检索结果-南通市图书馆

河南鹤壁地幔捕掳体内磷灰石的发现及地幔交代作用

在线全文

学校读者我要写书评

暂无评论

河南理工大学学报（自然科学版） 2024年第1期43卷 61-67页

作者：秦战营姜江任栩颖齐永安张艳林侯广顺河南省有色金属矿产探测工程技术研究中心河南郑州450016 河南理工大学资源环境学院河南焦作454000 成都理工大学沉积地质研究院四川成都610059

目的地幔交代作用是岩石圈演化的重要方式之一。显性交代作用以出现交代成因的地幔矿物为特征,可为地幔交代作用提供直接证据,磷灰石是地幔中交代成因的典型矿物。中生代以来,太行山构造带东侧的华北板块岩石圈明显减薄,而西侧仍保留较... 详细信息

目的地幔交代作用是岩石圈演化的重要方式之一。显性交代作用以出现交代成因的地幔矿物为特征,可为地幔交代作用提供直接证据,磷灰石是地幔中交代成因的典型矿物。中生代以来,太行山构造带东侧的华北板块岩石圈明显减薄,而西侧仍保留较厚的岩石圈,太行山构造带是华北克拉通东部被破坏区与西部稳定区的过渡带。因此,太行山构造带的地幔包体对研究华北克拉通破坏具有重要意义。鹤壁地区位于太行山构造带上,发育有金伯利岩等深源岩浆岩。方法本文以金伯利岩携带的地幔包体为研究对象,探讨鹤壁地区岩石圈地幔的性质。通过人工重砂的方法,从地幔包体中分选出数粒磷灰石和一粒被辉石包裹的磷灰石。结果体视显微镜下,磷灰石无色,透明,具玻璃光泽,呈短柱状;扫描电镜能谱分析表明,被包裹的矿物主要由Ca,P,O,F元素组成,寄主矿物主要由Si,Fe,Mg,Al,O元素组成;电子探针结果表明,磷灰石中w(CaO)为53.525%~56.514%,w(P_(2)O_(5))为37.372%~40.851%;实验岩石学研究认为,顽火辉石+方解石→橄榄石+透辉石+CO_(2),磷灰石等作为副矿物产出。因此,辉石包裹磷灰石的矿物组合属于地幔交代成因,指示了显性交代作用。结论磷灰石这种显性地幔交代成因矿物的发现,为华北克拉通岩石圈地幔经历显性交代作用提供了直接证据。

关键词：河南鹤壁华北克拉通破坏地幔捕掳体地幔交代作用磷灰石

Toll-like receptor 9 defciency induces osteoclastic bone loss via gut microbiota-associated systemic chronic inflammation

在线全文

学校读者我要写书评

暂无评论

Bone Research 2022年第3期10卷 594-614页

作者： Peng Ding Qiyuan Tan zhanying Wei Qiyu Chen Chun Wang Luyue Qi Li Wen Changqing zhang Chen Yao Department of Orthopedic Surgery Shanghai Jiaotong University affiliated Sixth People’s HospitalShanghaiChina Department of Endocrinology and Metabolism Shanghai Jiaotong University affiliated Sixth People’s HospitalShanghaiChina Department of Osteoporosis and Skeletal Disorders Shanghai Jiaotong University affiliated Sixth People’s HospitalShanghaiChina Department of Endocrinology and Metabolism Second Affiliated Hospital of Soochow UniversitySuzhouChina Section of Endocrinology Department of Internal MedicineYale University School of MedicineNew HavenUSA

Toll-like receptors(TLRs)play pivotal roles in inflammation and provide important links between the immune and skeletal systems.Although the activation of TLRs may affect osteoclast differentiation and bone metabolism,whether and how TLRs are required for normal bone remodeling remains to be fully explored.In the current study,we show for the first time that TLR9^(-/-)mice exhibit a low bone mass and low-grade systemic chronic inflammation,which is characterized by the expansion of CD4^(+)T cells and increased levels of inflammatory cytokines,including TNFα,RANKL,and IL1β.The increased levels of these cytokines significantly promote osteoclastogenesis and induce bone loss.Importantly,TLR9 deletion alters the gut microbiota,and this dysbiosis is the basis of the systemic inflammation and bone loss observed in TLR9^(-/-)mice.Furthermore,through single-cell RNA sequencing,we identified myeloid-biased hematopoiesis in the bone marrow of TLR9^(-/-)mice and determined that the increase in myelopoiesis,likely caused by the adaptation of hematopoietic stem cells to systemic inflammation,also contributes to inflammation-induced osteoclastogenesis and subsequent bone loss in TLR9^(-/-)mice.Thus,our study provides novel evidence that TLR9 signaling connects the gut microbiota,immune system,and bone and is critical in maintaining the homeostasis of inflammation,hematopoiesis,and bone metabolism under normal conditions.

关键词： inflammation metabolism osteoclast

Development of a surface plasmon resonance biosensor for accurate and sensitive quantitation of small molecules in blood samples

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2022年第6期12卷 929-936页

作者： Minyu Qi Diya Lv Ying zhang Dongyao Wang Xiaofei Chen Zhenyu Zhu zhanying Hong Yifeng Chai Hai zhang Yan Cao Department of Biochemical Pharmacy Faculty of PharmacyNaval Medical UniversityShanghai200433China Pharmaceutical Analysis and Testing Center Faculty of PharmacyNaval Medical UniversityShanghai200433China Department of Pharmaceutical Analysis Faculty of PharmacyNaval Medical UniversityShanghai200433China Department of Pharmacy Shanghai First Maternity and Infant HospitalTongji University School of MedicineShanghai201204China

Therapeutic drug monitoring(TDM)has played an important role in clinical medicine for precise dosing.Currently,chromatographic technology and immunoassay detection are widely used in TDM and have met most of the needs of clinical drug therapy.However,some problems still exist in practical applications,such as complicated operation and the influence of endogenous substances.Surface plasmon resonance(SPR)has been applied to detect the concentrations of small molecules,including pesticide residues in crops and antibiotics in milk,which indicates its potential for in vivo drug detection.In this study,a new SPR-based biosensor for detecting chloramphenicol(CAP)in blood samples was developed and validated using methodological verification,including precision,accuracy,matrix effect,and extraction recovery rate,and compared with the classic ultra-performance liquid chromatographyultraviolet(UPLC-UV)method.The detection range of SPR was 0.1-50 ng/mL and the limit of detection was 0.099±0.023 ng/mL,which was lower than that of UPLC-UV.The intra-day and inter-day accuracies of SPR were 98%-114% and 110%-122%,which met the analysis requirement.The results show that the SPR biosensor is identical to UPLC-UV in the detection of CAP in rat blood samples;moreover,the SPR biosensor has better sensitivity.Therefore,the present study shows that SPR technology can be used for the detection of small molecules in the blood samples and has the potential to become a method for therapeutic drug monitoring.

关键词： Surface plasmon resonance UPLC-UV Chloramphenicol Methodological verification

基于DMS传输平台的CTCS3-300H ATP车载设备数据无线下载及分析系统设计

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

铁道通信信号 2024年第2期60卷 6-12页

作者：赵志鹏高占盈黄红强张宇中国铁道科学研究院集团有限公司通信信号研究所北京100081 河南蓝信科技有限责任公司郑州450001 北京华铁信息技术有限公司北京100081

针对CTCS3-300H型ATP车载设备日常运维存在的数据下载接口多、数据下载时间长、缺少智能化分析手段等问题,设计一套基于动态监测系统(DMS)传输平台的ATP车载设备数据无线下载及分析系统。通过车载端的ATP数据无线下载单元实现对300H型AT... 详细信息

针对CTCS3-300H型ATP车载设备日常运维存在的数据下载接口多、数据下载时间长、缺少智能化分析手段等问题,设计一套基于动态监测系统(DMS)传输平台的ATP车载设备数据无线下载及分析系统。通过车载端的ATP数据无线下载单元实现对300H型ATP车载设备各关键单元数据的实时采集、存储、检索及传输;利用既有DMS传输平台中的无线传输通道实现车载设备数据的无线下载;通过部署于地面的ATP日志分析工作站和智能诊断分析终端,实现ATP车载设备数据分类存储、故障报警、故障数据自动下载、车载数据智能诊断分析和历史故障的查询统计。该系统不仅可有效提高运维数据分析效率,降低车载故障对现场运营的影响,还可提升运维数据的时效性和可追溯性,从而全面提高300H型ATP车载设备的运维效率及运维质量。

关键词：列车自动防护系统动态监测系统数据采集数据无线下载智能诊断分析

Effects of the Solution Treatment on Microstructural Evolution, Mechanical Properties, and Fracture Mechanism of Nickel-Based GH4099 Superalloy

在线全文

学校读者我要写书评

暂无评论

Journal of Minerals and Materials Characterization and Engineering 2021年第6期9卷 566-589页

作者： Guangsheng Xu Chuan Wu Zhenhua Liu Yilong Wang zhanying zhang Yun Li Ping Hu Engineering Research Center of High-Performance Aerospace Materials and Devices Universities of Shaanxi Province Shaanxi Polytechnic Institute Xianyang China Xianyang Key Laboratory of New power and Intelligent Microgrid System Xianyang China National-Local Joint Engineering Laboratory of Intelligent Manufacturing Oriented Automobile Die and Mould Tianjin University of Technology and Education Tianjin China

Grain growth, mechanical properties, and fracture mechanism of nickel-based GH4099 superalloy are investigated using heat treatments, tensile tests, optical microscopy (OM), and scanning electron microscopy (SEM) with energy dispersive X-ray spectroscopy (EDS). The OM observation shows that the matrix grains (γ-grains) undergo an apparent growth during the solution treatment. The grain size diameter increases from 100 to 174 μm when the solution temperature rises from 1100℃ to 1160℃ for 30 min. When the holding time increases from 15 to 60 min at 1140℃, the grain size diameter increases from 140 to 176 μm, indicating that the γ-grain growth is more sensitive to temperature than time. Standard deviation, Sv, and the grain size distribution are utilized to characterize the microstructural uniformity. To predict the grain size more accurately, we develop the grain growth kinetics and find that the growth index is close to 5. The yield strength (Rp0.2), tensile strength (Rm), and ductility (Af) are also measured. It is found that the effect decreases in the order cooling rate, solution temperature, time. Rp0.2 reduces by 47% with the increase in the cooling rate from 1℃ to 8000℃/min, while both strength and ductility exhibit little changes with time. The SEM results show that the fracture surfaces have typical mixed brittle and ductile characteristics when specimens are subjected to water quenching and air cooling. However, a complete brittle fracture occurs under furnace cooling conditions. The EDS analysis indicates that the brittle γ' (Ni3Ti) phase precipitates around the γ-grain boundary during the slow cooling process, which is the main factor yielding the complete brittle fracture. Finally, the optimal solution treatment scheme for the GH4099 superalloy is proposed—a temperature of 1140℃ for 30 min followed by air cooling.

关键词： Microstructural Evolution Mechanical Properties Fracture Mechanism GH4099 Nickel-Based Superalloy

基于DEA和熵权TOPSIS模型比较的高校科技创新效率分析

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

天津理工大学学报 2024年第2期40卷 111-119页

作者：李新龙张端乔亚平何占营李彭辉天津理工大学科学技术处天津300384 天津理工大学先进技术研究院天津300384

高校是国家创新体系的重要组成部分,为深入分析新形势下高校科技创新效率,完善高校科技创新效率评价方法,综合运用数据包络分析(data envelopment analysis,DEA)模型和基于信息熵法的理想点模型(technique for order preference by simi... 详细信息

高校是国家创新体系的重要组成部分,为深入分析新形势下高校科技创新效率,完善高校科技创新效率评价方法,综合运用数据包络分析(data envelopment analysis,DEA)模型和基于信息熵法的理想点模型(technique for order preference by similarity to an ideal solution model,TOPSIS),以天津市区域14所高校为例,对比分析了新形势下高校科技创新效率。基于DEA模型的分析结果表明,14所高校科技创新效率总体呈不规律波动趋势,即使继续加大投入力度,也仅能获得科技成果产出规模有限的增加;基于TOPSIS模型的分析结果表明,14所高校科技创新效率总体呈上升发展趋势,可继续加大投入力度,以促进科技成果更大规模地产出。通过两个模型的综合运用,实现了评价结果的交叉验证,为新形势下高校科技创新效率评价提供了新思路。

关键词：科技创新效率熵权信息熵法的理想点模型数据包络分析模型交叉验证

A periodic DFT study on adsorption of small molecules(CH4,CO,H2O,H2S,NH3)on the WO3(001) surface-supported Au

在线全文

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2020年第3期72卷 69-82页

作者： Long Lin Jingtao Huang Weiyang Yu Chaozheng He Hualong Tao Yonghao Xu Linghao Zhu Pengtao Wang zhanying zhang Cultivating Base for Key Laboratory of Environment-Friendly Inorganic Materials in Henan Province School of Materials Science and EngineeringHenan Polytechnic UniversityJiaozuo 454000China School of Mathematics and Informatics Henan Polytechnic UniversityJiaozuo 454000China School of Physics and Electronic Information Engineering Henan Polytechnic UniversityJiaozuo 454000China Institute of Environmental and Energy Catalysis School of Materials Science and Chemical EngineeringXi’an Technological UniversityXi’anShaanxi 710021China Liaoning Key Materials Laboratory for Railway School of Materials Science and EngineeringDalian Jiaotong UniversityDalian 116028Liaoning ProvinceChina

Gas molecules(such as CH4,CO,H2O,H2S,NH_3)adsorption on the pure and Au-doped WO3(001)surface have been studied by Density functional theory calculations with generalized gradient approximation.Based on the the calculation of adsorption energy,we found the most stable adsorption site for gas molecules by comparing the adsorption energies of different gas molecules on the WO3(001)surface.We have also compared the adsorption energy of five different gas molecules on the WO3(001)surface,our calculation results show that when the five kinds of gases are adsorbed on the pure WO3(001)surface,the order of the surface adsorption energy is CO>H2S>CH4>H2O>NH3.And the results show that NH3 is the most easily adsorbed gas among the other four gases adsorbed on the surface of pure WO3(001)surface.We also calculated the five different gases on the Au-doped WO3(001)surface.The order of adsorption energy was found to be different from the previous calculation:CO>CH4>H2S>H2O>NH3.These results provide a new route for the potential applications of Au-doped WO3 in gas molecules adsorption.

关键词： WO3 gas molecules adsorption density functional theory

在线全文

学校读者我要写书评

暂无评论

3D打印技术过程控制研究

模具制造 2024年第7期24卷 19-22页

作者：刘振华王一龙徐广胜张战英陕西工业职业技术学院陕西咸阳712000 高性能航空材料与器件陕西省高校工程研究中心陕西咸阳712000 航空航天用高温材料与器件航空航天用陕西高校青年创新团队陕西咸阳712000

近年来,3D打印技术作为制造业的一项革新技术迅速发展,其在航空、医疗、建筑等多个领域的应用展现出广阔前景。3D打印技术旨在通过逐层累积材料来构造物体,其独特的制造方式带来了诸多过程控制的难题。概述了3D打印技术的定义、问题及... 详细信息

近年来,3D打印技术作为制造业的一项革新技术迅速发展,其在航空、医疗、建筑等多个领域的应用展现出广阔前景。3D打印技术旨在通过逐层累积材料来构造物体,其独特的制造方式带来了诸多过程控制的难题。概述了3D打印技术的定义、问题及新方法,旨在为3D打印技术的进一步研究与应用提供参考。

关键词： 3D打印技术过程控制模型切片熔融沉积

维普期刊数据库博看期刊

Discovery of a Potent Botulinum Neurotoxin A Inhibitor ZM299 with Effective Protections in Botulism Mice

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2022年第3期40卷 357-364页

作者： Jianxin Wang Yuelin Wu Deyan Luo Chunlin Zhuang Nianzhi Ning Yanming zhang Zhili He Jie Gao zhanying Hong Xiguo Xv Wannian zhang Tao Li Zhenyuan Miao Hui Wang State Key Laboratory of Pathogens and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China School of Pharmacy Second Military Medical University325 Guohe RoadShanghai 200433China

Botulinum neurotoxins serotype A(BoNT/A)is the deadliest toxins known to humans and the"Category A"agent for bioterrorism.Over the past 20 years,significant efforts have been put forth to develop effective inhibitors of BoNT/A.Unfortunately,few identified inhibitors possess noteworthy efficacy against BoNT/A in vivo.Here,we performed a high-throughput virtual screening based on the structure-based docking simulations and found a novel potent scaffold 2-thionicotinate that inhibits the BoNT/A light chain(LC).We then synthesized and optimized a novel series of 2-thionicotinate derivatives and comprehensively evaluated their activity against BoNT/A in vitro and in vivo.An optimized compound ZM299 effectively exhibits anti-BoNT/A activity in primary neurons and displayed remarkably therapeutic efficacy against BoNT/A in vivo,which could raise the survival rate of intoxicated mice to 100%(12/12)after lethal doses of BoNT/A exposures.These findings demonstrate that 2-thionicotinates is a promising scaffold for producing more effective anti-BoNT/A analogs,and compound ZM299 is worthy of further preclinical evaluation as a drug candidate for the treatment of botulism.

关键词： Botulinum Neurotoxin A Botulism Virtual screening Drug design Inhibitors