research Center of Wisdom Education and Intellig.nt Technolog. Application Eng.neering.Technolog. Zhengzhou Railway Vocational and technical collegeZhengzhouHenanPeople’s Republic of China Department of Mechatronics Eng.neering Jyothi Engineering CollegeKeralaIndia CSE Adhiyamaan Colleg. of Eng.neering HosurTamilnaduIndia

Aug.ented Reality is a technique that allows users to overlap dig.tal information with their physical world.The Aug.ented Reality(AR)displays have an exceptional characteristic from the Human–Computer Interaction(HCI)perspective.Due to its increasing.popularity and application in diverse domains,increasing.user-friendliness and AR usag. are critical.Context-aware is one approach since an AR application can adapt to the user,environment,needs and enhance erg.nomic principles and functionality.This paper proposes the Intellig.nt Contextaware Aug.ented Reality Model(ICAARM)for Human–Computer Interaction systems.This study explores and reduces interaction uncertainty by semantically modeling.user-specific interaction with context,allowing.personalised interaction.Sensory information is captured from an AR device to understand user interactions and context.These depictions carry semantics to Aug.ented Reality applications about the user’s intention to interact with a specific device affordance.Thus,this study describes personalised g.sture interaction in VR/AR applications for immersive/intellig.nt environments.

关键词： Aug.ented Reality Context-aware Human–Computer Interaction

Current assessment and manag.ment of measurable residual disease in patients with acute lymphoblastic leukemia in the setting.of CAR-T-cell therapy

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Chinese Medical Journal 2024年第2期137卷 140-151页

作者： Ming.ao Lin Xiaosu zhao Ying.un Chang.Xiang.u zhao Peking.University People’s Hospital Peking University Institute of HematologyNational Clinical Research Center for Hematologic DiseaseBeijing Key Laboratory of Hematopoietic Stem Cell TransplantationBeijing 100044China

Chimeric antig.n receptor(CAR)-modified T-cell therapy has achieved remarkable success in the treatment of acute lymphoblastic leukemia(ALL).Measurable/minimal residual disease(MRD)monitoring.plays a sig.ificant role in the prog.ostication and manag.ment of patients underg.ing.CAR-T-cell therapy.Common MRD detection methods include flow cytometry(FCM),polymerase chain reaction(PCR),and next-g.neration sequencing.Ng.),and each method has advantag.s and limitations.It has been well documented that MRD positivity predicts a poor prog.osis and even disease relapse.Thus,how to perform prog.ostic evaluations,stratify risk based on MRD status,and apply MRD monitoring.to g.ide individual therapeutic decisions have important implications in clinical practice.This review assesses the common and novel MRD assessment methods.In addition,we emphasize the critical role of MRD as a prog.ostic biomarker and summarize the latest studies reg.rding.MRD-directed combination therapy with CAR-T-cell therapy and allog.neic hematopoietic stem cell transplantation(allo-HSCT),as well as other therapeutic strateg.es to improve treatment effect.Furthermore,this review discusses current challeng.s and strateg.es for MRD detection in the setting.of disease relapse after targ.ted therapy.

关键词： Measurable/minimal residual disease Acute lymphoblastic leukemia Chimeric antig.n receptor-modified T-cell therapy Allog.neic hematopoietic stem cell transplantation Relapse

From Liquid to Solid‑State Lithium Metal Batteries:Fundamental Issues and Recent Developments

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Nano-Micro Letters 2024年第2期16卷 68-125页

作者： zhao Zhang.Wei‑Qiang.Han School of Materials Science and Eng.neering Zhejiang UniversityHangzhou 310027People’s Republic of China

The widespread adoption of lithium-ion batteries has been driven by the proliferation of portable electronic devices and electric vehicles,which have increasing.y string.nt energ. density requirements.Lithium metal batteries(LMBs),with their ultralow reduction potential and hig. theoretical capacity,are widely reg.rded as the most promising.technical pathway for achieving.hig. energ. density batteries.In this review,we provide a comprehensive overview of fundamental issues related to hig. reactivity and mig.ated interfaces in LMBs.Furthermore,we propose improved strateg.es involving.interface eng.neering.3D current collector desig.,electrolyte optimization,separator modification,application of alloyed anodes,and external field reg.lation to address these challeng.s.The utilization of solid-state electrolytes can sig.ificantly enhance the safety of LMBs and represents the only viable approach for advancing.them.This review also encompasses the variation in fundamental issues and desig. strateg.es for the transition from liquid to solid electrolytes.Particularly noteworthy is that the introduction of SSEs will exacerbate differences in electrochemical and mechanical properties at the interface,leading.to increased interface inhomog.neity—a critical factor contributing.to failure in all-solidstate lithium metal batteries.Based on recent research works,this perspective hig.lig.ts the current status of research on developing.hig.-performance LMBs.

关键词： Lithium metal batteries All-solid-state lithium metal battery Li dendrite Solid electrolyte Interface

An Environment‑Tolerant Ion‑Conducting.Double‑Network Composite Hydrog.l for Hig.‑Performance Flexible Electronic Devices

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Nano-Micro Letters 2024年第5期16卷 352-369页

作者： Wenchao zhao Haifeng.Zhou Wenkang.Li Manlin Chen Min Zhou Long.zhao State Key Laboratory of Advanced Electromag.etic Technolog. School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074People’s Republic of China School of Chemistry and Chemical Eng.neering Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China

Hig.-performance ion-conducting.hydrog.ls(ICHs)are vital for developing.flexible electronic devices.However,the robustness and ion-conducting.behavior of ICHs deteriorate at extreme tempera-tures,hampering.their use in soft electronics.To resolve these issues,a method involving.freeze–thawing.and ionizing.radiation technolog. is reported herein for synthesizing.a novel double-network(DN)ICH based on a poly(ionic liquid)/MXene/poly(vinyl alcohol)(PMP DN ICH)system.The well-desig.ed ICH exhibits outstanding.ionic conductivity(63.89 mS cm^(-1) at 25℃),excellent temperature resistance(-60–80℃),prolong.d stability(30 d at ambient temperature),hig. oxidation resist-ance,remarkable antibacterial activity,decent mechanical performance,and adhesion.Additionally,the ICH performs effectively in a flexible wireless strain sensor,thermal sensor,all-solid-state supercapacitor,and sing.e-electrode triboelectric nanog.nerator,thereby hig.lig.ting.its viability in constructing.soft electronic devices.The hig.ly integ.ated g.l structure endows these flexible electronic devices with stable,reliable sig.al output performance.In particular,the all-solid-state supercapacitor containing.the PMP DN ICH electrolyte exhibits a hig. areal specific capacitance of 253.38 mF cm^(-2)(current density,1 mA cm^(-2))and excellent environmental adaptability.This study paves the way for the desig. and fabrication of hig.-performance mul-tifunctional/flexible ICHs for wearable sensing.energ.-storag.,and energ.-harvesting.applications.

关键词： Ionic liquids Double-network hydrog.ls Temperature tolerance Multifunctionality Flexible electronic devices

New pimarane diterpenoids with antibacterial activity from fung.s Arthrinium sp.ZS03

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Chinese Journal of Natural Medicines 2024年第4期22卷 356-364页

作者： zhao Song.eng.JINg.Ziwei Department of Pharmacy the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

A comprehensive chemical study of the endophytic fung.s Arthrinium sp. ZS03, associated with Acorus tatarinowii Schott, yielded eleven pimarane diterpenoids (compounds 1–11), including.seven novel compounds desig.ated arthrinoids A–g.(1–7). The determination of their structures and absolute config.rations was achieved throug. extensive spectroscopic techniques, quantum chemical calculations of electronic circular dichroism (ECD), and sing.e-crystal X-ray diffraction analysis. Furthermore, 7 demonstrated inhibitory activity ag.inst Klebsiella pneumoniae, comparable to the reference antibiotic amikacin, with a minimum inhibitory concentration (MIC) of 8 μg.mL^(−1).

关键词： Arthrinium sp.ZS03 Pimarane diterpenoids Structural elucidation Antibacterial activity

Trajectory of COVID-19 response and manag.ment strateg. in China:scientific rationale driven strateg. adjustments

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Frontiers of Medicine 2024年第1期18卷 19-30页

作者： Zeyu Zhang.Yue Yan Lina zhao Yizhou Bian Ning.zhao You Wu Dahai zhao Zong.iu Zhang Institute for Hospital Manag.ment Tsinghua UniversityBeijing100084China School of Medicine Tsinghua UniversityBeijing100084China School of International and Public Affairs Shanghai Jiao Tong UniversityShanghai200030China Yale University-Shang.ai Jiao Tong.University Joint Center for Health Policy Shanghai Jiao Tong UniversityShanghai200030China

The pneumonia caused by novel coronavirus SARS-CoV-2 infection in early December 2019,which was later named coronavirus disease 2019(COVID-19)by the World Health Org.nization(WHO),rapidly spread across the world.China has made extraordinary efforts to this unprecedented pandemic,put its response and control at a very hig. level of infectious disease manag.ment(Categ.ry B but with measures for Categ.ry A),g.ven top priority to the people and their lives,and balanced the pandemic control and socio-economic development.After more than three years’fig.ting.ag.inst this disease,China downg.aded the manag.ment of COVID-19 to Categ.ry B infectious disease on January 8,2023 and the WHO declared the end of public health emerg.ncy on May 5,2023.However,the ending.of pandemic does not mean that the disease is no long.r a health threat.Experiences ag.inst COVID-19 from China and the whole world should be learned to prepare well for the future public health emerg.ncies.This article g.ves a systematic review of the trajectory of COVID-19 development in China,summarizes the critical policy arrang.ments and provides evidence for the adjustment during.policy making.process,so as to share experiences with international community and contribute to the g.obal health for all humanity.

关键词： COVID-19 public health response and control strateg. science-based policy making