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Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2

Neural Regeneration Research 2025年第6期20卷 1776-1788页

作者： Zige Jiang dexiang Liu Tingting Li Chengcheng Gai danqing Xin Yijing zhao Yan Song Yahong Cheng Tong Li Zhen Wang department of Physiology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina department of m.d.cal Psychology and Ethics School of Basic Medicine SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina department of Neurosurgery Surgery Qingdao Municipal HospitalQingdaoShandong ProvinceChina

The pathophysiology of Huntington's disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic acid contributes to Huntington's disease pathology remain unknown. In this study, we established in vitro and in vivo m.d.ls of Huntington's disease by administering quinolinic acid to the PC12 neuronal cell line and the striatum of mice, respectively. We observed a decrease in the levels of hydrogen sulfide in both PC12 cells and mouse serum, which was accompanied by down-regulation of cystathionine β-synthase, an enzyme responsible for hydrogen sulfide production. However, treatment with NaHS(a hydrogen sulfide donor) increased hydrogen sulfide levels in the neurons and in mouse serum, as well as cystathionine β-synthase expression in the neurons and the mouse striatum, while also improving oxidative imbalance and mitochondrial dysfunction in PC12 cells and the mouse striatum. These beneficial effects correlated with upregulation of nuclear factor erythroid 2-related factor 2 expression. Finally, treatment with the nuclear factor erythroid 2-related factor 2inhibitor mL385 reversed the beneficial impact of exogenous hydrogen sulfide on quinolinic acid-induced oxidative stress. Taken together, our findings show that hydrogen sulfide reduces oxidative stress in Huntington's disease by activating nuclear factor erythroid 2-related factor 2,suggesting that hydrogen sulfide is a novel neuroprotective drug candidate for treating patients with Huntington's disease.

关键词： apoptosis cystathionine-β-synthase nuclear factor erythroid 2-related factor 2 Huntington's disease hydrogen sulfide mitochondrion neuroplasticity oxidative stress quinolinic acid reactive oxygen species

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Alternative （1＋1）-d dark Spatial Soliton-Like distributions in Kerr m.d.a

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Journal of Physical Science and Application 2011年第3期1卷 196-203页

作者： d. Ramirez martinez m.m. mendez Otero m.L. Arroyo Carrasco m.d. Iturbe Castillo Benemerita Universidad Autonoma de Puebla Avenida San Claudio y Rio Verde colonia San Manuel Ciudad Universitaria Puebla Puebla C.P. 72570 Mexico Instituto Nacional de Astrofisica Optica y Electronica Luis Enrique Erro#1 Tonantzintla Puebla C.P. 72840 Mexico

In this paper, we solve numerically the nonlinear Schrodinger equation for a defocusing Kerr m.d.a with initial conditions different to the hyperbolic tangent function. We demonstrate that initial conditions with a similar position dependence than the hyperbolic tangent evolve to a hyperbolic tangent function, therefore can be considered as （1＋1）-d spatial solitons. The waveguide induced by these conditions is not single m.d.; it has the capacity to confine one m.d. more.

关键词： Kerr effect solitons optical optical waveguide nonlinear

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A review of reflux esophagitis around the world

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World Journal of Gastroenterology 1998年第4期4卷 8-12页

作者： Edwin J. Zarling, m.d.

ＡｒｅｖｉｅｗｏｆｒｅｆｌｕｘｅｓｏｐｈａｇｉｔｉｓａｒｏｕｎｄｔｈｅｗｏｒｌｄＥｄｗｉｎＪ．Ｚａｒｌｉｎｇ，Ｍ．Ｄ．Ｓｕｂｊｅｃｔｓｈｅａｄｉｎｇｓｇａｓｔｒｏｅｓｏｐｈａｇｅａｌｒｅｆｌｕｘ／ｅｐｉｄｅｍｉｏｌｏ... 详细信息

ＡｒｅｖｉｅｗｏｆｒｅｆｌｕｘｅｓｏｐｈａｇｉｔｉｓａｒｏｕｎｄｔｈｅｗｏｒｌｄＥｄｗｉｎＪ．Ｚａｒｌｉｎｇ，Ｍ．Ｄ．Ｓｕｂｊｅｃｔｓｈｅａｄｉｎｇｓｇａｓｔｒｏｅｓｏｐｈａｇｅａｌｒｅｆｌｕｘ／ｅｐｉｄｅｍｉｏｌｏｇｙ；ｇａｓｔｒｏｅｓｏｐｈａｇｅ...

关键词： gastroesophageal reflux/epidemiology gastroesophageal reflux/pathophysiology gastroesophageal reflux/complications gastroesophageal reflux/diagnosis gastroesophageal reflux/therapy

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differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

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Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： Yanting Liu Wei Huang Jiayi Wen Xin Xiong Ting Xu Qi Wang Xiusheng Chen Xianxian zhao Shihua Li Xiaojiang Li Weili Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

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The complex roles of m^(6)A m.d.fications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing Xue Yuejia ma Ke Ye Xue zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao dayong Wang Qing Xia department of Biochemistry and molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic m.d.cal Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic m.d.cal Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically m.d.fied Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational m.d.cine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA m.d.fication in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A m.d.fication levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different m.d.ls of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease m.d.ls exposed to manganese compared to normal Parkinson's disease m.d.ls further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

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The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li Wei Zhang Jian Wu Hui Hong Wei Quan Xinyu Qiao Chun Cui Chenmeng Qiao Weijiang zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-m.d.ated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse m.d.l of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic m1 *** addition,si RNA-m.d.ated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,Cd16,Cd32,and Cd86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 m1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

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Siegmund duality for Continuous Time markov Chains on Z_+~d

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Acta mathematica Sinica,English Series 2018年第9期34卷 1460-1472页

作者： Pan zhao department of Basic Courses Beijing Union University

For the continuous time markov chain with transition function P（t） on Z d ＋ , we give the necessary and sufficient conditions for the existence of its Siegmund dual with transition function P - （t）. If Q, the q-matrix of P（t）, is uniformly bounded, we show that the Siegmund dual relation can be expressed directly in terms of q-matrices, and a sufficient condition under which the Q-function is the Siegnm.d.dual of some Q-function is also given.

关键词： Continuous time markov chains the Siegmund dual mobius function ↑-mobius mono-tonicity Feller Reuter Riley transition functions birth and death chains

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Nano-confined ammonia borane for chemical hydrogen storage

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Frontiers of Chemical Science and Engineering 2012年第1期6卷 27-33页

作者： m. A.WAHAB Huijun zhao X. d. YAO ARC Centre of Excellence for Functional Nanomaterials Australian Institute for Engineering and Nanotechnology the University of Queensland St Lucia 4072 Australia Centre for Clean Energy and Environment Griffith University Gold Coast 4222 Australia Queensland micro-and Nanotechnology Centre Griffith University Nathan 4111 Australia

There is a great demand for a sufficient and sustainable energy supply. Hence, the search for applicable hydrogen storage materials is extremely important owing to the diversified merits of hydrogen energy. In this regard, ammonia borane （NH3BH3, AB） containing 19.6wt-% hydrogen has been considered as a promising material for hydrogen storage applications to realize the ＂hydrogen economy＂, but with limits from slow kinetics of hydrogen release and by-product of trace gases such as ammonia and borazine. In this review, we introduce the recent research on AB, regarding to the nanoconfinement effect on improving the kinetics at a relatively low temperature and the prevention/reduction of undesirable gas formation.

关键词： ammonia borane hydrogen storage

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Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke:a special outlook on mitochondrial delivery

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Neural Regeneration Research 2025年第8期20卷 2181-2198页

作者： Jiali Chen Yiyang Li Xingping Quan Jinfen Chen Yan Han Li Yang manfei Zhou Greta Seng Peng mok Ruibing Wang Yonghua zhao Institute of Chinese m.d.cal Sciences State Key Laboratory of Quality Research in Chinese MedicineUniversity of MacaoTaipaMacao Special Administrative RegionChina department of Pharmacy Hunan Provincial People’s Hospitalthe First Affiliated Hospital of Hunan Normal UniversityChangshaHunan ProvinceChina department of Electrical and Computer Engineering University of MacaoTaipaMacao Special Administrative RegionChina department of Pharmaceutical Sciences Faculty of Health SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina

Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable m.d.cal and economic burdens on *** vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic ***,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery *** utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly ***,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic *** extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke *** this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle m.d.fication *** the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle m.d.fication approaches which are suited to different facets of the treatment ***,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.

关键词： delivery engineering extracellular vesicles identification ischemic stroke isolation mitochondria targeting strategy therapeutic effects

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Characterization of ultraviolet communication in a mixed aerosol environment

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Optoelectronics Letters 2025年第2期 77-84页

作者： zhao Taifei SUN Yuxin WANG Wuxin ZHANG Haijun PAN Feixiang WU Hao Artificial Intelligence Key Laboratory of Sichuan Province Sichuan University of Science & Engineering Faculty of Automation and Information Engineering Xi'an University of Technology

Wireless ultraviolet (UV) has strong scattering characteristics and can communicate through non-direct *** UV signals are transmitted in the atmosphere,they are affected by the absorption and scattering effects of atmospheric particles and atmospheric turbulence,resulting in attenuation of UV signal energy and reduced reliability of the communication *** paper focuses on the channel m.d.l of UV non-direct-view single scattering communication,and simulates and analyzes the communication characteristics of UV light in atmospheric turbulence and mixed aerosol environment under horizontal,vertical and oblique range communication *** results show that at equal relative hum.d.ty,the wireless UV non-directive scattering communication performance for vertical communication scenarios is more affected by the mixed aerosol environment and the communication performance is worse.

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