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Fulminant myocarditis induced by SARS-CoV-2 infection without severe lung involvement:insights into COvID-19 pathogenesis

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Journal of Genetics and Genomics 2024年第6期51卷 608-616页

作者： Han Du Zhongtao Du Liang Wang Hong Wang Mingjun Jia Chunge Zhang Yun Liu Cheng Zhang Ya Zhang Ruifeng Zhang Shuang Zhang Ning Zhang Zhenghai Ma Chen Chen Wenjun Liu Hui Zeng George F.gao Xiaotong Hou Yuhai bi College of Life Science and Technology Xinjiang UniversityUrumchiXinjiang 830046China CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyCenter for Influenza Research and Early-warning(CASCIRE)CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID)Chinese Academy of SciencesBeijing 100101China Beijing Anzhen Hospital Capital Medical UniversityBeijing 100029China College of Veterinary Medicine Shanxi Agricultural UniversityTaiyuanShanxi 030031China University of Chinese Academy of Sciences Beijing 100049China Beijing Shijitan Hospital Capital Medical UniversityBeijing 100038China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection often leads to pulmonary *** sequelae,including myocarditis and heart failure,have also been ***,the study presents two fulminant myocarditis cases infected by SARS-CoV-2 exhibiting remarkable elevation of cardiac biomarkers without significant pulmonary injury,as determined by imaging *** staining reveals the viral antigen within cardiomyocytes,indicating that SARSCoV-2 could directly infect the *** full viral genomes from respiratory,anal,and myocardial specimens are obtained via next-generation *** analyses of the whole genome and spike gene indicate that viruses in the myocardium/pericardial effusion and anal swabs are closely related and cluster together yet diverge from those in the respiratory *** addition,unique mutations are found in the anal/myocardial strains compared to the respiratory strains,suggesting tissue-specific virus mutation and *** findings indicate genetically distinct SARS-CoV-2 variants have infiltrated and disseminated within myocardial tissues,independent of pulmonary injury,and point to different infection routes between the myocardium and respiratory tract,with myocardial infections potentially arising from intestinal *** findings highlight the potential for systemic SARS-CoV-2 infection and the importance of a thorough multi-organ assessment in patients for a comprehensive understanding of thepathogenesisof COVID-19.

关键词： COVID-19 SARS-CoV-2 Fulminant myocarditis Myocardium Infection

Electrochemical reduction of carbon dioxide to produce formic acid coupled with oxidative conversion of biomass

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Journal of Energy Chemistry 2024年第5期92卷 705-729页

作者： Xi Liu Yifan Wang Zhiwei Dai Daihong gao Xuebing Zhao Key Laboratory of Industrial biocatalysis Ministry of EducationTsinghua UniversityBeijing 100084China Institute of Applied Chemistry Department of Chemical EngineeringTsinghua UniversityBeijing 100084China

Electrochemical reduction of CO_(2)(CO_(2)RR)has become a research hot spot in recent years in the context of carbon *** is one of the most promising products obtained by electrochemical reduction of CO_(2) due to its high energy value as estimated by market price per energy unit and wide application in chemical *** is the most abundant renewable resource in the natural *** biomass oxidative conversion with CO_(2)RR driven by renewable electricity would well achieve carbon *** this work,we comprehensively reviewed the current research progress on CO_(2)RR to produce HCOOH and coupled system for conversion of biomass and its derivatives to produce value-added ***-and bi-based electrocatalysts are discussed for CO_(2)RR with regards to the structure of the catalyst and reaction ***-oxidation reactions of biomass derived sugars,alcohols,furan aldehydes and even polymeric components of lignocellulose were reviewed as alternatives to replace oxygen evolution reaction(OER)in the conventional electrolysis *** was recommended that to further improve the efficiency of the coupled system,future work should be focused on the development of more efficient and stable catalysts,careful design of the electrolytic cells for improving the mass transfer and development of environment-friendly processes for recovering the formed formate and biomass oxidation products.

关键词： Electrochemical reduction of CO_(2) Formic acid Oxidative conversion of biomass Lignocellulose Coupled system

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Mn_(3)Sn薄膜磁相变的输运表征

物理学报 2024年第6期73卷 331-338页

作者：谭碧高栋邓登福陈姝瑶毕磊刘冬华刘涛电子科技大学国家电磁辐射控制材料工程技术研究中心成都611731 电子科技大学多频谱吸波材料与结构教育部重点实验室(B类)成都611731 电子科技大学材料与能源学院成都611731

六角笼目(Kagome)相拓扑反铁磁材料近年来引起了人们极大的研究兴趣,这主要是因为它们拥有众多独特的性能,例如虽然净磁矩跟反铁磁材料一样接近零,但确有与铁磁性材料强度相当的磁电、磁光和磁热效应,极具应用价值.以上的这些特性绝大... 详细信息

六角笼目(Kagome)相拓扑反铁磁材料近年来引起了人们极大的研究兴趣,这主要是因为它们拥有众多独特的性能,例如虽然净磁矩跟反铁磁材料一样接近零,但确有与铁磁性材料强度相当的磁电、磁光和磁热效应,极具应用价值.以上的这些特性绝大多数都与其磁结构紧密相关,然而人们却发现其磁结构对于生长条件和材料成分非常敏感.因此,开发一种简单、普适的Kagome相拓扑反铁磁材料磁结构相变测量方法,对于大多数难以获得高能中子衍射等先进实验手段的实验室来说,无论是材料的生长优化还是物理现象机理的理解都具有重要的意义.本文采用脉冲激光沉积方法在(1102)取向的Al_(2)O_(3)单晶衬底上成功外延制备了高质量(1120)取向的六角Kagome相Mn_(3)Sn薄膜,并系统地测量了不同温度下该Mn_(3)Sn薄膜的磁性和磁输运特性.结果发现,该Mn_(3)Sn薄膜的磁化曲线、霍尔电阻率曲线和磁电阻曲线在其三类磁相变温度中的某些或全部均表现出一定的异常特征.这些特征可以作为该六角Kagome相Mn_(3)Sn薄膜中磁相变的证据,甚至用于测量这些磁相变的温度.本工作有助于进一步推动六角Kagome相拓扑反铁磁材料在自旋电子器件中的应用.

关键词：拓扑反铁磁磁相变反常霍尔电阻各向异性磁电阻

Computed tomography-based radiomic model for the prediction of neoadjuvant immunochemotherapy response in patients with advanced gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4115-4128页

作者： Jun Zhang Qi Wang Tian-Hui Guo Wen gao Yi-Miao Yu Rui-Feng Wang Hua-Long Yu Jing-Jing Chen Ling-Ling Sun bi-Yuan Zhang Hai-Ji Wang Department of Radiation Oncology Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Department of Radiology Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Department of Pathology Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina

BACKGROUND Neoadjuvant immunochemotherapy(nICT)has emerged as a popular treatment approach for advanced gastric cancer(AGC)in clinical practice ***,the response of AGC patients to nICT displays significant heterogeneity,and no existing radiomic model utilizes baseline computed tomography to predict treatment *** To establish a radiomic model to predict the response of AGC patients to *** Patients with AGC who received nICT(n=60)were randomly assigned to a training cohort(n=42)or a test cohort(n=18).Various machine learning models were developed using selected radiomic features and clinical risk factors to predict the response of AGC patients to *** individual radiomic nomogram was established based on the chosen radiomic signature and clinical *** performance of all the models was assessed through receiver operating characteristic curve analysis,decision curve analysis(DCA)and the Hosmer Lemeshow goodness-of-fit *** The radiomic nomogram could accurately predict the response of AGC patients to *** the test cohort,the area under curve was 0.893,with a 95%confidence interval of *** indicated that the clinical application of the radiomic nomogram yielded greater net benefit than alternative *** A nomogram combining a radiomic signature and a clinical signature was designed to predict the efficacy of nICT in patients with *** tool can assist clinicians in treatment-related decision-making.

关键词： Gastric cancer Radiomics Computed tomography Neoadjuvant immunochemotherapy Machine learning Immunology

Constraints on axion-like particles from the observation of Galactic sources by the LHAASO

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Chinese Physics C 2024年第6期48卷 232-239页

作者：李军毕效军高林青黄晓渊姚润民殷鹏飞 Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210033China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China School of Nuclear Science and Technology University of South ChinaHengyang 421001China

High-energy photons may oscillate with axion-like particles(ALPs)when they propagate through the Milky Way's magnetic field,resulting in an alteration in the observed photon energy ***-high energy gamma-ray spectra,measured by the Large High Altitude Air Shower Observatory(LHAASO)up to O(1)PeV,provide a promising opportunity to investigate the ALP-photon oscillation *** this study,we utilize the gamma-ray spectra of four Galactic sources measured by the LHAASO,that is,the Crab Nebula,LHAASO J2226+6057,LHAASO J1908+0621,and LHAASO J1825-1326,to explore this *** employ the CLsmethod to set constraints on the ALP *** analysis of the observations of the four sources reveals that the ALPphoton coupling gaγis constrained to be smaller than 1.4×10^(-1)0GeV^(-1)for an ALP mass of~4×10^(-7)eV at 95%*** the observations of the Crab Nebula from the LHAASO and other experiments,we find that the ALP-photon coupling may be set to approximately 7.5×10^(-11)GeV^(-1)for an ALP mass of~4×10^(-7)eV,which is similar to the CAST constraint.

关键词： axion-like particles gamma-ray Galactic sources

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低碳城市试点政策与企业劳动收入份额

江西师范大学学报（哲学社会科学版） 2024年第2期57卷 78-90页

作者：高蕾田祥宇柳晓倩山西财经大学会计学院山西太原030006 西南财经大学经济与管理研究院四川成都611130

在中国实现碳达峰和碳中和目标以及促进共同富裕的背景下,利用中国2010年开始实施的低碳城市试点政策这一准自然实验,运用沪深A股2007—2019年的面板数据和多期双重差分方法,评估了低碳城市试点政策对企业劳动收入份额的影响。研究表明... 详细信息

在中国实现碳达峰和碳中和目标以及促进共同富裕的背景下,利用中国2010年开始实施的低碳城市试点政策这一准自然实验,运用沪深A股2007—2019年的面板数据和多期双重差分方法,评估了低碳城市试点政策对企业劳动收入份额的影响。研究表明:低碳城市试点政策能够促进企业劳动收入份额提高。并且采用PSM-DID方法、更换关键变量衡量方式、加入宏观控制变量进行稳健性检验后该结论依然成立。低碳城市试点政策通过调整人力资本结构和提高企业全要素生产率提升了企业劳动收入份额。增加企业研发投入与技术人员人数,有助于增强低碳城市试点政策对企业劳动收入份额的促进作用。异质性分析结果表明,低碳城市试点政策对国有企业、新企业、资本技术密集型企业、低碳排放企业以及处于中西部地区企业的劳动收入份额的提高作用更为明显。

关键词：低碳城市试点政策企业劳动收入份额人力资本结构调整企业全要素生产率

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新辅助免疫治疗开创胃癌治疗新时代

中华胃肠外科杂志 2024年第7期27卷 653-658页

作者：季科周凯高翔宇步召德季加孚北京大学肿瘤医院暨北京市肿瘤防治研究所胃肠肿瘤中心恶性肿瘤发病机制及转化研究教育部重点实验室北京100142 北京大学肿瘤医院暨北京市肿瘤防治研究所胃肠肿瘤中心消化系肿瘤整合防治全国重点实验室恶性肿瘤转化研究北京市重点实验室北京100142

近年来,随着肿瘤免疫学的发展,免疫治疗成为胃癌新辅助治疗的新方向。多项临床试验已经证实,将免疫治疗与化疗、靶向治疗等相结合,应用于胃癌新辅助治疗中,不仅可以改善患者的治疗反应,还能有效延长患者的生存期。本文旨在评述免疫治疗... 详细信息

近年来,随着肿瘤免疫学的发展,免疫治疗成为胃癌新辅助治疗的新方向。多项临床试验已经证实,将免疫治疗与化疗、靶向治疗等相结合,应用于胃癌新辅助治疗中,不仅可以改善患者的治疗反应,还能有效延长患者的生存期。本文旨在评述免疫治疗在胃癌新辅助治疗中的应用,并探讨其机制、与传统治疗方式的结合策略、安全性及个体化精准治疗等,从而为胃癌治疗领域提供新的思路与方向。

关键词：胃肿瘤新辅助治疗免疫治疗免疫检查点抑制剂

Porous Nickel-Molybdenum Phosphide Alloy Electrodes for Alkaline Hydrogen Evolution Reaction at the High-Current Density

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Renewables 2024年第2期2卷 150-161页

作者： Songhu bi Zhen Geng Linyi Zhao Zijian gao Chenxu Qu Wenbo Li Liming Jin Mingzhe Xue Cunman Zhang Clean Energy Automotive Engineering Center School of Automotive StudiesTongji UniversityShanghai 201804

Alkaline water electrolysis is a practical route for large-scale green hydrogen production to assist decarbonization,whereby carbon dioxide emissions are ***,the use of this process in hydrogen evolution reaction(HER)is hampered by the alkaline solution,which leads to slow H_(2)O dissociation kinetics,especially when nickel–molybdenum(NiMo)alloy catalysts are utilized;thus,an improvement of this approach for effective HER activity is *** this work,a porous phosphide NiMo-based(NiMoP)alloy electrode catalyst was engineered using a multistep electrodeposition *** experiments,combined with theoretical calculations,confirmed that the phosphide incorporation in the NiMo alloys promoted alkaline HER performance at a high current density of 1000 mA cm^(−2)with the potential−0.191 *** evaluation of the effect of electrodeposition current density on HER performance revealed that the P content indeed positively impacted the accompanying alkaline HER performance,attributable to phosphide contribution in the electron *** functional theory(DFT)calculations demonstrated that the P atom promoted the loss of Mo electrons and hindered Ni from gaining *** charge reconstruction allowed the optimization of the H^(*)adsorption,contributing to a stronger H_(2)O adsorption and encouraging H-OH^(*)bond *** current approach may provide the possibility of designing high-performance alkaline HER electrodes at high current density.

关键词： alkaline water electrolysis hydrogen evolution reaction porous electrodes NiMoP alloy density functional theory calculations

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美国情报文化研究:一个基本框架

情报杂志 2024年第1期43卷 1-13页

作者：高金虎陈震王祥宇国防科技大学国际关系学院南京210039

[研究目的]梳理情报文化的生成机理,阐述美国情报文化的主要内容。[研究方法]该文梳理了美国情报文化的发展脉络,剖析了美国情报文化的生成机理,并从情报观、情报协调、情报分析、安全与反情报、情报谋略等角度,剖析了美国情报文化的主... 详细信息

[研究目的]梳理情报文化的生成机理,阐述美国情报文化的主要内容。[研究方法]该文梳理了美国情报文化的发展脉络,剖析了美国情报文化的生成机理,并从情报观、情报协调、情报分析、安全与反情报、情报谋略等角度,剖析了美国情报文化的主要内容,从而为情报文化乃至兵学文化的研究提供一个基本范式。[研究结论]情报文化是影响情报工作的重要因素,它有效解释了各国情报工作之间的差异。情报文化具有恒久稳定性,但国家安全环境的变化、国家对外战略取向的改革、灾难性的情报失误、审时度势的决策者的出现,都会重塑情报文化。

关键词：情报文化兵学文化情报观国家安全情报美国情报工作