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核因子-κB诱捕物ODN对大鼠移植肾的转染及对细胞因子基因表达的影响

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中国血液净化 2005年第3期4卷 157-161页

作者：张宏涛赵显国丰贵文郑州大学第一附属医院血液净化中心郑州450000

目的　探讨核因子 -κB(NFκB)诱补物寡聚核苷酸 (ODN)对大鼠供肾的转染效率及对移植肾细胞因子基因表达影响。方法　建立大鼠移植肾模型 ,应用含有 1 μMLiposome/ODNEuro -Collins保存液(Ecs)灌注移植肾并低温缺氧保存 6h后移植到受... 详细信息

目的　探讨核因子 -κB(NFκB)诱补物寡聚核苷酸 (ODN)对大鼠供肾的转染效率及对移植肾细胞因子基因表达影响。方法　建立大鼠移植肾模型 ,应用含有 1 μMLiposome/ODNEuro -Collins保存液(Ecs)灌注移植肾并低温缺氧保存 6h后移植到受体大鼠 ;2 4只大鼠分成 4组 :假手术组 (control组 ) ,ECs组 ,NFκB诱补物 (decoyODN)组 ,错配ODN(scrambledODN)组。应用荧光显微镜和多光子共聚焦显微镜观察转染有FITC标记的ODN移植肾 ,并观看其分布 ;用RT -PCR技术 ,检测术后移植肾中ICAM - 1、VCAM- 1、CINC的mRNA表达。结果　移植术后 1 5min ,FITC标记的decoyODN主要分布在移植肾的肾小球 ,并且有部分ODN进入细胞核 ;在术后 6h时 ,诱补物ODN主要分布在肾小球和近曲肾小管中 ,并且大部分进入细胞核。而不含有脂质体诱补物ODN复合物的Ecs保存的移植肾中则无荧光颗粒 ;与control组相比 ,ECs组移植肾 ,ICAM - 1、VCAM - 1、CINC的mRNA水平明显升高 (P 0 .0 5 )。结论　诱捕物ODN脂质体复合物在ECs中及低温缺氧条件下可?

关键词： NFKB诱补物ODN 细胞因子肾移植

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华南埃迪卡拉纪晚期深水相氮循环过程重建

地球科学 2024年第9期49卷 3212-3227页

作者：叶凯云赵坤童霞李松倬郎咸国成都理工大学沉积地质研究院四川成都610059 中国石油大庆油田有限责任公司成都勘探开发研究院四川成都610051

重建地质历史时期的古海洋氮循环过程有助于了解当时的海洋氧化还原状态,而目前埃迪卡拉纪晚期的海洋氮循环研究程度较低,因此对桂北泗里口和黔东南上地坪剖面开展了详细的全岩氮(δ15N)和有机碳同位素(δ13C_(org))研究.结果显示,泗里... 详细信息

重建地质历史时期的古海洋氮循环过程有助于了解当时的海洋氧化还原状态,而目前埃迪卡拉纪晚期的海洋氮循环研究程度较低,因此对桂北泗里口和黔东南上地坪剖面开展了详细的全岩氮(δ15N)和有机碳同位素(δ13C_(org))研究.结果显示,泗里口和上地坪剖面的δ15N平均值分别为(1.6±2.0)‰和(3.5±1.1)‰,总体上均表现为由老到新逐渐降低,两个剖面的δ13_(Corg)平均值分别为(-30.0±1.4)‰和(-30.6±1.4)‰.较高的δ15N值表明该时期为硝化‒反硝化作用相耦合的好氧氮循环,海洋中存在一个稳定的硝酸盐库.研究剖面δ15N值由老到新均表现为逐渐降低,可解释为底层缺氧水体的扩张,反硝化作用和厌氧氨氧化作用消耗了表层水体中大量的NO3‒,刺激了固氮作用.因此,埃迪卡拉纪末期深部缺氧水体的扩张可能加剧了~542 Ma埃迪卡拉生物群的灭绝.

关键词：氮同位素埃迪卡拉纪晚期深水相华南地球化学地层学.

核电厂凝汽器泄漏监测系统问题研究及改进应用

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电站辅机 2022年第3期43卷 38-42页

作者：赵显国孙振平刘伟中广核工程有限公司广东深圳518124

通过对核电厂凝汽器泄漏监测系统运行中存在问题的改进,解决了凝汽器发生泄漏时无法准确判断和定位的问题,缩短了机组维修时间。提出了凝汽器泄漏监测系统在设计选型时应满足的技术条件,对设备采购有一定指导意义。

关键词：凝汽器检漏泄漏应用

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连续性血液净化对重症急性胰腺炎预后的影响

中国实用医刊 2008年第16期35卷 23-24页

作者：郑守华张水军赵显国郑州大学第一附属医院普外科郑州450052

目的观察连续性血液净化对重症急性胰腺炎（SAP）患者预后的影响。方法我院入住的所有重症急性胰腺炎患者中37例符合血液净化治疗指征者，均行连续性血液净化治疗，观察患者多器官功能衰竭（MODS）发生率和病死率。结果血液净化组MODS... 详细信息

目的观察连续性血液净化对重症急性胰腺炎（SAP）患者预后的影响。方法我院入住的所有重症急性胰腺炎患者中37例符合血液净化治疗指征者，均行连续性血液净化治疗，观察患者多器官功能衰竭（MODS）发生率和病死率。结果血液净化组MODS发生率和病死率明显下降，P值均〈0．05。结论血液净化可以有效减低SAP患者病死率和MODS发生率，改善其预后。

关键词：重症急性胰腺炎血液净化预后

上海市社区卫生服务中心口腔诊室建设情况调查及城郊差异分析

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中华全科医师杂志 2024年第3期23卷 251-257页

作者：陈斌徐先国盛璐上海市闵行区华漕社区卫生服务中心上海201107 上海市浦东新区张江社区卫生服务中心上海201210 上海市口腔医院口腔颌面外科上海200237

目的了解上海市社区卫生服务中心口腔诊室的建设情况及城郊差异。方法该研究为横断面研究。于2023年3月10—17日,采用问卷调查的形式通过自行设计的《上海市社区卫生服务中心口腔诊疗服务能力调查表》,收集上海市249家社区卫生服务中心... 详细信息

目的了解上海市社区卫生服务中心口腔诊室的建设情况及城郊差异。方法该研究为横断面研究。于2023年3月10—17日,采用问卷调查的形式通过自行设计的《上海市社区卫生服务中心口腔诊疗服务能力调查表》,收集上海市249家社区卫生服务中心的口腔诊室相关信息,根据上海市卫生统计年鉴的分区类型分为中心城区、近郊地区、远郊地区3类,从口腔诊室基本设施、开展的临床诊疗项目、人员结构等方面比较城郊差异情况。结果调查有效问卷回收率为100.0%(249/249)。(1)全市249家社区卫生服务中心中,220家设置了口腔诊室(88.4%),29家(11.6%)未设置,近郊地区、中心城区和远郊地区设置了口腔诊室的社区卫生服务中心占比分别为98.2%(107/109)、95.0%(76/80)和61.7%(37/60),近郊地区>中心城区>远郊地区(H=35.44,P中心城区>远郊地区(H=25.07,P中心城区>远郊地区(H=66.35、50.33、11.19、42.17,均P<0.05)。结论上海市社区卫生服务中心口腔服务能力具备一定的基础,但中心城区、近郊地区和远郊地区差异较大,其中近郊地区发展较好,中心城区在建筑面积等方面需要加强,远郊在设施设备、人才队伍方面需要加强。

关键词：社区卫生服务问卷调查口腔保健牙科诊室

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树脂基复合材料摩擦噪声特性研究

摩擦学学报（中英文） 2024年第6期44卷 811-821页

作者：鄢枫宸凤维民宋晖胡献国合肥工业大学机械工程学院安徽合肥230009

树脂基复合材料被广泛应用于多种制动系统中,但其在摩擦过程中易产生严重的环境噪声污染.通过摩擦试验和有限元模拟方法,总结了不同试验条件下摩擦系数、摩擦力波动系数以及摩擦噪声有效声压级的变化规律,分析了摩擦噪声与摩擦界面稳定... 详细信息

树脂基复合材料被广泛应用于多种制动系统中,但其在摩擦过程中易产生严重的环境噪声污染.通过摩擦试验和有限元模拟方法,总结了不同试验条件下摩擦系数、摩擦力波动系数以及摩擦噪声有效声压级的变化规律,分析了摩擦噪声与摩擦界面稳定性之间的关系,揭示了酚醛树脂基复合材料摩擦噪声的产生机理,同时研究了温度对其摩擦学性能及摩擦噪声行为的影响.结果表明:摩擦系数和摩擦力波动系数随载荷、相对滑动速度以及温度的改变呈现出不同的变化趋势,摩擦噪声的有效声压级与摩擦力波动系数正相关,且噪声的自功率谱与摩擦界面振动自功率谱相吻合.摩擦噪声的产生归因于接触界面的不稳定振动,研究结果为树脂基复合材料摩擦噪声的控制及发生机理提供了一定的理论基础.

关键词：摩擦噪声有效声压级摩擦力波动系数不稳定振动有限元模拟

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Structure,Property,and Performance of Catalyst Layers in Proton Exchange Membrane Fuel Cells

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Electrochemical Energy Reviews 2023年第1期6卷 403-463页

作者： Jian zhao Huiyuan Liu xianguo Li Department of Mechanical and Mechatronics Engineering University of Waterloo200 University Avenue WestWaterlooON N2L 3G1Canada

Catalyst layer(CL)is the core component of proton exchange membrane(PEM)fuel cells,which determines the performance,durability,and ***,difficulties remain for a thorough understanding of the CLs’inhomogeneous structure,and its impact on the physicochemical and electrochemical properties,operating performance,and *** inhomogeneous structure of the CLs is formed during the manufacturing process,which is sensitive to the associated materials,composi-tion,fabrication methods,procedures,and *** state-of-the-art visualization and characterization techniques are crucial to examine the CL *** structure-dependent physicochemical and electrochemical properties are then thoroughly scrutinized in terms of fundamental concepts,theories,and recent progress in advanced experimental *** relation between the CL structure and the associated effective properties is also examined based on experimental and theoretical *** studies indicated that the CL inhomogeneous structure also strongly affects the performance and degradation of the whole fuel cell,and thus,the interconnection between the fuel cell performance,failure modes,and CL structure is comprehensively *** analytical model is established to understand the effect of the CL structure on the effective properties,performance,and durability of the PEM fuel ***,the challenges and prospects of the CL structure-associated studies are highlighted for the development of high-performing PEM fuel cells.

关键词： PEM fuel cell Catalyst layer Microstructure Effective property Performance Durability

Controlled Synthesis of Carbon-Supported Pt-Based Electrocatalysts for Proton Exchange Membrane Fuel Cells

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Electrochemical Energy Reviews 2022年第4期5卷 138-189页

作者： Huiyuan Liu Jian zhao xianguo Li Department of Mechanical and Mechatronics Engineering University of Waterloo200 University Avenue WestWaterlooON N2L 3G1Canada

Proton exchange membrane fuel cells are playing an increasing role in postpandemic economic recovery and climate action ***,their performance,cost,and durability are significantly related to Pt-based electrocatalysts,hampering their large-scale commercial ***,considerable efforts have been devoted to improving the activity and durability of Pt-based electrocatalysts by controlled synthesis in recent years as an effective method for decreasing Pt use,and consequently,the ***,this review article focuses on the synthesis processes of carbon-supported Pt-based electrocatalysts,which significantly affect the nanoparticle size,shape,and dispersion on supports and thus the activity and durability of the prepared *** reviewed processes include(i)the functionalization of a commercial carbon support for enhanced catalyst-support interaction and additional catalytic effects,(ii)the methods for loading Pt-based electrocatalysts onto a carbon support that impact the manufacturing costs of electrocatalysts,(iii)the preparation of spheri-cal and nonspherical Pt-based electrocatalysts(polyhedrons,nanocages,nanoframes,one-and two-dimensional nanostruc-tures),and(iv)the postsynthesis treatments of supported *** influences of the supports,key experimental parameters,and postsynthesis treatments on Pt-based electrocatalysts are scrutinized in *** research directions are outlined,including(i)the full exploitation of the potential functionalization of commercial carbon supports,(ii)scaled-up one-pot synthesis of carbon-supported Pt-based electrocatalysts,and(iii)simplification of postsynthesis ***-pot synthesis in aqueous instead of organic reaction systems and the minimal use of organic ligands are preferred to simplify the synthesis and postsynthesis treatment processes and to promote the mass production of commercial carbon-supported Pt-based electrocatalysts.

关键词： Carbon-supported Pt-based electrocatalysts Synthesis Shape Functionalization of commercial carbon support Postsynthesis treatment

Return to the Moon:New perspectives on lunar exploration

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Science Bulletin 2024年第13期69卷 2136-2148页

作者： Yangting Lin Wei Yang Hui Zhang Hejiu Hui Sen Hu Long Xiao Jianzhong Liu Zhiyong Xiao Zongyu Yue Jinhai Zhang Yang Liu Jing Yang Honglei Lin Aicheng Zhang Dijun Guo Sheng Gou Lin Xu Yuyang He xianguo Zhang Liping Qin Zongcheng Ling Xiongyao Li Aimin Du Huaiyu He Peng Zhang Jinbin Cao Xianhua Li Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China State Key Laboratory for Mineral Deposits Research and School of Earth Sciences and Engineering Nanjing UniversityNanjing 210023China State Key Laboratory of Geological Processes and Mineral Resources School of Earth SciencesChina University of GeosciencesWuhan 430074China Institute of Geochemistry Chinese Academy of SciencesGuiyang 550002China Planetary Environmental and Astrobiological Research Laboratory School of Atmospheric SciencesSun Yat-sen UniversityZhuhai 519082China National Space Science Center Chinese Academy of SciencesBeijing 100190China Deep Space Exploration Laboratory/CAS Key Laboratory of Crust-Mantle Materials and Environments University of Science and Technology of ChinaHefei 230026China Shandong Key Laboratory of Optical Astronomy and Solar-Terrestrial Environment Institute of Space SciencesShandong UniversityWeihai 264209China Technology and Engineering Center for Space Utilization Chinese Academy of SciencesBeijing 100094China School of Space and Environment Beihang UniversityBeijing 100191China

Lunar exploration is deemed crucial for uncovering the origins of the Earth-Moon system and is the first step for advancing humanity’s exploration of deep *** the past decade,the Chinese Lunar Exploration Program(CLEP),also known as the Chang’e(CE)Project,has achieved remarkable *** has successfully developed and demonstrated the engineering capability required to reach and return from the lunar ***,the CE Project has made historic firsts with the landing and on-site exploration of the far side of the Moon,along with the collection of the youngest volcanic samples from the Procellarum KREEP *** achievements have significantly enhanced our understanding of lunar *** on this success,China has proposed an ambitious crewed lunar exploration strategy,aiming to return to the Moon for scientific exploration and *** plan encompasses two primary phases:the first crewed lunar landing and exploration,followed by a thousand-kilometer scale scientific expedition to construct a geological cross-section across the lunar *** the limitations of current lunar exploration efforts and China’s engineering and technical capabilities,this paper explores the benefits of crewed lunar exploration while leveraging synergies with robotic *** study refines fundamental lunar scientific questions that could lead to significant breakthroughs,considering the respective engineering and technological *** research lays a crucial foundation for defining the objectives of future lunar exploration,emphasizing the importance of crewed missions and offering insights into potential advancements in lunar science.

关键词： Crewed lunar exploration Water and volatiles Composition and structure of lunar interior Volcanic activity and evolution of lunar mantle Space weathering and radiation environments Exploration technology