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Encoding and display technologies for combinatorial libraries in drug discovery:The coming of age from biology to therapy

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3362-3384页

作者： Yu Fan Ruibing feng Xinya zhang Zhen-Liang Wang feng Xiong Shuihua zhang zhang-feng zhong Hua Yu Qing-Wen zhang zhang zhang Yitao Wang Guodong Li Macao Centre for Research and Development in Chinese Medicine State Key Laboratory of Quality Research in Chinese MedicineInstitute of Chinese Medical SciencesUniversity of MacaoMacao SAR 999078China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SAR 999078China International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development Ministry of Education(MoE)of People’s Republic of ChinaCollege of PharmacyJinan UniversityGuangzhou 510632China Zhuhai UM Science and Technology Research Institute Zhuhai 519031China Department of Pharmacy Guangzhou Red Cross HospitalFaculty of Medical ScienceJinan UniversityGuangzhou 510632China Geriatric Medicine First People’s Hospital of XinXiang and the Fifth Affiliated Hospital of Xinxiang Medical CollegeXinxiang 453100China Shenzhen Innovation Center for Small Molecule Drug Discovery Co. Ltd.Shenzhen 518000China

Drug discovery is a sophisticated process that incorporates scientific innovations and cuttingedge *** to traditional bioactivity-based screening methods,encoding and display technologies for combinatorial libraries have recently advanced from proof-of-principle experiments to promising tools for pharmaceutical hit discovery due to their high screening efficiency,throughput,and resource *** review systematically summarizes the development history,typology,and prospective applications of encoding and displayed technologies,including phage display,ribosomal display,mRNA display,yeast cell display,one-bead one-compound,DNA-encoded,peptide nucleic acidencoded,and new peptide-encoded technologies,and examples of preclinical and clinical *** discuss the progress of novel targeted therapeutic agents,covering a spectrum from small-molecule inhibitors and nonpeptidic macrocycles to linear,monocyclic,and bicyclic peptides,in addition to *** also address the pending challenges and future prospects of drug discovery,including the size of screening libraries,advantages and disadvantages of the technology,clinical translational potential,and market *** review is intended to establish a comprehensive high-throughput drug discovery strategy for scientific researchers and clinical drug developers.

关键词： Drug screening Phage display DNA-encoded chemical libraries Peptide-encoded chemical libraries Clinical drugs

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基于IE及整数规划理论的家具生产线平衡优化

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林产工业 2024年第3期61卷 45-51页

作者：王辉张蕾张仲凤张继娟中南林业科技大学湖南长沙410004 国家林业和草原局绿色家具工程技术研究中心湖南长沙410004 湖南省绿色家居工程技术研究中心湖南长沙410004 东阳市家具研究院浙江东阳322100

为解决S企业门扇生产线平衡性差、效率低等问题,本文从定性与定量相结合的角度提出了优化方案。首先,采用传统工业工程方法对生产线进行定性改善;然后,建立以生产节拍最小化为目标的0~1整数规划模型,并利用Lingo软件进行求解;最后,通过... 详细信息

为解决S企业门扇生产线平衡性差、效率低等问题,本文从定性与定量相结合的角度提出了优化方案。首先,采用传统工业工程方法对生产线进行定性改善;然后,建立以生产节拍最小化为目标的0~1整数规划模型,并利用Lingo软件进行求解;最后,通过对比生产线平衡指标以及Flexsim仿真,验证了方案的有效性。结果表明,该方案使生产线平衡率由51.04%提高至84.73%,平滑性指数由15.65下降至3.35,月模拟产能由350扇提升至570扇,对提高企业效率、增强企业竞争力具有重要意义。

关键词：生产线优化工业工程整数规划 Lingo Flexsim仿真

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基于神经网络的仿生避难椅创新设计

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林产工业 2024年第1期61卷 53-60页

作者：杨昕妍杨洋张继娟张仲凤中南林业科技大学家具与艺术设计学院湖南长沙410004 国家林业和草原局绿色家具工程技术研究中心湖南长沙410004 湖南省绿色家居工程技术研究中心湖南长沙410004

近年来,地震发生的强度和频率不断增加,基于仿生设计和神经网络在地震情境下设计了一款避难椅,通过拟合优度检验和系统聚类方法分析调研结果得到6大类18小类功能需求,并依据共性需求确定仿生对象。利用Gabor滤波提取其纹理特征并抽象为... 详细信息

近年来,地震发生的强度和频率不断增加,基于仿生设计和神经网络在地震情境下设计了一款避难椅,通过拟合优度检验和系统聚类方法分析调研结果得到6大类18小类功能需求,并依据共性需求确定仿生对象。利用Gabor滤波提取其纹理特征并抽象为本体象元空间,利用神经网络和象元理论建立与用户偏好之间的映射关系模型,得到MSE值为0.09212和0.00744,说明模型性能良好。利用形状文法规则进行设计创新,得到三款方案,通过验证对比映射关系模型中与之相似且排名前三的本体象元满意度,均方误差MSE值为0.00324,证明该方法能够为相关产品设计提供参考。

关键词：工业设计神经网络象元理论形状文法避难椅

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圆棒榫旋转摩擦焊接技术的研究进展

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林产工业 2024年第8期61卷 32-38页

作者：何佳容吴嘉伟杨洋张仲凤中南林业科技大学湖南长沙410004 国家林业和草原局绿色家具工程技术研究中心湖南长沙410000 湖南省绿色家居工程技术研究中心湖南长沙410000 河北木槐智能家居有限公司河北邯郸056000

圆棒榫旋转摩擦焊接技术作为一种创新的木材无胶结合技术,具有无醛环保、性能优良和生产高效等优点,在木制品制造领域正逐渐展现出其重要作用,有替代传统木工连接方式的潜力。本文概述了此技术的优势、焊接机理及其广阔的应用前景;探讨... 详细信息

圆棒榫旋转摩擦焊接技术作为一种创新的木材无胶结合技术,具有无醛环保、性能优良和生产高效等优点,在木制品制造领域正逐渐展现出其重要作用,有替代传统木工连接方式的潜力。本文概述了此技术的优势、焊接机理及其广阔的应用前景;探讨了改善和加强焊接制品的方法和机理,旨在进一步推广此技术的应用范围。最后,综述了此技术的反应机理,介绍了其在工程木制品(EWP)和家具领域的实际应用案例与发展趋势。并指出未来圆棒榫旋转摩擦焊接技术会朝着工业化、自动化的方向发展,有关此技术的有限元分析方法和全生命周期评价方法体系有待深入研究。

关键词：木材焊接圆棒榫旋转焊接工程木制品(EWP) 木材焊接机理木材焊接应用

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City Network Evolution Characteristics of Smart Industry: Evidence from Yangtze River Delta, China

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Chinese Geographical Science 2024年第5期34卷 829-848页

作者： SHEN Lizhen zhong Zhaocheng CHEN Cheng zhang Shanqi ZHEN feng School of Architecture and Urban Planning Nanjing UniversityNanjing 210093China Hefei Urban Planning&Design Institute Hefei 230041China

The dual-path model of industrial evolution and spatial progression has been widely acknowledged and incorporated into the strategic planning to promote the development of urban industries and regional ***,current research on inter-enter-prise city networks mainly focuses on the single sector of flows on all enterprise branches,such as product value chains and production factors,but neglects that of particular industry *** upon the new economic geography and city networks theory,this paper develops a methodological framework that focuses on the analysis of city network evolution characteristics of smart ***-larly,a conceptual model of smart industry enterprise-industry-city is proposed and then applied to a case study of smart industry in the Yangtze River Delta Region,*** enterprise supplier-customer data,a city network of smart industry is constructed and sub-sequently analyzed with the proposed *** indicate that the smart industry network in Yangtze River Delta Region exhibits a hierarchical structure and the expansion of the network presents a small-world network *** study not only makes a meth-odological contribution for revealing the industrial and spatial evolution path of the current smart industry,but also provides empirical support for the formulation of new economic development policies focused on smart industries,demonstrating the role of city clusters as carriers of regional synergistic development.

关键词： smart industry city networks social network analysis methodological framework Yangtze River Delta,China

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Evolution of In783 alloy in microstructure and properties enduring different service times

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Rare Metals 2024年第1期43卷 334-341页

作者： zhong-Shuai Han Jin-feng Du Jun Liang Zheng zhang School of Material Science and Engineering Beihang UniversityBeijing 100191China Shenhua Guohua(Beijing)Electric Power Research Institute Co. Ltd.Beijing 100025China

Impact, tensile, and fatigue tests were performed in In783 alloy serving 4000, 23,000 and 48,000 h. The microstructure was then analysed by optical microscopy(OM), scanning electron microscopy(SEM), and transmission electron microscopy(TEM) to probe the relationship between microstructure and properties. The results show that a new Ni_(5)Al_(3) phase is found, which grows gradually in β phase with serving time increasing,destroying the martensitic structure of the β phase, and degenerating the toughness of the β phase(approximately13.88% reduction). Therefore, the degradation of the βphase results in a sharp dropping of the resistance to stress accelerated grain boundary oxygen(SAGBO) during serving;thus, the intergranular fracture morphology degree increases with duration of service(almost 40% increase from the fractured surface). In addition, the strength of alloy will be gradually enhanced when the γ'phase becomes relatively bulky with serving time increasing due to considerable distortion of the dislocations as a result of the spacing of individual particles, in which any movement of the dislocation will have to overcome a larger number of obstacles per unit length.

关键词： In783 Microstructure Properties βphase Ni_(5)Al_(3)phase

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Investigating Periodic Dependencies to Improve Short-Term Load Forecasting

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Energy Engineering 2024年第3期121卷 789-806页

作者： Jialin Yu Xiaodi zhang Qi zhong Jian feng State Grid Zhejiang Jiaxing Electric Power Co. Ltd.Jiaxing314000China State Grid Zhejiang Electric Power Co. Ltd.Hangzhou310000China

With a further increase in energy flexibility for customers,short-term load forecasting is essential to provide benchmarks for economic dispatch and real-time alerts in power *** electrical load series exhibit periodic patterns and share high associations with metrological ***,current studies have merely focused on point-wise models and failed to sufficiently investigate the periodic patterns of load series,which hinders the further improvement of short-term load forecasting ***,this paper improved Autoformer to extract the periodic patterns of load series and learn a representative feature from deep decomposition and *** addition,a novel multi-factor attention mechanism was proposed to handle multi-source metrological and numerical weather prediction data and thus correct the forecasted electrical *** paper also compared the proposed model with various competitive *** the experimental results reveal,the proposed model outperforms the benchmark models and maintains stability on various types of load consumers.

关键词： Load forecasting transformer attention mechanism power grid

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1例TAVI术后突发卒中患者抗栓治疗分析

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海峡药学 2024年第2期36卷 68-71页

作者：高年婷张锋忠李波霞陈万强青海省交通医院药剂科青海西宁810000 兰州大学第一医院药剂科甘肃兰州730000 兰州大学第一医院康复科甘肃兰州730000

目的分析讨论房颤合并TAVI术后脑卒中抗栓治疗策略。方法临床药师参与1例67岁男性主动脉瓣重度狭窄合并持续性心房颤动患者TAVI术后突发急性缺血性脑卒中,经充分评估患者卒中分型(NIHSS评分4分)及出血风险(HAS-BLED评分3分)后制定抗栓方... 详细信息

目的分析讨论房颤合并TAVI术后脑卒中抗栓治疗策略。方法临床药师参与1例67岁男性主动脉瓣重度狭窄合并持续性心房颤动患者TAVI术后突发急性缺血性脑卒中,经充分评估患者卒中分型(NIHSS评分4分)及出血风险(HAS-BLED评分3分)后制定抗栓方案,停用DAPT,换用利伐沙班(20 mg,po,qd)长期抗凝治疗。结果临床药师通过查阅文献及循证证据,结合患者临床情况,对抗栓治疗策略及药物的选择提出建议,患者病情得到有效控制,未再发缺血相关症状,无出血倾向,服药依从性良好。结论临床药师在开展工作期间,应熟练掌握抗栓药物特点,以及不同情况下抗栓治疗策略,结合患者个体情况协助医师制定个体化治疗方案,进一步提高临床药物治疗的有效性和安全性。

关键词：心房颤动 TAVI 急性缺血性脑卒中抗栓治疗

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A novel algorithm for evaluating cement azimuthal density based on perturbation theory in horizontal well

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Petroleum Science 2024年第1期21卷 244-251页

作者： Ji-Lin Fan feng zhang Qian Chen Hao-Chen Song Lu-Yu zhong Yue-Xiang Dai National Key Laboratory of Deep Oil and Gas School of GeosciencesChina University of Petroleum(East China)Qingdao 266580ShandongChina China National Logging Corporation Xi'an 710076ShaanxiChina Sinopec Matrix Corporation Qingdao 266001ShandongChina

Cement density monitoring plays a vital role in evaluating the quality of cementing projects,which is of great significance to the development of oil and ***,the presence of inhomogeneous cement distribution and casing eccentricity in horizontal wells often complicates the accurate evaluation of cement azimuthal *** this regard,this paper proposes an algorithm to calculate the cement azimuthal density in horizontal wells using a multi-detector gamma-ray detection *** spatial dynamic response functions are simulated to obtain the influence of cement density on gamma-ray counts by the perturbation theory,and the contribution of cement density in six sectors to the gamma-ray recorded by different detectors is obtained by integrating the spatial dynamic response *** with the relationship between gamma-ray counts and cement density,a multi-parameter calculation equation system is established,and the regularized Newton iteration method is employed to invert casing eccentricity and cement azimuthal *** approach ensures the stability of the inversion process while simultaneously achieving an accuracy of 0.05 g/cm^(3) for the cement azimuthal *** accuracy level is ten times higher compared to density accuracy calculated using calibration ***,this algorithm enhances the accuracy of cement azimuthal density evaluation,provides valuable technical support for the monitoring of cement azimuthal density in the oil and gas industry.

关键词： Cement azimuthal density Perturbation theory Casing eccentricity Spatial dynamic response function Regularized Newton iteration

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Bending Failure Mode and Prediction Method of the Compressive Strain Capacity of A Submarine Pipeline with Dent Defects

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China Ocean Engineering 2024年第4期38卷 636-647页

作者： HOU Fu-heng JIA Lu-sheng CHEN Yan-fei zhang Qi zhong Rong-feng WANG Chun-sha School of Mechanical and Transportation Engineering China University of PetroleumBeijingBeijing 102249China CNOOC Research Institute Ltd.Beijing 100028 China

A dent is a common type of defects for submarine *** submarine pipelines,high hydrostatic pressure and internal pressure are the main *** pipelines bend due to complex subsea conditions,the compression strain capacity may be *** into the local buckling failure and accurate prediction of the compressive strain capacity are important.A finite element model of a pipeline with a dent is *** buckling failure under a bending moment is investigated,and the compressive strain capacity is *** effects of different parameters on pipeline local buckling are *** results show that the dent depth,external pressure and internal pressure lead to different local buckling failure modes of the pipeline.A higher internal pressure indicates a larger compressive strain capacity,and the opposite is true for external *** the ratio of external pressure to collapse pressure of intact pipeline is greater than 0.1,the deeper the dent,the greater the compressive strain capacity of the *** as the ratio is less than 0.1,the opposite is *** the basis of these results,a regression equation for predicting the compressive strain capacity of a dented submarine pipeline is proposed,which can be referred to during the integrity assessment of a submarine pipeline.

关键词： submarine pipeline dent defect bending load local buckling compressive strain capacity

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