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Study of Composite Hardcoat Anodizing of Aluminum Alloy 6063 and Its Friction Behaviors

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材料热处理学报 2004年第05B期25卷 1146-1148页

作者： LIUShi-yong zhanghui-chen GAOXue-min LIUWei SHIYa-qin InstituteofMetafandTechnology DalianMaritimeUniversity Datian116026 China

A composite hard-anodized coating containing micro PTFE (polytetrafluoroethylene) particles on aluminum alloy 6063 was produced by adding micro PTFE particles into the traditional hardcoat anodizing solution. The size of the PTFE particles is around 2 v- m in diameter and the content of the PTFE particles in the composite coating is within 2%-3% by area percentage. Thickness of the composite coating can reach up to 70 v m after one hour’s anodizing. Surface hardness of the composite coating is between 400-480 HVo.i- The average friction coefficient of the composite coating against steel under dry friction test is 0.11, which is 17% lower than that obtained by traditional hardcoat anodizing.

关键词： 6063铝合金硬盖阳极氧化复合涂层 PTEE 摩擦系数

The role of ATF3 in ZnO nanoparticle-induced genotoxicity and cytotoxicity in bronchial epithelial cells

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The role of ATF3 in ZnO nanoparticle-induced genotoxicity an...

华东六省一市生物化学与分子生物学会联盟2019年学术与教学交流会

作者： Saisai Wei Tiezheng Li Renxiang Xie Bingqi Ye Jie Xiang Kangli Liu zhanghui chen Xiangwei Gao Institute of Environmental Health and Sir Run-Run Shaw Hospitaland Institute of Environmental HealthZhejiang University School of Medicine Affiliated Hospital of Guangdong Medical University Institute of Environmental Medicine Zhejiang University School of Medicine

ZnO nanoparticle(ZnO NP) exposure causes oxidative stress in the respiratory system,leading to pulmonary *** transcription factor 3(ATF3) participates in a variety of cellular stress ***,the role of ATF3 in ZnO NP genotoxicity and cytotoxicity remains to be *** we reported that ZnO NP treatment dramatically induced the expression of ATF3 in human bronchial epithelial(HBE) cells,which was mediated by the nuclear factor erythroid 2-related factor 2(Nrf2).ATF3 was required for the repair of ZnO NP induced DNA damage as gamma foci number increased when endogenous ATF3 was ***,ATF3 also contributed to ZnO NP-induced cell *** study revealed that ATF3 interacted with the p53 protein and upregulated its expression under ZnO NP ***,our findings demonstrated ATF3 as an important regulator of epithelial homeostasis by promoting both DNA repair and the death of damaged cells under ZnO NP-induced genotoxic stress.

关键词： ZnO nanoparticle ATF3 DNA repair Apoptosis p53

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污水处理厂工程施工管理实践研究

建设科技 2023年第14期 88-90页

作者：陈章辉厦门同安城建工程有限公司厦门361000

在城市化进程不断推进的背景下,城市人口逐渐增多,工业企业的数量也在增加,使得污水排放量也在增加,污水处理厂是污水处理的主要场所,所以必须保证施工质量,而工程施工管理是关键。在部分污水处理厂的施工管理中风险较多,需要施工单位... 详细信息

在城市化进程不断推进的背景下,城市人口逐渐增多,工业企业的数量也在增加,使得污水排放量也在增加,污水处理厂是污水处理的主要场所,所以必须保证施工质量,而工程施工管理是关键。在部分污水处理厂的施工管理中风险较多,需要施工单位严格遵守设计方案,完善管理措施,进而提升污水的净化与回用能力。基于此,本文以洪塘污水处理厂中水回用工程为例,从污水处理厂工程建设的难点入手,讨论污水处理厂建设施工管理问题,最后分析污水处理厂建设施工管理对策,希望为相关研究增加了借鉴。

关键词：污水处理厂工程施工施工管理

Inhibition of RNA polymerase Ⅲ transcription by Triptolide attenuates colorectal tumorigenesis

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华东六省一市生物化学与分子生物学会联盟2019年学术与教学交流会

作者： Xia Liang Renxiang Xie Jinfeng Su Bingqi Ye Saisai Wei Zhibing Liang Rongpan Bai zhanghui chen Zhongxiang Li Xiangwei Gao Medical Research Institute & Guangdong Women and Children's Disease Precision Diagnosis and Treatment Engineering Technology Research CenterBaoan Maternal and Child Health HospitalJinan University Department of Public Health Zhejiang University School of Medicine

Background:Upregulation of RNA polymerase(Pol) Ⅲ products,including tRNAs and 5 S rRNA,in tumor cells leads to enhanced protein synthesis and tumor formation,making it a potential target for cancer *** this study,we evaluated the inhibition of Pol Ⅲ transcription by triptolide and the anti-cancer effect of this drug in colorectal ***:The effect of triptolide on colorectal cancer development was assessed in colorectal cancer mouse models,3 D organoids,and cultured *** cancer cells were treated with *** Ⅲ transcription was measured by realtime quantitative polymerase chain reaction(PCR).The formation of TFⅢB,a multi-subunit transcription factor for Pol Ⅲ,was determined by chromatin immunoprecipitation(ChIP),co-immunoprecipitation(Co-IP),and fluorescence resonance energy transfer(FRET).Results:Triptolide reduced both tumor number and tumor size in adenomatous polyposis coli(Apc) mutated(ApcMin/+) mice as well as AOM/DSS-induced ***,triptolide effectively inhibited colorectal cancer cell proliferation,colonyformation,and organoid growth in vitro,which was associated with decreased Pol Ⅲ target ***,triptolide treatment blocked TBP/Brfl interaction,leading to the reduced formation of TFⅢB at the promoters of tRNAs and 5 S ***:Together,our data suggest that inhibition of Pol Ⅲ transcription with existing drugs such as triptolide provides a new avenue for developing novel therapies for colorectal cancer.

关键词： Triptolide Colorectal cancer RNA polymerase Ⅲ TFIIIB

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基于SAW-RFID的SF6分解特性研究

电子测量与仪器学报 2018年第4期32卷 21-27页

作者：何怡刚陈张辉李兵张悦合肥工业大学电气与自动化工程学院

为提高分解特征组分在故障诊断中的准确性,需对影响分解特征组分的SF6气体湿度进行在线监测。现有湿度在线监测技术存在耗气量大、实现困难且复杂成本高等不足,提出了一种基于声表面波射频识别（SAW-RFID）的SF6气体湿度在线监测方法。... 详细信息

为提高分解特征组分在故障诊断中的准确性,需对影响分解特征组分的SF6气体湿度进行在线监测。现有湿度在线监测技术存在耗气量大、实现困难且复杂成本高等不足,提出了一种基于声表面波射频识别（SAW-RFID）的SF6气体湿度在线监测方法。首先对该SAW-RFID湿度传感器芯片进行了中心频率测试和性能测试,再利用该湿度传感器监测用针-板放电模型模拟金属突出物绝缘缺陷所产生的局部放电（PD）下SF6气体的湿度,在不同湿度下定量测定了SO2F2和SOF2的累积体积分数。实验结果表明,SAW-RFID湿度传感器的性能满足要求,精度高、误差小;SO2F2与SOF2的累积体积分数随湿度增加变大,与放电时间呈正相关;相对产气速率在前期与湿度负相关,在后期与湿度无关且趋同。

关键词：声表面波射频识别 SF6 相对湿度局部放电

静脉血栓栓塞症中遗传性蛋白C和蛋白S缺乏及其遗传危险因素的研究现状

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国际输血及血液学杂志 2021年第3期44卷 191-197页

作者：陈艳刘天陈璋辉广东医科大学湛江524023 广东医科大学附属医院血液疾病研究室湛江524001

静脉血栓栓塞症(VTE)是由遗传和环境因素共同引起的疾病。与欧洲和北美洲人群常见的遗传危险因素不同,亚洲人群VTE的主要遗传危险因素是遗传性抗凝蛋白缺乏。蛋白C和蛋白S均为维生素K依赖的抗凝蛋白,在调节机体凝血功能过程中发挥重要... 详细信息

静脉血栓栓塞症(VTE)是由遗传和环境因素共同引起的疾病。与欧洲和北美洲人群常见的遗传危险因素不同,亚洲人群VTE的主要遗传危险因素是遗传性抗凝蛋白缺乏。蛋白C和蛋白S均为维生素K依赖的抗凝蛋白,在调节机体凝血功能过程中发挥重要作用。因此,遗传性蛋白C和蛋白S缺乏症相关遗传危险因素的鉴定,对亚洲人群VTE的临床研究具有重要意义。近年来,相关研究已明确部分亚洲人群中遗传性蛋白C和蛋白S缺乏症常见的PROC和PROS1基因突变,并证实其与VTE发生风险增加密切相关。为了提高对VTE的诊治水平,笔者拟就亚洲人群中遗传性蛋白C和蛋白S缺乏症的常见遗传危险因素进行阐述。

关键词：静脉血栓栓塞蛋白C 蛋白S 突变危险因素血栓形成

The attenuation of Th1 and Th17 responses via autophagy protects against methicillin-resistant staphylococcus aureus-induced sepsis

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2019年浙江省医学会医学微生物与免疫学分会学术大会

作者： Shufang Zhang Xiaofang Huang Huiqing Xiu Zhongheng Zhang Kai Zhang Jiachang Cai Zhijian Cai zhanghui chen Zhaocai Zhang Wei Cui Gensheng Zhang Meixiang Xiang Department of Cardiology Second Affiliated HospitalZhejiang University School of MedicineCardiovascular Key Lab of Zhejiang Province Department of Critical Care Medicine Second Affiliated HospitalZhejiang University School of Medicine Department of Emergency Medicine Sir Run-Run Shaw HospitalZhejiang University School of Medicine Clinical Microbiology Laboratory Second Affiliated HospitalZhejiang University School of Medicine Institute of Immunology School of MedicineZhejiang University Clinical Research Center Zhanjiang Central HospitalGuangdong Medical university

Objective:Whether autophagy affects methicillin-resistant Staphylococcus aureus(MRSA)-induced sepsis and associated mechanisms are largely *** purpose of the study was to investigate the role of autophagy and the contribution of autophagy to T helper(Th) 1 and Th17 responses in MRSA-induced ***:MRSA-induced sepsis model was established by intravenous injection of USA3000 in C57 BL/6 ***-related genes knockout(LC3 B and Beclin-1) mice and autophagy-enhanced agent rapamycin were *** levels of microtubule-associated protein 1 light chain 3(LC3)-Ⅱ/Ⅰ,Beclin-1 and p62 after USA300 infection were examined by western blot and immunohistochemical *** burden,hematoxylineosin staining,and Kaplan-Meier analysis were performed to evaluate the effect of autophagy on MRSA-induced *** addition,cytokine productions of interferon-γ(IFN-γ) and interleukin-17(IL-17) were analyzed by enzyme-linked immunosorbent assay,and CD4+T cells differentiation was assessed by flow cytometry to observe the contribution of autophagy on Thl and Th17 polarization after USA3000 ***:Compared with baseline level,LC3-Ⅱ/Ⅰ levels were increased at 3 h,peaked at 6 h,and declined at 12 h after USA300 infection in lung,liver,kidney,and peripheral blood mononuclear cells;Beclin-1 protein levels were also significantly increased,while p62 protein levels were significantly decreased at 6 h after ***,increased LC3-II aggregation in CD4+T cells was also observed at 6 h after *** with sepsis model group,survival rates were significantly decreased in LC3 B and Beclin-1 groups(67% vs.25%;67% vs.33%,both P<0.01),accompanied with aggravated organ injuries likes lung,liver,and kidney;whereas enhancing autophagy with rapamycin alleviated these organ damages,and improved survival rate(67% vs.92%,P<0.01).However,LC3-II and Beclin-1 knockout or enhancing autophagy by rapamycin had no significant effects on bacterial burden

关键词： Autophagy CD4+T Methicillin-resistant Staphylococcus aureus Sepsis Th1,Th17

改进AFSA-BP神经网络的湿度传感器温度补偿研究

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电子测量与仪器学报 2018年第7期32卷 95-100页

作者：何怡刚陈张辉李兵苏蓓蕾合肥工业大学电气与自动化工程学院

为减小温度对声表面波射频识别(SAW-RFID)湿度传感器测量精度引起的误差,需要对实测的湿度进行温度补偿。通过对人工鱼群算法(AFSA)中鱼群初始化方式、视野和步长以及拥挤度因子的改进研究,得到改进的AFSA。采用改进的AFSA对反向传播(BP... 详细信息

为减小温度对声表面波射频识别(SAW-RFID)湿度传感器测量精度引起的误差,需要对实测的湿度进行温度补偿。通过对人工鱼群算法(AFSA)中鱼群初始化方式、视野和步长以及拥挤度因子的改进研究,得到改进的AFSA。采用改进的AFSA对反向传播(BP)神经网络的初始权值阈值进行全局寻优,再用寻优后的权值阈值建立的BP神经网络对SAW-RFID湿度传感器进行温度补偿。最后将此方法建立的BP神经网络、传统BP神经网络和遗传算法神经网络(GA-BP)的性能及温度补偿结果比较。实验结果显示,改进的AFSA收敛速度快、寻优能力强,建立的网络模型能有效降低温度对湿度测量精度的影响,提高了湿度测量的精度。

关键词：相对湿度温度补偿人工鱼群算法 BP神经网络

The attenuation of Th1 and Th17 responses via autophagy protects against methicillin-resistant staphylococcus aureus-induced sepsis

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第四届重症心脏全国学术大会暨第五届西湖重症医学大会、2019年浙江省重症医学学术大会（重症心脏-心与心外器官)

作者： Shufang Zhang Xiaofang Huang Huiqing Xiu Zhongheng Zhang Kai Zhang Jiachang Cai Zhijian Cai zhanghui chen Zhaocai Zhang Wei Cui Gensheng Zhang Meixiang Xiang

Background:Whether autophagy affects methicillin-resistant Staphylococcus aureus(MRSA)-induced sepsis and associated mechanisms are largely *** purpose of the study was to investigate the role of autophagy and the contribution of autophagy to T helper(Th) 1 and Th17 responses in MRSA-induced ***:MRSA-induced sepsis was established by intravenous injection of *** of microtubuleassociated protein 1 light chain 3(LC3)-II/I,Beclin-1 and p62 after USA300 infection were examined by western blot and immunohistochemical *** burden,hematoxylin-eosin staining,and Kaplan-Meier analysis were performed to evaluate the effect of autophagy on MRSA-induced ***-γ(IFN-γ) and interleukin-17(IL-17) were analyzed by enzyme-linked immunosorbent assay,and CD4+ T cells differentiation was assessed by flow cytometry to observe the contribution of autophagy on Th1 and Th17 polarization after USA300 ***:LC3-II/I and Beclin-1 were increased,while p62 were decreased after *** rates were decreased in LC3 B-/-and Beclin-1+/-groups(67% vs.25%;67% vs.33%,both P<0.01),accompanied with aggravated organ injuries and increased IFN-γ and IL-17 in the serum;whereas rapamycin alleviated organ damages,decreased IFN-γ and IL-17,and improved survival rate(67% vs.92%,P<0.01).However,there was no significant difference in bacterial *** cytometric analysis showed rapamycin treatment decreased the frequencies of Th1 and Th17 in the lymphocytes of spleen;whereas they were up-regulated in LC3 B-/-and Beclin-1+/-***:Autophagy plays a protective role in MRSA-induced sepsis,which may be partly associated with the alleviation of organ injuries via the down-regulation of Th1 and Th17 response.

关键词： Autophagy CD4+ T MRSA Sepsis Th1,Th17