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Multimodal emotion recognition in the metaverse era:New needs and transformation in mental health work

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World Journal of Clinical Cases 2024年第34期12卷 6674-6678页

作者： Yan Zeng Jun-Wen zhang Jian Yang Department of Psychology The Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China Department of Gastroenterology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

This editorial comments on an article recently published by López del Hoyo et *** metaverse,hailed as"the successor to the mobile Internet",is undoubtedly one of the most fashionable terms in recent *** metaverse development is a complex and multifaceted evolutionary process influenced by many factors,it is almost certain that it will significantly impact our lives,including mental health *** any other technological advancements,the metaverse era presents a double-edged sword for mental health work,which must clearly understand the needs and transformations of its target *** this editorial,our primary focus is to contemplate potential new needs and transformation in mental health work during the metaverse era from the pers-pective of multimodal emotion recognition.

关键词： Multimodal emotion recognition Metaverse Needs Transformation Mental health

Mindfulness and mindful parenting:Strategies for preschoolers with behavioral issues

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World Journal of Clinical Cases 2024年第31期12卷 6447-6450页

The behavior issues of preschoolers are closely related to their parents'parenting *** editorial discusses the value and strategies for solving behavior issues in preschoolers from the perspectives of mindfulness and mindful *** expect that upcoming studies will place greater emphasis on the behavioral concerns of preschoolers and the parenting practices that shape them,particularly focusing on proactive interventions for preschoolers'behavioral issues.

关键词： Mindfulness Mindful parenting Preschoolers Behavioral issues Parenting strategies

Optimal traditional Chinese medicine formulas in treating ulcerative colitis:Choose one or take it all?

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World Journal of Clinical Cases 2024年第32期12卷 6570-6574页

Ulcerative colitis(UC)is a chronic inflammatory bowel disease that presents significant treatment challenges due to its complexity,especially in terms of the various side effects that traditional medications may bring during the chronic course of the *** Chinese medicine(TCM)has emerged as a promising complementary therapy for *** on the latest research,our editorial explored the current issues and potential essential research directions for TCM in treating *** anticipate that future high-quality research will pave the way for the optimization of TCM formulas for UC and their broader global application.

关键词： Traditional Chinese medicine Ulcerative colitis Inflammatory bowel disease Formula Treatment

Toosendanin: upgrade of an old agent in cancer treatment

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Chinese Journal of Natural Medicines 2024年第10期22卷 887-899页

作者： LI Shuwei XIONG Qingyi SHEN Yiwen LIN Jiayi zhang Lijun WU Ye JIN Jinmei LUAN Xin Shanghai Frontiers Science Center for Chinese Medicine Chemical Biology Institute of Interdisciplinary Integrative Medicine Research and Shuguang Hospital Shanghai University of Traditional Chinese Medicine

Toosendanin(TSN), a tetracyclic triterpenoid derived from Melia toosendan and M. azedarach, demonstrates broad application prospects in cancer treatment. Although previously employed as a pesticide, recent studies have revealed its potential therapeutic value in treating various types of cancer. TSN exerts an anticancer effect via mechanisms including proliferation inhibition, apoptosis induction, migration suppression, and angiogenesis inhibition. However, TSN's toxicity, particularly its hepatotoxicity, significantly limits its therapeutic application. This review explored the dual nature of TSN, evaluating both its anticancer potential and toxicological risks, emphasizing the importance of balancing these aspects in therapeutic applications. Furthermore, we investigated the incorporation of TSN into novel therapeutic strategies, such as Proteolysis-targeting chimeras(PROTAC) technology and nanotechnology-based drug delivery systems(DDS), which enhance treatment efficacy while mitigating toxicity in normal tissues.

关键词： Cancer therapy Hepatotoxicity Nano-delivery systems PROTAC Toosendanin

Heterocyclic Molecules Tethered Branched Polymers with Innate Immune Stimulating Activity

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CCS Chemistry 2024年第5期6卷 1278-1288页

作者： Jiayu Zhao Liping Liu Yibo Wang Zichao Huang Yu zhang Ruirui Qiao Thomas P.Davis Zhaohui Tang Wantong Song Xuesi Chen Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022 School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026 Laboratory of Chemical Biology Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022 Jilin Biomedical Polymers Engineering Laboratory Changchun 130022 Australian Institute of Bioengineering and Nanotechnology The University of QueenslandBrisbaneQueensland 4072

We report herein an interesting finding that heterocyclic molecules tethered branched polymers exhibit innate immune stimulating *** we conjugated a series of five-,six-,or seven-membered heterocyclic molecules to branched polyethylenimine(bPEI),over 70%of them could induce the secretion of interferon-β(IFN-β)from murine dendritic and human leukemia monocytic(DC2.4 and THP-1)cells through activating the stimulator of interferon genes(STING)*** further proved that this kind of innate stimulating activity was dependent on the macromolecular architecture as heterocyclic molecules tethered linear PEI(lPEI)or dendritic polyamidoamine(PAMAM)induced no or much less IFN-β***,we prepared a series of poly-L-lysine(PLL)-derivatives with different branches to tether with heterocyclic molecules and proved that this kind of bPEI-like structure was important in en hancing the binding affinity with STING proteins and for exhibiting innate stimulating activity.

关键词： bioactive materials polymers heterocycles branched structure immunity

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顺铂临床疗效和毒性相关基因多态性研究进展

中国医院药学杂志 2024年第18期44卷 2179-2185页

作者：张蝶钱凤丹张立超上海中医药大学附属上海市中医医院药学部上海200071

顺铂是临床上治疗乳腺癌、膀胱癌等实体瘤的常用化疗药物,但是随着DNA修复、解毒、排泄等过程的发生,顺铂及其代谢产物的疗效及毒副作用个体差异较大,越来越多证据支持基因多态性对顺铂疗效及毒副反应的预测作用。该文从核苷酸切除修复... 详细信息

顺铂是临床上治疗乳腺癌、膀胱癌等实体瘤的常用化疗药物,但是随着DNA修复、解毒、排泄等过程的发生,顺铂及其代谢产物的疗效及毒副作用个体差异较大,越来越多证据支持基因多态性对顺铂疗效及毒副反应的预测作用。该文从核苷酸切除修复途径、肝脏解毒及肾脏排泄过程的基因多态性进行综述,结合亚裔人群的突变概率,分析影响顺铂临床疗效及毒性相关的基因多态性,其中rs25487、rs11615、rs316019作为亚裔中突变率较高的单核苷酸多态性,在制定化疗方案前进行基因多态性检测,将有利于减少毒副作用,提高顺铂的临床疗效,为制定顺铂个体化给药提供借鉴意义。

关键词：基因多态性顺铂精准医学

Magnetotransport of Q1D Electrons Through Magnetic Barriers

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Journal of Materials Science & Technology 1999年第4期15卷 382-382页

作者： Zeng, zy zhang, LD Yan, XH Acad Sinica Inst Solid State Phys Hefei 230031 Peoples R China Xiangtian Univ Dept Phys Xiangtan 411105 Peoples R China

Ballistic transport of Q1D electrons through multiple magnetic barriers is investigated. It is shown that ballistic conductance peaks disappear progressively with the increase of the oscillation frequency of the confi... 详细信息

关键词： NANOSTRUCTURES TRANSPORT

硫酸锌胁迫对萌发青稞功能成分及抗氧化能力的影响

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食品与发酵工业 2024年第8期50卷 114-120,129页

作者：徐宁莉陶瑾张莉方张国强安徽工程大学生物与食品工程学院安徽芜湖241000

该研究以藏青2000为原料,采用酶联免疫吸附法等方法测定了不同浓度硫酸锌胁迫下萌发青稞的功能成分含量及抗氧化能力,同时记录其萌发率等指标。结果表明,硫酸锌胁迫对青稞的萌发率、水分含量、根长和芽长有抑制作用。随着时间的延长,在... 详细信息

该研究以藏青2000为原料,采用酶联免疫吸附法等方法测定了不同浓度硫酸锌胁迫下萌发青稞的功能成分含量及抗氧化能力,同时记录其萌发率等指标。结果表明,硫酸锌胁迫对青稞的萌发率、水分含量、根长和芽长有抑制作用。随着时间的延长,在不同浓度硫酸锌胁迫下,褪黑素、γ-氨基丁酸含量先增加后降低;还原糖、可溶性含量先上升后达到动态平衡;β-葡聚糖、总黄酮及总酚含量先降低后升高。其中,0.6 mmol/L硫酸锌胁迫萌发第7天时总酚含量是对照组的1.12倍;0.8 mmol/L硫酸锌胁迫萌发第6天时褪黑素与γ-氨基丁酸含量分别是对照组的1.35、1.40倍,第7天时总黄酮含量是对照组1.28倍。抗氧化能力结果显示,萌发青稞的抗氧化能力与其含有的总黄酮总酚含量显著正相关(P<0.01)。综上,萌发可改善青稞品质,0.6~0.8 mmol/L的硫酸锌胁迫可有效提高萌发青稞功能成分含量及抗氧化能力。

关键词：青稞萌发硫酸锌胁迫功能成分抗氧化能力

Theoretical analysis of the double-differential cross-sections of neutron,proton,deuteron,^(3)He,andαfor the p+^(6) Li reaction

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Nuclear Science and Techniques 2024年第3期35卷 181-197页

作者： Fang-Lei Zou Xiao-Jun Sun Jing-Shang zhang Hai-Rui Guo Yin-Lu Han Rui-Rui Xu Xi Tao Ji-Min Wang Xiao-Dong Sun Yuan Tian Tao Ye Yong-Li Xu Chun-Tian Liang College of Physics Guangxi Normal University541004 GuilinChina Guangxi Key Laboratory of Nuclear Physics and Nuclear Technology 541004 GuilinChina China Institute of Atomic Energy P.O.Box 275(41)102413 BeijingChina Institute of Applied Physics and Computational Mathematics 10094 BeijingChina College of Physics and Electronic Shanxi Datong University037009 DatongChina School of Science Tianjin Chengjian University300384 TianjinChina

Based on the unified Hauser–Feshbach and exciton model,which can describe the particle emission processes between discrete energy levels with energy,angular momentum,and parity conservations,a statistical theory of light nucleus reaction(STLN)is developed to calculate the double-differential cross-sections of the outgoing neutron and light charged particles for the proton-induced^(6) Li reaction.A significant difference is observed between the p+^(6) Li and p+^(7) Li reactions owing to the discrepancies in the energy-level structures of the *** reaction channels,including sequential and simultaneous emission processes,are analyzed in *** the double-differential cross-sections of the outgoing proton as an example,the influence of contaminations(such as^(1) H,^(7)Li,^(12)C,and^(16)O)on the target is identified in terms of the kinetic energy of the first emitted *** optical potential parameters of the proton are obtained by fitting the elastic scattering differential *** calculated total double-differential cross-sections of the outgoing proton and deuteron at E_(p)=14 MeV agree well with the experimental data for different outgoing ***,the mixed double differential cross-sections of^(3) He andαare in good agreement with the *** agreement between the measured data and calculated results indicates that the two-body and three-body breakup reactions need to be considered,and the pre-equilibrium reaction mechanism dominates the reaction *** on the STLN model,a PLUNF code for the p+^(6) Li reaction is developed to obtain an ENDF-6-formatted file of the double-differential cross-sections of the nucleon and light composite charged particles.

关键词： Statistical theory of light nucleus reaction p+^(6)Li reaction Light composite charged particle Double-differential cross-sections Two-body breakup Three-body breakup