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基于英语作业设计的校本研修实践探索——以人教版七年级下册英语Unit12 What did you do last weekend?为例

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科教文汇 2024年第7期 152-155页

作者：吴清晰张皖东安徽省枞阳县教师发展中心安徽枞阳246700 安徽省枞阳县枞阳中心学校安徽枞阳246700

校本研修是教师教学能力提升的研究性学习活动。在校本研修活动中,运用诊断评估性测验等方法,分析初中英语作业现状及作业设计效果不佳的原因,把作业问题提炼为校本研修活动主题。围绕主题开展:聚焦作业目标,明确研修活动任务;重视学生... 详细信息

校本研修是教师教学能力提升的研究性学习活动。在校本研修活动中,运用诊断评估性测验等方法,分析初中英语作业现状及作业设计效果不佳的原因,把作业问题提炼为校本研修活动主题。围绕主题开展:聚焦作业目标,明确研修活动任务;重视学生差异,自主设计作业示例;构建合研“共同体”,实现优质作业共享。以期提升英语作业设计质量,增强英语作业育人功能。

关键词：校本研修作业设计研修主题作业示例

Novel n-channel organic semiconductor based on pyrene-phenazine fused monoimide and bisimides

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Chinese Chemical Letters 2018年第2期29卷 331-335页

作者： Xiaoyu Song Jing Zhao wandong zhang Long Chen Tianjin Key Laboratory of Molecular Optoelectronic School of ScienceTianjin University Collaborative Innovation Centre of Chemical Science Engineering (Tianjin)

Large π-conjugated pyrene-phenazine monoimide and bisimides were synthesized by imine condensation reaction. These imides form well ordered 1D nanotapes upon self-assembly in solution. Electrochemical and electric conductivity measurement reveal it can be served as an n-channel semiconductor with large charge carrier mobility up to 4.1 cm^2 V^-1 s^-1. Both alkylated imides are highly luminescent, and can be quenched via protonization using trifluoroacetic acid, which could be served as potential colorimetric acid sensors.

关键词： n-Channel semiconductor Phenazinelmides Charge carrier mobility Acid sensor

全香型优质高产杂交水稻新组合太两优珍香的选育

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杂交水稻 2024年第2期39卷 65-67页

作者：梅建虎王伍梅章万东杜士云安徽省农业科学院水稻研究所/安徽省水稻遗传育种重点实验室安徽合肥230031 铜陵国家农业科技园安徽铜陵244100 安徽原谷公社生态农业科技有限公司安徽合肥230000

太两优珍香是安徽原谷公社生态农业科技有限公司利用两系香稻不育系太206S与常规香稻品种原谷珍香配组育成的全香型优质高产两系杂交水稻新组合,于2022年通过安徽省品种审定。该组合综合抗性好,丰产性好,米粒细长、整精米率高、口感优... 详细信息

太两优珍香是安徽原谷公社生态农业科技有限公司利用两系香稻不育系太206S与常规香稻品种原谷珍香配组育成的全香型优质高产两系杂交水稻新组合,于2022年通过安徽省品种审定。该组合综合抗性好,丰产性好,米粒细长、整精米率高、口感优良、有香味,米质优异。介绍了该组合的选育过程、特征特性及其栽培与制种技术要点。

关键词：杂交水稻香稻太两优珍香优质高产选育

Ab-Induced Insulin Resistance and the Effects of Insulin on the Cholesterol Synthesis Pathway and Ab Secretion in Neural Cells

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Neuroscience Bulletin 2016年第3期32卷 227-238页

作者： Dema Najem Michelle Bamji-Mirza Ze Yang wandong zhang Faculty of Medicine University of Ottawa Human Health Therapeutics National Research Council of Canada Beijing Hospital Institute of Geriatrics-Chinese Health Ministry

Alzheimer＇s disease（AD） is characterized by amyloid-b（Ab） toxicity,tau pathology,insulin resistance,neuroinflammation,and dysregulation of cholesterol homeostasis,all of which play roles in *** has polytrophic effects on neurons and may be at the center of these pathophysiological *** this study,we investigated possible relationships among insulin signaling and cholesterol biosynthesis,along with the effects of Ab42 on these pathways in *** found that neuroblastoma 2a（N2a） cells transfected with the human gene encoding amyloid-b protein precursor（Ab PP）（N2aAb PP） produced Ab and exhibited insulin resistance by reduced p-Akt and a suppressed cholesterol-synthesis pathway following insulin treatment,and by increased phosphorylation of insulin receptor subunit-1 at serine 612（p-IRS-S612） as compared to parental N2 a *** of human neuroblastoma SH-SY5 Y cells with Ab42 also increased p-IRS-S612,suggesting that Ab42 is responsible for insulin *** insulin resistance was alleviated when N2a-Ab PP cells were treated with higher insulin *** increased Ab release from N2 aAb PP cells,by which it may promote Ab *** increased cholesterol-synthesis gene expression in SHSY5 Y and N2 a cells,including 24-dehydrocholesterol reductase（DHCR24） and 3-hydroxy-3-methyl-glutaryl-Co A reductase（HMGCR） through sterol-regulatory element-binding protein-2（SREBP2）.While Ab42-treated SH-SY5 Y cells exhibited increased HMGCR expression and c-Jun phosphorylation as pro-inflammatory responses,they also showed down-regulation of neuro-protective/antiinflammatory *** results suggest that Ab42 may cause insulin resistance,activate JNK for c-Jun phosphorylation,and lead to dysregulation of cholesterol homeostasis,and that enhancing insulin signaling may relieve the insulin-resistant phenotype and the dysregulated cholesterol-synthesis pathway to promote Ab release for clearance from neural cells.

关键词： Alzheimer's disease Insulin resistance Ab peptides Insulin signaling Cholesterol synthesis pathway Pro-inflammatory response

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高强度柔性钻杆研制及试验

石油机械 2024年第7期52卷 54-61页

作者：马涛张万栋方胜杰吴江董凯刘先明中海石油(中国)有限公司湛江分公司中海油田服务股份有限公司长江大学机械工程学院

随着超短半径钻井水平距离逐步延伸,对其中重要工具柔性钻杆的力学与密封性能不断提出更高的强度要求。针对现阶段柔性钻杆结构强度要求高、寿命短、密封难的问题,研制了一种高强度柔性钻杆,采用球铰结构连接钻杆短节,使节与节既可以弯... 详细信息

随着超短半径钻井水平距离逐步延伸,对其中重要工具柔性钻杆的力学与密封性能不断提出更高的强度要求。针对现阶段柔性钻杆结构强度要求高、寿命短、密封难的问题,研制了一种高强度柔性钻杆,采用球铰结构连接钻杆短节,使节与节既可以弯曲一定角度,又可以传递扭矩和钻压。利用有限元软件建立了该柔性钻杆单节三维有限元模型,采用应力分类法对柔性钻杆结构强度进行校核。开展了三节柔性钻杆的抗拉、抗压、抗扭结构强度以及承载后的密封性能的室内试验。试验结果表明:所研制的高强度柔性钻杆单独受载时,在承受31 kN·m极限扭矩,1 120 kN拉伸载荷,270 kN压缩载荷时仍能满足强度要求。所得结论可为油田高强度柔性钻杆的研制提供理论依据。

关键词：柔性钻杆超短半径有限元分析等效应力室内试验

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Apolipoprotein E, amyloid-beta, and neuroinflammation in Alzheimer's disease

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Neuroscience Bulletin 2014年第2期30卷 317-330页

作者： Evan Dorey Nina Chang Qing Yan Liu Ze Yang wandong zhang Faculty of Medicine University of Ottawa Human Health Therapeutics National Research Council of Canada Institute of Geriatrics/Beijing Hospital Ministry of Health of China

Alzheimer＇s disease （AD） is characterized by the accumulation and deposition of amyloid-beta （Aβ） peptides in the brain. Neuroinflammation occurs in the AD brain and plays a critical role in the neurodegenerative pathology. Particularly, Aβ evokes an inflammatory response that leads to synaptic dysfunction, neuronal death, and neurodegeneration. Apolipoprotein E （ApoE） proteins are involved in cholesterol transport, Aβ binding and clearance, and synaptic functions in the brain. The ApoE4 isoform is a key risk factor for AD, while the ApoE2 isoform has a neuroprotective effect. However, studies have reached different conclusions about the roles of the isoforms; some show that both ApoE3 and ApoE4 have anti-inflammatory effects, while others show that ApoE4 causes a predisposition to inflammation or promotes an inflammatory response following lipopolysaccharide treatment. These discrepancies may result from the differences in models, cell types, experimental conditions, and inflammatory stimuli used. Further, little was known about the role of ApoE isoforms in the Aβ-induced inflammatory response and in the neuroinflammation of AD. Our recent work showed that ApoE isoforms differentially regulate and modify the Aβ-induced inflammatory response in neural cells, with ApoE2 suppressing and ApoE4 promoting the response. In this article, we review the roles, mechanisms, and interrelations among Aβ, ApoE, and neuroinflammation in AD.

关键词： ApoE Alzheimer's disease Aβ neuroinflammation

A Comprehensive Method for the Optimization of Cement Slurry and to Avoid Air Channeling in High Temperature and High-Pressure Conditions

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Fluid Dynamics & Materials Processing 2023年第5期19卷 1237-1248页

作者： Yanjun Li wandong zhang Jiang Wu Yuhao Yang Chao zhang Huanqiang Yang Zhanjiang Branch of CNOOC(China)Co. Ltd.Zhanjiang524000China College of Petroleum Engineering Yangtze UniversityWuhan430100China

Air channeling in the annulus between the casing and the cement sheath and/or between the cement sheath and formation is the main factor affecting the safe operation of natural gas wells at high temperatures and *** of this problem requires,in general,excellent anti-channeling performances of the cement *** methods to predict such anti-channeling performances are proposed here,which use the weightless pressure of cement slurry,the permeability of cement stone and the volume expansion rate of cement sheath as input *** by this approach,the anti-channeling performances of the cement slurry are evaluated by means of indoor experiments,and the cement slurry is optimized *** results show that the dangerous transition time of the cement slurry with optimized dosage of admixture is only 76 min,the permeability of cement stone is 0.005 md,the volume shrinkage at final setting is only 0.72%,and the anti-channeling performances are therefore *** effective utilization of the optimized cement slurry in some representative wells(LD10–1-A1 and LD10–1-A2 in LD10–1 gas field)is also discussed.

关键词： High temperature and high pressure cement slurry anti-channeling weightlessness pressure permeability volume shrinkage

强直性脊柱炎患者外周血单个核细胞微小RNA的差异表达及其与免疫炎症反应的相关性

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细胞与分子免疫学杂志 2024年第2期40卷 142-147页

作者：黄旦刘健汪元曹云祥万磊张皖东方妍妍安徽中医药大学第一附属医院风湿科安徽合肥230031 安徽省中医科学院风湿病研究所安徽合肥230031

目的检测强直性脊柱炎(AS)患者外周血单个核细胞(PBMC)中微小RNA(miRNA)的表达及其与免疫炎症反应的关系。方法选取AS患者(AS组)及健康志愿者(对照组),每组15例。利用高通量测序技术筛选PBMC中miRNA表达,利用实时定量PCR检测6个差异表达... 详细信息

目的检测强直性脊柱炎(AS)患者外周血单个核细胞(PBMC)中微小RNA(miRNA)的表达及其与免疫炎症反应的关系。方法选取AS患者(AS组)及健康志愿者(对照组),每组15例。利用高通量测序技术筛选PBMC中miRNA表达,利用实时定量PCR检测6个差异表达miRNA水平,ELISA检测外周血细胞因子肿瘤坏死因子α(TNF-α)、白细胞介素1β(IL-1β)、IL-17、IL-23表达,Spearman法分析差异miRNA与疾病活动、免疫炎症指标的相关性。结果与对照组相比,AS患者组共有44个miRNA差异表达,其中有22个上调,22个下调(差异倍数≥1);其中miR-1-3p、miR-133a-5p表达明显上调,miR-127-5p、miR-345-3p、miR-136-3p表达明显下调;且AS患者TNF-α、IL-1β、IL-17、IL-23表达明显升高,miR-1-3p与TNF-α、C反应蛋白(CRP)、Bath强直性脊柱炎疾病活动性指数(BASDAI)呈正相关,miR-133a-5p与TNF-α呈正相关,miR-127-5p与红细胞沉降率(ESR)、脊柱疼痛视觉模拟评分法(VAS)评分呈负相关,miR-345-3p与IL-17呈负相关,miR-136-3p与IL-17、BASDAI呈负相关。结论AS患者PBMC中miRNA异常表达,差异表达miRNA与患者疾病活动及免疫炎症指标存在相关性。

关键词：强直性脊柱炎(AS) 微小RNA(miRNA) 高通量测序细胞因子免疫炎症

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含油岩屑处理和资源利用的研究进展

化工技术与开发 2024年第1期53卷 99-104,114页

作者：张雪菲张万栋方胜杰张可谢露马涛中海石油(中国)有限公司湛江分公司广东湛江524000

本文介绍了国内外油基钻屑的管理办法,总结了各类油基钻屑的处理技术,分析了各类技术的原理、优缺点和应用情况,提出了未来资源化利用的新方法,指出油基钻屑的高效降解和高值利用是研究重点,未来处理技术的发展方向是实现可持续发展。

关键词：热处理含油钻屑污泥油基钻井岩屑灰渣危险废弃物高值利用