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Collected Works of Ri-Zhi:5 *** zhang qiang and LIU ***:Higher Education Press,2012

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Journal of Ancient Civilizations 2012年 150-156页

作者： zhang.Nan IHAC NENU

The Collected Works of Ri-Zhi(CWR) was presented in a ceremony held in Beijing on July 22,*** publication of CWR by Higher Education Press represents the monumental task of compiling the works of Ri-Zhi(pseudonym of *... 详细信息

关键词： work World Collected Works of Ri-Zhi

An Online Q-Learning Method for Linear-Quadratic Nonzero-Sum Stochastic Differential Games with Completely Unknown Dynamics

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Journal of Systems Science & Complexity 2024年第5期37卷 1907-1922页

作者： zhang Bao-qiang WANG Bing-Chang CAO Ying School of Control Science and Engineering Shandong University

In this paper, the authors design a reinforcement learning algorithm to solve the adaptive linear-quadratic stochastic n-players non-zero sum differential game with completely unknown dynamics. For each player, a critic network is used to estimate the Q-function, and an actor network is used to estimate the control input. A model-free online Q-learning algorithm is obtained for solving this kind of problems. It is proved that under some mild conditions the system state and weight estimation errors can be uniformly ultimately bounded. A simulation with five players is given to verify the effectiveness of the algorithm.

关键词： Actor-critic algorithm model-free adaptive control nonzero-sum stochastic game reinforcement learning

Protective Effects of Phellodendron Species on Bone Health: A Novel Perspective on Their Potentials in Treating Osteoporosis and Osteoarthritis

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Chinese Journal of Integrative Medicine 2024年第4期30卷 379-384页

作者： XIN Li TAN Guo-yao zhang qiang zhang Qun Good Clinical Practice Development Guangdong Provincial Key Laboratory of Bone and Joint Degeneration DiseasesThe Third Affiliated Hospital of Southern Medical UniversityGuangzhou(510630)China Department of Pharmacy Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou(510120)China

Phellodendron(PN)species,traditionally used in Chinese medicine for centuries,hold promise as a potential treatment for osteoporosis(OP)and osteoarthritis(OA)due to their bioactive *** bioactive compounds,including berberine and palmatine,exhibit anti-inflammatory,antioxidant,and bone-protective properties,contributing to their potential therapeutic benefits in promoting bone health and preventing bone ***,challenges such as the need for standardized preparation and dosing,limited clinical studies,and potential interactions with other medications hinder their clinical ***,the rich history of PN species in Chinese medicine provides a promising foundation for future investigation into their potential as alternative treatments for OP and *** research is needed to fully understand the underlying mechanisms of action and explore the clinical implications of PN for bone health.

关键词： Phellodendron species bone health osteoporosis osteoarthritis review

Intermittent disturbance mechanical behavior and fractional deterioration mechanical model of rock under complex true triaxial stress paths

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International Journal of Mining Science and Technology 2024年第1期34卷 117-136页

作者： Zhi Zheng Hongyu Xu Kai zhang Guangliang Feng qiang zhang Yufei Zhao State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures Key Laboratory of Disaster Prevention and Structural Safety of Ministry of EducationCollege of Civil Engineering and ArchitectureGuangxi UniversityNanning 530004China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan 430071China State Key Laboratory of Simulation and Regulation of Water Cycle in River Basin China Institute of Water Resources and Hydropower ResearchBeijing 100080China State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China

Mechanical excavation,blasting,adjacent rockburst and fracture slip that occur during mining excavation impose dynamic loads on the rock mass,leading to further fracture of damaged surrounding rock in three-dimensional high-stress and even causing ***,a novel complex true triaxial static-dynamic combined loading method reflecting underground excavation damage and then frequent intermittent disturbance failure is *** triaxial static compression and intermittent disturbance tests are carried out on *** effects of intermediate principal stress and amplitude on the strength characteristics,deformation characteristics,failure characteristics,and precursors of monzogabbro are analyzed,intermediate principal stress and amplitude increase monzogabbro strength and tensile fracture *** increases in microseismic parameters during rock loading can be precursors for intermittent rock *** on the experimental result,the new damage fractional elements and method with considering crack initiation stress and crack unstable stress as initiation and acceleration condition of intermittent disturbance irreversible deformation are proposed.A novel three-dimensional disturbance fractional deterioration model considering the intermediate principal stress effect and intermittent disturbance damage effect is established,and the model predicted results align well with the experimental *** sensitivity of stress states and model parameters is further explored,and the intermittent disturbance behaviors at different f are *** study provides valuable theoretical bases for the stability analysis of deep mining engineering under dynamic loads.

关键词： True triaxial static and disturbance test Mechanical properties Failure mechanism and precursor Intermittent disturbance effect Fractional mechanical model

Degradable magnesium alloy suture promotes fibrocartilaginous interface regeneration in a rat rotator cuff transosseous repair model

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Journal of Magnesium and Alloys 2024年第1期12卷 384-393页

作者： Baoxiang zhang Wen zhang Fei zhang Chao Ning Mingyang An Ke Yang Lili Tan qiang zhang Department of Sports Medicine Chinese PLA General HospitalBeijing 100853China Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Medical School of PLA Beijing 100853China Institute of Orthopedics Chinese PLA General HospitalBeijing Key Lab of Regenerative Medicine in OrthopedicsKey Lab of Musculoskeletal Trauma&War Injuries of Chinese PLABeijing 100853China

Despite transosseous rotator cuff tear repair using sutures is widely accepted for tendon-bone fixation,the fibrocartilaginous enthesis regeneration is still hardly achieved with the traditional *** the present work,degradable magnesium(Mg)alloy wire was applied to suture supraspinatus tendon in a rat acute rotator cuff tear model with Vicryl Plus 4±0 absorbable suture as *** shoulder joint humerus-supraspinatus tendon complex specimens were retrieved at 4,8,and 12 weeks after *** Mg alloy suture groups showed better biomechanical properties in terms of ultimate load to *** observation showed that hyperplastic response of the scar tissue at the tendon-bone interface is progressively alleviated over time in the both Mg alloy suture and Vicryl suture *** the histological analysis,for Mg alloy suture groups,chondrocytes appear to proliferate at 4 weeks postoperatively,and the tendon-bone interface showed an orderly structural transition zone at 8 weeks *** collagenous fiber tended to be aligned and the tendon-bone interlocking structures apparently formed,where transitional structure from unmineralized fibrocartilage to mineralized fibrocartilage was closer to the native fibrocartilaginous *** vivo degradation of the magnesium alloy wire was completed within 12 *** results indicated that Mg alloy wire was promising as degradable suture with the potential to promotes fibrocartilaginous interface regeneration in rotator cuff repair.

关键词： Rotator cuff repair Mg alloy wire Tendon-bone healing Fibrocartilaginous interface

3D-Printed Flat-Bone-Mimetic Bioceramic Scaffolds for Cranial Restoration

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Research 2024年第3期6卷 259-272页

作者： Yihang zhang Fupo He qiang zhang Haotian Lu Shengtao Yan Xuetao Shi School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006P.R.China School of Materials Science and Engineering South China University of TechnologyGuangzhou 510641P.R.China Peking Union Medical College Graduate School Bejing 100730P.R.China Department of Emergency China-Japan Friendship HospitalBeijing 100029P.R.China.

The limitations of autologous bone grafts necessitate the development of advanced biomimetic biomaterials for efficient cranial defect *** cranial bones are typical flat bones with sandwich structures,consisting of a diploe in the middle region and 2 outer compact *** this study,we originally developed 2 types of flat-bone-mimeticβ-tricalcium phosphate bioceramic scaffolds(Gyr-Comp and Gyr-Tub)by high-precision vat-photopolymerization-based 3-dimensional *** scaffolds had 2 outer layers and an inner layer with gyroid pores mimicking the diploe *** outer layers of Gyr-Comp scaffolds simulated the low porosity of outer tables,while those of Gyr-Tub scaffolds mimicked the tubular pore structure in the tables of flat *** Gyr-Comp and Gyr-Tub scaffolds possessed higher compressive strength and noticeably promoted in vitro cell proliferation,osteogenic differentiation,and angiogenic activities compared with conventional scaffolds with cross-hatch *** implantation into rabbit cranial defects for 12 weeks,Gyr-Tub achieved the best repairing effects by accelerating the generation of bone tissues and blood *** work provides an advanced strategy to prepare biomimetic biomaterials that fit the structural and functional needs of efficacious bone regeneration.

关键词： rabbit tables outer

Quantitative geochemical reconstruction of Eocene paleoenvironment in Fushun Basin,northeast China

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Acta Geochimica 2024年第3期43卷 571-587页

作者： Yuanji Li Pingchang Sun qiang zhang Junxian Wang Department of Safety Engineering Heilongjiang University of Science and TechnologyHarbin 150022China National Professional Center Lab of Safety Basic Research for Hydrocarbon Gas Pipeline Transportation Network Harbin 150022China College of Earth Sciences Jilin UniversityChangchun 130061JilinChina Beijing Research Institute of Uranium Geology Beijing 100029China

The quantitative estimation of key parameters of paleotemperature and paleoprecipitation is crucial for paleoclimate *** data from mod-ern sediments are highly consistent with climate data,and their relationship can provide an important reference for the quantitative reconstruction of the *** this study,detailed inorganic geochemical analysis was carried out using high-precision sampling of the Paleogene(LFD-1 well)Guchengzi,Jijuntun and Xiloutian Formations in the Fushun Basin located in the mid-latitudes of the Northern *** Eocene Guchengzi Formation(54.51–47.8 Ma)and Jijuntun Formation(47.8–41.2 Ma)in the Fushun Basin were found to have been deposited under a humid *** lower(41.2–40.1 Ma)and upper(40.1–37.8 Ma)parts of the Xiloutian Formation were character-ized by semiarid and semihumid–semiarid climates,respec-tively,which is very similar to the paleoclimatic information reflected by organic carbon *** Eocene Thermal Maximum 2(ETM2,~53.7 Ma),Early Eocene Climatic Optimum(EECO,~53.1–46.5 Ma),Eocene Thermal Maxi-mum 3(ETM 3,~52.8 Ma),and Middle Eocene Climatic Optimum(MECO,~40.7–40.1 Ma)events significantly enhanced chemical weathering during these *** rapid increase in pCO_(2)concentration leads to an increase in temperature,precipitation,and surface runoff,exhibiting strong chemical *** mean annual temperature(MATa)and mean annual precipitation(MAPa,MAPb,and MAPc)were estimated using parameters,such as the corrosion index without potassium(CIA-K),CaO/Al_(2)O_(3),and(Na_(2)O+K_(2)O)/Al_(2)O_(3).Comparing MAPa,MAPb,and MAPc with the MAP estimated using pollen data,MAPa and MAPb were found to be more sensitive to the climate during high precipitation periods(precipitation>1000 mm,Guchengzi Formation),and the recovered average precipi-tation was similar to *** contrast,MAPc was more sensitive to the climate during low precipitation periods(precipitation<1000 mm,Jijuntun,and Xilouti

关键词： Eocene Fushun Basin Major element Paleoclimate Geochemical reconstruction

A multi-stream network for retrosynthesis prediction

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Frontiers of Computer Science 2024年第2期18卷 231-233页

作者： qiang zhang Juan LIU Wen zhang Feng YANG Zhihui YANG Xiaolei zhang Institute of Artificial Intelligence School of Computer ScienceWuhan UniversityWuhan 430072China College of Informatics Huazhong Agricultural UniversityWuhan 430072China

1 Introduction Retrosynthesis aims to predict a set of reactants for producing given molecules[1],which plays a significant part in the biochemistry field,such as molecular pathway design and drug *** existing methods perform better in solving this problem,most of these methods[2,3]only describe the molecules from one kind of perspective,such as they use Simplified Molecular Input Line Entry System(SMILES)strings[4]to represent the atomic components and the relationship between atoms of molecules or leverage Extended Connectivity Fingerprints(ECFPs)represent the information of the molecular sub-structure composition via binary vectors[5].

关键词： synthesis reactant hough

Coordination environments build up and tune a superior synergistic “genome” toward novel trifunctional (TM-N_(x)O_(4−x))@g- C_(16)N_(3)-H_(3): High-throughput inspection of ultra-high activity for water splitting and oxygen reduction reactions

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Nano Research 2024年第4期17卷 2337-2351页

作者： Chunyao Fang Xian Wang qiang zhang Xihang zhang Chenglong Shi Jingcheng Xu Mengyu Yang Department of Physics University of Shanghai for Science and TechnologyShanghai 200093China School of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai 200093China

Emerging as a prominent area of focus in energy conversion and storage technologies,the development of highly active metal-based single-atom catalysts(SACs)holds great signiﬁcance in searching alternatives to replace precious metals toward the efficient,stable,and low-cost hydrogen evolution reaction(HER),as well as the oxygen evolution reaction(OER)and the oxygen reduction reaction(ORR).Combining the tremendous tunability of ligand and coordination environment with rich metal-based electrocatalysts can create breakthrough opportunities for achieving both high stability and ***,we propose a novel and stable holey graphene-like carbon nitride monolayer g-C_(16)N5(N_(4)@g-C_(16)N_(3))stoichiometries interestingly behaving as a natural substrate for constructing SACs((TM-N_(4))@g-C_(16)N_(3)),whose evenly distributed holes map rich and uniform nitrogen coordination positions with electron-rich lone pairs for anchoring transition metal(TM)***,we employed density functional theory(DFT)calculations to systematically investigate the electrocatalytic activity of(TM-N_(4))@g-C_(16)N_(3) toward HER/OER/ORR,meanwhile considering the synergistic modulation of H-loading and O-coordination((TM-N_(x)O_(4-x))@g-C_(16)N_(3)^(-)H_(3),x=0–4).Together a“four-step procedure”screening mechanism with the first-principles high-throughput calculations,we find that(Rh-N_(4))and(Ir-N_(2)O_(2)-II)distributed on g-C_(16)N_(3)^(-)H_(3) can modulate the adsorption strength of the adsorbates,thus achieving the best HER/OER/ORR performance among 216 candidates,and the lowest overpotential of 0.098/0.3/0.46 V and 0.06/0.48/0.45 V,***,the d-band center,crystal orbital Hamilton population(COHP),and molecular orbitals are used to reveal the OER/ORR activity ***,the Rh/Ir-d orbital is dramatically hybridized with the O-p orbital of the oxygenated adsorbates,so that the lone-electrons incipiently locate at the antibonding orbital pair up and popula

关键词： single atom catalysts loading and coordination hydrogen evolution reaction oxygen evolution reaction oxygen reduction reaction