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Resolving the developmental mechanisms of cardiac microthrombosis of SARS-CoV-2 based on single-cell transcriptome analysis

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Science China(Life Sciences) 2025年第1期68卷 103-115页

作者： Xizi Luo Nan Zhang Yuntao Liu Beibei Du Xuan Wang Tianxu zhao Bingqiang Liu Shishun zhao Jiazhang Qiu Guoqing Wang State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of EducationCollege of Basic MedicineJilin UniversityChangchun 130012China College of Mathematics Jilin UniversityChangchun 130021China Department of Cardiology China-Japan Union HospitalJilin UniversityChangchun 130033China Bioinformatic Lab School of MathematicsShandong UniversityJinan 250100China State Key Laboratory for Diagnosis andTreatmentof Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministryof EducationCollegeof Veterinary MedicineJilin UniversityChangchun 130062China

The coronavirus disease 2019(COVID-19)outbreak caused by the severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)developed into a global health *** microthrombus caused by SARS-CoV-2 infection is a common complication in patients with *** microthrombosis as a complication of SARS-CoV-2 infection is the primary cause of cardiac injury and death in patietns with severe *** this study,we performed single-cell sequencing analysis of the right ventricular free wall tissue from healthy donors,patients who died during the hypercoagulable period of characteristic coagulation abnormality(CAC),and patients who died during the fibrinolytic period of *** collected 61,187 cells enriched in 24 immune cell subsets and 13 cardiac-resident cell *** found that in the course of SARS-CoV-2 infected heart microthrombus,MYO1 Ehigh RASGEF1 Bhighmonocyte-derived macrophages promoted hyperactivation of the immune system and initiated the extrinsic coagulation pathway by activating chemokines CCL3,*** series of events is the main cause of cardiac microthrombi following SARS-CoV-2 *** a SARS-CoV-2 infected heart microthrombus,excessive immune activation is accompanied by an increase in cellular iron content,which in turn promotes oxidative stress and intensifies intercellular *** induces cells to alter their metabolic environment,resulting in increased sugar uptake via the glycosaminoglycan synthesis *** addition,high levels of reactive oxygen species generated by elevated iron levels promote increased endogenous malondialdehyde synthesis in a subpopulation of cardiac endothelial *** exacerbates endothelial cell dysfunction and exacerbates the coagulopathy process.

关键词： SARS-CoV-2 cardiac microthrombosis immune hyperactivation cell competition

Carbon Dots-Modified Hollow Mesoporous Photonic Crystal Materials for Sensitivityand Selectivity-Enhanced Sensing of Chloroform Vapor

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Nano-Micro Letters 2025年第4期17卷 381-398页

作者： Junchen Liu Ji Liu Zhipeng Li Liupeng zhao Tianshuang Wang Xu Yan Fangmeng Liu Xiaomin Li Qin Li Peng Sun Geyu Lu Dongyuan zhao State Laboratory On Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012People’s Republic of China Department of Chemistry and Laboratory of Advanced Materials Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsState Key Laboratory of Molecular Engineering of PolymersCollaborative Innovation Center of Chemistry for Energy Materials(2011-iChEM)College of Chemistry and MaterialsFudan UniversityShanghaiPeople’s Republic of China School of Engineering and Built Environment Griffith UniversityNathanQLD 4111Australia

Chloroform and other volatile organic pollutants have garnered widespread attention from the public and researchers,because of their potential harm to the respiratory system,nervous system,skin,and ***,research on chloroform vapor sensing is still in its early stages,primarily due to the lack of specific recognition *** we report a mesoporous photonic crystal sensor incorporating carbon dots-based nanoreceptor(HMSS@CDs-PCs)for enhanced chloroform *** colloidal PC packed with hollow mesoporous silica spheres provides an interconnected ordered macro-meso-hierarchical porous structure,ideal for rapid gas sensing utilizing the photonic bandgap shift as the readout *** as-synthesized CDs with pyridinic-N-oxide functional groups adsorbed in the hollow mesoporous silica spheres are found to not only serve as the chloroform adsorption sites,but also a molecular glue that prevents crack formation in the colloidal *** sensitivity of HMSS@CDs-PCs sensor is 0.79 nm ppm^(-1)and an impressively low limit of detection is 3.22 ppm,which are the best reported values in fast-response chloroform vapor sensor without multi-signal *** positive response time is 7.5 s and the negative response time 9 ***,relatively stable sensing can be maintained within a relative humidity of 20%-85%RH and temperature of 25-55℃.This study demonstrates that HMSS@CDs-PCs sensors have practical application potential in indoor and outdoor chloroform vapor detection.

关键词： Carbon dots Photonic crystal sensors Sensitivity-enhanced sensing Selectivity-enhanced sensing Chloroform vapor sensing

Solitons in the Fifth-Order Kd V Equation with a Perturbation

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Chinese Physics Letters 2025年第1期42卷 10-14页

作者： Wentao Li Yipu Chen zhao Zhang Xiangyu Yang Biao Li School of Mathematics and Statistics Ningbo UniversityNingbo 315211China School of Mathematics and Statistics Lingnan Normal UniversityZhanjiang 524048China School of Mathematical Sciences Dalian University of TechnologyDalian 116024China

The fifth-order Kd V equation with a perturbation term is naturally consistent with the shallow-water wave *** this study,the leading-order asymptotic solution of the perturbed fifth-order Kd V equation was derived using the multi-scale perturbation expansion ***,the asymptotic solution was reconsidered from the perspective of conservation laws,and consistent results were *** addition,the numerical solution of the slowly varying solitary wave asymptotic solution was obtained using the Fourier spectral method under appropriate initial conditions to better understand its dynamic *** results enrich research on fluid dynamics.

关键词： dynamics. method. asymptotic

COMPrompter: reconceptualized segment anything model with multiprompt network for camouflaged object detection

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Science China(Information Sciences) 2025年第1期68卷 189-203页

作者： Xiaoqin ZHANG Zhenni YU Li zhao Deng-Ping FAN Guobao XIAO Zhejiang Province Key Laboratory of Intelligent Informatics for Safety and Emergency Wenzhou University Nankai International Advanced Research Institute (SHENZHEN FUTIAN) College of Computer Science Nankai University School of Computer Science and Technology Tongji University

We rethink the segment anything model(SAM) and propose a novel multiprompt network called COMPrompter for camouflaged object detection(COD). SAM has zero-shot generalization ability beyond other models and can provide an ideal framework for COD. Our network aims to enhance the single prompt strategy in SAM to a multiprompt strategy. To achieve this, we propose an edge gradient extraction module, which generates a mask containing gradient information regarding the boundaries of camouflaged objects. This gradient mask is then used as a novel boundary prompt, enhancing the segmentation process. Thereafter, we design a box-boundary mutual guidance module, which fosters more precise and comprehensive feature extraction via mutual guidance between a boundary prompt and a box prompt. This collaboration enhances the model's ability to accurately detect camouflaged objects. Moreover, we employ the discrete wavelet transform to extract high-frequency features from image embeddings. The high-frequency features serve as a supplementary component to the multiprompt ***, our COMPrompter guides the network to achieve enhanced segmentation results, thereby advancing the development of SAM in terms of COD. Experimental results across COD benchmarks demonstrate that COMPrompter achieves a cutting-edge performance, surpassing the current leading model by an average positive metric of 2.2% in COD10K. In the specific application of COD, the experimental results in polyp segmentation show that our model is superior to top-tier methods as well. The code will be made available at https://***/guobaoxiao/COMPrompter.

关键词： segment anything model camouflaged object detection boundary prompt

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An improved method to evaluate trap depth from thermoluminescence

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Journal of Rare Earths 2025年第2期43卷 262-269页

作者： Shiyou Zhang Fangyi zhao Shengqiang Liu Zhen Song Quanlin Liu The Beijing Municipal Key Laboratory of New Energy Materials and Technologies School of Materials Science and EngineeringUniversity of Science and Technology Beijing

Rare earth-doped inorganic compounds contribute mostly to the family of persistent luminescent materials due to the versatile energy levels of rare earth *** of the key research aims is to match the trap level stemming from the doped rare earth ion or intrinsic defects to the electronic structure of the host,and therefore thermoluminescence measurement becomes a radical technology in studying trap depth,which is one of the significant parameters that determine the properties of persistent luminescence and photostimulated ***,the results of trap depth obtained by different thermoluminescence methods are quite different so that they are not ***,we analyzed different thermoluminescence methods,selected and improved the traditional peak position method of Tm/500 to be E=（-0.94Inβ+30.09）*** the experimental heating rate（β） is needed additionally,but the accuracy is improved greatly in most *** convenient and accurate method will accelerate the discovery of novel rare earth-doped materials.

关键词： Persistent luminescence Photostimulated luminescence Rare earths Thermoluminescence Trap depth

Performance Analysis of a Coupled System based on Organic Rankine Cycle and Double Effect Absorption Refrigeration for Waste Heat Recovery in Data Center

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Journal of Thermal Science 2025年第1期34卷 188-205页

作者： LI Peng XU Jiaqi WANG Binbin LIU Jianyang zhao Wensheng HAN Zhonghe School of Energy Power and Mechanical Engineering North China Electric Power UniversityBaoding 071003China Hebei Key Laboratory of Low Carbon and High Efficiency Power Generation Technology North China Electric Power UniversityBaoding 071003China

During data center operation,it generates a significant volume of low-grade waste *** recover waste heat,a coupled system including solar collector,double effect absorption refrigeration and organic Rankine cycle is *** system performance is analyzed in *** the organic Rankine cycle,five organic working fluids(R245fa,R245ca,R123,R11,and R113)are selected.R245fa,R113 and R245ca obtain the maximum net power output,thermal efficiency and exergy efficiency,*** the double effect absorption refrigeration system,the evaporation temperature,condensation temperature,and generation pressure affect the COP and exergy *** the generator pressure is unchanged,the COP increases with increasing evaporation temperature and decreasing condensation *** the COP reaches 1.3,the COP slightly decreases as the evaporation temperature or condensation temperature ***,the exergy efficiency of refrigeration systems exhibits the same trend as the COP,and the exergy efficiency maximum value appears at approximately 0.32.A new performance indicator,rPUE,was defined to evaluate the data center power utilization *** flow distribution ratio and heat source temperature were optimized with multi-objective *** the mass flow distribution rate is 0.6 and the heat source temperature is 441.5 K,rPUE and the total unit production costs of the system obtain the optimal solution.

关键词： data center solar heat collection organic Rankine cycle double effect absorption refrigeration waste heat recovery

Seismic design of variable cross-section damped steel support frame for post equipment

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Earthquake Engineering and Engineering Vibration 2025年第1期24卷 155-167页

作者： Yang Zhenyu Ma Yuhong zhao Guifeng Feng Zhiwei Fu Mingyang Earthquake Engineering Research&Test Center Guangzhou UniversityGuangzhou 510405China School of Civil Engineering Guangzhou UniversityGuangzhou 510620China Guangdong Provincial Key Laboratory of Earthquake Engineering and Applied Technology Guangzhou 510405China

High-voltage electrical post equipment is generally installed on steel supports,which amplifies the seismic inputs and degrades the seismic performance of *** study proposed a variable cross-section damped steel support frame(VCDFS)with viscous dampers to reduce seismic responses of both tall and low-rise electrical *** VCDFS contains a trapezoidal damper layer to generate rocking motions,enabling the diagonal viscous dampers to dissipate seismic inputs.A theoretical model of post equipment with VCDFS is established,and an optimal design procedure is *** analysis shows that the remaining static stiffness ratio λ_(k) is the key parameter that determines the effectiveness of the *** VCDFS reduces the average displacement and stress response of a post insulator by 39.4%and 44.6%,respectively,together with a significant decrease in the dynamic amplification ***,it is recommended to use the VCDFS instead of the conventional latticed-steel frame in earthquake zones.

关键词： electrical post equipment steel support frame passive control seismic performance upgrading

Unraveling the significance of cobalt on transformation kinetics,crystallography and impact toughness in high-strength steels

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 380-390页

作者： Yishuang Yu Jingxiao zhao Xuelin Wang Hui Guo Zhenjia Xie Chengjia Shang Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China

This work reveals the significant effects of cobalt(Co)on the microstructure and impact toughness of as-quenched highstrength steels by experimental characterizations and thermo-kinetic *** results show that the Co-bearing steel exhibits finer blocks and a lower ductile-brittle transition temperature than the steel without ***,the Co-bearing steel reveals higher transformation rates at the intermediate stage with bainite volume fraction ranging from around 0.1 to *** improved impact toughness of the Co-bearing steel results from the higher dense block boundaries dominated by the V1/V2 variant ***,the addition of Co induces a larger transformation driving force and a lower bainite start temperature(BS),thereby contributing to the refinement of blocks and the increase of the V1/V2 variant *** findings would be instructive for the composition,microstructure design,and property optimization of high-strength steels.

关键词： high-strength steel cobalt transformation kinetics crystallography impact toughness

Preparation of FeCoNi medium entropy alloy from Fe^(3+)-Co^(2+)-Ni^(2+)solution system

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 92-101页

作者： Zongyou Cheng Qing zhao Mengjie Tao Jijun Du Xingxi Huang Chengjun Liu Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-carbon Steelmaking(Ministry of Education) Shenyang 110819China

In recent years,medium entropy alloys have become a research hotspot due to their excellent physical and chemical *** controlling reasonable elemental composition and processing parameters,the medium entropy alloys can exhibit similar properties to high entropy alloys and have lower *** this paper,a FeCoNi medium entropy alloy precursor was prepared via sol-gel and coprecipitation methods,respectively,and FeCoNi medium entropy alloys were prepared by carbothermal and hydrogen *** phases and magnetic properties of FeCoNi medium entropy alloy were *** showed that FeCoNi medium entropy alloy was produced by carbothermal and hydrogen reduction at 1500℃.Some carbon was detected in the FeCoNi medium entropy alloy prepared by carbothermal *** alloy prepared by hydrogen reduction was uniform and showed a relatively high ***,the hydrogen reduction product exhibited better saturation magnetization and lower coercivity.

关键词： medium entropy alloy sol-gel co-precipitation carbothermal hydrogen reduction