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Traditional Chinese medicine in the treatment of Helicobacter pylorirelated gastritis:The mechanisms of signalling pathway regulations

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World Journal of Gastroenterology 2025年第3期31卷 11-28页

作者： Pei-Pei zhang liang Li Hao-Yu Qu Guang-Yu Chen Meng-Zhou xie Yan-Kun Chen School of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina Hunan Engineering Technology Research Center for Medicinal and Functional Food Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina Key Laboratory of Traditional Chinese Medicine Heart and Lung Syndrome Differentiation and Medicated Diet and Dietotherapy Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina School of Informatics Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Precision Medicine Research and Development Center Zhuhai Institute of Advanced TechnologyChinese Academy of SciencesZhuhai 519000Guangdong ProvinceChina

Helicobacter pylori-associated gastritis(HPAG)is a common condition of the gastrointestinal ***,extensive and long-term antibiotic use has resulted in numerous adverse effects,including increased resistance,gastrointestinal dysfunction,and increased recurrence *** these concerns develop,traditional Chinese medicine(TCM)may have *** is based on the concept of completeness and aims to eliminate pathogens and strengthen the *** has the potential to prevent this condition while also boosting the rate of Helicobacter pylori *** review elaborates on the mechanism of TCM treatment for HPAG based on cellular signalling pathways,which reflects the flexibility of TCM in treating diseases and the advantages of multi-level,multipathway,and multi-target treatments for HPAG.

关键词： Helicobacter pylori Helicobacter pylori-associated gastritis Traditional Chinese medicine Signalling pathway Eliminate pathogens Strengthen the body

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96例胃肠道间质瘤临床诊治分析

中华肿瘤杂志 2004年第7期26卷 437-439页

作者：娄越亮陈华张燮良战忠利天津医科大学附属肿瘤医院盆腔科 300060 天津医科大学附属肿瘤医院病理科 300060

目的　探讨胃肠道间质瘤的病理诊断、外科治疗及预后相关因素。方法　回顾分析 96例经手术治疗的胃肠道间质瘤患者的临床病理资料 ;免疫组织化学方法检测CD117、CD34、平滑肌肌动蛋白 (SMA)和S 10 0的表达情况。结果　免疫组织化学阳性... 详细信息

目的　探讨胃肠道间质瘤的病理诊断、外科治疗及预后相关因素。方法　回顾分析 96例经手术治疗的胃肠道间质瘤患者的临床病理资料 ;免疫组织化学方法检测CD117、CD34、平滑肌肌动蛋白 (SMA)和S 10 0的表达情况。结果　免疫组织化学阳性表达率CD117为 79.2 % (76 / 96 )、CD34为 5 8.3% (5 6 / 96 )、SMA为 35 .4 % (34/ 96 )、S 10 0为 9.4 % (9/ 96 )。良性 2 3例 ,恶性 73例。恶性组病例中 ,首次手术中切除大网膜 39例 ,未切除大网膜 34例 ,转移复发率分别为 5 .1%和 2 6 .5 % (P 5cm 4 6例 ,≤ 5cm 2 7例 ,转移复发率分别为 6 .5 %和 2 9.6 % (P <0 .0 5 )。良、恶性胃肠道间质瘤 5年生存率分别为 91.5 %和 5 7.3%。结论　CD117及CD34等免疫标记物配合使用可以提高胃肠道间质瘤的病理诊断准确率。采用合理的首次手术治疗及大网膜预防性切除可减少胃肠道间质瘤的复发。

关键词：胃肠道间质瘤免疫组织化学 CD117 CD34 GISTs 肿瘤

Trinuclear gold-catalyzed site-selective alkylation of peptides

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Science China Chemistry 2025年第01期 249-256页

作者： Qing-Yun Fang Chengyihan Gu Yinghan Chen Wencheng Yan Yong liang Weipeng Li Chengjian Zhu Jie Han Jin xie State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic Materials Chemistry and Biomedicine Innovation Center (Chem BIC) School of Chemistry and Chemical Engineering Nanjing University Green Catalysis Center College of Chemistry Zhengzhou University State Key Laboratory of Natural Medicines China Pharmaceutical University

Selective modification of peptides has always been a challenging issue. The selective alkylation of peptides can alter the biological activity and physical properties of molecules, and it has gained significant research interest. We herein disclose an intriguing gold-catalyzed alkylation of peptides using bench-stable unactivated alkyl bromides under photoredox catalysis. A wide range of structurally diverse primary, secondary and tertiary alkyl bromides serve as effective coupling partners to precisely connect with the α-C(sp3)–H in glycine residue of peptides. This protocol demonstrates an exceptionally broad scope for alkyl halides and excellent tolerance for a wide range of useful functional groups. A series of relay transformations to construct cyclic peptides, to proceed click reaction and to realize peptide fluorescence labeling further enhance its synthetic practicality. In addition, mechanistic studies and density functional theory(DFT) calculations reveal an inner-sphere and subsequent outersphere single electron transfer(SET) mechanism.

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Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan xie Jian Yu Kun-Ning zhang Zhou-Bo Guo Di Wang Zhao-Xian Li Wei-Qi zhang Yu-Ying Tan Li zhang Wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

Superhydrophobic and corrosion-resistant siloxane-modified MgAl–LDHs coatings on magnesium alloy prepared under mild conditions

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International Journal of Minerals,Metallurgy and Materials 2025年第02期 450-463页

作者： Wenxi zhang zhangzelong Zhuo Dan Xu liang Wu Zhihui xie Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province College of Chemistry and Chemical EngineeringChina West Normal University College of Materials Science and Engineering/National Engineering Research Center for Magnesium Alloys Chongqing University

We have developed a superhydrophobic and corrosion-resistant LDH-W/PFDTMS composite coating on the surface of Mg alloy. This composite comprised a tungstate-intercalated(LDH-W) underlayer that was grown at low temperature(relative to hydrothermal reaction conditions) under atmospheric pressure and an outer polysiloxane layer created from a solution containing perfluorodecyltrimethoxysilane(PFDTMS) using a simple immersion method. The successful intercalation of tungstate into the LDH phase and the following formation of the polysiloxane layer were confirmed through X-ray diffraction(XRD), Fourier transform infrared(FTIR) spectroscopy, and X-ray photoelectron spectroscopy(XPS). The corrosion resistance of the LDH-W film, both before and after the PFDTMS modification, was evaluated using electrochemical impedance spectroscopy(EIS), Tafel curves, and immersion experiments. The results showed that Mg coated with LDH-W/PFDTMS exhibited significantly enhanced corrosion protection compared to the unmodified LDHW film, with no apparent signs of corrosion after exposure to 3.5wt% NaCl solution for 15 d. Furthermore, the LDH-W/PFDTMS coating demonstrated superior superhydrophobicity and self-cleaning properties against water and several common beverages, as confirmed by static contact angle and water-repellency tests. These results offer valuable insights into preparing superhydrophobic and corrosion-resistant LDH-based composite coatings on Mg alloy surfaces under relatively mild reaction conditions.

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Study on the hydrogen absorption properties of a YGdTbDyHo rare-earth high-entropy alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 127-135页

作者： Tongyue Li Ziliang xie Wenjiao Zhou Huan Tong Dawen Yang Anjia zhang Yuan Wu Xiping Song State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China Whole Win(Beijing)Materials Sci.&Tech.Co. Ltd.Beijing 100083China

This study investigated the microstructure and hydrogen absorption properties of a rare-earth high-entropy alloy(HEA),*** indicated that the YGdTbDyHo alloy had a microstructure of equiaxed grains,with the alloy elements distributed *** hydrogen absorption,the phase structure of the HEA changed from a solid solution with an hexagonal-close-packed(HCP)structure to a high-entropy hydride with an faced-centered-cubic(FCC)structure without any secondary phase *** alloy demonstrated a maximum hydrogen storage capacity of 2.33 H/M(hydrogen atom/metal atom)at 723 K,with an enthalpy change(ΔH)of-141.09 kJ·mol^(-1)and an entropy change(ΔS)of-119.14 J·mol^(-1)·K^(-1).The kinetic mechanism of hydrogen absorption was hydride nucleation and growth,with an apparent activation energy(E_(a))of 20.90 kJ·mol^(-1).Without any activation,the YGdTbDyHo alloy could absorb hydrogen quickly(180 s at 923 K)with nearly no incubation period *** reason for the obtained value of 2.33 H/M was that the hydrogen atoms occupied both tetrahedral and octahedral *** results demonstrate the potential application of HEAs as a high-capacity hydrogen storage material with a large H/M ratio,which can be used in the deuterium storage field.

关键词： rare-earth high-entropy alloy hydrogen absorption capacity pressure–composition–temperature curves kinetics

新铌酸盐Ba_3Ni_(0.33)Nb_(4.67)O_(15)的合成与X射线衍射分析

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分析测试学报 2001年第4期20卷 40-42页

作者：张辉方亮谢济仁吴伯麟袁润章武汉理工大学材料复合新技术国家重点实验室湖北武汉430070

在BaO -Ni2O3 -Nb2O5 三元系统中 ,用固相反应法合成了新铌酸盐Ba3Ni0.33Nb4.67O15。以BaCl2 和B2O3为主要助熔剂制备了Ba3Ni0.33Nb4.67O15 的单晶体。利用四圆单晶衍射仪测定晶胞参数 ,然后采用X射线粉晶衍射法进行了物相分析,对该化... 详细信息

在BaO -Ni2O3 -Nb2O5 三元系统中 ,用固相反应法合成了新铌酸盐Ba3Ni0.33Nb4.67O15。以BaCl2 和B2O3为主要助熔剂制备了Ba3Ni0.33Nb4.67O15 的单晶体。利用四圆单晶衍射仪测定晶胞参数 ,然后采用X射线粉晶衍射法进行了物相分析,对该化合物的粉晶衍射数据进行了指标化 ,并报道了其X射线衍射数据。分析结果表明 ,该化合物属于填满型四方钨青铜结构 ,空间群P4bm(100),晶胞参数为 :a=1.26092(5)nm ,c=0.40096(4)nm ,α=β=γ=90°,Z=2。

关键词：铌酸盐 X射线衍射钨青铜矿型结构合成铁电材料

Advances in Graphene‑Based Electrode for Triboelectric Nanogenerator

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Nano-Micro Letters 2025年第1期17卷 378-403页

作者： Bin xie Yuanhui Guo Yun Chen Hao zhang Jiawei Xiao Maoxiang Hou Huilong Liu Li Ma Xin Chen Chingping Wong State Key Laboratory of Precision Electronic Manufacturing Technology and Equipment Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

With the continuous development of wearable electronics,wireless sensor networks and other micro-electronic devices,there is an increasingly urgent need for miniature,flexible and efficient nanopower generation *** nanogenerator(TENG)technology can convert small mechanical energy into electricity,which is expected to address this *** the core component of TENG,the choice of electrode materials significantly affects its *** metal electrode materials often suffer from problems such as durability,which limits the further application of ***,as a novel electrode material,shows excellent prospects for application in TENG owing to its unique structure and excellent electrical *** review systematically summarizes the recent research progress and application prospects of TENGs based on graphene *** precision processing methods of graphene electrodes are introduced,and the applications of graphene electrode-based TENGs in various scenarios as well as the enhancement of graphene electrodes for TENG performance are *** addition,the future development of graphene electrode-based TENGs is also prospectively discussed,aiming to promote the continuous advancement of graphene electrode-based TENGs.

关键词： Triboelectric nanogenerator Precision processing Graphene electrode Self-powered sensor

视觉刺激下心算减法与乘法相关皮层的fMRI研究

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实用放射学杂志 2006年第9期22卷 1032-1034页

作者：张妤郭亮谢道海陈剑华苏州大学第一附属医院影像中心苏州大学第一附属医院影像中心江苏苏州215006

目的研究正常成年人在执行减法与乘法任务时的脑功能状态及激活模式。方法对13例右利手正常青年志愿者分别给予组块设计的减法和乘法2种实验任务,同时运用1.5T的Marconi磁共振成像系统采集其脑部的血氧水平依赖性功能成像(BOLD-fMRI)数... 详细信息

目的研究正常成年人在执行减法与乘法任务时的脑功能状态及激活模式。方法对13例右利手正常青年志愿者分别给予组块设计的减法和乘法2种实验任务,同时运用1.5T的Marconi磁共振成像系统采集其脑部的血氧水平依赖性功能成像(BOLD-fMRI)数据。运用SPM99软件包进行t检验统计学处理,以获取执行不同任务与静息状态对比的脑功能图像。结果减法任务中,明显激活左侧额中回(MFG)、额下回(IFG)、顶上小叶(SPL)、顶下小叶(IPL)、角回(AG)、颞上回(STG),右侧MFG、SPL、IPL以及两侧视觉联合皮质、两侧小脑半球。乘法任务中,明显激活左侧额上回(SFG)、MFG、IFG、SPL、AG,右侧SPL,以及中央前回(PCG)、两侧视觉联合皮质。结论(1)额前区、顶叶、颞枕交界区参与计算并对应工作记忆、数量操作、视空间注意等作用机制;(2)小脑参与个体的数字计算的认知活动。

关键词：功能磁共振成像脑正常成人心算减法与乘法