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Vitamin D-binding protein in plasma microglia-derived extracellular vesicles as a potential biomarker for major depressive disorder

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Genes & Diseases 2024年第2期11卷 1009-1021页

作者： Gaojia zhang Ling Li Yan Kong Dandan Xu Yu Bao Zhiting zhang Zhixiang Liao Jiao Jiao Dandan Fan Xiaojing Long Ji Dai Chunming Xie Zhiqiang Meng zhijun zhang Department of Neurology Affiliated Zhongda HospitalResearch Institution of NeuropsychiatrySchool of MedicineSoutheast UniversityNanjingJiangsu 210009China Department of Biochemistry and Molecular Biology School of MedicineSoutheast UniversityNanjingJiangsu 210009China Shenzhen Key Laboratory of Drug Addiction Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of Sciences (CAS)ShenzhenGuangdong 518000China CAS Key Laboratory of Brain Connectome and Manipulation The Brain Cognition and Brain Disease Institute (BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China Lauterbur Research Center for Biomedical Imaging Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China Shenzhen-Hong Kong Institute of Brain Sciences-Shenzhen Fundamental Research Institutions ShenzhenGuangdong 518000China Brain Cognition and Brain Disease Institute Department of Mental Health and Public HealthFaculty of Life and Health SciencesShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China

No well-established biomarkers are available for the clinical diagnosis of major depressive disorder(MDD).Vitamin D-binding protein(VDBP)is altered in plasma and postmortem dorsolateral prefrontal cortex(DLPFC)tissues of MDD patients.Thereby,the role of VDBP as a potential biomarker of MDD diagnosis was further assessed.Total extracellular vesicles(EVs)and brain cell-derived EVs(BCDEVs)were isolated from the plasma of first-episode drug-naïve or drug-free MDD patients and well-matched healthy controls(HCs)in discovery(20 MDD patients and 20 HCs)and validation cohorts(88 MDD patients and 38 HCs).VDBP level in the cerebrospinal fluid(CSF)from chronic glucocorticoid-induced depressed rhesus macaques or prelimbic cortex from lipopolysaccharide(LPS)-induced depressed mice and wild control groups was measured to evaluate its relationship with VDBP in plasma microglia-derived extracellular vesicles(MDEVs).VDBP was significantly decreased in MDD plasma MDEVs compared to HCs,and negatively correlated with HAMD-24 score with the highest diagnostic accuracy among BCDEVs.VDBP in plasma MDEVs was decreased both in depressed rhesus macaques and mice.A positive correlation of VDBP in MDEVs with that in CSF was detected in depressed rhesus macaques.VDBP levels in prelimbic cortex microglia were negatively correlated with those in plasma MDEVs in depressed mice.The main results suggested that VDBP in plasma MDEVs might serve as a prospective candidate biomarker for MDD diagnosis.

关键词： Biomarker Cerebrospinal fluid Major depressive disorder Microglia derived extracellular vesicles Vitamin-D binding protein

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Prediction-based dynamic routing intelligent algorithm in power optical communication network

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The Journal of China Universities of Posts and Telecommunications 2022年第6期29卷 46-52页

作者： Guo Xuerang Li Feng Zhu Bohan zhang zhijun Guo Qingrui Yang Huiting Electric Power Research Institute State Grid Xinjiang Electric Power Co.Ltd.Urumqi 830000China State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and TelecommunicationsBeijing 100876China Dispatching and Control Center State Grid Xinjiang Electric Power Co.Ltd.Urumqi 830000China

New energy power generation equipment has the characteristics of diurnal, perturbative, seasonal, and periodic power generation, which makes new power optical communication network(POCN) more dynamic and changeable. This is directly reflected in the dynamics of the link risk and service importance of the POCN. In this paper, aiming at the problem of the dynamic importance of service in POCN, and the resulting power optical communication network reliability decline problem, a new energy POCN dynamic routing intelligence algorithm based on service importance prediction is proposed. Based on the short-term power generation of new energy power station, the importance of each service and the risk degree of each link are predicted. Link weights are dynamically adjusted, and k-shortest path(KSP) algorithm is used to calculate route results. When network resources are insufficient, low-importance services can give way to prevent a large number of high-importance services from being blocked. Simulation results show that compared with the traditional KSP algorithm, the prediction-based dynamic routing intelligent(P-DRI) algorithm can reduce the service blocking probability by 55.59%, and reduce the average importance of blocking services by 44.77% at the cost of about 6.17% of the calculation delay.

关键词： new power optical communication network(POCN) traffic diversion new energy power generation network risk degree

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湍流环境下颗粒与气泡黏附过程的数值模拟研究

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煤炭学报 2024年第4期49卷 2057-2066页

作者：张志军黄旭贝中国矿业大学(北京)化学与环境工程学院北京100083

研究湍流环境中颗粒与气泡的黏附过程对于探究浮选微观过程具有重要意义。基于EDEM的API(应用程序编程接口)二次开发模块,建立了颗粒与气泡黏附过程相互作用的三维离散元法(DEM)模型。在Fluent软件中通过构建规则格栅以激发各向同性的湍... 详细信息

研究湍流环境中颗粒与气泡的黏附过程对于探究浮选微观过程具有重要意义。基于EDEM的API(应用程序编程接口)二次开发模块,建立了颗粒与气泡黏附过程相互作用的三维离散元法(DEM)模型。在Fluent软件中通过构建规则格栅以激发各向同性的湍流,并将湍流环境通过计算流体力学-离散元(CFD-DEM)加入到EDEM软件中。模拟了颗粒粒径为0.10、0.15、0.20、0.25和0.30 mm,颗粒密度为1500、2000和2500 kg/m^(3),球形度为0.746~0.854的不规则颗粒,和气泡直径为1.00、1.20、1.60和2.00 mm,在气泡与格栅间距离为1.00、1.50、2.00和3.00 mm的湍流环境下颗粒与气泡的黏附过程。研究了颗粒、气泡、流场各参数对于颗粒与气泡黏附过程的影响。结果发现,无论规则颗粒还是不规则颗粒在湍流环境中与气泡的黏附均存在临界脱附流速(颗粒与气泡发生脱附的最小湍流流场流速)。密度大的颗粒和粒径大的颗粒与气泡黏附的临界脱附流速更小,表明粒径和密度大的颗粒与气泡难以稳定黏附。气泡的直径越大,颗粒与气泡稳定黏附的临界脱附流速越小,颗粒越难以稳定黏附。在相同的流速下,气泡与格栅间距离越小,则流场湍流强度越大,颗粒与气泡稳定黏附的临界脱附流速越小,表明湍流强度的增加不利于颗粒与气泡的稳定黏附。球形度小的颗粒与气泡稳定黏附的临界脱附流速也较小,表明球形度小的颗粒与气泡难以稳定黏附。

关键词：浮选 CFD-DEM 颗粒气泡黏附湍流数值模拟

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中国当代音乐创作中“戏曲音乐元素”的腔化修辞

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中国音乐 2024年第2期 182-191页

作者：张智军陕西师范大学音乐学院

“戏曲音乐元素”是中国作曲家在创作中大量运用的材料之一,其“腔化”特征尤为体现戏曲本质。本文基于前人大量的研究文献,通过对多部中国当代音乐作品中“戏曲音乐元素”的腔化修辞手段进行分析,来提炼“戏曲音乐元素”之旋律腔化修... 详细信息

“戏曲音乐元素”是中国作曲家在创作中大量运用的材料之一,其“腔化”特征尤为体现戏曲本质。本文基于前人大量的研究文献,通过对多部中国当代音乐作品中“戏曲音乐元素”的腔化修辞手段进行分析,来提炼“戏曲音乐元素”之旋律腔化修辞、结构腔化修辞、音腔腔化修辞及混响腔化修辞等不同手段的实践路径及特征。

关键词：当代音乐戏曲元素腔化修辞

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激光尾波场电子加速及新型辐射源(特邀)

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中国激光 2024年第1期51卷 44-68页

作者：余昌海秦志勇张志钧刘建胜上海师范大学物理系上海200234 中国科学院上海光学精密机械研究所强场激光物理国家重点实验室上海201800

受益于超短超强激光技术的持续迅猛发展,飞秒强激光为人类提供了全新的实验手段与极端的物理条件,使激光物质相互作用进入到一个极端非线性的强场超快新范畴,催生了大量新原理、新现象,推动了技术变革。飞秒强激光驱动的等离子体尾波场... 详细信息

受益于超短超强激光技术的持续迅猛发展,飞秒强激光为人类提供了全新的实验手段与极端的物理条件,使激光物质相互作用进入到一个极端非线性的强场超快新范畴,催生了大量新原理、新现象,推动了技术变革。飞秒强激光驱动的等离子体尾波场加速原理是一种具有超高加速梯度的粒子加速新原理,该技术的加速梯度可达100 GV/m,相比于传统射频加速器提高了3个数量级以上,可在厘米量级的加速长度内获得GeV量级的高品质高能电子束,极大地降低了加速器的成本,为发展新一代粒子加速技术和新型超快辐射源提供了新机遇和新途径。从飞秒强激光驱动等离子体尾波场中的电子注入、能量啁啾控制和高品质电子束产生以及基于高品质电子束的betatron X射线辐射、高能伽马射线和小型化自由电子激光这几个方面介绍了激光等离子体尾波场电子加速的若干主要研究进展,并对未来进行了展望。

关键词：激光光学激光尾波场电子加速能量啁啾 betatron辐射逆康普顿散射自由电子激光

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Iterative list decoding approach for Reed-Solomon codes

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The Journal of China Universities of Posts and Telecommunications 2019年第3期26卷 8-14,24页

作者： zhang zhijun Niu Kai Dong Chao Key Laboratory of Universal Wireless Communications Beijing University of Posts and Telecommunications

A novel adaptively iterative list decoding(ILD) approach using for Reed-Solomon(RS) codes was investigated. The proposed scheme is exploited to reduce the complexity of RS Chase algorithm(CA) via an iterative decoding attempt mode. In each decoding attempt process, a test pattern is generated by flipping the bits of the least reliable positions(LRPs) within the received hard-decision(HD) vector. The ILD algorithm continues until a test pattern is successfully decoded by the underlying Berlekamp-Massey algorithm(BMA) of RS codes. Flipping within the same bits, the ILD algorithm provides the same test pattern set as the conventional RS CA, thus there is no degradation in error-rate performance. Without decoding all test patterns, the ILD algorithm can simplify the decoding complexity by its early termination. Simulation results show that the average complexity of the ILD algorithm is much lower than that of the conventional RS CA(and is similar to that of BMA decoding) at high signal-to-noise ratio(SNR) region with no less to the RS CA decoding error-rate performance.

关键词： iterative decoding soft-decision decoding Reed-Solomon codes low-complexity decoding

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不同加载速率作用下含平行裂隙岩石的试验研究:能量耗散与损伤演化

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岩石力学与工程学报 2024年第S1期43卷 3397-3412页

作者：戴兵赵桂锋张雷张志军刘永陈英南华大学资源环境与安全工程学院湖南衡阳421001 矿山岩土工程灾害预测与控制工程技术研究中心湖南衡阳421001 深圳大学物理与光电工程学院广东深圳518060

为了研究平行双裂隙岩石在动荷载作用下的能量耗散和损伤变化规律,利用改进的分离式霍普金森杆(SHPB)试验装置,对预制平行裂隙岩石进行动态冲击试验,探究裂隙角度和加载速率对岩石能耗规律和损伤变化的影响。试验结果表明:随着加载速率... 详细信息

为了研究平行双裂隙岩石在动荷载作用下的能量耗散和损伤变化规律,利用改进的分离式霍普金森杆(SHPB)试验装置,对预制平行裂隙岩石进行动态冲击试验,探究裂隙角度和加载速率对岩石能耗规律和损伤变化的影响。试验结果表明:随着加载速率的增大,0°裂隙岩石的弹性应变能先下降后上升,45°和90°裂隙岩石表现出相反的规律。根据能量转换和分配原理,建立应变能密度变化函数模型,该模型能较好地反应峰值应力前岩石的能量耗散特性。弹性应变能与塑性应变能的比值可以用来表示岩石破坏前能量的变化指标,峰值应力前岩石能量吸收、储存和释放的过程中存在自我控制行为。不同加载速率作用下岩石的损伤变量分为稳定和加速发展两个阶段,加载速率效应影响损伤变量置信区间的变化趋势,损伤变量随着裂隙角度的增大先减小后增大。损伤变量分别和加载速率、单位体积吸收能具有良好的非线性拟合关系。基于数学推导法研究了裂隙角度和加载速率对岩石损伤曲线的影响,建立了损伤力学模型。损伤曲线的斜率先增大后减小,损伤因子m_(0)整体逐渐上升,F_(0)逐渐下降。其研究结果可以为深部裂隙岩石工程设计和岩石破碎效率优化等工程实践提供科学依据。

关键词：岩石力学分离式霍普金森杆(SHPB) 加载速率平行裂隙能量耗散损伤演化

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Review of application of biomimetics for designing soil-engaging tillage implements in Northeast China

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International Journal of Agricultural and Biological Engineering 2016年第4期9卷 12-21页

作者： zhang zhijun Jia Honglei Sun Jiyu School of Mechanical Science and Engineering Jilin UniversityChangchun 130022China Key Laboratory of Bionic Engineering(Ministry of Education) Jilin UniversityChangchun 130022China

The reduction of water resources and soil fertility in Northeast China will have a requirement on higher working efficiency of agricultural soil-engaging components.The adhesion and resistance are main problems for soil-engaging tillage components.However,the soil-burrowing or soil-digging animals give inspirations to resolve those problems.Their fair,claw,toe,textured surface and scales have functions of anti-adhesion or resistance reduction.Those results provide a way to realize the sustainable development of modern agriculture by developing novel biomimetic agricultural machinery systems with independent intellectual property rights to meet conservation tillage requirements in the Northern China region.Biological structures of some soil-burrowing or soil-digging animals,such as beetle,mole cricket,earthworm,mole,vole,pangolin,and snake,as well as their mechanisms of anti-adhesion or reducing resistance were reviewed in this paper.Bioinspired applications in Northeast China were also presented in the paper,including moldboard,subsoiler components,furrow opener,roller,and biomimetic rototilling-stubble-breaking blade.In addition,the existed problems in agricultural engineering and the future development trends were discussed.

关键词： review agricultural engineering biomimetics soil-engaging tillage implements conservation tillage

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Structured-Light-Field 3D Imaging System With Coaxial Projection

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激光与光电子学进展 2023年第8期60卷 261-267页

作者： zhang zhijun Wu Qingyang Jiang Yifan Deng Yifeng College of Big Data and Internet Shenzhen Technology UniversityShenzhen 518118GuangdongChina

This paper presents a novel 3D measurement method for a light field camera(LFC)in which 3D information of object space is encoded by a microlens array(MLA).The light ray corresponding to each pixel of the LFC is calibrated.Once the matching points from at least two subviews exhibit sub-pixel accuracy,the 3D coordinates can be calculated optimally by intersecting light rays of these points matched through phase coding.Moreover,the proposed method obtains high-resolved results that exceed the subview resolution due to the virtual continuous phase search strategy.Finally,we combine the LFC and coaxial projection to solve the 3D data loss caused by shadowing and occlusion problems.Experimental results verify the feasibility of the proposed method,and the measurement error is about 30μm in a depth range of 60 mm.

关键词： light field 3D imaging microlens array structured light

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Coal petrology characteristics of middlings from Qianjiaying fat coal mine

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International Journal of Mining Science and Technology 2013年第5期23卷 777-782页

作者： Zou Wenjie Cao Yijun zhang zhijun Liu Jiongtian School of Chemical Engineering and Technology China University of Mining & Technology National Engineering Research Center of Coal Preparation and Purifcation China University of Mining & Technology School of Chemical and Environmental Engineering China University of Mining & Technology

The objective of this paper is to evaluate the coal petrology characteristics of slack middlings(13–0.5 mm)of dense media separation and flotation middlings from Qianjiaying fat coal preparation plant.Phase composition,macerals distribution,microlithotype and mineral occurrence of the two middlings were studied by XRD analysis and polarized light microscopy observation.Macerals distribution and wettability of the float-and-sink products separated from the middlings after grinding was investigated to determine the liberation degree.Studies show that there are more vitrinite and mineral,but less inertinite in slack middlings than in flotation middlings.Macerals associated with mineral in slack middlings is 69.85%,by volume,which is 17.86%higher than that in flotation middlings.Minerals in slack middlings are dominated by pyrite and clay,which are disseminated with the diameter less than2 lm.The main mineral in flotation middlings is clay with size range of 2–20 lm.Single macerals in the slack middlings are diffcult to liberate due to the fne-grained minerals.After grinding,macerals associated with minerals in the slack middlings decrease to 46.73%,by volume,which is higher than in flotation middlings by 25.89%,by volume.For slack middlings with poor liberation degree,density fractions below1.8 g/cm3is hydrophobic with contact angle above 71.5°.For the well liberated flotation middlings,there is signifcant wettability difference among the float-and-sink products.This research is the theoretical basis to realize re-separation of middlings.

关键词： Middlings Macerals Mineral liberation Wettability

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