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Chinese Journal of Polymer Science 2019年第1期37卷 1-10页

作者： Shu-Yan Jiang Xin zhao CAS Key Laboratory of Synthetic and Self-assembly Chemistry for Organic Functional molecules Center for Excellence in Molecular Synthesis Shanghai Institute of Organic Chemistry Chinese Academy of Sciences

Two-dimensional(2d) materials have been demonstrated to exhibit unique properties originating from its 2d nature. In recent years, the construction of 2d materials has become a topic of great interest. This article summarizes the recent advance of 2d supramolecular organic frameworks(SOFs) which are homogeneously constructed in solution phase through self-assembly of rationally designed building blocks. These 2d SOFs are soluble and still maintain stable network structures in solutions, which exhibit uniqueness not only in structures but also in properties. In this concise review, the SOFs-related background is briefly introduced firstly, followed by outlining the research progress of soluble 2d SOFs from the perspective of monomer design, assembly, and structural *** article ends with a personal outlook on the future development of this new class of supramolecular polymers.

关键词： Supramolecular organic frameworks(SOFs) Self-assembly Two-dimensional Supramolecular polymers

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阿尔茨海默病的临床表现、病程、治疗和管理

中国心理卫生杂志 1999年第5期13卷 272-275页

作者： BarryReisberg m.d. Zachary and Elizabeth m.Fisher Alzheimer's disease Education and Resources Program at the New York University m.d.cal Center

阿尔茨海默病(Alzheimer's disease,Ad)是导致智力衰退这类疾病的主要原因.经典研究表明:阿尔茨海默病大约占所有痴呆病例的四分之三.最近20年来对阿尔茨海默病的临床演变过程有了极其深入的了解.现在,无论是专业人员还是外行人士都能... 详细信息

阿尔茨海默病(Alzheimer's disease,Ad)是导致智力衰退这类疾病的主要原因.经典研究表明:阿尔茨海默病大约占所有痴呆病例的四分之三.最近20年来对阿尔茨海默病的临床演变过程有了极其深入的了解.现在,无论是专业人员还是外行人士都能应用通俗的术语对这一演变过程做详细地叙述.更进一步的是,基于目前掌握的(阿尔茨海默病)的知识,阿尔茨海默病患者还有可能获得适当的治疗.以后随着临床知识的不断积累,对于这种在人生晚年普遍发生的严重疾病的治疗也必将不断得到改善.

关键词：老年性痴呆临床表现病程治疗管理

Chlorine-substituted chiral 2d perovskite microwires with enhanced lattice rigidity for sensitive circularly polarized light detection

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Science China Chemistry 2023年第12期66卷 3602-3610页

作者： meng Yuan Yuchen Qiu Yingjie zhao Yuyan zhao Hui Li Xiao Wei Gaosong Chen Jiangang Feng Hanfei Gao Jinjin zhao Jiahui zhao Lei Jiang Yuchen Wu Key Laboratory of Bio-inspired materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China College of Chemistry Zhengzhou UniversityZhengzhou 450001China College of Chemistry Jilin UniversityChangchun 130012China Key Laboratory for Special Functional materials of ministry of Education National and Local Joint Engineering Research Center for High-Efficiency Display and Lighting TechnologyCollaborative Innovation Center of Nano Functional Materials and ApplicationsHenan UniversityKaifeng 475004China University of Chinese Academy of Sciences(UCAS) Beijing 100049China department of Electrical and Computer Engineering National University of SingaporeSingapore 117585Singapore Suzhou Institute for Advanced Research University of Science and Technology of ChinaSuzhou 215123China Ji Hua Laboratory Foshan 528000China department of Physics Shanxi Datong UniversityDatong 037009China

Chiral two-dimensional(2d) perovskites offer numerous attractive features for optoelectronics owing to their soft, deformable lattices and a high degree of chemical tunability. While tremendous advances have been m.d. in perovskite-based direct circularly polarized light(CPL) detection, the low circular polarization anisotropy factor and sensitivity of those photodetectors arising from large lattice distortion still limit practical applications. Herein, chiral 2d perovskite-based single-crystalline microwire arrays with enhanced circular dichroism(Cd) absorption are fabricated with the synergy of the capillary-bridgeconfined assembly method and chlorine-substituted phenethylamine(Cl-mBA). Compared with phenethylamine(mBA)-inserted perovskites, the smaller lattice distortion and increased halogen–halogen interaction within Cl–mBA-inserted perovskites strengthen lattice rigidity and weaken electron–phonon coupling to improve carrier transport and thermal stability, resulting in high-performance CPL photodetectors with an anisotropy factor of 0.25, responsivity exceeding 95.7±9.3 A W^(-1)and detectivity exceeding(3.05±0.30)×10^(13)Jones. This work opens a new perspective to m.d.late circular polarization sensitivity and will be helpful to realize promising implementations in quantum computation and communication.

关键词： chiral perovskites microwire arrays lattice rigidity circular polarization photodetectors

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

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生物3d打印仿生支架促进肩袖损伤后的愈合

中国组织工程研究 2025年第22期29卷 4761-4770页

作者：徐杰酒精卫刘海峰赵斌山西医科大学第二医院骨科山西省太原市030000 骨与软组织损伤修复山西省重点实验室山西省太原市030000

背景:大多数肩袖损伤发生于冈上肌腱,由于肌腱组织缺少血管以及肩袖复杂的解剖结构,临床治疗效果非常有限。组织工程技术和干细胞生物学的快速发展为提高肌腱修复质量带来了新的希望。目的:通过生物3d打印技术制备人脐带间充质干细胞/... 详细信息

背景:大多数肩袖损伤发生于冈上肌腱,由于肌腱组织缺少血管以及肩袖复杂的解剖结构,临床治疗效果非常有限。组织工程技术和干细胞生物学的快速发展为提高肌腱修复质量带来了新的希望。目的:通过生物3d打印技术制备人脐带间充质干细胞/甲基丙烯酸酐化明胶复合支架,观察该支架修复肩袖损伤的效果。方法:(1)体外细胞实验:制备明胶微载体,将人脐带间充质干细胞接种于明胶微载体表面构建组织工程化干细胞。制备甲基丙烯酸酐化明胶水凝胶打印墨水,使用甲基丙烯酸酐化明胶水凝胶打印墨水重悬组织工程化干细胞,放入3d打印机的生物墨水容器中进行打印,蓝光照射固化5 min后即得人脐带间充质干细胞/甲基丙烯酸酐化明胶复合支架。通过死活染色、CCK-8实验检测支架内人脐带间充质干细胞的活性。(2)动物体内实验:采用随机区组设计方法将24只Sd大鼠随机4组,每组6只:正常组不进行任何处理,肩袖损伤组、单纯支架组、细胞支架组建立冈上肌腱撕裂的肩袖损伤模型,单纯支架组、细胞支架组造模后分别将甲基丙烯酸酐化明胶支架、人脐带间充质干细胞/甲基丙烯酸酐化明胶复合支架植入肌腱损伤处。术后4周,分别进行大鼠行为学测试及肩袖冈上肌腱组织学病理组织形态观察。结果与结论:(1)体外细胞实验:死活染色结果显示,明胶微载体可减轻3d打印过程对人脐带间充质干细胞造成的损伤,随着培养时间的延长,支架内的人脐带间充质干细胞存活率升高;CCK-8实验结果显示,随着培养时间的延长,支架内的人脐带间充质干细胞活性无明显变化。(2)动物体内实验:行为学测试结果显示,相较于肩袖损伤组、单纯支架组,细胞支架组大鼠四肢运动功能明显改善;肩袖冈上肌腱苏木精-伊红与masson染色结果显示,相较于肩袖损伤组、单纯支架组,细胞支架组肌纤维排列较规律,无明显的炎性细胞浸润,胶原容积百分比降低;免疫荧光染色结果显示,相较于肩袖损伤组、单纯支架组,细胞支架组肩袖冈上肌腱内白细胞介素6、肿瘤坏死因子α蛋白表达明显降低。(3)结果表明,生物3d打印的人脐带间充质干细胞/甲基丙烯酸酐化明胶复合支架可促进肩袖损伤组织修复再生。

关键词：肩袖损伤冈上肌腱损伤人脐带间充质干细胞细胞治疗组织工程化干细胞生物支架甲基丙烯酸化明胶生物3d打印

2d materials Boost Advanced Zn Anodes:Principles,Advances,and Challenges

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Nano-micro Letters 2023年第4期15卷 1-22页

作者： Songhe Zheng Wanyu zhao Jianping Chen Xiaoli zhao Zhenghui Pan Xiaowei Yang School of materials Science and Engineering Tongji UniversityShanghai 201804People’s Republic of China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Aqueous zinc-ion battery(ZIB)featuring with high safety,low cost,environmentally friendly,and high energy density is one of the most promising systems for large-scale energy storage *** extensive research progress m.d. in developing high-performance cathodes,the Zn anode issues,such as Zn dendrites,corrosion,and hydrogen evolution,have been observed to shorten ZIB’s lifespan seriously,thus restricting their practical *** advanced Zn anodes based on two-dimensional(2d)materials are widely investigated to address these *** atomic thickness,2d materials possess ultrahigh specific surface area,much exposed active sites,superior mechanical strength and flexibility,and unique electrical properties,which confirm to be a promising alternative anode material for *** review aims to boost rational design strategies of 2d materials for practical application of ZIB by combining the fundamental principle and research ***,the fundamental principles of 2d materials against the drawbacks of Zn anode are ***,the designed strategies of several typical 2d materials for stable Zn anodes are comprehensively ***,perspectives on the future development of advanced Zn anodes by taking advantage of these unique properties of 2d materials are proposed.

关键词： Zinc-ion battery Large-scale energy storage application Zn anode Lifespan 2d materials

3d reconstruction of movable cultural relics based on salient region optimization

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The Journal of China Universities of Posts and Telecommunications 2023年第5期30卷 11-31页

作者： Wang Wenhao zhao Haiying School of Information and Communication Engineering Beijing Information Science and Technology UniversityBeijing 100192China School of Artificial Intelligence Beijing University of Posts and TelecommunicationsBeijing 100876China

How to protect cultural retics is of great significance to the transmission and dissemination of history and *** 3-dimensional(3d)m.d.ling of cultural relics is an effective way to preserve *** efficiency and complexity of cultural relic m.d.l reconstruction algorithms are significant challenges due to redundant *** tackle the above issue,a 3d reconstruction algorithm,nam.d.COLmAP+LSH,was proposed for movable cultural relics based on salient region ***+LSH algorithm introduces saliency region detection and locality-sensetive Hashing(LSH)to achieve efficient,accurate,and robust digital 3d m.d.ling of cultural ***,400 cultural m.d.l data were collected through offline and online ***+LSH algorithm.d.tects the salient region interactively and reduces the number of images in the salient region by feature ***,COLmAP+LSH algorithm utilizes LSH to calculate the image selection scores and employs the image selection scores to reduce the redundant *** experiments on the self-constructed cultural relics dataset show that COLmAP+LSH algorithm can efficiently achieve image feature diffusion and ensure the quality of artifact reconstruction while selecting most of the redundant image data.

关键词： digitization of cultural relics 3-dimensional(3d)reconstruction saliency region detection locality-sensetive Hashing(LSH)

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Kinetics of blue-green light-induced state transition and fluorescence quenching in the wild-type cyanobacterium Synechocystis PCC 6803 and apc d2 and apc F2 mutants

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Chinese Science Bulletin 2014年第34期59卷 4712-4719页

作者： Wenfeng zhao Jie Xie Jingquan zhao Beijing National Laboratory for molecular Sciences (BNLmS) CAS Key Laboratory of Photochemistry Institute of ChemistryChinese Academy of Sciences

State transition and blue-green light-induced fluorescence quenching are two short-term processes in cyanobacteria. The details of their kinetics and the relationship between these processes have not been *** this work, these two processes were studied in the wildtype cyanobacterium Synechocystis PCC 6803 cells as well as in apc d-and apc F-mutants by monitoring their tim.d.pendent 77 K fluorescence responses to blue-green light(430–540 nm) at a series of intensities ranging from20–800 l E m-2s-1. The lowest light intensity to induce fluorescence quenching in wild-type cells was160 l E m-2s-1under the selected experimental conditions, while state transition took place at the intensities lower than 160 l E m-2s-1at a conservative level, but at variable rates. The quenching level increased at intensities higher than 160 l E m-2s-1, reaching the maximum level at intensities equal to or higher than 200 l E *** kinetics indicated that both the length of the induction period and time required to reach the maximum level were functions of light intensity. State transitions as well as fluorescence quenching took place in both wildtype and mutant cells, but might involve different mechanisms.

关键词：荧光动力学状态转换野生型光诱导突变体 PCC 集胞藻蓝绿色

Nanocarrier-m.d.ated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： Jie Jin Huajing Zhang Qianying Lu Linqiang Tian Sanqiao Yao Feng Lai Yangfan Liang Chuanchuan Liu Yujia Lu Sijia Tian Yanmei zhao Wenjie Ren Institute of disaster and Emergency m.d.cine Tianjin UniversityTianjinChina Key Laboratory for disaster m.d.cine Technology TianjinChina Henan m.d.cal Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical m.d.cal Center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific m.d.fied siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschm.d.-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschm.d. damien d.Pearse W.dalton dietrich Allan d.Levi James d.Guest miller School of m.d.cine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirm.d.that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell