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In situ investigation of lysozyme adsorption into polyelectrolyte brushes by quartz crystal microbalance with dissipation

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Chinese Journal of Chemical Engineering 2022年第8期35卷 106-115页

作者： Fenfen you Qing-Hong Shi Department of Biochemical Engineering School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300350China Key Laboratory of Systems Bioengineering(Ministry of Education) Tianjin UniversityTianjin 300072China

A well understanding about protein adsorption into charged polymer brushes is of importance in the elucidation of mechanism and important phenomena(such as “chain delivery”effect) in protein adsorption on polymer-grafted ion exchange adsorbents. In this work, quartz crystal microbalance with dissipation(QCM-D) was introduced to in situ investigate lysozyme adsorption on QCM sensors grafted with poly(3-sulfopropyl methacrylate)(pSPM) via atom transfer radical polymerization. It was achieved by analyzing frequency(f) and energy dissipation(D) shift simultaneously on pSPM-grafted sensors. The result showed that an initial decrease in ΔD was typical of lysozyme adsorption on pSPM-grafted sensor and more significant with an increase of chain length and grafting density. It was attributed to significant water release in the hydration layer of protein and polymer chains in lysozyme adsorption into pSPM *** pSPM-grafted sensors with long and dense chains, furthermore, lysozyme transitioned from monolayer to multilayer adsorption and the maximum adsorbed amount was obtained to be 374.0 ng·cmamong all pSPM-grafted sensors in this work. The results in D-f plot further revealed that lysozyme adsorption into pSPM brushes increased the rigidity of adsorbed layer and little structure adjustment of adsorbed lysozyme. It was unfavorable for “chain delivery” effect for facilitated transport of adsorbed protein. This work provided valuable insight into protein adsorption in pSPM brushes and outlined a feasible approach to increasing mass transport in polymer-grafted ion exchange adsorbents.

关键词： Adsorption Polymers Protein Water release Graft density Chain length

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Lowered testosterone in male obesity： mechanisms, morbidity and management

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Asian Journal of Andrology 2014年第2期16卷 223-231,I0008页

作者： Mark ng Tang Fui Department of Medicine Austin Health University of Melbourne Melbourne Department of Endocrinology Austin Health Melbourne Victoria Australia

With increasing modernization and urbanization of Asia, much of the future focus of the obesity epidemic will be in the Asian region. Low testosterone levels are frequently encountered in obese men who do not otherwise have a recognizable hypothalamic-pituitary-testicular （HPT） axis pathology. Moderate obesity predominantly decreases total testosterone due to insulin resistance-associated reductions in sex hormone binding globulin. More severe obesity is additionally associated with reductions in free testosterone levels due to suppression of the HPT axis. Low testosterone by itself leads to increasing adiposity, creating a self-perpetuating cycle of metabolic complications. Obesity-associated hypotestosteronemia is a functional, non-permanent state, which can be reversible, but this requires substantial weight loss. While testosterone treatment can lead to moderate reductions in fat mass, obesity by itself, in the absence of symptomatic androgen deficiency, is not an established indication for testosterone therapy. Testosterone therapy may lead to a worsening of untreated sleep apnea and compromise fertility. Whether testosterone therapy augments diet- and exercise-induced weight loss requires evaluation in adequately designed randomized controlled clinical trials.

关键词： androgens hypogonadism obesity testosterone weight loss

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On compact splitting complex submanifolds of quotients of bounded symmetric domains

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Science China Mathematics 2017年第6期60卷 1057-1076页

作者： MOK ngaiming ng SuiChung Department of Mathematics The University of Hong Kong Department of Mathematics Shanghai Key Laboratory of PMMPEast China Normal University

We study compact complex submanifolds S of quotient manifolds X =Ω/F of irreducible bounded symmetric domains by torsion free discrete lattices of automorphisms, and we are interested in the characterization of the totally geodesic submanifolds among compact splitting complex submanifolds S C X, i.e., under the assumption that the tangent sequence over S splits holomorphically. We prove results of two types. The first type of results concerns S C X which are characteristic complex submanifolds, i.e., embedding Ω as an open subset of its compact dual manifold M by means of the Borel embedding, the non-zero （1, 0）-vectors tangent to S lift under a local inverse of the universal covering map π → X to minimal rational tangents of M. We prove that a compact characteristic complex submanifold S C X is necessarily totally geodesic whenever S is a splitting complex submanifold. Our proof generalizes the case of the characterization of totally geodesic complex submanifolds of quotients of the complex unit ball B^n obtained by Mok （2005）. The proof given here is however new and it is based on a monotonic property of curvatures of Hermitian holomorphic vector subbundles of Hermitian holomorphic vector bundles and on exploiting the splitting of the tangent sequence to identify the holomorphic tangent bundle Ts as a quotient bundle rather than as a subbundle of the restriction of the holomorphic tangent bundle Tx to S. The second type of results concerns characterization of total geodesic submanifolds among compact splitting complex submanifolds S C X deduced from the results of Aubin （1978） and Yau （1978） which imply the existence of Kahler-Einstein metrics on S C X. We prove that compact s- plitting complex submanifolds S C X of sufticiently large dimension （depending on ） are necessarily totally geodesic. The proof relies on the Hermitian-Einstein property of holomorphic vector bundles associated to TS, which implies that endomorphisms of such bundles are parallel, and the co

关键词： bounded symmetric domains tangent sequence splitting complex submanifolds varieties of minimal rational tangents K/ihler-Einstein metrics

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AN APPROACH TO ANALYSIS OF SIngLE PIER BASED ON THE VARIATIONAL PRINCIPLE IN MULTI-LAYERED SOIL

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Acta Mechanica Solida Sinica 2001年第3期14卷 275-282页

作者： ng Shiu Cho Department of Civil Enginddring The Hong Kong University of Science and TechnologyClearwaler BayHong Kong

In this study, a variational approach to the settlement analysisof an axially loaded pier em- bedded in a multi-layered soil profileis presented. In this method, the soil profile and the embedded pierare divided into a number of sub-layers according to the actualnumber o soil layers observed in the field. The displacement shapefunction of each soil layer is given as a product of an exponentialequation along the pier depth and the Bessel's solution in the radialdirection.

关键词： pier pile settlement

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Physical scientists research biomedicine: a call for caution

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Chinese Journal of Cancer Research 2015年第1期27卷 94-95页

作者： Yì-Xiáng J.Wáng Department of Imaging and Interventional Radiology Faculty of Medicine The Chinese University of Hong Kong Prince of Wales Hospital

It is noticeable that nowadays there are more and more scientists with physical science or engineering background working on or started to work on biomedical projects, but rarely vice versa. This reflects the multi-discipline nature of some projects, however, also at least partially can be explained that biomedical research is seen as trendy, fundable, and likely to get more citations and with results more publishable in high impact journals （1,2）. It is also apparent with some publications and lectures that not all these physical scientists/engineers are well-prepared to work on projects which do not align with their own expertise. Some studies are against very basic principles of pharmacology or biology, while others try to solve medical problems which do not exist clinically. I reviewed a number of submissions including a few from prestigious American universities to Nature journals which made no sense with the study design. Much of manpower and financial resource are being wasteful spent. There are also examples of clinical trials which were ill-planned right from the start and in the end only causing much inconvenience to patients to say at the least. In addition, ample examples exist where experienced physical scientists worked with inexperienced medical scientists and resulted in avoidable failures.

关键词： a call for caution very Physical scientists research biomedicine

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ON INTEGRITY ASSESSMENT OF AXISYMMETRIC COMPONENTS OPERATIng WITHIN CREEP REGIME

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Chinese Journal of Mechanical Engineering 2006年第4期19卷 492-495页

作者： ZARRABI K LAWRENCE ng School of Mechanical and Manufacturing Engineering University of New South Wales Sydney NSW 2052 Australia

A multiaxial paradigm for predicting creep damage/lives of components is described. Although in principle the paradigm is general, it is verified using axisymmetric experimental data. It is shown that the proposed paradigm is capable of predicting creep lives with an error of less than 2%. It is also shown that the proposed paradigm is more accurate than the reference stress method.

关键词： Creep damage Creep life

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Multiomics approaches to uncover endometrial receptivity in embryo implantation:a mini-review

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Reproductive and Developmental Medicine 2024年第3期8卷 178-185页

作者： Sudini R.Fernando Yang Yan Manish Kumar Hoi-Lam Lai Yin-Lau Lee Ernest H.Y.ng William S.B.Yeung Kai-Fai Lee Department of Obstetrics and Gynaecology Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong SAR 999077China Department of Animal Science Faculty of Animal Science and Export AgricultureUva Wellassa UniversityBadullaSri Lanka Shenzhen Key Laboratory of Fertility Regulation The University of Hong Kong-Shenzhen HospitalFutian DistrictShenzhen 518053China

Successful implantation requires concerted interactions during the apposition,adhesion,and invasion of the embryo into a receptive ***,the embryo implantation rate for assisted reproduction remains low despite the transfer of good quality *** in endometrial transcriptomics,proteomics,lipidomics,and even microbiota all play important roles in embryo ***,the expression of steroid hormone-regulated adhesive and anti-adhesive molecules during the embryo implantation window is becoming an area of increasingly intense *** review(a)summarizes the different molecules expressed in the receptive endometrium and(b)proposes the use of surface protein markers to predict pregnancy outcomes from assisted reproduction.

关键词： Cell surface proteins Steroid regulation Endometrial receptivity Receptivity marker Infertility

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Improved GaN grown on Si(111) substrate using ammonia flow modulation on SiN_x mask layer by MOCVD

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Science China(Technological Sciences) 2009年第9期52卷 2758-2761页

作者： ng KaiWei LAU KeiMay Department of Electrical and Electronic Engineering Hong Kong University of Science & Technology Clear Water BayKowloon Hong Kong China

In this paper,1 μm n-GaN was grown by using varied and fixed ammonia flow (NH3) on SiNx mask layer on Si(111) substrate using metal organic chemical vapor deposition (MOCVD). In-situ optical reflectivity traces of GaN growth show that the three-to two-dimensional process has been prolonged by using varied ammonia flow on SiNx mask layer method compared with that grown by fixing ammonia flow. Structural and optical properties were characterized by high-resolution X-ray diffraction and photolu-minescence,and compared with the sample grown by fixing ammonia flow,GaN grown using the varied ammonia flow on SiNx mask layer showed better structure and optical quality. It was assumed that the low NH3 flow in the initial growth stage considerably increased the GaN island density on the nano-porous SiNx layer by enhancing vertical growth. Lateral growth was significantly favored by high NH3 flow in the subsequent step. As a result,the improved crystal and optical quality was achieved utilizing NH3 flow modulation for GaN buffer growth on Si(111) substrate.

关键词： GaN epilayer MOCVD NH3 modulation

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PSEUDO ALMOST PERIODIC SOLUTIONS OF DIFFERENTIAL EQUATIONS WITHPIECEWISE CONSTANT ARGUMENT

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Chinese Annals of Mathematics,Series B 1999年第4期20卷 489-494页

作者： PIAODAX10ng YUANROng SchoolofMathematicalSciences PekingUniversityBeijing100871China. DpaRmentofMathematics BeijingNormniUniversityBejLug100875China

The authors discuss the existence of pseudo almost periodic solutions of differential equations with piecewise constant argument by means of introducing new concept, pseudo almost periodic sequence.

关键词： Pseudo almost periodic functions Pseudo almost periodic sequences Piecewise constant arguments Ergodic perturbation

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Mechanical and hydraulic properties of carbonate rock:The critical role of porosity

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第4期15卷 814-825页

作者： Kam ng J.Carlos Santamarina Department of Civil and Architectural Engineering and Construction Management University of WyomingLaramieWY82071USA Physical Science and Engineering Division King Abdullah University of Science and TechnologyThuwal23955-6900Saudi Arabia

Carbonate rocks are extensively used in civil infrastructure and play a critical role in geoenergy geoengineering,either as hydrocarbon reservoirs or potential repositories for CO_(2)geological *** genesis and diagenetic overprint determine the properties of carbonate *** study combines recent data gathered from Madison Limestone and an extensive dataset compiled from published sources to analyze the hydraulic and mechanical properties of limestone carbonate *** models and data analyses recognize the inherently granular genesis of carbonate rocks and explain the strong dependency of physical properties on *** asymptotically-correct power model in terms of(1-Ф/Ф*)a is a good approximation to global trends of unconfined stiffness E and unconfined compressive strength UCS,cohesive intercept in Mohr-Coulomb failure envelopes,and the brittle-toductile transition *** power model is the analytical solution for the mechanical properties of percolating granular *** adopted a limiting granular porosityФ*=0.5 for all models,which was consistent with the loosest packing of monosize *** fitted power model has exponent(α=2)in agreement with percolation theory and highlights the sensitivity of mechanical properties to *** and models confirm a porosity-independent ratio between unconfined stiffness and strength,and the ratio follows a log-normal distribution with mean(E/UCS)≈*** high angle of internal shear strength measured for carbonate rocks reflects delayed contact failure with increased confinement,and it is not sensitive to *** spans more than six orders of *** size controls pore size and determines the reference permeability k^(*)at the limiting porosityФ*=*** a given grain size from fine to coarse-grained dominant carbonates,permeability is very sensitive to changes in porosity,suggesting preferential changes in the internal pore network during compaction.

关键词： Rock porosity Carbonate permeability Rock unconfined stiffness Unconfined compressive strength(UCS)

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