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Study on attrition of spherical-shaped Mo/HZSM-5 catalyst for methane dehydro-aromatization in a gas–solid fluidized bed

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Chinese Journal of Chemical Engineering 2021年第10期34卷 172-183页

作者： Xinzhuang zhang Yunda Han Dapeng Li Zhanguo Zhang Xiaoxun Ma School of Chemical Engineering Northwest UniversityXi’an 710069China Research Institute of Shaanxi Yanchang Petroleum(Group)Co. Ltd.Xi’an 710065China Chemical Engineering Research Center of the Ministry of Education(MOE)for Advanced Use Technology of Shanbei Energy Xi’an 710069China Shaanxi Research Center of Engineering Technology for Clean Coal Conversion Xi’an 710069China Collaborative Innovation Center for Development of Energy and Chemical Industry in Northern Shaanxi Xi’an 710069China International Scientific and Technological Cooperation Base of the Ministry of Science and Technology(MOST)for Clean Utilization of Hydrocarbon Resources Xi’an 710069China Hydrocarbon High-efficiency Utilization Technology Research Center of Shaanxi Yanchang Petroleum(Group)Co. Ltd.Xi’an 710065China Key Laboratory on Resources Chemicals and Materials Shenyang University of Chemical TechnologyShenyang 110142China Longdong University Qingyang 745000China

As a potential methane efficient conversion process,non-oxidative aromatization of methane in fluidized bed requires a catalyst with good attrition resistance,especially in the states of high temperature,longtime rapid movement and chemical reaction.Existing evaluation methods for attrition resistance,such as ASTM D5757 and Jet Cup test,are targeted for fresh catalysts at ambient temperature,which cannot well reflect the real process.In this study,spherical-shaped Mo/HZSM-5 catalyst prepared by dipping and spray drying was placed in a self-made apparatus for attrition testing,in which the catalyst attrition under different system temperatures,running time and process factors was investigated with percent mass loss(PML),particle size-mass distribution(PSMD)and scanning electron microscope(SEM).Carbon deposition on the catalyst before and after activation,aromatization and regeneration was analyzed by thermogravimetry(TG),and the attrited catalysts were evaluated for methane dehydro-aromatization(MDA).The results show that the surface abrasion and body breakage of catalyst particles occur continuously,with the increase of system temperature and running time,and make the PML rise gradually.The process factors of activation,aromatization and regeneration can cause the catalyst attrition and carbon deposits,which broaden the PSMD in varying degrees,and the carbon-substances on catalysts greatly improve their attrition resistance at high temperature.Catalyst attrition has a certain influence on its catalytic performance,and the main reasons point to particle breakage and fine powder escape.

关键词： Attrition Mo/HZSM-5 Fluidized-bed Catalyst activation Methane dehydro-aromatization

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Incomplete radiofrequency ablation provokes colorectal cancer liver metastases through heat shock response by PKCα/Fra-1 pathway

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Cancer Biology & Medicine 2019年第3期16卷 542-555页

作者： Zhanguo Zhang Yuxin zhang Lei zhang Youliang Pei Yanhui Wu Huifang Liang Wanguang zhang Bixiang zhang Hepatic Surgery Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Hubei Clinical Medicine Research Center for Hepatic Surgery

Objective: Incomplete radiofrequency ablation(ICR) has been proposed as a major cause of recurrence in the treatment of hepatic metastatic tumors.We tried to determine the mechanisms of this progression in colorectal cancer(CRC) liver metastasis(CRLMs)Methods: We have established a mouse model of radiofrequency ablation(RFA) therapy to demonstrate increased risk of recurrence of CRLMs with ICR.Here we focused on heat shock-induced CRC malignancy.Sub-lethal heat shock(HS) in CRC cell lines provoked cell growth, invasion, and tumor initiation in vitro and in vivo.Results: We found that Fra-1, which lies downstream of PKCα-ERK1/2 signaling, was significantly increased by HS compared with the untreated CRC cells.Silencing Fra-1 reversed the tumor promoting effects of HS.Furthermore, proliferation and tumor initiation inducer c-Myc, together with tumor invasion inducer matrix-metalloprotase 1(MMP-1) expression were up-regulated by AP-1/Fra-1 induced genes transcription.Conclusions: Our study demonstrated that ICR generated HS induces CRC malignancy by targeting Fra-1, which could be a potential prognostic marker and a promising therapeutic strategy to prevent disease recurrence after radiofrequency ablation treatment.

关键词： Radiofrequency ablation heat shock colorectal cancer liver metastases cancer stem cells recurrence

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Combination Therapies for Advanced Biliary Tract Cancer

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Journal of Clinical and Translational Hepatology 2023年第2期11卷 490-501页

作者： Weifeng Zeng Ruiqi Mao Zhanguo Zhang Xiaoping Chen Hepatic Surgery Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Hubei Province for the Clinical Medicine Research Center of Hepatic Surgery WuhanHubeiChina Hubei key laboratory of Hepato-Pancreato-Biliary Diseases Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Clinic Center of Human Genomic Research Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Department of Cardiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina

Biliary tract cancers(BTCs)are a group of malignant neoplasms that have recently increased in incidence and have a poor prognosis.Surgery is the only curative therapy.However,most patients are only indicated for palliative therapy because of advanced-stage disease at diagnosis and rapid progression.The current first-line treatment for advanced BTC is gemcitabine and cisplatin chemotherapy.Nonetheless,many patients develop resistance to this regimen.Over the years,few chemotherapy regimens have managed to improve the overall survival of patients.Accordingly,novel therapies such as targeted therapy have been introduced to treat this patient population.Extensive research on tumorigenesis and the genetic profiling of BTC have revealed the heterogenicity and potential target pathways,such as EGFR,VEGF,MEK/ERK,PI3K and mTOR.Moreover,mutational analysis has documented the presence of IDH1,FGFR2,HER2,PRKACA,PRKACB,BRAF,and KRAS gene aberrations.The emergence of immunotherapy in recent years has expanded the treatment landscape for this group of malignancies.Cancer vaccines,adoptive cell transfer,and immune checkpoint inhibitors have been extensively investigated in trials of BTC.Therefore,patient stratification and a combination of various therapies have become a reasonable and important clinical strategy to improve patient outcomes.This review elaborates the literature on combined treatment strategies for advanced BTC from the past few years and ongoing clinical trials to provide new inspiration for the treatment of advanced BTC.

关键词： Biliary tract cancer Drug therapy,Combination Immunotherapy Molecular targeted therapy Clinical trials

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From fundamentals to chemical engineering on oxidative coupling of methane for ethylene production:A review

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Carbon Resources Conversion 2022年第1期5卷 1-14页

作者： Jiao Liu Junrong Yue Mei Lv Fang Wang Yanbin Cui Zhanguo Zhang Guangwen Xu Institute of Process Engineering Chinese Academy of SciencesBeijing 100190China Institute of Industrial Chemistry and Energy Technology Shenyang University of Chemical TechnologyShenyang 110142LiaoningChina School of Ecology and Environment Beijing Technology and Business UniversityBeijing 100048China

A comprehensive overview is presented to summarize the research works since 1982 on oxidative coupling of methane(OCM),a complex reaction network combining heterogeneous and homogeneous reaction steps.Fundamentals on reaction mechanisms and thermodynamics have revealed that the OCM process is highly exothermic and its C2+selectivity and yield is critical in evaluating its commercial viability.Catalytic strategies have been put to enhance C2+selectivity,improve C2+yield and lower reaction temperature.The catalyst MnNa2WO4/SiO2 enables methane activation at a temperature of 800◦C and simultaneously a high C2+selectivity of 70–80%,while the nanowire and La2O3-based catalysts enable to lower the reaction temperature to 200–300◦C and 500◦C,respectively.Reaction engineering aspects have also been dealt in many investigations in order to make the process technically feasible.Particularly,research works on reaction kinetics,reactor selection and reactor operating mode choice have been addressed.Intermediate cooling and distributed oxygen feed have been integrated into a multi-stage adiabatic fixed-bed reactor system to suppress the side oxidation reactions and improve the performance of the catalysts towards CH4 conversion and C2+yield.This review paper proposes employing a circulating reactor system coupled with catalyst fine particles but having little internal diffusion resistance to maximize one-pass C2+selectivity and yield of the OCM reaction and evaluate its industrial application potential.

关键词： Oxidative coupling of methane Methane C2+ Ethylene OCM Reactor

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Platelet phagocytosis by neutrophils in a patient with antiphospholipid syndrome

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Rheumatology & Autoimmunity 2021年第1期1卷 64-66页

作者： Xiaoying zhang Chun Li zhanguo Li Department of Rheumatology and Immunology Peking University People's HospitalBeijingChina

A 49-year-old man presented to the emergency department with 1-week history of periumbilical abdominal pain with bloody stools.He did not vomit and was afebrile.He was well with no medical history of note.On examinati... 详细信息

关键词： antiphospholipid syndrome neutrophil platelet phagocytosis

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Development of a CH4 dehydroaromatization–catalyst regeneration fluidized bed system

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Chinese Journal of Chemical Engineering 2018年第9期26卷 1928-1936页

作者： Peng Yan Zhanguo Zhang Dapeng Li Xu Cheng Xinzhuang zhang Fan Yang Chuanfeng Huang Xiaoxun Ma School of Chemical Engineering Northwest University229 North Taibai RoodXi'an 710069China Research Institute of Yanchang Petroleum(Group)Co.Ltd Xi'an 710075China Chemical Engineering Research Center of the Ministry of Education(MOE)for Advanced Use Technology of Shanbei Energy Xi'an 710069China Shaanxi Research Center of Engineering Technology for Clean Coal Conversion Xi'an 710069China Collaborative Innovation Center for Development of Energy and Chemical Industry in Northern Shaanxi Xi'an 710069China International Scientific and Technological Cooperation Bose of the Ministry of Science and Technology(MOST)for Clean Utilization of Hydrocarbon Resources Xi'an 710069China National Institute of Advanced Industrial Science and Technology(AIST) 16-1 OnogawaTsukuba305-8569IbarakiJapan Hydrocarbon High-efficiency Utilization Technology Research Center of Yanchang Petroleum(Group)Co.Ltd Xi'an 710075China

A pilot-scale methane dehydroaromatization–H_2regeneration fluidized bed system(MDARS)was developed.In the MDARS,the catalyst circulation between a fluidized bed reactor and a fluidized bed regenerator with the help of a catalyst feeder allowed methane dehydroaromatization(MDA)and H_2regeneration to be carried out simultaneously,which is good for maintaining a stable MDA catalytic activity.A fixed bed reactor(FB)and a single fluidized bed reactor(SFB)were also used for a comparative study.The experimental results showed that the catalytic activity in the MDARS was more stable than that in the FB and SFB reactors.The effects of some parameters of MDARS on the CH_4conversion and product selectivity were investigated.To verify the feasibility and reliability of the MDARS,an eight-hour long-term test was carried out,which demonstrated that the operation of the MDARS was stable and that the catalytic activity remained stable throughout the entire experimental period.

关键词：流体化催化剂系统 CH4 开发新生反应堆 MDA

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Preparation and Characterization of Ultra-thin Pd-Ag Alloy Membranes

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Acta Metallurgica Sinica(English Letters) 2013年第4期26卷 361-365页

作者： Renguo SONG Zhanguo Zhang Chao WANG Hai LI Zhixiu WANG School of Materials Science and Engineering Changzhou University National Institute of Advanced Industrial Science and Technology(AIST)

Ultra-thin Pd-Ag alloy membranes were prepared initially by cold rolling, and it was found that there exist a large number of defects such as pinholes or cracks in the as-rolled membranes. Subsequently, these defects were repaired using electroless plating technique. The morphologies of the membranes have been examined by scanning electron microscopy （SEM）. It was observed in some as-repaired membranes that the defects were disappeared. A hydrogen permeation study has demonstrated that the as-repaired Pd-Ag alloy membranes were of high hydrogen permeation flux and hydrogen selectivity.

关键词： Pd-Ag alloy membrane Cold rolling Electroless plating Hydrogen permeation

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Comparison of the activities of binder-added and binder-free Mo/HZSM-5 catalysts in methane dehydroaromatization at 1073 K in periodic CH_4-H_2 switch operation mode

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Journal of Natural Gas Chemistry 2012年第6期21卷 729-744页

作者： Yuebing Xu Hongtao Ma Yo Yamamoto Yoshizo Suzuki Zhanguo Zhang National Institute of Advanced Industrial Science and Technology (AIST) 16-10nogawa Tsukuba 305-8569 Japan Meidensha Co. Osaki 2-8-1 Shinagawa-ku Tokyo141-8565 Japan

Three industry-supplied, well-shaped Mo/HZSM-5 catalysts, two binder-added and one binder-free, were tested for the first time in methane dehydroaromatization to benzene at 1073 K and 10000 mL/（g·h） in periodic CH4-H2 switch operation mode, and their catalytic performances were compared with those of three self-prepared, binder-free powder Mo/HZSM-5 catalysts. XRD, 27Al NMR, SEM, BET and NH3-TPD characterizations of all the catalysts show that the zeolites in the two binder-added catalysts are comparable to those in the three binder-free powder catalysts in crystallinity, crystal size, micropore volume and Br{／o}nsted acidity. The test results, on the other hand, show that the catalytic performances of the two binder-added catalysts are worse than those of the four binder-free catalysts on both catalyst mass and zeolite mass bases. Then, TPO and BET measurements of all spent samples were conducted to get a deep insight into the negative effects of binder addition, and the results suggest that the binder additives functioned mainly to enhance the polyaromatization of formed aromatics to coke on their external surfaces and consequently lower the catalysts＇ benzene formation activity and selectivity.

关键词： methane dehydroaromatization Mo/HZSM-5 binder coke formation

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Additional risk factors associated with thrombosis and pregnancy morbidity in a unique cohort of antiphospholipid antibody-positive patients

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Chinese Medical Journal 2022年第6期135卷 658-664页

作者： Chun Li Yu Zuo Song zhang Una E.Makris David R.Karp zhanguo Li Department of Rheumatology and Immunology Peking University People's HospitalBeijing 100044China Division of Rheumatology Department of Internal MedicineUniversity of MichiganAnn ArborMichiganUSA Division of Biostatistics Department of Clinical SciencesUT Southwestern Medical CenterDallasTXUSA Medical Service VA North Texas Health Care SystemDallasTXUSA Division of Rheumatic Disease Department of Internal MedicineThe University of Texas Southwestern Medical CenterDallasTXUSA

Background:Antiphospholipid syndrome(APS)is an autoimmune prothrombotic condition with significant morbidity.The objective of this study was to identify additional clinical and epidemiological risks of arterial thrombosis,venous thrombosis,and pregnancy morbidities in a large cohort of persistent antiphospholipid antibodies(aPLs)-positive carriers.Methods:This was a cross-sectional cohort study of 453 consecutive patients with a documented positive aPL who attended Peking University People's Hospital.Among 453 patients screened,297 patients had persistent positive aPL.We compared asymptomatic aPL carriers with thrombotic and obstetric APS patients.And the univariate analysis and multivariable logistic regression were used to evaluate the association between different risk factors and APS clinical manifestations.The levels of circulating markers of neutrophil extracellular traps(NETs)(cell-free DNA and citrullinated histone H3[Cit-H3])were assessed and compared among aPL-positive carriers with or without autoimmune disease and APS patients.Results:Additional risk factors associated with arterial thrombosis among aPL-positive carriers included:smoking(odds ratio[OR]=6.137,95%confidence interval[CI]=2.408-15.637,P=0.0001),hypertension(OR=2.368,95%CI=1.249-4.491,P=0.008),and the presence of underlying autoimmune disease(OR=4.401,95%CI=2.387-8.113,P<0.001).Additional risks associated with venous thrombosis among aPL carriers included:smoking(OR=4.594,95%CI=1.681-12.553,P=0.029)and the presence of underlying autoimmune disease(OR=6.330,95%CI=3.355-11.940,P<0.001).The presence of underlying autoimmune disease(OR=3.301,95%CI=1.407-7.744,P=0.006)is the additional risk,which demonstrated a significant association with APS pregnancy morbidity.Higher circulating levels of cell-free DNA and Cit-H3 were observed among APS patients and aPL patients with autoimmune diseases compared with those aPL carriers without underlying autoimmune diseases.Furthermore,control neutrophils that are conditioned with APS patients'sera have more

关键词： Antiphospholipid antibodies Antiphospholipid syndrome Arterial thrombosis Pregnancy risk Venous thrombosis

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SPM-IS: An auto-algorithm to acquire a mature soybean phenotype based on instance segmentation

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The Crop Journal 2022年第5期10卷 1412-1423页

作者： Shuai Li Zhuangzhuang Yan Yixin Guo Xiaoyan Su Yangyang Cao Bofeng Jiang Fei Yang Zhanguo Zhang Dawei Xin Qingshan Chen Rongsheng Zhu College of Engineering Northeast Agricultural UniversityHarbin 150030HeilongjiangChina College of Arts and Sciences Northeast Agricultural UniversityHarbin 150030HeilongjiangChina College of Agriculture Northeast Agricultural UniversityHarbin 150030HeilongjiangChina

Mature soybean phenotyping is an important process in soybean breeding;however, the manual process is time-consuming and labor-intensive. Therefore, a novel approach that is rapid, accurate and highly precise is required to obtain the phenotypic data of soybean stems, pods and seeds. In this research, we propose a mature soybean phenotype measurement algorithm called Soybean Phenotype Measure-instance Segmentation(SPM-IS). SPM-IS is based on a feature pyramid network, Principal Component Analysis(PCA) and instance segmentation. We also propose a new method that uses PCA to locate and measure the length and width of a target object via image instance segmentation. After 60,000 iterations, the maximum mean Average Precision(m AP) of the mask and box was able to reach 95.7%. The correlation coefficients R^(2) of the manual measurement and SPM-IS measurement of the pod length, pod width, stem length, complete main stem length, seed length and seed width were 0.9755, 0.9872, 0.9692, 0.9803,0.9656, and 0.9716, respectively. The correlation coefficients R^(2) of the manual counting and SPM-IS counting of pods, stems and seeds were 0.9733, 0.9872, and 0.9851, respectively. The above results show that SPM-IS is a robust measurement and counting algorithm that can reduce labor intensity, improve efficiency and speed up the soybean breeding process.

关键词： Soybean Feature pyramid network PCA Instance segmentation Deep learning

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