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Validity and reliability of Chinese version of Fatigue Impact Scale in cerebral infarction patients

Neural Regeneration Research 2008年第2期3卷 177-181页

作者： Chunwei Wu Zhandong liu Yongbo zhang Jimei li Dexin wang Department of Neurology Beijing Friendship Hospital Capital Medical University Beijing 100050 China

BACKGROUND： Post-stroke fatigue has received much attention recently. Three evaluation scales are available, including the Fatigue Impact Scale （FIS）. Yet none of these has been proven to be of use in the evaluation of psychological quality after post-stroke fatigue. OBJECTIVE： To introduce FIS into China, and to evaluate the validity and reliability of the Chinese Version in patients with cerebral infarction. DESIGN： Scale evaluation. SETTING： Department of Rehabilitation, Beijing Friendship Hospital, Capital Medical University. PARTICIPANTS： A total of 330 patients with cerebral infarction were selected from the Department of Neurology, Beijing Friendship Hospital, Capital Medical University from June 2005 to December 2006. All patients met diagnostic standards from the Fourth National Cerebrovascular Disease Academic Meeting of China Medical Association and were diagnosed with CT or MRI examination. Patients who were not willing to accept scale evaluation were excluded. METHODS： The English version of FIS was translated into Chinese and subsequently translated back to English again. FIS was given to the discharged patients, and they returned them upon completion. In-patients completed and immediately returned the FIS. Validity and reliability of the retrieved scales were ascertained with descriptive and inference analysis. MAIN OUTCOME MEASURES： Total scores and subscale scores of FIS. RESULTS： Out of 330 questionnaires, 214 valid questionnaires were deemed valid in total. Six components were extracted in factor analysis, and the total cumulative contribution was 73.919%, which suggested the questionnaire was valid. After correlation analysis, 6 components were divided into 3 subscales, including cognitive, physical, and social, which was the same as the English version. The Cronbach α value for the three subscales was 0.937 7, 0.918 8, and 0.940 6, respectively （〉 0.7）. CONCLUSION： The reliability and validity of the Chinese version of FIS met with

关键词： cerebral infarction fatigue validity reliability scales

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AG490: An inhibitor of hepcidin expression in vivo

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World Journal of Gastroenterology 2011年第45期17卷 5032-5034页

作者： Shu-Ping zhang Zhe wang li-Xin wang Si-Jin liu State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China

A liver-produced hormone, hepcidin, appears to be the key player in iron metabolism. The overexpression of hepcidin is the underlying cause of anemia of inflammation. The identification of compounds inhibiting hepcidin expression could ameliorate anemia associated with inflammation. In the current study, we have demonstrated for the first time that AG490 signifi cantly abolishes hepcidin expression in mice. Our work represents a novel approach to suppress hepcidin expression for treatment of anemia of inflammation and anemias occurring under other conditions.

关键词： AG490 Hepcidin Anemia Inflammation

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A wideband CMOS variable gain low noise amplifier

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High Technology Letters 2010年第2期16卷 194-198页

作者：李海松 li Zhiqun zhang Hao li Wei wang Zhigong Institute of RF-＆OE-ICS Southeast University Nanjing 210096 P.R.China

In this paper, a novel structure of linear-in-dB gain control is introduced. Based on this structure, a wideband variable gain low noise amplifier （VGLNA） has been designed and implemented in 0.18μm RF CMOS technology. The measured resuhs show a good linear-in-dB gain control characteristic with 15 dB dynamic range. It can operate in the frequency range of MHz and consumes 30mW from 1.8V power supply. The minimum noise figure is 4.1 dB at the 48 - 860 maximum gain and the input P1dB is greater than - 16.5dBm.

关键词： low noise amplifier (LNA) wideband linear-in-dB CMOS

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Changes of brain neuropeptide Y and its receptors in rats with flurazepam tolerance and dependence

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Acta Pharmacologica Sinica 2005年第11期26卷 1290-1296页

作者： li-ping zhang, li wang~2 Department of Pediatrics, Peking University First Hospital, Beijing 100034, China Department of Pediatrics Peking University First Hospital Beijing China

Aim: Anticonvulsant tolerance and dependence are two obstacles that restrict the clinical use of benzodiazepines (BDZ). In order to explore the mechanism of these two adverse reactions, changes of neuropeptide Y (NPY) and its receptors in the hippocampus of rat models, in relation to flurazepam (FZP, a member of BDZ) tolerance and dependence, were investigated. Methods: The mRNA of preproNPY and its receptors (Y1, Y2, and Y5) in the hippocampus were determined by competitive RT-PCR, and the distribution of NPY in the hippocampus was examined by immunohistochemistry. Results: A decrease of preproNPY mRNA in the hippocampus was found in tolerant and dependent rats. The level of preproNPY mRNA in the hippocampus was reversely correlated with the degree of tolerance and dependence, measured by the threshold of pentylenetetrazol-induced seizures. Immunohistochemistry indicated a decrease of NPY-immunoreactive material in neurons of the CA1, CA3, and dentate gyrus regions of both tolerant and dependent rats. The mRNA of NPY receptors Y,and Y5decreased in tolerant rats but did not change in dependent rats. The mRNA of NPY receptor Y2increased in tolerant rats but decreased in dependent rats. Conclusion: A decrease of NPY in the hippocampus might be involved in anticonvulsant tolerance and dependence following long-term treatment with FZP. Y,, Y2, and Y5mRNA were also altered in FZP tolerance and dependence.

关键词： benzodiazepines neuropeptide Y flura zepam

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Study of a Novel Brain Relatively Specific Gene LRRC4 Involved in Glioma Tumorigenesis Suppression Using the Tet-on System

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Acta Biochimica et Biophysica Sinica 2005年第8期37卷 532-540页

作者： Qiu-Hong zhang li-li wang li CAO Cong PENG Xiao-ling li Ke TANG Wei-Fang li Ping liAO Jie-Ru wang Gui-Yuan li~* Cancer Research Institute,Central South University,Changsha 410078,China Cancer Research Institute Central South UniversityChangsha 410078 China

LRRC4 is a novel relatively specific gene,which displays significant down-regulation inprimary brain tumor biopsies and has the potential to suppress brain tumor *** this study,we inves-tigated the growth inhibitory effect of LRRC4 on tumorigencity in vivo and on cell proliferation in vitro by atetracycline-inducible expression *** showed that LRRC4 significantly reduced the growth andmalignant grade of xenografts arising from glioblastoma U251MG *** proliferation was markedlyinhibited after U251MG Tet-on-LRRC4 cell induction with *** cytometry and Western blotanalysis demonstrated that LRRC4 mediated a delay of the cell cycle in late G1,possibly through up-regulat-ing the expressions of p21Wafl/cip 1 and p27Kip 1 and down-regulating the expressions of cyclin-dependentkinase 2,retinoblastoma protein and epidermal growth factor ***,these findings provideclues to the function of LRRC4 as a negative regulator of cell growth and underscore a link between theabove-mentioned cyclins,cyclin-associated molecules and tumorigenicity.

关键词： LRRC4 tumorigencity cell proliferation cell cycle delay

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Seepage laws of two kinds of disastrous gas in complete stress-strain process of coal

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Mining Science and Technology 2011年第6期21卷 851-856页

作者： Cao Shugang Guo Ping zhang Zunguo li Yi wang Yong State and Lock Joint Engineering Laboratory of Methane Drainage in Complex Coal Gas Seam Chongqing University Chongqing 400044 China

The similarities and differences in seepage flow evolution laws of CH4 and CO2 during complete stress- strain process of samples were comparatively analyzed. The results show that the seepage flow evolution laws of CH4 and CO2 are extremely similar during the stress-strain process, showing that the character- istic first decreased and then increased. A mathematical model was also established according to the rela- tionship of seepage velocity and axial strain. However, due to the strong adsorption ability of CO2, the coal samples generated a more serious ''Klinkenberg effect'' under the condition of CO2. Owing to this, the CO2 seepage flow resulted into occurrence of ''stagnation'' phenomenon during the late linear elastic stage II. In the strain consolidation stage III, the increment rate of CH4 seepage velocity was significantly greater than that of CO2. In the stress descent stage IV, when the axial load reached the peak pressure of coal, the increment rates of CH4 seepage velocity presented a turning point. But the changing rate of CO2 seepage velocity still remained slow and a turning point was presented at one time after the peak of thestrain pressure, which showed an obvious feature of hysteresis.

关键词： Outburst coal CH4 CO2 Klinkenberg effect Complete stress–strain

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Strongly Gorenstein Flat Dimensions

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Journal of Mathematical Research and Exposition 2011年第6期31卷 977-988页

作者： Chun Xia zhang li Min wang Department of Mathematics Northwest Normal University Gansu 730070 P. R. China

This article is concerned with the strongly Gorenstein flat dimensions of modules and *** show this dimension has nice properties when the ring is coherent,and extend the well-known Hilbert＇s syzygy theorem to the strongly Gorenstein flat dimensions of ***,we investigate the strongly Gorenstein flat dimensions of direct products of rings and（almost）excellent extensions of rings.

关键词： strongly Gorenstein flat module strongly Gorenstein flat dimension coherent ring direct product (almost)excellent extension

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De novo combination therapy with lamivudine and adefovir dipivoxil in chronic hepatitis B patients

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World Journal of Gastroenterology 2011年第43期17卷 4804-4809页

作者： Xiao-Hong Fan Jian-zhang Geng li-Fen wang Ying-Ying Zheng Hai-Ying Lu Jing li Xiao-Yuan Xu Department of Infectious Diseases Peking University First Hospital Beijing 100034 China

AIM:To investigate the appropriate time for combination therapy in HBeAg positive chronic hepatitis B(CHB) patients with decompensated ***:Thirty HBeAg positive CHB patients with decompensated cirrhosis were enrolled in the *** of the patients were given 48 wk combination therapy with lamivudine(LAM) and adefovir dipivoxil(ADV) .Briefly,10 patients were given the de novo combination therapy with LAM and ADV,whereas the other 20 patients received ADV in addition to LAM after hepatitis B virus(HBV) genetic ***:Serum alanine aminotransferase and total bilirubin were both improved in the two groups at 4,12,24 and 48 wk after *** albumin was also improved at 24 and 48 wk after combination therapy in both *** serum HBV DNA level wasstill detectable in every patient in the two groups at 4 and 12 wk after combination ***,in the de novo combination group,serum HBV DNA levels in 4(40%) and 9(90%) patients was decreased to below 1×10 3 copies/mL at 24 and 48 wk after the combination treatment,*** parallel,serum HBV DNA levels in 2(20%) and 8(40%) patients in the add-on combination group became undetectable at 24 and 48 wk after combination treatment,***,6(60%) patients in the de novo combination group achieved HBeAg seroconversion after 48 wk treatment,whereas only 4(20%) patients in the add-on combination group achieved ***-Pugh score of patients in the de novo combination group was better than that of patients in the add-on combination group after 48 wk ***,patients in the de novo combination group had a significantly decreased serum creatinine level and elevated red blood cell ***:De novo combination therapy with LAM and ADV was better than add-on combination therapy in terms of Child-Pugh score,virus inhibition and renal function.

关键词： Hepatitis B Chronic Cirrhosis Decompensated De novo combination Lamivudine Adefovir dipivoxil

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N Accumulation and Translocation in Four Japonica Rice Cultivars at Different N Rates

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Pedosphere 2007年第6期17卷 792-800页

作者： zhang Yao-Hong FAN Jian-Bo zhang Ya-li wang Dong-Sheng HUANG Qi-Wei SHEN Qi-Rong College of Resources and Environmental Sciences Nanjing Agricultural University Nanjing 210095 （China）

Developing high-yielding rice(Oryza sativa L.)cultivars depends on having a better understanding of nitrogen(N) accumulation and translocation to the ear during the reproductive *** experiments were carried out to evaluate the genetic variation for N accumulation and translocation in different Japonica rice cultivars at different N rates and to identify any relationship to grain yield in southeast *** Japonica cultivars with similar agronomic characteristics were grown at two experimental sites in 2004 with three N rates of 0,60,and 180 kg N ha^(-1).Dry weights and N contents of rice plants were measured at tillering,initiation,anthesis,and *** yields exhibited significant differences (Plication *** N rates improved N uptake at anthesis and maturity in all four cultivars(Plinear to N uptake at anthesis(r^2=0.78^(**))and N translocation(r^2=0.67^(**)).Thus,cultivars with a high N uptake at anthesis,low residual N in the straw at maturity,and appropriate low N fertilizer supply in southeast China should efficiently increase N-recovery rate while maintaining grain yield and soil fertility.

关键词： rain yield Japonica rice cultivar N accumulation N application rate N translocation

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Research of multilayers in EUV, soft X-ray and X-ray

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光学精密工程 2005年第4期13卷 512-518页

作者： wang Zhan-shan wang Feng-li zhang Zhong wang Hong-chang WU Wen-juan zhang Shu-min XU Yao GU Zhong-xiang CHENG Xin-bin L1 Cun-xia WU Yong-rong wang Bei QIN Shu-jin CHEN ling-yan Institute of Precision Optical Engineering Department of Physics Tongji University Shanghai 200092 China

To develop beam splitters for soft X-ray laser Michelson interferometer at 13.9 nm, Mo/Si multilayers of 100 nm thickness deposited on both sides of silicon nitride were fabricated by using DC magnetron sputtering. Initial evaluation of their reflectivity and transmission showed that reflectivity and transmission were above 10% and 25%. The broadband analyzers have been designed, fabricated and characterized for 13～20 nm polarization measurements. The measured results are in good agreement with the design. The supermirrors with different angular intervals at 0.154 nm have been designed, fabricated and characterized.

关键词： EUV X射线多层性激光宽带光纤

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