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Glycolytic dysregulation in Alzheimer's disease:unveiling new avenues for understanding pathogenesis and improving therapy

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Neural Regeneration Research 2025年第8期20卷 2264-2278页

作者： you wu Lijie Yang Wanrong Jiang Xinyuan zhang Zhaohui Yao Department of Geriatrics Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Alzheimer's disease poses a significant global health challenge owing to the progressive cognitive decline of patients and absence of curative *** current therapeutic strategies,primarily based on cholinesterase inhibitors and N-methyl-Daspartate receptor antagonists,offer limited symptomatic relief without halting disease progression,highlighting an urgent need for novel research directions that address the key mechanisms underlying Alzheimer's *** studies have provided insights into the critical role of glycolysis,a fundamental energy metabolism pathway in the brain,in the pathogenesis of Alzheimer's *** in glycolytic processes within neurons and glial cells,including microglia,astrocytes,and oligodendrocytes,have been identified as significant contributors to the pathological landscape of Alzheimer's *** changes impact neuronal health and function,thus offering promising targets for therapeutic *** purpose of this review is to consolidate current knowledge on the modifications in glycolysis associated with Alzheimer's disease and explore the mechanisms by which these abnormalities contribute to disease onset and *** focus on the pathways through which glycolytic dysfunction influences Alzheimer's disease pathology should provide insights into potential therapeutic targets and strategies that pave the way for groundbreaking treatments,emphasizing the importance of understanding metabolic processes in the quest for clarification and management of Alzheimer's disease.

关键词： Alzheimer’s disease glial cells glycolysis neuronal metabolism pathogenesis therapeutic targets

Expression and role of specificity protein 1 in the sclera remodeling of experimental myopia in guinea pigs

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International Journal of Ophthalmology(English edition) 2017年第4期10卷 550-554页

作者： Bo Jiang zhang-you wu Zi-Cheng Zhu Gen-Jie Ke Yue-Chun Wen Si-Qin Sun Department of Ophthalmology Anhui Provincial HospitalAnhui Medical University

AIM：To study the expression of collagen I and transcription factor specificity protein 1（Sp1）,a transforming growth factor-β1（TGF-β1） downstream target,and reveal the impact of the TGF-β1-Sp1 signaling pathway on collagen remodeling in myopic ***：Seventy-five 1-week-old guinea pigs were randomly divided into normal control,form deprivation myopia（FDM）,and self-control *** was induced for different times using coverage with translucent latex balloons and FDM recovery was performed for 1wk after 4wk treatment;then,changes in refractive power and axial length were *** and reverse transcription-polymerase chain reaction were used to evaluate dynamic changes in collagen I and Sp1 expression in the sclera of guinea pigs with emmetropia and experimental myopia,and the relationship between collagen I and Sp1 levels was ***：In the FDM group,the refractive power was gradually changed（from 2.09±0.30 D at week 0 to-1.23±0.69 D,-4.17±0.59 D,-7.07±0.56 D,and-4.30±0.58 D at weeks 2,4,6,and 1wk after 4wk,respectively;P〈0.05）,indicating deepening of *** axial length was increased（from 5.92±0.39 mm at week 0 to 6.62±0.36 mm,7.30±0.34 mm,7.99±0.32 mm,and 7.41±0.36 mm at weeks 2,4,6,and 1wk after 4wk;P〈0.05）.The m RNA and protein expression of Sp1 and collagen I in the sclera of the FDM group was lower than that of the control groups（P〈0.05）,and the reduction was eye-coverage ***,correlation between Sp1 and collagen I down-regulation in the myopic sclera was ***：Our data indicate that transcription factor Sp1 may be involved in the regulation of type I collagensynthesis/degradation during myopic sclera remodeling,suggesting that TGF-β1 signaling plays a role in the development and progression of myopia.

关键词： form-deprivation myopia sclera remodeling transforming growth factor-β1 specificity protein 1 collagen I

学校内部治理中的学生参与:缘由阐释、困境分析与对策探赜

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教育理论与实践 2021年第16期41卷 27-32页

作者：张有武山西金融职业学院思政部山西太原030008

学生参与学校内部治理有助于学校真正践行“以生为本”的理念、打造和谐文明校园、促进学生全面成长成才、增强决策的科学性、提升学校治理体系和治理能力现代化。当前,学生参与学校治理存在学生、学校和国家社会层面的困境。保证学生... 详细信息

学生参与学校内部治理有助于学校真正践行“以生为本”的理念、打造和谐文明校园、促进学生全面成长成才、增强决策的科学性、提升学校治理体系和治理能力现代化。当前,学生参与学校治理存在学生、学校和国家社会层面的困境。保证学生参与学校治理的有序和高效开展,可采取以下措施:学生要增强参与意识、提升参与能力;学校要转变观念、规范制度、完善机制;全社会要支持并营造鼓励学生参与学校治理的氛围。

关键词：学校内部治理学生参与学校治理参与意识学校治理体系现代化学校治理氛围

社会主义核心价值观融入高职院校思想政治理论课教学的思考

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教育理论与实践 2015年第9期35卷 33-34页

作者：张有武山西金融职业学院信息技术系

高职院校将社会主义核心价值观融入高职院校思想政治理论课教学是由社会主义核心价值观的性质和地位决定的,是高职院校大学生思想政治教育的本质要求,是高职院校大学生成才和全面发展的必然要求。将社会主义核心价值观融入高职院校思想... 详细信息

高职院校将社会主义核心价值观融入高职院校思想政治理论课教学是由社会主义核心价值观的性质和地位决定的,是高职院校大学生思想政治教育的本质要求,是高职院校大学生成才和全面发展的必然要求。将社会主义核心价值观融入高职院校思想政治理论课教学,教师应加强对社会主义核心价值观的研究,把握其内涵,同时应提升自身综合素养,发挥榜样示范作用;学校应加强实践教学环节,发挥校园文化的环境育人作用,充分利用网络载体,开设思想政治理论课网络课堂。

关键词：社会主义核心价值观高职院校思想政治理论课教学

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社会主义公正价值观的培育路径

教育理论与实践 2016年第9期36卷 49-51页

作者：张有武山西金融职业学院山西太原030008

公正是维护人类社会和谐有序发展中重要的价值秩序,是社会主义核心价值观社会层面的重要内容。针对我国当前国情,社会主义公正价值观的培育应通过物质环境建设、文化环境建设、制度建设和评价指标体系构建几个方面着手进行。

关键词：社会主义公正价值观物质环境建设文化环境建设制度建设评价指标体系

红色文化资源融入高校思想政治教育的价值与实现维度

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教育理论与实践 2022年第6期42卷 32-35页

作者：张有武内蒙古大学马克思主义学院内蒙古呼和浩特010070

红色文化资源是建党百年来形成的宝贵精神财富,已经成为了中国共产党和中国人民的精神密码,政治性、人民性、历史传承性是其鲜明的特征。将其融入高校思想政治教育中,能够树牢学生的马克思主义信仰,增强学生的文化自信,提升思想政治教... 详细信息

红色文化资源是建党百年来形成的宝贵精神财富,已经成为了中国共产党和中国人民的精神密码,政治性、人民性、历史传承性是其鲜明的特征。将其融入高校思想政治教育中,能够树牢学生的马克思主义信仰,增强学生的文化自信,提升思想政治教育说服力、感染力与实效性。高校要在课堂教学、校园文化建设、文体活动、社会实践、智慧校园建设多角度全方位融入。

关键词：高校思想政治教育红色文化资源马克思主义信仰文化自信课堂教学智慧校园社会实践

A quantum-search-based multi-classifier for image recognition

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 21-31页

作者： Lu Liu Xingyu wu Lufan zhang Chuan Wang School of Artificial Intelligence Beijing Normal University Applied Optics Beijing Area Major Laboratory Beijing Normal University

The multi-class classification of images is a pivotal challenge within the realm of image processing. As the volume of visual data continues to expand, there is a burgeoning interest in harnessing the unique capabilities of quantum computation to augment the efficiency of classification tasks. However, many existing methods for training quantum image multi-classifiers parallel classical machine learning techniques, where the requisite circuit measurements increase linearly with the volume of training data. This work introduces a novel approach for training a quantum image multi-classifier based on the quantum search algorithm. We have meticulously conducted rigorous experiments on a handwritten digit dataset, a classic benchmark in the field. The results have been meticulously compared with previous works, and the comparative analysis not only validates the efficiency of our proposed approach, requiring only O(N/b) measurements during training, but also highlights a significant quadratic speedup of the algorithm.

关键词： quantum computation image recognition quantum search algorithm

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蟹脚壳肉分离装置的设计与试验

农业工程学报 2016年第23期32卷 297-302页

作者：陈超李彤张拥军周游吴凡农业部渔业装备与工程技术重点试验室上海200092 中国水产科学研究院渔业机械仪器研究所上海200092

针对河蟹蟹脚人工壳肉分离劳动强度大、效率低下且蟹肉易污染等问题,设计了一种辊筒挤压式蟹脚壳肉分离装置。该装置通过倾斜的输送滑道将蟹脚输送到一对直径相同、转动方向相反,转速相同的圆柱辊筒之间,利用其挤压作用完成蟹脚的壳肉... 详细信息

针对河蟹蟹脚人工壳肉分离劳动强度大、效率低下且蟹肉易污染等问题,设计了一种辊筒挤压式蟹脚壳肉分离装置。该装置通过倾斜的输送滑道将蟹脚输送到一对直径相同、转动方向相反,转速相同的圆柱辊筒之间,利用其挤压作用完成蟹脚的壳肉分离。为确定蟹脚壳肉分离装置的最佳工作参数,以分离效率、得肉率及蟹肉品质为性能指标,以送料角度、辊筒间隙和辊筒转速为影响因素对样机开展了正交试验。结果表明:影响壳肉分离效率的极显著因素为辊筒转速,送料角度和辊筒间隙影响不显著;影响得肉率的极显著因素为辊筒间隙,显著因素为送料角度,辊筒转速影响不显著;影响蟹肉品质的极显著因素为辊筒间隙,送料角度和辊筒转速影响不显著。试验结果表明:最佳工作参数为:送料角度40?,辊筒转速35 r/min、辊筒间隙1.2 mm,在此最优组合参数下,分离率23.1 kg/h,得肉率98.5%,蟹肉品质8.9分,该研究可为后续的设计优化与性能提高提供参考。

关键词：加工机械蟹脚壳肉分离设计试验参数优化

Ammonia pyrolysis oxidation excited by nanosecond pulsed discharge:Global/fluid models hybrid solution

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Journal of Energy Chemistry 2025年第1期100卷 385-396页

作者： Mingming zhang Hanyu wu Qi Chen Jiaxin Yang Bonan Liu School of Mechanical Electronic and Control Engineering Beijing Jiaotong University China University of Petroleum

The kinetic characteristics of plasma-assisted oxidative pyrolysis of ammonia are studied by using the global/fluid models hybrid solution ***,the stable products of plasma-assisted oxidative pyrolysis of ammonia are *** results show that the consumption of NH3/O2and the production of N2/H2change linearly with the increase of voltage,which indicates the decoupling of nonequilibrium molecular excitation and oxidative pyrolysis of ammonia at low ***,the detailed reaction kinetics mechanism of ammonia oxidative pyrolysis stimulated by a nanosecond pulse voltage at low pressure and room temperature is *** on the reaction path analysis,the simplified mechanism is *** detailed and simplified mechanism simulation results are compared with experimental data to verify the accuracy of the simplified ***,based on the simplified mechanism,the fluid model of ammonia oxidative pyrolysis stimulated by the nanosecond pulse plasma is established to study the pre-sheath/sheath behavior and the resultant consumption and formation of key *** results show that the generation,development,and propagation of the pre-sheath have a great influence on the formation and consumption of *** consumption of NH3by the cathode pre-sheath is greater than that by the anode pre-sheath,but the opposite is true for OH and O（1S）.However,within the sheath,almost all reactions do not ***,by changing the parameters of nanosecond pulse power supply voltage,it is found that the electron number density,electron current density,and applied peak voltages are not the direct reasons for the structural changes of the sheath and ***,the discharge interval has little effect on the sheath structure and gas mixture *** research results of this paper not only help to understand the kinetic promotion of non-equilibrium excitation in the process of oxidative pyrolysis but also help to explore th

关键词： Nanosecond pulsed discharge Ammonia Oxidative pyrolysis Fluid model Global model