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Structural evolution and high-temperature sensing performance of polymer-derived SiAlBCN ceramics

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Journal of Advanced Ceramics 2024年第4期13卷 478-485页

作者： Chao Ma Kun Liu Pengfei Shao Daoyang Han kang Wang Mengmeng Yang Rui zhao Hailong Wang Rui zhang Gang Shao School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China Zhongyuan Critical Metal Laboratory Zhengzhou UniversityZhengzhou 450001China State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentZhengzhou UniversityZhengzhou 450002China

In situ temperature monitoring has become extremely imperative in high-temperature harsh environments and polymer-derived ceramics(PDCs)as sensing materials have attracted great ***,the stability and oxidation/corrosion resistance of PDCs cannot be simultaneously achieved at the moment,limiting their practical ***,polymer-derived SiAlBCN ceramics were synthesized via polymer conversion method under different pyrolysis *** microstructure evolution,high temperature sensing properties,and stability were investigated in *** results show that the amorphous SiAlBCN phase grows more orderly and the size of the free carbon phase enlarges with the increasing *** defect concentration displays a decreasing ***,the SiAlBCN ceramics as sensing materials exhibit a good temperature-resistance property from roo temperature to 1100℃.The fabricated SiAlBCN temperature sensor possesses excellent stability,repeatability,and ***,SiAlBCN ceramics exhibit distinguished oxidation/corrosion resistance after 100 h treatment at 1200℃in a water/oxygen environment,which is attributed to their low corrosive rate constant(0.57 mg/(cm^(2)·h))and oxidative rate constant(3.43 mg^(2)/(cm^(4)·h)).Therefore,polymer-derived SiAlBCN ceramics as sensing materials,which possess outstanding stability and oxidation/corrosion resistance,have great potential for in-situ monitoring of extreme environmental temperatures in the future.

关键词： polymer-derived SiAlBCN ceramics temperature sensor harsh environments oxidation and corrosion resistance

A method for detecting two-dimensional plane stress distribution in basin-type insulator based on critically refracted longitudinal wave

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High Voltage 2024年第1期9卷 105-116页

作者： zhaoyang kang Fuqiang Ren Hongru zhang Jingjing Yang Kaining Hou Qingquan Li Dongxin He Hongshun Liu Yongzhi zhao Huaxin Wen Shandong Provincial Key Laboratory of UHV Transmission Technology and Equipment School of Electrical EngineeringShandong UniversityJinanChina Shandong Electrical Engineering&Equipment Group Co.Ltd JinanChina SDEE Hitachi High-voltage Switchgear Co. LtdJinanChina

Basin-type insulator often has small cracks due to stress *** current method cannot accurately reflect the stress condition of the insulator to find the stress concentration *** solve these problems,a method for detecting two-dimensional plane stress(δ_(1) andδ_(2))within different depth ranges in a basin-type insulator is proposed based on critically refracted longitudinal(LCR)***,the acoustoelastic equation characterising the relationship between the variation of LCR wave propagation time and the plane stress was ***,the propagation characteristics of LCR wave in epoxy resin samples were ***,the stress distribution within different depth ranges of the insulator subjected to hydraulic load was measured using the proposed method,including direction(θ),δ_(1) andδ_(2).The results show that the magnitude of the stress alone cannot accurately characterise the stress *** with equal distances to the centre have similar stress magnitudes,but their directions are not the *** increasing depth,θremains essentially unchanged at the same location,whileδ1 andδ2 decrease,and the rate of decrease varies at different *** the measured and simulated data,the results showed that they were in good agreement,and the maximum errors of stress value andθwere 0.69 MPa and 2.97°,respectively,which confirmed the feasibility and accuracy of the stress detection in the proposed method.

关键词： stress insulator wave

Improving lipid production by Rhodotorula glutinis for renewable fuel production based on machine learning

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Frontiers of Chemical Science and Engineering 2024年第5期18卷 23-35页

作者： Lihe zhang Changwei zhang Xi zhao Changliu He Xu zhang National Energy R&D Center for Biorefinery Beijing University of Chemical TechnologyBeijing 100029China Collage of Life Science and Technology Beijing University of Chemical TechnologyBeijing 100029China Beijing Key Laboratory of Bioprocess Beijing University of Chemical TechnologyBeijing 10029China

Microbial lipid fermentation encompasses intricate complex cell growth processes and heavily relies on expert experience for optimal *** modeling of the fermentation process assists researchers in making intelligent decisions,employing logical reasoning and strategic planning to optimize lipid *** this study,the effects of medium components and concen-trations on lipid fermentation were investigated,*** then,leveraging the collated data,a variety of machine learning algorithms were used to model and optimize the lipid fermentation *** models,based on artificial neural networks and support vector machines,achieved R?values all higher than 0.93,ensuring accurate predictions of the fermentation *** linear regression was used to evaluate the respective target parameter,which were affected by the medium components of lipid ***,single and multi-objective optimiza-tion were conducted for lipid fermentation using the genetic *** results demonstrated the maximum biomass of 50.3 g·L^(-1) and maximum lipid concentration of 14.1 g:L^(-1) with the error between the experimental and predicted values less than 5%.The results of the multi-objective optimization reveal the synergistic and competitive relationship between biomass,lipid concentration,and conversion rate,which lay a basis for in-depth optimization and amplification.

关键词： microbial lipid machine learning artificial neural network support vector machine genetic algorithm

A Multi-Stage Differential-Multifactorial Evolutionary Algorithm for Ingredient Optimization in the Copper Industry

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IEEE/CAA Journal of Automatica Sinica 2024年第10期11卷 2135-2153页

作者： Xuerui zhang Zhongyang Han Jun zhao School of Control Science and Engineering Dalian University of TechnologyDalian 116024China IEEE

Ingredient optimization plays a pivotal role in the copper industry,for which it is closely related to the concentrate utilization rate,stability of furnace conditions,and the quality of copper *** acquire a practical ingredient plan,which should exhibit long duration time with sufficient utilization and feeding stability for real applications,an ingredient plan optimization model is proposed in this study to effectively guarantee continuous production and stable furnace *** address the complex challenges posed by this integer programming model,including multiple coupling feeding stages,intricate constraints,and significant non-linearity,a multi-stage differential-multifactorial evolution algorithm is *** the proposed algorithm,the differential evolutionary(DE)algorithm is improved in three aspects to efficiently tackle challenges when optimizing the proposed ***,unlike traditional time-consuming serial approaches,the multifactorial evolutionary algorithm is utilized to optimize multiple complex models contained in the population of evolutionary algorithm caused by the feeding stability in a parallel ***,a repair algorithm is employed to adjust infeasible ingredient lists in a timely *** addition,a local search strategy taking feedback from the current optima and considering the different positions of global optimum is developed to avoiding premature convergence of the differential evolutionary ***,the simulation experiments considering different planning horizons using real data from the copper industry in China are conducted,which demonstrates the superiority of the proposed method on feeding duration and stability compared with other commonly deployed *** is practically helpful for reducing material cost as well as increasing production profit for the copper industry.

关键词： Copper industry differential-multifactorial evolution ingredient optimization multi-stage optimization

Digital Twin Technology of Human-Machine Integration in Cross-Belt Sorting System

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 195-212页

作者： Yanbo Qu Ning zhao Haojue zhang School of Mechanical Engineering University of Science and Technology BeijingBeijing 100083China Institute of Microelectronics of the Chinese Academy of Sciences Beijing 100029China Wayzim Technology Co. LtdWuxi 214108China Business School Beijing Technology and Business UniversityBeijing 100048China

The Chinese express delivery industry processes nearly 110 billion items in 2022,averaging an annual growth rate of 200%.Among the various types of sorting systems used for handling express items,cross-belt sorting systems stand out as the most ***,despite their high degree of automation,the workload for operators has intensified owing to the surging volume of express *** the era of Industry 5.0,it is imperative to adopt new technologies that not only enhance worker welfare but also improve the efficiency of cross-belt *** a balance between efficiency in handling express items and operator well-being is *** twin technology offers a promising solution in this respect.A realization method of a human-machine integrated digital twin is proposed in this study,enabling the interaction of biological human bodies,virtual human bodies,virtual equipment,and logistics equipment in a closed loop,thus setting an operating *** technologies in the proposed framework include a collection of heterogeneous data from multiple sources,construction of the relationship between operator fatigue and operation efficiency based on physiological measurements,virtual model construction,and an online optimization module based on real-time *** feasibility of the proposed method was verified in an express distribution center.

关键词： Industry 5.0 Cross-belt sorting system Human-machine integrated Digital twin Online optimization

QL1706 (anti-PD-1 IgG4/CTLA-4 antibody) plus chemotherapy with or without bevacizumab in advanced non-small cell lung cancer: a multi-cohort, phase II study

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Signal Transduction and Targeted Therapy 2024年第2期9卷 797-806页

作者： Yan Huang Yunpeng Yang Yuanyuan zhao Hongyun zhao Ningning Zhou Yaxiong zhang Likun Chen Ting Zhou Gang Chen Ting Wu Lu Lu Shilin Xue Xiaoyan kang Li zhang Wenfeng Fang Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineNo.651 Dongfeng East RoadGuangzhouGuangdong 510060China Department of Medicine Qilu Pharmaceutical Co.Ltd.JinanChina

First-line chemoimmunotherapy(with or without bevacizumab)has improved outcomes in advanced non-small cell lung cancer(NSCLC).Here,this open-label,multi-cohort phase II study(NCT05329025)was done to investigate the safety and efficacy of QL1706(a single bifunctional MabPair product against PD-1 and CTLA-4)and chemotherapy with or without bevacizumab in this *** were enrolled into five different cohorts based on genotype(cohorts 1-4,epidermal growth factor receptor[EGFR]wild-type;cohort 5,EGFR-mutant and progressed on EGFR-tyrosine kinase inhibitors[TKIs]).Between June 11,2021 and December 29,2021,91 patients were *** frequent treatment-related adverse events(TRAEs)included decreased appetite(60[65.9%]),anemia(60[65.9%]),infusion-related reactions(48[52.7%]),and pruritus(44[48.4%]).Grade≥3 TRAEs occurred in 30(33.0%)***-seven(45%)patients with wild-type EGFR achieved partial response(PR)(objective response rate[ORR]=45%)and had a median progression-free survival(mPFS)of 6.8 months(95%CI:5.2-9.7).For 31 patients harboring mutated EGFR,17(54.8%)achieved PR(ORR=54.8%),with an mPFS of 8.5 months(95%CI:5.72-not evaluable).Overall,QL1706 plus chemotherapy,regardless of having bevacizumab,was generally tolerable and had promising antitumor activity for EGFR wild-type advanced NSCLC in first-line ***,QL1706 plus chemotherapy and bevacizumab showed favorable antitumor activity for patients who had EGFR mutated NSCLC but failed in TKI therapy,demonstrating a potential for treating this population.

关键词： bevacizumab chemotherapy phase

Structure-based design and optimization lead to the identification of novel dihydrothiopyrano[3,2-d]pyrimidine derivatives as potent HIV-1 inhibitors against drug-resistant variants

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1257-1282页

作者： zhao Wang Heng zhang Zhen Gao Zihao Sang Erik De Clercq Christophe Pannecouque Dongwei kang Peng Zhan Xinyong Liu Department of Medicinal Chemistry Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China Rega Institute for Medical Research Laboratory of Virology and ChemotherapyK.U.LeuvenLeuven B-3000Belgium China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province Jinan 250012China Suzhou Research Institute Shandong UniversitySuzhou 215123China

With our continuous endeavors in seeking potent anti-HIV-1 agents,we reported here the discovery,biological characterization,and druggability evaluation of a class of nonnucleoside reverse transcriptase *** fully explore the chemical space of the NNRTI-binding pocket,novel series of dihydrothiopyrano[3,2-d]pyrimidines were developed by employing the structure-based design *** of the derivatives were endowed with prominent antiviral activities against HIV-1 wild-type and resistant strains at nanomolar *** them,compound 23h featuring the aminopiperidine moiety was identified as the most potent inhibitor,with EC50values ranging from 3.43 to 21.4 nmol/***,for the challenging double-mutants F227L+V106A and K103N+Y181C,23h exhibited 2.3-to 14.5-fold more potent activity than the first-line drugs efavirenz and ***,the resistance profiles of 23h achieved remarkable improvement compared to efavirenz and *** binding target of 23h was further confirmed to be HIV-1 reverse *** modeling studies were also performed to elucidate the biological evaluation results and give guidance for the optimization ***,no apparent inhibition of the major CYP450 enzymes and hERG channel was observed for *** importantly,23h was characterized by good pharmacokinetic properties and excellent safety in ***,23h holds great promise as a potential candidate for its effective antiviral efficacy and favorable drug-like profiles.

关键词： HIV-1 Reverse transcriptase Dihydrothiopyrano[3,2-d]pyrimidine Antiviral agent

Recent progress in lanthanide ions doped inorganic metal halide perovskites

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Journal of Rare Earths 2024年第2期42卷 237-250,I0001页

作者： Yiyan zhang Tianyu zhao Guanying Chen MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringState Key Laboratory of Urban Water Resource and EnvironmentKey Laboratory of Micro-systems and Micro-structuresMinistry of EducationHarbin Institute of TechnologyHarbin150001China

Benefiting from their large molar extinction coefficient,high carrier mobility,narrow and tunable emissions,inorganic metal halide perovskites(IMHPs) demonstrate great potential in various optoelectrical devices including solar cells,light emitting diodes and photodetectors in the past few *** ions doping,well-known as a modification method of semiconductors,has been extensively applied in IMHPs as *** metal ions have been doped in IMHPs including alkali metals,alkali earth metals,transition metals and lanthanide metals,which either improve their optical performances or induce intriguing brand-new *** them,lanthanide metals feature plentiful energy levels and stable optical properties and are one of the most noteworthy *** we review recent progress in lanthanide ions doped *** summarize Yb,Eu or Er ions singly doping in detail,which was the most investigated species in *** lanthanide ions are also reviewed ***,we introduce lanthanide ions multi-doped IMHPs and at last we put forward several potential development *** the interests in lanthanide ions doped IMHPs rise,researchers have made some achievements in the *** though,there are more unexplored *** there are review articles focusing on metal ions doped IMHPs or lanthanide ions doped perovskites,this review aims to provide an overall introduction of lanthanide ions doped *** review may help researchers learn about lanthanide ions doped IMHPs and is to inspire researchers to make further promotion in this field.

关键词： Halide perovskite Lanthanide Doping Rare earths

Materials design and preparation of ultrathin two-dimensional metal halide perovskites

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Nano Research 2024年第7期17卷 6231-6246页

作者： Xiaomin zhang Sihan zhao Junran zhang Lin Wang School of Flexible Electronics(Future Technologies)and Institute of Advanced Materials Key Laboratory of Flexible ElectronicsJiangsu National Synergetic Innovation Center for Advanced MaterialsSchool of Physical and Mathematical SciencesNanjing Tech UniversityNanjing 211816China

Metal halide perovskites(MHPs)have emerged as highly promising candidates for the next generation of photonics and optoelectronic devices,owing to their prominent optical and excitonic properties,as well as the convenience of ***,ultrathin two-dimensional(2D)MHPs,which are generally prepared by exfoliation,solution growth,and chemical vapor deposition method,have attracted dramatically increasing attentions owing to their combined features of ultrathin 2D morphology and superior performance of *** the growing interest in ultrathin 2D MHPs,there is currently a lack of a comprehensive and systematic overview of the distinct advantages offered by each growth method for producing these *** review critically assesses the preliminary studies on the materials design and preparation of ultrathin ***,it explores heterostructures based on ultrathin MHPs and offers insights into the challenges and opportunities that lie ahead for this enticing class of 2D materials.

关键词： ultrathin perovskites material preparation exfoliation solution growth chemical vapor deposition