检索结果-南通市图书馆

Frontiers of Medicine 2022年第1期16卷 102-110页

作者： Huai-yu Wang Suyuan Peng zhanghui ye Pengfei Li Qing Li Xuanyu Shi Rui Zeng Ying Yao Fan He Junhua Li Liu Liu Shuwang Ge Xianjun Ke Zhibin Zhou Gang Xu Ming-hui Zhao Haibo Wang Luxia Zhang Erdan Dong National Institute of Health Data Science at Peking University Beijing 100191China Peking University Advanced Institute of Information Technology Hangzhou 311215China Department of Nephrology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Clinical Nutrition Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Taikang Tongji(Wuhan)Hospital Wuhan 430050China First Affiliated Hospital of Sun Yat-sen University Guangzhou 510080China Renal Division Department of MedicinePeking University First HospitalPeking University Institute of NephrologyBeijing 100034China Peking-Tsinghua Center for Life Sciences Beijing 100871China Department of Cardiology and Institute of Vascular Medicine Peking University Third HospitalKey Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesMinistry of HealthKey Laboratory of Molecular Cardiovascular SciencesMinistry of EducationBeijing Key Laboratory of Cardiovascular Receptors ResearchBeijing 100191China

Consecutively hospitalized patients with confirmed coronavirus disease 2019(COVID-19)in Wuhan,China were retrospectively enrolled from January 2020 to March 2020 to investigate the association between the use of renin–angiotensin system inhibitor(RAS-I)and the outcome of this *** between the use of RAS-I(angiotensin-converting enzyme inhibitor(ACEI)or angiotensin receptor blocker(ARB)),ACEI,and ARB and in-hospital mortality were analyzed using multivariate Cox proportional hazards regression models in overall and subgroup of hypertension status.A total of 2771 patients with COVID-19 were included,with moderate and severe cases accounting for 45.0%and 36.5%,respectively.A total of 195(7.0%)patients ***-I(hazard ratio(HR)=0.499,95%confidence interval(CI)0.325–0.767)and ARB(HR=0.410,95%CI 0.240–0.700)use was associated with a reduced risk of all-cause mortality among patients with *** patients with hypertension,RAS-I and ARB applications were also associated with a reduced risk of mortality with HR of 0.352(95%CI 0.162–0.764)and 0.279(95%CI 0.115–0.677),***-I exhibited protective effects on the survival outcome of *** use was associated with a reduced risk of all-cause mortality among patients with COVID-19.

关键词： COVID-19 RAS inhibitor hypertension all-cause mortality

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南平市延平区滨江路污水管网改造工程设计

江西建材 2023年第3期 394-395,400页

作者：叶章辉南平市城乡规划设计研究院有限责任公司福建南平353000

文中以南平市延平区滨江路污水管网改造工程为例,对管网的现状进行了调查,对存在问题进行了分析,提出了旧城区污水管网改造的主要设计要点及施工要求。

关键词：污水管网改造设计要点管道

基于智能数据和机器学习的尿液检验结果解释性报告

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中华检验医学杂志 2021年第6期44卷 524-531页

作者：胡长爱杨大干叶章辉刘震陈瑜浙江大学医学院附属第一医院检验科浙江省临床体外诊断技术研究重点实验室杭州310003 浙江省北大信息技术高等研究院杭州311215 杭州同烁信息技术有限公司杭州311121

目的:建立一种基于人工智能的尿液检验结果解释性报告系统。方法:收集2008—2018年浙江大学医学院附属第一医院患者2899917份、体检710971份尿检数据,统计每个项目不同结果的频数分布建立大人群分布,再根据数据分布、项目重要性和结果... 详细信息

目的:建立一种基于人工智能的尿液检验结果解释性报告系统。方法:收集2008—2018年浙江大学医学院附属第一医院患者2899917份、体检710971份尿检数据,统计每个项目不同结果的频数分布建立大人群分布,再根据数据分布、项目重要性和结果异常程度,建立每个样本的健康指数和各项目的异常等级。收集糖尿病、尿路感染、肾小球肾炎、肾病综合征等疾病数据,按性别、年龄匹配同数量的健康对照组。基于AdaBoost算法的集成学习器建立模型并评估算法性能。用JAVA开发数据展示软件。用199份异常尿液检验结果,人工验证模型的准确性。结果:每份报告分为正常、异常、疾病、危重4个等级;单个项目结果判断为正常、轻度、中度、重度、极度5个等级并提供大数据的人群分布;基于AdaBoost机器学习模型运用于7种疾病的训练准确度(≥88.3%)、真阳性率(≥80.0%)、曲线下面积(≥0.954)。开发的JAVA软件展示上述结果,并包括病历和结果、历史结果、个性化建议、异常项目科普、在大人群数据中的位置等内容。异常尿液结果可能的疾病相似度,人工验证机器学习模型的准确率为82.41%(164/199)。结论:本研究建立了智能的结果解释性报告系统,能区分报告异常程度,具有较高疾病预测准确性,可提供个性化的临床决策信息。

关键词：人工智能机器学习大数据尿干化学

The role of ATF3 in ZnO nanoparticle-induced genotoxicity and cytotoxicity in bronchial epithelial cells

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The role of ATF3 in ZnO nanoparticle-induced genotoxicity an...

Inhibition of RNA polymerase Ⅲ transcription by Triptolide attenuates colorectal tumorigenesis

华东六省一市生物化学与分子生物学会联盟2019年学术与教学交流会

作者： Saisai Wei Tiezheng Li Renxiang Xie Bingqi ye Jie Xiang Kangli Liu zhanghui Chen Xiangwei Gao Institute of Environmental Health and Sir Run-Run Shaw Hospitaland Institute of Environmental HealthZhejiang University School of Medicine Affiliated Hospital of Guangdong Medical University Institute of Environmental Medicine Zhejiang University School of Medicine

ZnO nanoparticle(ZnO NP) exposure causes oxidative stress in the respiratory system,leading to pulmonary *** transcription factor 3(ATF3) participates in a variety of cellular stress ***,the role of ATF3 in ZnO NP genotoxicity and cytotoxicity remains to be *** we reported that ZnO NP treatment dramatically induced the expression of ATF3 in human bronchial epithelial(HBE) cells,which was mediated by the nuclear factor erythroid 2-related factor 2(Nrf2).ATF3 was required for the repair of ZnO NP induced DNA damage as gamma foci number increased when endogenous ATF3 was ***,ATF3 also contributed to ZnO NP-induced cell *** study revealed that ATF3 interacted with the p53 protein and upregulated its expression under ZnO NP ***,our findings demonstrated ATF3 as an important regulator of epithelial homeostasis by promoting both DNA repair and the death of damaged cells under ZnO NP-induced genotoxic stress.

关键词： ZnO nanoparticle ATF3 DNA repair Apoptosis p53

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Inhibition of RNA polymerase Ⅲ transcription by Triptolide ...

华东六省一市生物化学与分子生物学会联盟2019年学术与教学交流会

作者： Xia Liang Renxiang Xie Jinfeng Su Bingqi ye Saisai Wei Zhibing Liang Rongpan Bai zhanghui Chen Zhongxiang Li Xiangwei Gao Medical Research Institute & Guangdong Women and Children's Disease Precision Diagnosis and Treatment Engineering Technology Research CenterBaoan Maternal and Child Health HospitalJinan University Department of Public Health Zhejiang University School of Medicine

Background:Upregulation of RNA polymerase(Pol) Ⅲ products,including tRNAs and 5 S rRNA,in tumor cells leads to enhanced protein synthesis and tumor formation,making it a potential target for cancer *** this study,we evaluated the inhibition of Pol Ⅲ transcription by triptolide and the anti-cancer effect of this drug in colorectal ***:The effect of triptolide on colorectal cancer development was assessed in colorectal cancer mouse models,3 D organoids,and cultured *** cancer cells were treated with *** Ⅲ transcription was measured by realtime quantitative polymerase chain reaction(PCR).The formation of TFⅢB,a multi-subunit transcription factor for Pol Ⅲ,was determined by chromatin immunoprecipitation(ChIP),co-immunoprecipitation(Co-IP),and fluorescence resonance energy transfer(FRET).Results:Triptolide reduced both tumor number and tumor size in adenomatous polyposis coli(Apc) mutated(ApcMin/+) mice as well as AOM/DSS-induced ***,triptolide effectively inhibited colorectal cancer cell proliferation,colonyformation,and organoid growth in vitro,which was associated with decreased Pol Ⅲ target ***,triptolide treatment blocked TBP/Brfl interaction,leading to the reduced formation of TFⅢB at the promoters of tRNAs and 5 S ***:Together,our data suggest that inhibition of Pol Ⅲ transcription with existing drugs such as triptolide provides a new avenue for developing novel therapies for colorectal cancer.

关键词： Triptolide Colorectal cancer RNA polymerase Ⅲ TFIIIB

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原发性胆囊绒毛膜癌1例

中华肝胆外科杂志 2023年第8期29卷 628-629页

作者：章杰李张辉汪春年叶盛黄静宁波市医疗中心李惠利医院东部院区肝胆胰外科宁波315048 宁波市临床病理诊断中心宁波315021

原发性胆囊绒毛膜癌是一种罕见的高度恶性的胆囊肿瘤,同时也是罕见的滋养细胞肿瘤。关于原发性胆囊绒毛膜癌的相关报道较少,目前胆囊绒毛膜癌尚无规范的诊疗指南,且患者预后极差,生存时间一般不超过1年。本文报道1例原发性胆囊绒毛膜癌... 详细信息

原发性胆囊绒毛膜癌是一种罕见的高度恶性的胆囊肿瘤,同时也是罕见的滋养细胞肿瘤。关于原发性胆囊绒毛膜癌的相关报道较少,目前胆囊绒毛膜癌尚无规范的诊疗指南,且患者预后极差,生存时间一般不超过1年。本文报道1例原发性胆囊绒毛膜癌患者,该例患者接受了腹腔镜下胆囊癌根治术+肝门区域淋巴结清扫术治疗,且在术后接受了mFOLFOX-6方案化疗,随访18个月,无肿瘤复发转移。

关键词：绒毛膜癌滋养细胞肿瘤胆囊肿瘤胆囊癌根治术肝门 FOLFOX 肿瘤复发转移诊疗指南

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女书文化与瑶族服饰的交融设计创新研究

山东纺织经济 2021年第3期38卷 27-29页

作者：何张慧叶洁嘉兴学院设计学院浙江嘉兴314000

从女书与瑶族的前世、今生、乘风、破浪这四部分,了解关于江永女书文化和千家峒瑶族服饰的历史渊源。通过过往经历的磨难、动荡,如今的互相融合、发展,进一步思考未来其服饰文化交融的创新设计。

关键词：女书文化瑶族服饰前世今生乘风破浪创新设计

从“表演的分回”到“文本的分回”——论章回小说分回体制的形成

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文学遗产 2020年第1期 144-156页

作者：叶楚炎中央民族大学文学与新闻传播学院

在宋元话本小说中广泛存在的分回标志物也大量出现于宋元讲史话本里。这些标志物既标识了说话伎艺表演时的分回痕迹,也显现出文本所经历的修改。在说话伎艺的分回被不断打磨的过程中,原本只是分回次要标志物的问句却在复合标志物及其被... 详细信息

在宋元话本小说中广泛存在的分回标志物也大量出现于宋元讲史话本里。这些标志物既标识了说话伎艺表演时的分回痕迹,也显现出文本所经历的修改。在说话伎艺的分回被不断打磨的过程中,原本只是分回次要标志物的问句却在复合标志物及其被删改后的残存文字中留存下来,并具有了更为重要的分回潜能。而当修订者在面对文本内部的分回问题并要采取靠近说话伎艺现场表演的文本策略时,问句的分回潜能被充分激发,成为最为重要的分回标志物,文本的分回也以问句为基础逐步建立起来。经由这一迂曲的过程,“表演的分回”最终演化成为“文本的分回”,章回小说中的分回体制也由此而渐次确立。

关键词：讲史话本分回章回小说

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从华东电网远景规划看全国电网互联问题

电网技术 1999年第5期23卷 28-30,34页

作者：张滨卢章辉岑文辉叶肇基马则良上海交通大学电力系华东电力联合集团

针对华东电网远景规划中面临的一些问题，结合金沙江溪落渡、向家坝水电东送工程的几种方案之比较，提出了华东电网远景规划中目标网架的设想，在此基础上探讨了全国电网互联的方式方法并进行了论述。

关键词：电力系统远景规划电网互联电力工业华东电网