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Cohort study on the treatment of BRAF V600E mutant metastatic colorectal cancer with integrated Chinese and western medicine

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World Journal of Clinical Oncology 2025年第1期16卷 25-33页

作者： Jiang-Yu Bian Yu-Fang Feng Wen-Ting He tong zhang Department of Oncology Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China Department of Oncology The Fourth Clinical Medical College of Xinjiang Medical UniversityUrumqi 830001China Department of Oncology Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical UniversityUrumqi 830001China

BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor *** the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal ***,we further explored the survival benefits in the population with BRAF V600E mutant *** To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal *** A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December *** patients were divided into two *** A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,*** analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.

关键词： Metastatic colorectal cancer BRAF V600E mutation Integrated Chinese and Western medicine Cohort study

TWO-GRID CHARACTERISTIC FINITE VOLUME METHODS FOR NONLINEAR PARABOLIC PROBLEMS＊

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Journal of Computational Mathematics 2013年第5期31卷 470-487页

作者： tong zhang School of Mathematics and Information Science Henan Polytechnic University Jiaozuo China

In this work, two-grid characteristic finite volume schemes for the nonlinear parabolic problem are considered. In our algorithms, the diffusion term is discretized by the finite volume method, while the temporal differentiation and advection terms are treated by the characteristic scheme. Under some conditions about the coefficients and exact solution, optimal error estimates for the numerical solution are obtained. Furthermore, the two- grid characteristic finite volume methods involve solving a nonlinear equation on coarse mesh with mesh size H, a large linear problem for the Oseen two-grid characteristic finite volume method on a fine mesh with mesh size h = O（H2） or a large linear problem for the Newton two-grid characteristic finite volume method on a fine mesh with mesh size h = 0（I log hll/2H3）. These methods we studied provide the same convergence rate as that of the characteristic finite volume method, which involves solving one large nonlinear problem on a fine mesh with mesh size h. Some numerical results are presented to demonstrate the efficiency of the proposed methods.

关键词： Two-grid Characteristic finite volume method Nonlinear parabolic problem,Error estimate Numerical example.

Measuring positive public transit accessibility using big transit data

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Geo-Spatial Information Science 2021年第4期24卷 722-741页

作者： tong zhang Wenyuan zhang Zhenxuan He State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhanChina Department of Computer Science and Engineering New York UniversityNew YorkNYUSA

Most of the current existing accessibility measures quantify the potential of reaching desirable opportunities across space and ***,these potential measurements only illus-trate the maximum possible accessibility a person can have,which may not accurately measure real-world transit accessibility in urban *** paper introduces a novel methodology to measure positive public transit accessibility based on multi-source big public transit data such as Smart Card Data(SCD)and Global Navigation Satellite System trajectory data,which embed rich travel information and real-world spatio-temporal ***,we use multi-source transit data to reconstruct trip chains,which are used to extract popular destinations.A novel transit accessibility measure is defined to account for latent trip information such as mode/route preference,opportunity attraction,and travel impedance that are difficult to capture explicitly via traditional normative ***,we produce accessibility maps to visualize time-varying and heterogeneous accessibility patterns distributed over the study *** performed an empirical evaluation on real-world transit data collected in Shenzhen City,China,demonstrating the applicability and effectiveness of the proposed method in mapping positive transit accessibility over large metropolitan *** results and findings of the empirical study demonstrate that the proposed positive accessibility measure can better capture travel behavior characteristics and constraints than traditional normative *** measure-ment method can be used as a practical high-resolution mapping tool for transit decision makers in evaluating public transit systems,supporting strategic transit planning,and improv-ing daily transit management.

关键词： Public transit positive accessibility smart card data spatio-temporal

Recent advances toward high voltage, EC-free electrolytes for graphite-based Li-ion battery

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Frontiers of Chemical Science and Engineering 2018年第3期12卷 577-591页

作者： tong zhang Elie Paillard Helmholtz Institute Muenster- Forschungszentrum Juelich (IEK 12) Corrensstr. 46 48149 Muenster Germany

Lithium-ion batteries are a key technology in today＇s world and improving their performances requires, in many cases, the use of cathodes operating above the anodic stability of state-of-the-art electrolytes based on ethylene carbonate （EC） mixtures. EC, however, is a crucial component of electrolytes, due to its excellent ability to allow graphite anode operation-also required for high energy density batteries-by stabilizing the electrode/ electrolyte interface. In the last years, many alternative electrolytes, aiming at allowing high voltage battery operation, have been proposed. However, often, graphite electrode operation is not well demonstrated in these electrolytes. Thus, we review here the high voltage, EC- free alternative electrolytes, focusing on those allowing the steady operation of graphite anodes. This review covers electrolyte compositions, with the widespread use of additives, the change in main lithium salt, the effect of anion （or Li salt） concentration, but also reports on graphite protection strategies, by coatings or artificial solid electrolyte interphase （SEI） or by use of water-soluble binder for electrode processing as these can also enable the use of graphite in electrolytes with suboptimal intrinsic SEI formation ability.

关键词： lithium-ion electrolyte solid electrolyte interphase additives high voltage graphite

Formulation development and evaluation of gastroretentive floating beads with Brucea javanica oil using ionotropic gelation technology

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Chinese Journal of Natural Medicines 2018年第4期16卷 293-301页

作者： zhang Yue zhang Xi-tong zhang Qi WANG Bing zhang tong Experiment Center for Teaching and Learning Shanghai University of Traditional Chinese Medicine School of Pharmacy Shanghai University of Traditional Chinese Medicine

In the present study, a gastric retention floating system for Brucea javanica oil, composed of alginate and carrageenan, was prepared using ionotropic gelation. Parameters for floatability, drug load, encapsulation efficiency, bead morphology, in vitro release, and in vivo gastric retention were evaluated. The optimized formulation via Box–Behnken design consisted of 1.7% alginate(W/V), 1.02% carrageenan(W/V), 1.4% CaCO_3(W/V), and a gelling bath of pH 0.8. The alginate–carrageenan–Brucea javanica oil beads had a porous structure and exhibited up to 24 h of in vitro floatability with a load capacity of 45%–55% and an encapsulation efficiency of 70%–80%. A 6-h sustained release was observed in vitro. The beads had a prolonged gastric retention(> 60% at 6 h) in fasted rats, compared to non-floating beads(15% at 6 h), as measured by gamma scintigraphy with single-photon emission tomography/computed tomography(SPET/CT). In conclusion, the alginate–carrageenan–Brucea javanica oil system showed enhanced oil encapsulation efficiency, excellent floating and gastric retention abilities, and a favorable release behavior.

关键词： Brucea javanica oil Simaroubaceae Alginate–carrageenan beads Gastric retention Box–Behnken design SPET/CT

Broadband and efficient second harmonic generation in LiNbO_(3)-LiTaO_(3) composite ridge waveguides at telecom-band

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Chinese Physics B 2021年第1期30卷 256-261页

作者： Xin-tong zhang Department of Optics and Optical Engineering University of Science and Technology of ChinaHefei 230026China

Broadband nonlinear frequency conversions of optical waves are widely employed in multiple areas of optics and photonics. However, the broadening of conversion bandwidth is often at a cost of reduction in efficiency, which may induce a limitation on practical applications. Here we theoretically propose a novel design of LiNbO_(3) ridge waveguides on LiTaO_(3) substrates which can be used for efficient and broadband second harmonic generation. Through group velocity engineering of the ridge waveguides, acceptance bandwidth over 20 nm with a high conversion efficiency of > 25%W^(-1)·cm^(-2) is achieved at telecom-band.

关键词： second harmonic generation lithium niobate ridge waveguide dispersion manipulation

The effect of different high pressure die casting parameters on 3D microstructure and mechanical properties of AE44 magnesium alloy

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Journal of Magnesium and Alloys 2023年第9期11卷 3141-3150页

作者： tong-tong zhang Wen-bo Yu Chao-sheng Ma Wan-tong Chen Lin zhang Shou-mei Xiong Center of Materials Science and Engineering School of Mechanical and Electronic Control EngineeringBeijing Jiaotong UniversityBeijing 100044China China Academy of Machinery Science and Technology Group Co. LtdBeijing 100044China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

To understand the relationship between the process-microstructure-mechanical properties of the high-pressure die-casting(HPDC) AE44 magnesium alloy, 3D reconstruction and 2D characterization were carried out on the HPDC castings produced with different process parameters(low slow-shot speed, fast slow-shot speed, solidification pressure). Microstructural characterization revealed that the formation of shrinkage pores are closely related to ESCs, which were mainly controlled by the low slow-shot speed in shot sleeve(ESCs growth time) and fast slow-shot speed into the die cavity(distribution of ESCs). In addition, solidification pressure can significantly reduce the shrinkage porosity in the center by improving the feeding capacity of liquid metal. Tensile fracture revealed that the tearing ridge is mainly evolved from the slip band of ESCs. The quantity and distribution of ESCs determine the fracture mode of castings. The relationship between mechanical properties of castings and the morphology of ESCs and porosity is also statistically discussed.

关键词： HPDC parameters Porosity Externally solidified crystals(ESCs) Tensile fracture 3D reconstruction

Repetitive transcranial magnetic stimulation improves consciousness disturbance in stroke patients A quantitative electroencephalography spectral power analysis

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Neural Regeneration Research 2012年第31期7卷 2465-2472页

作者： Ying Xie tong zhang Capital Medical University School of Rehabilitation Medicine Department of Rehabilitation Electric Power Teaching Hospital of CapitalMedical University Beijing 100073 China Department of Neurology and Rehabilitation Capital Medical University School of Rehabilitation Medicine China Rehabilitation ResearchCenter Beijing 100068 China

Repetitive transcranial magnetic stimulation is a noninvasive treatment technique that can directly alter cortical excitability and improve cerebral functional activity in unconscious patients. To investigate the effects and the electrophysiological changes of repetitive transcranial magnetic stimulation cortical treatment, 10 stroke patients with non-severe brainstem lesions and with disturbance of consciousness were treated with repetitive transcranial magnetic stimulation. A quantitative electroencephalography spectral power analysis was also performed. The absolute power in the alpha band was increased immediately after the first repetitive transcranial magnetic stimulation treatment, and the energy was reduced in the delta band. The alpha band relative power values slightly decreased at 1 day post-treatment, then increased and reached a stable level at 2 weeks post-treatment. Glasgow Coma Score and JFK Coma Recovery Scale-Revised score were improved. Relative power value in the alpha band was positively related to Glasgow Coma Score and JFK Coma Recovery Scale-Revised score. These data suggest that repetitive transcranial magnetic stimulation is a noninvasive, safe, and effective treatment technology for improving brain functional activity and promoting awakening in unconscious stroke patients.

关键词： repetitive transcranial magnetic stimulation consciousness disturbance stroke quantitative electroencephalography nervous excitation consciousness neuroregenerative disease regeneration neural regeneration

Study on Catalytic Wet Oxidation of H_2S into Sulfur on Fe/Cu Catalyst

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Journal of Natural Gas Chemistry 2006年第1期15卷 63-69页

作者： Junfeng zhang Zhiquan tong Environmental Engineering Department of Xiangtan University Xiangtan 411105 China

A wet catalytic oxidation at room temperature was investigated with solution containing ferric, ferrous and cupric ions for H2S removal. The experiments were carried out in a two step process, and the results obtained show that the removal efficiency of H2S can always reach 100% in a 300 mm scrubbing column with four sieve plates, and the regeneration of ferric ions in 200 mm bubble column can match the consumed ferric species in absorption. Removal of H2S, production of elemental sulfur and regeneration of ferric, cupric ions can all be accomplished at the same time. No raw material is consumed except O2 in flue gas or air, the process has no secondary pollution and no problem of catalyst degradation and congestion.

关键词： wet oxidation H2S catalytic sulfur ferric ion ferrous ion cupric ion