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Effect of Dangfei Liganning capsule(当飞利肝宁胶囊) on liver X receptor α/steroid regulatory element binding protein-1/fatty acid synthase signal pathway in rats with metabolic-associated fatty liver disease

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Journal of Traditional Chinese Medicine 2022年第6期42卷 940-947页

作者： LI Xiaoling SUN Fengxia SHANG Zimeng zhang yingxue LI Jie zhang Qiuxiang Infections Department Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing 100010China Infections Department Beijing Hospital of Traditional Chinese Medicine Shunyi BranchBeijing 101300China

OBJECTIVE: To study the mechanism of Dangfei Liganning capsule(当飞利肝宁胶囊) in the treatment of rats with metabolic associated fatty liver disease(MAFLD). METHODS: Totally 48 specific pathogen free SpragueDawley male rats were randomly divided into normal Group, model group, Dangfei Liganning high, moderate, and low-dose groups and Essentiale group which were fed with high fat diet for 8 weeks, and gavage and molding were carried out simultaneously. Dangfei Liganning high, middle and low-dose group were given 0.27, 0.135 and 0.0675 g·kg-1·d-1 respectively by gavage, Essentiale group was given 0.123 g·kg-1·d-1 by gavage, the same amount of distilled water was given by gavage in the normal group and the model group. The rats were weighed at the 0th week, 2nd week, 4th week, 6th week and 8th weekend respectively. The rats were sacrificed at the end of the 8th week. Serum levels of alanine aminotransferase(ALT), alanine aminotransferase(AST),triglyceride(TG), total cholesterol(CHO), high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein (LDL-C), total protein(TP), albumin(Alb), globulin(GLB), total bilirubin(TBIL), direct bilirubin(DBIL), tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) were measured. The levels of liver tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) and liver pathology [hematoxylin and eosin(HE) staining, oil red O staining] were detected. The expression levels of liver X receptor α(LXRα), steroid regulatory element binding protein-1(SREBP-1) and fatty acid synthase(FAS) were detected by immunohistochemistry, Western blot and reverse transcription-polymerase chain reaction reverse transcription-polymerase chain reaction. RESULTS: From the beginning to the 8th week, the growth rate of body weight in the Dangfei Liganning highdose group was slower than all other groups. There was no significant difference in ALB level in all groups(P > 0.05). Compared with the model group, the levels of ALT, AST, LDL-C, TG, CHO, TP, GLB, TBIL, DBIL,

关键词： metabolic associated fatty liver disease liver X receptors steroid regulatory element binding protein-1 fatty acid synthases signal transduction Dangfei Liganning capsule

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种族·文化·伦理——从世界主义视角看拉维尔斯坦的人性复归

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外国文学研究 2020年第5期42卷 124-134页

作者：张英雪厦门大学外文学院

奎迈·安东尼·阿皮亚主张将有根的世界主义、多元文化的世界主义和普遍伦理的世界主义统一到对个体“种族身份”、“文化身份”和“伦理身份”三种具体身份的关注之中,而具体身份之下的个体关怀是“人性”得以复归的前提。面对自我与... 详细信息

奎迈·安东尼·阿皮亚主张将有根的世界主义、多元文化的世界主义和普遍伦理的世界主义统一到对个体“种族身份”、“文化身份”和“伦理身份”三种具体身份的关注之中,而具体身份之下的个体关怀是“人性”得以复归的前提。面对自我与世界的关系,以索尔·贝娄为代表的族裔作家提倡个体在回归种族身份的基础上追求文化身份的多重性,并在多样性世界中进行伦理身份的选择。在《拉维尔斯坦》中,主人公拉维尔斯坦不仅回归自己的犹太种族身份,还继承了犹太民族的传统。同时,拉维尔斯坦尊重文化的差异性,在多元文化的美国社会重塑文化身份。拉维尔斯坦将世界主义伦理作为维系人际关系的准则,从对他人伦理职责的实践中探索抵抗精神异化的途径,最终实现了由“兽性因子”向“人性因子”的转变。通过《拉维尔斯坦》主要人物种族身份的回归、文化身份的重塑以及伦理身份的构建,贝娄重新审视人性问题,以一位世界主义作家的责任感和使命感探求个体生存意义,为和谐的人文世界的发展提供了有益借鉴。

关键词：索尔·贝娄《拉维尔斯坦》种族身份文化身份伦理身份

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Autophagy receptor ZmNBR1 promotes the autophagic degradation of ZmBRI1a and enhances drought tolerance in maize

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Journal of Integrative Plant Biology 2024年第6期66卷 1068-1086页

作者： Yang Xiang Guangdong Li Qian Li yingxue Niu Yitian Pan Yuan Cheng Xiangli Bian Chongyang Zhao Yuanhong Wang Aying zhang College of Life Sciences Nanjing Agricultural UniversityNanjing210095 China State Key Laboratory of Crop Genetics&Germplasm Enhancement and Utilization Nanjing Agricultural UniversityNanjing210095 China Sanya Institute of Nanjing Agricultural University Nanjing Agricultural UniversitySanya572025 China

Drought stress is a crucial environmental factor that limits plant growth,development,and *** of misfolded proteins can help alleviate the damage caused in plants experiencing ***,the mechanism of autophagy-mediated drought tolerance in plants remains largely ***,we cloned the gene for a maize(Zea mays)selective autophagy receptor,NEXT TO BRCA1GENE 1(ZmNBR1),and identified its role in the response to drought *** observed that drought stress increased the accumulation of *** sequencing and reverse transcriptionquantitative polymerase chain reaction showed that ZmNBR1 is markedly induced by drought ***1 overexpression enhanced drought tolerance,while its knockdown reduced drought tolerance in *** results established that ZmNBR1 mediates the increase in autophagosomes and autophagic activity under drought ***1 also affects the expression of genes related to autophagy under drought ***,we determined that BRASSINOSTEROID INSENSITIVE1A(ZmBRI1a),a brassinosteroid receptor of the BRI1-like family,interacts with *** analysis showed that ZmBRI1a negatively regulates drought tolerance in maize,and genetic analysis indicated that ZmNBR1 acts upstream of ZmBRI1a in regulating drought ***,ZmNBR1facilitates the autophagic degradation of ZmBRI1a under drought *** together,our results reveal that ZmNBR1 regulates the expression of autophagy-related genes,thereby increasing autophagic activity and promoting the autophagic degradation of ZmBRI1a under drought stress,thus enhancing drought tolerance in *** findings provide new insights into the autophagy degradation of brassinosteroid signaling components by the autophagy receptor NBR1 under drought stress.

关键词： autophagy receptor drought tolerance Zea mays ZmBRI1a ZmNBR1

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The RING zinc finger protein LbRZF1 promotes salt gland development and salt tolerance in Limonium bicolor

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Journal of Integrative Plant Biology 2024年第4期66卷 787-809页

作者： Zongran Yang Ziwei zhang Ziqi Qiao Xueying Guo Yixuan Wen yingxue Zhou Chunliang Yao Hai Fan Baoshan Wang Guoliang Han Shandong Provincial Key Laboratory of Plant Stress College of Life SciencesShandong Normal UniversityJi'nan 250014China National Center of Technology Innovation for Comprehensive Utilization of Saline-Alkali Land Agricultural High-tech Industrial Demonstration Area of the Yellow River Delta of Shandong ProvinceDongying 257000China Dongying Institute Shandong Normal UniversityDongying 257000China

The recretohalophyte Limonium bicolor thrives in high-salinity environments because salt glands on the above-ground parts of the plant help to expel excess ***,we characterize a nucleus-localized C3HC4(RING-HC)-type zinc finger protein of *** named RING ZINC FINGER PROTEIN 1(LbRZF1).LbRZF1 was expressed in salt glands and in response to NaCl ***1 showed no E3 ubiquitin ligase *** phenotypes of overexpression and knockout lines for LbRZF1 indicated that LbRZF1 positively regulated salt gland development and salt tolerance in ***1 mutants had fewer salt glands and secreted less salt than did the wild-type,whereas LbRZF1-overexpressing lines had opposite phenotypes,in keeping with the overall salt tolerance of these plants.A yeast two-hybrid screen revealed that LbRZF1 interacted with LbCATALASE2(LbCAT2)and the transcription factor LbMYB113,leading to their *** of LbCAT2 or LbMYB113 decreased salt gland density and salt *** heterologous expression of LbRZF1 in Arabidopsis thaliana conferred salt tolerance to this *** also identified the transcription factor LbMYB48 as an upstream regulator of LbRZF1 *** study of LbRZF1 in the regulation network of salt gland development also provides a good foundation for transforming crops and improving their salt resistance.

关键词： LbRZF1 Limonium bicolor molecular mechanism salt gland development salt tolerance

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框架结构剪切刚度的实用计算方法

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世界地震工程 2015年第1期31卷 27-37页

作者：裴星洙张映雪江苏科技大学土木工程与建筑学院江苏镇江212003 上海凯德数值信息科技有限公司上海200335

以6、8、12层平面钢筋混凝土框架结构作为算例模型,首先介绍了从层间水平总位移中减掉弯曲位移以得到剪切位移、并利用此位移来确定真实剪切刚度的计算方法;其次,提出了利用D值法理论刚度调整值和本文推导的刚度比与层数比的拟合曲线,... 详细信息

以6、8、12层平面钢筋混凝土框架结构作为算例模型,首先介绍了从层间水平总位移中减掉弯曲位移以得到剪切位移、并利用此位移来确定真实剪切刚度的计算方法;其次,提出了利用D值法理论刚度调整值和本文推导的刚度比与层数比的拟合曲线,来确定真实剪切弹性刚度实用值的方法和恢复力模型相关参数的方法。最后通过一个10层结构的例子进行了地震反应弹塑性时程分析,验证了真实剪切刚度实用计算方法的合理性和恢复力模型相关参数的可靠性。结果表明,所提的框架结构剪切弹性刚度实用值计算方法和各层恢复力模型参数的确定方法简单易懂,精度高,在确定剪切刚度环节中,可以替代繁琐复杂的推覆分析。

关键词：框架结构弯曲变形剪切刚度 D值法刚度比与层数比拟合曲线

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Effect of Poly-β-hydroxybutyrate on Reproductive Performance and Larval Development of Fenneropenaeus chinensis

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Animal Husbandry and Feed Science 2018年第3期10卷 145-150页

作者： zhang Hengheng Meng Xianhong Kong Jie Luo Kun Luan Sheng Cao Baoxiang Cao Jiawang zhang yingxue Key Laboratory of Sustainable Development of Marine Fisheries Ministry of Agriculture Yellow Sea Fisheries Research Institute Chinese Academy of Fishery Sciences Laboratory for Marine Fisheries Science and Food Production Processes Qingdao National Laboratory for Marine Science and Technology College of Fisheries and Life Science Dalian Ocean University

In the present study, Fenneropenaeus chinensis individuals were assigned into six groups, and fed with a diet supplemented with 0 （Control）, 0.5% （Group Eos）, 1.0% （Group E1.0）, 2.0% （Group E2.0）, 3.0% （Group E3.0） or 5.0% （Group E5.0） of poly-13-hydroxybutyrate （PHB） during their growth and spawning periods, to explore the effect of PHB on the reproductive performance of parents and the development of larvae. The experi- ment was lasted for 192 d to measure the mortality rate, relative percentage of survival（RPS）, weight gain rate（WGR）, specific growth rate （SGR） and cycle of gonadal development of parental shrimps, number of eggs, number of nauplii, stages of larval development and metamorphosis. The results indicated that PHB had an obvious effect on the fecundity of parental shrimps and growth performance of larva. Compared with control group, the mortality rate of broodstock in experimental groups decreased initially and increased subsequently with the increase of PHB concentration, while RPS showed an opposite pattern. The mortality rate of group E2.0 was the lowest among all groups, showing significant difference from that of other groups（P 〈 0.05） except group E1.0 （P 〉 0.05）. WGR of all experimental groups was higher than that of the control group, among which, group E2.0 and group E5.0 had significantly higher WGR than the control （P〈0.05）. However, there was no significant difference in the cycle of gonadal development between the experimental groups and the control group （P 〉 0.05）. The numbers of eggs and nauplii in the experimental groups were higher than those of the control group. And the numbers of eggs and nauplii in group E2.0 were significantly higher than those of the control （P 〈 0.05）, bud showed no significant difference from those of other groups （P 〉 0.05）. However, there was no significant difference in the duration of larval development and metamorphosis among all the groups. In summary, PHB is capable of improving the reproductive perfor

关键词： Fenneropenaeus chinensis Poly-β-hydroxybutyrate Mortality rate Reproductive performance Metamorphosis

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Effect of Poly-β-Hydroxybutyrate on the Activity of Nonspecific Immunity Related Enzymes in Fenne rope naeus chinensis

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Animal Husbandry and Feed Science 2018年第1期10卷 18-23,74页

作者： zhang Hengheng Meng Xianhong Kong Jie Luo Kun Luan Sheng Cao Baoxiang Cao Jiawang zhang yingxue Key Laboratory of Sustainable Development of Marine Fisheries Ministry of Agriculture Yellow Sea Fisheries Research Institute Chinese Academy of Fishery SciencesQingdao 266071China Laboratory for Marine Fisheries Science and Food Production Processes Qingdao National Laboratory for Marine Science and TechnologyQingdao 266071China College of Fisheries and Life Science Dalian Ocean University Dalian 116023 China

[Objective] This study was carried out to explore the effect of poly-β-hydroxybutyrate（PHB） on the performance of the nonspecific immune system in Fenneropenaeus chinensis. [Method] F. chinensis individuals were assigned into six groups, and each group was fed with a diet containing 0（Control）, 0.5%（Group E0.5）, 1.0%（Group E1.0）, 2.5%（Group E2.5）, 5.0%（Group E5.0） or 10.0% PHB（Group E10.0）. The mortality rate and relative percent of survival（RPS） of each group were calculated after 6 weeks. Meanwhile, the total antioxidant capacity（T-AOC）, the activity of acid phosphatase（ACP）, peroxidase（POD） and catalase（CAT）, and the content of malondialdehyde（MDA） in hepatopancreas and serum were measured,and their correlation with PHB concentration was analyzed. [Result] The RPS in PHB treated shrimps increased initially and decreased subsequently with increasing PHB concentration. RPS of Group E1.0 was the highest, showing significant difference from that of other groups（ P 〈0.05）.With the increase in PHB concentration, the activity of immunity related enzymes changed in a similar pattern with RPS： increasing at first and decreasing subsequently. In addition, the activity of the enzymes was elevated in the 2nd and 3rd weeks of PHB administration. Among them, T-AOC in serum of groups E1.0 and E2.5, T-AOC in hepatopancreas of Group E1.0, ACP activity in serum of groups E1.0 and E2.5, ACP activity in hepatopancreas of Group E1.0, CAT activity in groups E0.5, E1.0 and E2.5, CAT activity in hepatopancreas of groups E0.5, E1.0 and E10.0, POD activity in both serum and hepatopancreas of groups E0.5, E1.0 and E2.5, SOD activity in both serum and hepatopancreas of Group E1.0, MDA content in serum of Group E1.0 and MDA content in hepatopancreas of groups E0.5 and E1.0 showed significant difference from those of other groups（P〈0.05）. [Conclusion] PHB can improve the immunity of F. chinensis, 1.0% in feed has the best effect, and the total enzyme activity reaches the highest level in the

关键词： Fenneropenueus chinensis poly-β-hydroxybutyrate (PHIl): Relative percent of survival Enzyme activity

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Modulation of vagal activity to atria electrical remodeling resulted from rapid atrial pacing

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Journal of Geriatric Cardiology 2008年第3期5卷 159-163页

作者： Shulong zhang yingxue Dong Lianjun Gao Donghui Yang Chunyue Zhao Hongwei Zhao Xiaomeng Yin Jinqiu Liu Zhihu Lin Yanzong Yang Department of Cardiology, The First Affiliated Hospital, Dalian Medical University, Dalian 116011, China Department of Cardiology First Affiliated Hospital Dalian Medical University Dalian 116011 China

Background Atrial electrical remodeling(AER) plays an important role in the pathogenesis and maintenance of atrial ***,little is known about modulation of vagal activity to *** study aimed to investigate the relationship between vagal moduation and *** Twenty four adult mongrel dogs under general anesthesia were randomized into 3 *** activity was blocked by administration of metoprolol in 3 *** changes in vagal modulation to atria after AER were observed in 10 dogs without vagal interruption in group *** effects ofvagal intervention on AER were investigated in 8 dogs with administration of atropine in group *** impact of aggressively vagal activity on AER was studied in 6 dogs with bilateral cervical vag sympathetic trunks stimulation during AER in group *** cervical vagosympathetic trunks were decentralized. Multipolar catheters were placed into high right atria (RA),coronary sinus (CS) and right ventricle (RV).AER was induced by 600 bpm pacing through RA catheter for 30 *** effective refractory period (ERP) and vulnerability window (VW) of atrial fibrillation were measured with and without vagal stimulation before and after *** In group A,ERP decreased significantly at baseline and during vagal stimulation after AER compared with that before AER (all P0.05).In group C,ERP shortened significantly at baseline and vagal stimulation after AER compared with that before AER (all P<0.05).ERP shortening after AER in Groups A and C increased significantly than that in group B (all P<0.05).Atrial fibrillation could not be induced at baseline (VW close to 0) before and after AER in three *** became widen significantly during vagal stimulation after AER compared with that before AER in Groups A and C (all P<0.05),while VW remained unchanged in group B (V

关键词： atrial fibrillation vagus atrial electrical remodeling

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高效液相色谱化学发光检测人体血清及尿样中的盐酸肾上腺素

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分析化学 2005年第12期33卷 1771-1774页

作者：陈福南张迎雪章竹君何德勇西南师范大学分析科学研究所琼州大学

研究发现,盐酸肾上腺素在碱性条件下能显著增强铁氰化钾-鲁米诺化学发光强度。基于此建立了新的测定肾上腺素的方法。本方法以C18反相键合相为色谱柱,用0.01 mol/L邻苯二甲酸氢钾-甲醇（92∶8,V/V）为流动相,实现了对人体血清及尿样中... 详细信息

研究发现,盐酸肾上腺素在碱性条件下能显著增强铁氰化钾-鲁米诺化学发光强度。基于此建立了新的测定肾上腺素的方法。本方法以C18反相键合相为色谱柱,用0.01 mol/L邻苯二甲酸氢钾-甲醇（92∶8,V/V）为流动相,实现了对人体血清及尿样中盐酸肾上腺素的分离与测定。在最适宜条件下,方法的线性范围为10;000μg/L;检出限为4.0×10-6g/L;相对标准偏差为3.0%（n=11）。

关键词：高效液相色谱化学发光人体血清尿样盐酸肾上腺素

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高层钢框架结构抗震设计最佳刚度分布研究

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建筑科学 2014年第3期30卷 22-28页

作者：张映雪裴星洙江苏科技大学土木工程与建筑学院江苏镇江212003

通过对5种不同刚度分布的18层多质点系模型及其消能减震结构模型进行弹塑性时程分析,从地震响应和能量耗散的角度,讨论它们的抗震性能,并得出侧移刚度为Ai分布时最佳。建立18层空间钢框架计算模型,利用推覆分析法使楼层侧移刚度大致满... 详细信息

通过对5种不同刚度分布的18层多质点系模型及其消能减震结构模型进行弹塑性时程分析,从地震响应和能量耗散的角度,讨论它们的抗震性能,并得出侧移刚度为Ai分布时最佳。建立18层空间钢框架计算模型,利用推覆分析法使楼层侧移刚度大致满足Ai刚度分布,得出结构层数比与梁柱线刚度的分布规律。对该算例模型及其相应的多质点系模型进行地震响应时程分析,并与理想Ai刚度分布多质点系模型的地震响应值对比,研究表明实际结构中刚度为Ai分布是有效可行的。

关键词：多质点系模型能量耗散最佳刚度分布设计方法

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