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Heavy haze pollution during the COVID-19 lockdown in the Beijing-Tianjin-Hebei region,China

Journal of Environmental Sciences 2022年第4期34卷 170-178页

作者： Xin Zhang zhongzhi Zhang Zhisheng Xiao Guigang Tang Hong Li Rui Gao Xu Dao Yeyao Wang Wenxing Wang Environment Research Institute Shandong UniversityQingdao 266237China State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China China National Environmental Monitoring Centre Beijing 100012China

To investigate the characteristics of particulate matter with an aerodynamic diameter less than 2.5μm(PM_(2.5))and its chemical compositions in the Beijing-Tianjin-Hebei(BTH)region of China during the novel coronavirus disease(COVID-19)lockdown,the ground-based data of PM_(2.5),trace gases,water-soluble inorganic ions,and organic and elemental carbon were analyzed in three typical cities(Beijing,Tianjin,and Baoding)in the BTH region of China from 5-15 February *** PM_(2.5)source apportionment was established by combining the weather research and forecasting model and comprehensive air quality model with extensions(WRF-CAMx).The results showed that the maximum daily PM_(2.5)concentration reached the heavy pollution level(>150μg/m^(3))in the above three *** sum concentration of SO_(4)^(2-),NO_(3)^(-)and NH_(4)^(+)played a dominant position in PM_(2.5)chemical compositions of Beijing,Tianjin,and Baoding;secondary transformation of gaseous pollutants contributed significantly to PM_(2.5)generation,and the secondary transformation was enhanced as the increased PM_(2.5)*** results of WRF-CAMx showed obviously inter-transport of PM_(2.5)in the BTH region;the contribution of transportation source decreased significantly than previous reports in Beijing,Tianjin,and Baoding during the COVID-19 lockdown;but the contribution of industrial and residential emission sources increased significantly with the increase of PM_(2.5)concentration,and industry emission sources contributed the most to PM_(2.5)***,control policies should be devoted to reducing industrial emissions and regional joint control strategies to mitigate haze pollution.

关键词： COVID-19 lockdown Heavy haze pollution Chemical compositions Source apportionment Beijing-Tianjin-Hebei region

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Angiography findings and endovascular management of acute nonvariceal gastrointestinal bleeding:A pictorial essay

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Journal of Interventional Medicine 2022年第1期5卷 1-5页

作者： Haiyang Yu Junhao Mei Lihao Qin zhongzhi Jia Department of Interventional and Vascular Surgery Changzhou No.2 People’s HospitalChangzhou213003China

Patients with acute nonvariceal gastrointestinal bleeding(GIB)not treatable via endoscopic therapy require angiography and endovascular *** the source of the bleeding can be identified on angiography,the bleeding can be controlled with minimal complications by endovascular treatments such as intra-arterial infusion of vasopressin,embolization,covered stent placement,or a combination *** pictorial essay reviews the angiographic findings for and the endovascular management of acute nonvariceal GIB.

关键词： Gastrointestinal Bleeding Angiography Management Embolization

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Small molecule conjugates with selective estrogen receptor β agonism promote anti-aging benefits in metabolism and skin recovery

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2137-2152页

作者： Tarik Zahr Vijay K.Boda Jian Ge Lexiang Yu zhongzhi Wu Jianwen Que Wei Li Li Qiang Naomi Berrie Diabetes Center Columbia UniversityNew YorkNY 10032USA Department of Molecular Pharmacology and Therapeutics Columbia UniversityNew YorkNY 10032USA Department of Pharmaceutical Sciences College of PharmacyUniversity of Tennessee Health Science CenterMemphisTN 38163USA Drug Discovery Center College of PharmacyUniversity of Tennessee Health Science CenterMemphisTN 38163USA Division of Digestive and Liver Diseases Columbia UniversityNew YorkNY 10032USA Center for Human Development Columbia UniversityNew YorkNY 10027USA Department of Pathology and Cell Biology Columbia UniversityNew YorkNY 10032USA Department of Medicine Columbia UniversityNew YorkNY 10032USA

Estrogen is imperative to mammalian reproductivity,metabolism,and ***,the hormone activating estrogen receptor(ERs)αcan cause major safety concerns due to the enrichment of ERαin female tissues and certain *** contrast,ERβis more broadly expressed in metabolic tissues and the ***,it is desirable to generate selective ERβagonist conjugates for maximizing the therapeutic effects of ERs while minimizing the risks of ERα***,we report the design and production of small molecule conjugates containing selective non-steroid ERβagonists Gtx878 or *** of aged mice with our synthesized conjugates improved aging-associated declines in insulin sensitivity,visceral adipose integrity,skeletal muscle function,and skin health,with validation in *** further uncovered the benefits of ERβconjugates in the skin using two inducible skin injury mouse models,showing increased skin basal cell proliferation,epidermal thickness,and wound ***,our ERβ-selective agonist conjugates offer novel therapeutic potential to improve aging-associated conditions and aid in rejuvenating skin health.

关键词： Estrogen receptorβ Aging Metabolism Skin injury Muscle metabolism Small molecule conjugates Regeneration Adiposity

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Cognitive Machine Learning

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International Journal of Intelligence Science 2019年第4期9卷 111-121页

作者： zhongzhi Shi Institute of Computing Technology Chinese Academy of Sciences Beijing China

Cognitive machine learning refers to the combination of machine learning and brain cognitive mechanism, specifically, combining machine learning with mind model CAM. Three research directions are proposed in this pape... 详细信息

关键词： Cognitive Machine Learning Emergency of Learning Complementary Learning System Evolution of Learning Intelligence Science Mind Model CAM

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Foundations of Intelligence Science

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International Journal of Intelligence Science 2011年第1期1卷 8-16页

作者： zhongzhi Shi 不详

In order to make significant progress toward achievement of human level machine intelligence a paradigm shift is needed. More specifically, the natural intelligence and artificial intelligence should be closely interacted in Intelligence Science study, instead of separate from each other. In order to reach the paradigm, brain science, cognitive science, artificial intelligence and others should cross-research together. Brain science explores the essence of brain, research on the principle and model of natural intelligence in molecular, cell and behavior level. Cognitive science studies human mental activity, such as perception, learning, memory, thinking, consciousness etc. Artificial intelligence attempts simulation, extension and expansion of human intelligence using artificial methodology and technology. All together pursue to explore the mechanism and principle of intelligence which is the engine of advanced science and technology. The paper will give the definition of intelligence and discuss ten big issues of Intelligence Science. The conclusion and perspective will be given in last section.

关键词： Intelligence Intelligence Science Machine Intelligence

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Radiation segmentectomy for hepatic malignancies: Indications, devices,dosimetry, procedure, clinical outcomes, and toxicity of yttrium-90 microspheres

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Journal of Interventional Medicine 2019年第1期2卷 1-4页

作者： zhongzhi Jia Caoye Wang Ricardo Paz-Fumagalli Weiping Wang Department of Interventional Radiology Second People’s Hospital of ChangzhouChangzhou213003China The Center of Medical Physics with Nanjing Medical University Changzhou213003China Department of Interventional Radiology First People's Hospital of ChangzhouChangzhou213000China Department of Radiology Mayo ClinicJacksonvilleFL32224USA

Radiation segmentectomy(RS) is a new approach to90 Y radioembolization that has been designed to increase the safety and efficacy of radioembolization in patients with unresectable hepatic malignancies. With this technique,high doses(>190 Gy) of radiation are delivered to the tumor through radioembolization performed in a segmental fashion, potentially increasing the radiation dose to the tumor while minimizing injury to the liver parenchyma. The aim of this review is to provide a summary of the indications, device choice, dosimetry, procedure, clinical outcomes, and toxicity of RS based on the clinical series currently available.

关键词： Hepatic malignancy Yttrium-90 Radioembolization Radiation segmentectomy

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DNA Binding Properties and Cytotoxic Activities of Two Trinuclear Ruthenium（Ⅱ） Polypyridyl Complexes

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Chemical Research in Chinese Universities 2014年第3期30卷 461-467页

作者： XU Li CHEN Yu WEI Hui WU Wenshan LI zhongzhi LIN Yiwei CHAO Hui JI Liangnian School of Chemistry and Chemical Engineering Guangdong Pharmaceutical University Zhongshan 528458 P R. China State Key Laboratory of Biocontrol Department of Biochemistry College of Life Sciences Sun Yat-sen University Guangzhou 510006 P. R. China School of Chemistry and Chemical Engineering Sun Yat-sen University Guangzhou 510275 P. R. China

The interactions between two trinuclear Ru（II） complexes and calf thymus DNA（CT DNA） were studied via absorption spectroscopy, reverse salt titrations, binding stoichiometry, DNA melting experiments, as well as viscosity measurement. The results indicate that complexes 1 and 2 bind to DNA via the interaction of the planar π-delocalized system of the complexes with intrinsic binding constants of 4.18 × 10^5 and 3.85 × 10^6 L/tool, respectively, and non-electrostatic binding free energy makes a predominant contribution to the binding free energy. The in vitro cytotoxic activity of complexes 1 and 2 was evaluated by the MTT[3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyl- 2H-tetrazolium bromide] method. Complex I shows higher anticancer potency than complex 2 against four tumor cell lines. Further mechanism study indicates that complexes 1 and 2 can cause cell cycle arrest in the G2/M phase.

关键词： Ruthenium(Ⅱ) complex DNA binding Cell cycle

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PARALLEL NONLINEAR MULTISPLITTING RELAXATION METHODS

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Applied Mathematics(A Journal of Chinese Universities) 1995年第3期10卷 251-266页

作者： WANG DEREN AND BAI zhongzhi(Department of Mathematics, Shanghai University of Science and Technology, Shanghai 201800). Department of Mathematics Shanghai University of Science and Technology Shanghai

By further generalizing Frommer's results in the sense of nonlinear multisplitting, we build a class of nonlinear multisplitting AOR-type methods, which covers many rather practical nonlinear multisplitting relaxation methods such as multisplitting AOR-Newton method, multisplitting AOR-chord method and multisplitting AOR-Steffensen method, etc.. Furthermore,a general convergence theorem for the nonlinear multisplitting AOR-type methods and the local convergence for the multisplitting AOR-Newton method are discussed in detail.A lot of numerical tests show that our new methods are feasible and satisfactory.

关键词： Nonlinear system of equations,nonlinear multisplitting,relaxed method local convergence

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Dielectric Properties and Lattice Distortion in Rhombohedral Phase Region and Phase Coexistence Region of PZT Ceramics

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Communications in Theoretical Physics 2005年第5期43卷 855-860页

作者： ZHANGDuan-Ming zhongzhi-Cheng HANXiang-Yun YANWen-Sheng SUNHong-Zhang YANGFeng-Xia ZHENGKe-Yu WEINian LIZhi-Huai DepartmentofPhysics HuazhongUniversityofScienceandTechnologyWuhan430074China／／FacultyofPhysicsandElectronicTechnologyHubeiUniversityWuhan430062China DepartmentofPhysics HuazhongUniversityofScienceandTechnologyWuhan430074China／／DepartmentofPhysicsXiangfanCollegeXiangfan441053China

In this paper, the relation between the dielectric properties and the lattice distortion in the phase coexistence region is discussed using a phase statistical distribution model, and in the rhombohedral phase region the two connection equations on the dielectric properties and the lattice distortion are established. Particularly, the relation between the dielectric properties and the lattice distortion is investigated in the phase coexistence region of PZT ceramics, and the fitting value of the volume fraction of the tetragonal phase VT to composition x in the equation is determined. Further,the fitting results are well consistent with the related experimental data. It involves more profound physical process than relation between the dielectric properties and composition x.

关键词： lattice distortion dielectric properties rhombohedral phase phasecoexistence PZT

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Differentiating Data Collection for Cloud Environment Monitoring

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China Communications 2014年第4期11卷 13-24页

作者： MENG You LUAN zhongzhi QIAN Depei Sino-German Joint Software Institute (JSI) Beihang University (BUAA) Beijing 100083 China

In a growing number of information processing applications,data takes the form of continuous data streams rather than traditional stored *** systems that seek to provide monitoring services in cloud environment must be prepared to deal gracefully with huge data collections without compromising system *** this paper,we show that by using a concept of urgent data,our system can shorten the response time for most 'urgent' queries while guarantee lower bandwidth *** argue that monitoring data can be treated *** data capture critical system events;the arrival of these data will significantly influence the monitoring reaction speed which is called urgent *** speed urgent data collections can help system to react in real time when facing fatal errors.A cloud environment in production,MagicCube,is used as a test *** experiments over both real world and synthetic traces show that when using urgent data,monitoring system can lower the response latency compared with existing monitoring approaches.

关键词： cloud computing cloud monitoring urgent data rule engine constraint

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