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云南牟定安益铂钯钛磁铁矿床铂族矿物特征及成因初探

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矿床地质 2024年第2期43卷 415-428页

作者：殷顺媛张爱萍黄锦辉杨兆鑫马致远李泽姗夏自辛孙涛云南大学地球科学学院云南昆明650500 云南省高校关键矿产成矿学重点实验室云南昆明650500 云南省中老孟缅自然资源遥感监测国际联合实验室云南昆明650500 自然资源部三江成矿作用及资源勘查利用重点实验室云南昆明650504

云南牟定安益矿床为一处铂族金属与钛磁铁矿共同产出的大型钛磁铁矿铂族金属矿床。目前对该矿床中铂族元素的赋存状态研究甚少。结合野外宏观地质特征和室内岩矿鉴定,笔者利用TIMA和LA-ICP-MS-Mapping分析方法,对安益矿床中铂族金属矿... 详细信息

云南牟定安益矿床为一处铂族金属与钛磁铁矿共同产出的大型钛磁铁矿铂族金属矿床。目前对该矿床中铂族元素的赋存状态研究甚少。结合野外宏观地质特征和室内岩矿鉴定,笔者利用TIMA和LA-ICP-MS-Mapping分析方法,对安益矿床中铂族金属矿物学特征进行研究,发现安益矿床中的铂族元素(PGEs)主要以独立矿物的形式存在。铂族矿物(PGMs)多为铂和钯的砷化物、碲化物,如砷铂矿、砷钯矿、黄碲钯矿、碲钯矿等;主要分布于硅酸盐矿物中,其次为硫化物边缘,部分分布于磁铁矿边缘;铂族矿物成因主要有岩浆成因和热液成因2种。岩浆作用形成的铂族矿物分布于硅酸盐矿物中或硫化物边缘,硅酸盐中的铂族矿物是早期PGE与半金属元素形成的纳米团簇颗粒随岩浆演化形成矿物颗粒,被结晶的硅酸盐矿物包裹;分布于硫化物边缘的铂族矿物是残余熔浆结晶的结果。热液作用将PGE以类质同象的形式富集于钛磁铁矿单辉岩的部分矿物中,如热液蚀变较强烈的黄铜矿中含有较高的Rh,这也与铂族矿物集中分布在钛磁铁矿单辉岩中一致。

关键词：铂族矿物矿物成因岩浆铂钯钛磁铁矿床安益云南

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A G-type lectin receptor-like kinase regulates the perception of oomycete apoplastic expansin-like proteins

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Journal of Integrative Plant Biology 2022年第1期64卷 183-201页

作者： Lei Pi zhiyuan yin Weiwei Duan Nan Wang Yifan zhang Jinghao Wang Daolong Dou College of Plant Protection China Agricultural UniversityBeijing 100193China College of Plant Protection Nanjing Agricultural UniversityNanjing 210095China

Phytophthora capsici is one of the most harmful pathogens in agriculture, which threatens the safe production of multiple crops and causes serious economic losses worldwide. Here, we identified a P. capsici expansin-like protein, Pc EXLX1, by liquid chromatography-tandem mass spectrometry from Nicotiana benthamiana apoplastic fluid infected with P. capsici. Clustered regularly interspaced short palindromic repeats/crispr associated protein9(CRISPR/Cas9)-mediated Pc EXLX1 knockout mutants exhibited significantly enhanced virulence,while the overexpression of Pc EXLX1 impaired the virulence. Prokaryotically expressed Pc EXLX1 activated multiple plant immune responses, which were BRI1-associated kinase 1(BAK1)-and suppressor of BIR1-1(SOBIR1)-dependent. Furthermore, overexpression of Pc EXLX1 homologs in N. benthamiana could also increase plant resistance to P. capsici. A G-type lectin receptor-like kinase from N. benthamiana, expansin-regulating kinase 1(ERK1), was shown to regulate the perception of Pc EXLX1 and positively mediate the plant resistance to P. capsici. These results reveal that the expansin-like protein, Pc EXLX1, is a novel apoplastic effector with plant immunity-inducing activity of oomycetes, perception of which is regulated by the receptor-like kinase, ERK1.

关键词： apoplastic effector elicitor Nicotiana benthamiana oomycete receptor-like kinase

A Nicotiana benthamiana receptor-like kinase regulates Phytophthora resistance by coupling with BAK1 to enhance elicitin-triggered immunity

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Journal of Integrative Plant Biology 2023年第6期65卷 1553-1565页

作者： Yifan zhang zhiyuan yin Lei Pi Nan Wang Jinghao Wang Hao Peng Daolong Dou College of Plant Protection China Agricultural UniversityBeijing 100094China College of Plant Protection Nanjing Agricultural UniversityNanjing 210095China Institute of Plant Protection Jiangsu Academy of Agricultural SciencesNanjing 210014China Department of Plant Pathology Washington State UniversityPullmanWashington 99164USA

Cell-surface-localized leucine-rich-repeat receptorlike kinases(LRR-RLKs)are crucial for plant *** LRR-RLKs that act as receptors directly recognize ligands via a large extracellular domain(ECD),whereas LRR-RLK that serve as regulators are relatively small and contain fewer ***,we identified LRR-RLK regulators using high-throughput tobacco rattle virus(TRV)-based gene silencing in the model plant Nicotiana *** used the cell-death phenotype caused by INF1,an oomycete elicitin that induces pattern-triggered immunity,as an *** screening 33 small LRR-RLKs(≤6 LRRs)of unknown function,we identified ELICITIN INSENSITIVE RLK 1(NbEIR1)as a positive regulator of INF1-induced immunity and oomycete *** benthamiana mutants of eir1 generated by CRISPR/Cas9-editing showed significantly compromised immune responses to INF1 and were more vulnerable to the oomycete pathogen Phytophthora ***1 associates with BRI1-ASSOCIATED RECEPTOR KINASE 1(NbBAK1)and a downstream component,BRASSINOSTEROIDSIGNALING KINASE 1(NbBSK1).NbBSK1 also contributes to INF1-induced defense and *** *** INF1 treatment,NbEIR1 was released from NbBAK1 and NbBSK1 in ***,the silencing of NbBSK1 compromised the association of NbEIR1 with *** also showed that NbEIR1 regulates flg22-induced immunity and associates with its receptor,FLAGELLIN SENSING 2(NbFLS2).Collectively,our results suggest that NbEIR1 is a novel regulatory element for BAK1-dependent ***1-NbEIR1 association is required for maintaining the NbEIR1/NbBAK1 complex in the resting state.

关键词： BAK1 BSK1 INF1 leucine-rich repeat(LRR) LRR-RLK Oomycete

全球心血管疾病学术影响力评价(CAPE)体系的方法探索

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中国循环杂志 2024年第1期39卷 3-16页

作者：尹潞张雪燕曹也丁李卫姚焰薄致远魏良蔡军杨进刚胡盛寿中国医学科学院北京协和医学院国家心血管病中心阜外医院科研处北京100037 中国医学科学院北京协和医学院国家心血管病中心阜外医院医学统计部北京102308 中国医学科学院北京协和医学院国家心血管病中心阜外医院心律失常中心北京100037 中国医学科学院北京协和医学院国家心血管病中心阜外医院高血压中心北京100037 中国医学科学院北京协和医学院国家心血管病中心阜外医院健康教育中心北京100037 中国医学科学院北京协和医学院国家心血管病中心阜外医院成人外科中心北京100037

目的:构建全球心血管疾病学术影响力评价(Cardiovascular Academic Performance Evaluation,CAPE)体系,并对全球医疗机构心血管疾病学术影响力进行排名。方法:由心血管疾病领域人员和图书情报人员提取医学主题词表(MeSH)、Embase同义词... 详细信息

目的:构建全球心血管疾病学术影响力评价(Cardiovascular Academic Performance Evaluation,CAPE)体系,并对全球医疗机构心血管疾病学术影响力进行排名。方法:由心血管疾病领域人员和图书情报人员提取医学主题词表(MeSH)、Embase同义词表、国际疾病分类(ICD)中心血管疾病相关术语,建立心血管术语词表(即阜外词表),设定缺血性心脏病、高血压、血管疾病、心律失常、肺血管疾病、心力衰竭、先天性心脏病、心肌病和瓣膜性心脏病等9个亚学科,实现亚学科分类、心血管术语词、入口词的映射。检索Web of Science、PubMed、Scopus数据库2016年1月1日至2022年12月31日的心血管领域论文,并对元数据进行去重融合;应用阜外词表对论文中主题词、题目、关键词、摘要等4个位置的内容进行检索匹配,生成论文“位置-心血管术语词-频次”的信息表,计算每一篇论文心血管学科相关度积分及亚学科积分。对论文的机构名、学者名进行规范化清洗,基于心血管强相关(相关度积分≥4分)原创性论文开展全球心血管疾病领域学术影响力的评价。针对全国医疗机构(心血管)的科技评价,还采集了国家自然科学基金项目、授权发明专利、获奖成果、科研平台、注册试验[国家药品监督管理局药品审评中心(CDE)药物临床试验登记数据]等数据。结果:检索到全球2016~2022年心血管领域论文1545103篇,剔除摘要、书籍、传记、新闻、视频、音频、撤稿、更正声明后为1178019篇,使用阜外词表标引“心血管强相关”论文518058篇。还采集到11143项心血管相关国家自然科学基金项目、19382项心血管相关有效授权发明专利、103项心血管相关国家级获奖成果、24个心血管相关国家科研平台、2084项CDE心血管相关药物临床试验登记等数据。经组织心血管疾病及其亚学科专家团队针对各自亚学科论文进行核对和验证,改进学科分类规则,最终锁定11项指标构建了心血管疾病和9个亚学科领域的综合评价指标体系。2016~2022年,中国发表心血管疾病研究论文数量增幅为123.5%,共发表约7.68万篇,平均每天约30篇,仅次于美国(约11.41万篇),居世界第二位。但中国期刊引证报告(JCR)分区和中国科学院分区论文占比仅居世界第八位。在2020~2022年全球医疗机构心血管原创研究论文影响力综合评估中,仅2家中国医疗机构进入前20名。结论:CAPE项目基于2016~2022年多源数据基础,首次探索建立了心血管领域机构学术影响力综合评价指标体系。

关键词：心血管疾病学术影响力评价(CAPE) 阜外词表心血管疾病科技评价

Proppant transport in rough fractures of unconventional oil and gas reservoirs

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Petroleum Exploration and Development 2023年第3期50卷 712-721页

作者： yin Bangtang zhang Chao WANG zhiyuan SUN Baojiang GAO Yonghai WANG Xiaopeng BI Chuang zhang Qilong WANG Jintang SHI Juntai Key Laboratory of Unconventional Oil&Gas Development Ministry of EducationQingdao 266580China School of Petroleum Engineering China University of Petroleum(East China)Qingdao 266580China National Engineering Research Center of Oil&Gas Drilling and Completion Technology Beijing 102206China Tianjin Branch of CNOOC(China)Co. LtdTianjin 300452China School of Petroleum Engineering China University of Petroleum(Beijing)Beijing 102249China

A method to generate fractures with rough surfaces was proposed according to the fractal interpolation *** the particle-particle,particle-wall and particle-fluid interactions,a proppant-fracturing fluid two-phase flow model based on computational fluid dynamics(CFD)-discrete element method(DEM)coupling was *** simulation results were verified with relevant experimental *** was proved that the model can match transport and accumulation of proppants in rough fractures *** cases of numerical simulations were carried *** with proppant transport in smooth flat fractures,bulge on the rough fracture wall affects transport and settlement of proppants significantly in proppant transportation in rough *** higher the roughness of fracture,the faster the settlement of proppant particles near the fracture inlet,the shorter the horizontal transport distance,and the more likely to accumulate near the fracture inlet to form a sand plugging in a short *** wall roughness could control the migration path of fracturing fluid to a certain degree and change the path of proppant filling in the *** the one hand,the rough wall bulge raises the proppant transport path and the proppants flow out of the fracture,reducing the proppant sweep *** the other hand,the sand-carrying fluid is prone to change flow direction near the contact point of bulge,thus expanding the proppant sweep area.

关键词： unconventional oil and gas reservoir fracturing stimulation rough fracture fractal interpolation CFD-DEM coupling proppant transport

Inverse Problem and Variation Method to Optimize Cascade Heat Exchange Network in Central Heating System

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Journal of Thermal Science 2017年第6期26卷 545-551页

作者： zhang yin WEI zhiyuan zhang yinping WANG Xin College of Architecture and Environment Sichuan University Department of Building Science Tsinghua University

Urban heating in northern China accounts for 40% of total building energy usage. In central heating systems, heat is often transferred from heat source to users by the heat network where several heat exchangers are installed at heat source, substations and terminals respectively. For given overall heating capacity and heat source temperature, increasing the terminal fluid temperature is an effective way to improve the thermal performance of such cascade heat exchange network for energy saving. In this paper, the mathematical optimization model of the cascade heat exchange network with three-stage heat exchangers in series is established. Aim at maximizing the cold fluid temperature for given hot fluid temperature and overall heating capacity, the optimal heat exchange area distribution and the medium fluids' flow rates are determined through inverse problem and variation method. The preliminary results show that the heat exchange areas should be distributed equally for each heat exchanger. It also indicates that in order to improve the thermal performance of the whole system, more heat exchange areas should be allocated to the heat exchanger where flow rate difference between two fluids is relatively small. This work is important for guiding the optimization design of practical cascade heating systems.

关键词：集中供热系统换热器变分法逆问题网络优化串级 northern 流体温度

烟酰胺单核苷酸对乙醇诱导L02细胞DNA损伤的保护作用研究

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预防医学 2024年第6期36卷 548-552页

作者：狄春红阴洁钟文英张盈盈曹月佳谭晓华杭州师范大学附属医院检验科浙江杭州310015 杭州师范大学浙江杭州311121

目的探究烟酰胺单核苷酸(NMN)对乙醇诱导L02细胞DNA损伤的保护作用,为NMN辅助治疗酒精性肝病提供依据。方法采用不同浓度NMN(1、2、4和8 mmol/L)预处理L02细胞6 h后,暴露于0.4%乙醇12 h,分为对照组、0.4%乙醇组和不同浓度NMN组。采用台... 详细信息

目的探究烟酰胺单核苷酸(NMN)对乙醇诱导L02细胞DNA损伤的保护作用,为NMN辅助治疗酒精性肝病提供依据。方法采用不同浓度NMN(1、2、4和8 mmol/L)预处理L02细胞6 h后,暴露于0.4%乙醇12 h,分为对照组、0.4%乙醇组和不同浓度NMN组。采用台盼蓝染色分析细胞活力,确定NMN作为保护剂的浓度;通过碱性彗星实验、H2组蛋白家族X(γH2AX)免疫荧光检测和活性氧(ROS)检测评估NMN对乙醇诱导L02细胞DNA损伤的影响。L02细胞暴露于0.4%乙醇12 h后,采用含保护浓度NMN的培养基继续培养,分为PBS对照组和NMN组,分别在0、2、4、8、16和32 h检测细胞活力;通过碱性彗星实验评估NMN对乙醇诱导L02细胞DNA损伤修复的影响。结果与对照组比较,0.4%乙醇组L02细胞活力降低;与0.4%乙醇组比较,各浓度NMN组L02细胞活力升高(均Ρ0.05),故选用4 mmol/L为NMN作为保护剂的浓度。与对照组比较,0.4%乙醇组L02细胞尾矩增加,γH2AX免疫荧光相对强度和ROS相对水平升高(均Ρ<0.05);与0.4%乙醇组比较,4 mmol/L及以上NMN组L02细胞尾矩缩短,γH2AX免疫荧光相对强度和ROS相对水平下降(均Ρ<0.05)。随着4 mmol/LNMN干预时间增加,L02细胞活力逐渐升高,尾矩逐渐缩短;与PBS对照组比较,干预4 h及以上NMN组L02细胞活力较高,尾矩较短(均Ρ<0.05)。结论NMN以剂量依赖方式减轻DNA损伤,并以时间依赖方式促进DNA损伤的修复,NMN对乙醇诱导肝细胞DNA损伤具有保护作用。

关键词：烟酰胺单核苷酸乙醇 DNA损伤活性氧

基于水力过渡过程的西藏扎拉水电站调压室设计优化

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水利水电快报 2024年第8期45卷 42-46页

作者：蔡爽张永健邓清树杨彬殷成成彭志远大唐西藏能源开发有限公司西藏拉萨850000 长江勘测规划设计研究有限责任公司湖北武汉430010

针对西藏扎拉水电站调压室顶拱上方存在的不良地质条件问题,提出了一种利用施工支洞作为调压室上室的优化布置方案,并结合水力过渡过程计算,分析了涌浪的波动过程。结果表明:施工支洞作为调压室上室能够有效削减最高涌浪水位。当最高涌... 详细信息

针对西藏扎拉水电站调压室顶拱上方存在的不良地质条件问题,提出了一种利用施工支洞作为调压室上室的优化布置方案,并结合水力过渡过程计算,分析了涌浪的波动过程。结果表明:施工支洞作为调压室上室能够有效削减最高涌浪水位。当最高涌浪低于施工支洞顶拱时,涌浪不会对支洞顶拱的结构安全造成危害,也不会阻碍支洞的排气过程。利用施工支洞作为上游调压室可显著降低调压室顶拱,并成功避开不良地质带,有利于水电站安全稳定运行。

关键词：调压室水力过渡过程施工支洞扎拉水电站

A Global Multiregional Proteomic Map of the Human Cerebral Cortex

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Genomics, Proteomics & Bioinformatics 2022年第4期20卷 614-632页

作者： Zhengguang Guo Chen Shao Yang zhang wenying Qiu Wenting Li Weimin Zhu Qian Yang yin Huang Lili Pan Yuepan Dong Haidan Sun Xiaoping Xiao Wei Sun Chao Ma Liwei zhang Core Facility of Instrument Institute of Basic Medical SciencesChinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100005China State Key Laboratory of Proteomics Beijing Proteome Research CenterNational Center for Protein Sciences(Beijing)Beijing Institute of LifeomicsBeijing 102206China Department of Neurosurgery China National Clinical Research Center for Neurological DiseasesBeijing Tiantan HospitalCapital Medical UniversityBeijing 100050China Department of Human Anatomy Histologyand EmbryologyInstitute of Basic Medical SciencesNeuroscience CenterChinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100005China

The Brodmann area(BA)-based map is one of the most widely used cortical maps for studies of human brain functions and in clinical practice;however,the molecular architecture of BAs remains *** present study provided a global multiregional proteomic map of the human cerebral cortex by analyzing 29 *** 29 BAs were grouped into 6 clusters based on similarities in proteomic patterns:the motor and sensory cluster,vision cluster,auditory and Broca’s area cluster,Wernicke’s area cluster,cingulate cortex cluster,and heterogeneous function *** identified 474 cluster-specific and 134 BA-specific signature proteins whose functions are closely associated with specialized functions and disease vulnerability of the corresponding cluster or *** findings of the present study could provide explanations for the functional connections between the anterior cingulate cortex and sensorimotor cortex and for anxiety-related function in the sensorimotor *** brain transcriptome and proteome comparison indicates that they both could reflect the function of cerebral cortex,but show different *** proteomic data are publicly available at the Human Brain Proteome Atlas(***).Our results may enhance our understanding of the molecular basis of brain functions and provide an important resource to support human brain research.

关键词： Brodmann area Proteomics Cerebral cortex Cingulate cortex Sensorimotor cortex