检索结果-南通市图书馆

Efficacy and Safety of Chinese Herbal Medicines Combined with Chemical Drugs for Alzheimer's Disease:A Systematic Review and Meta-Analysis

引用

World Journal of Traditional Chinese Medicine 2024年第1期10卷 1-13页

作者： Li Xu Wen-Jun Chen cai-Jun Tian Yan zhang Yan Ma Tian-Hao Li Hong-jie liu Zhe zhang Department of the First College English College of Foreign LanguageShandong University of Traditional Chinese MedicineJinanChina Department of Oncology Linyi People's HospitalLinyiChina Department of Internal Medicine of Traditional Chinese Medicine The First Clinical CollegeShandong University of Traditional Chinese MedicineJinanChina Department of Chinese Materia Medica College of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineJinanChina Department of Medicinal Chemistry College of PharmacyShandong University of Traditional Chinese MedicineJinanChina Community Healthcare Center Shenzhen Traditional Chinese Medicine HospitalShenzhenChina Department of Fundamentals of Traditional Chinese Medicine School of Traditional Chinese MedicineJinan UniversityGuangzhouChina Shandong Co-Innovation Center of Classic TCM Formula College of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineJinanChina

Objective:To evaluate the efficacy and safety of Chinese herbal medicines(CHMs)combined with chemical drugs for the treatment of Alzheimer's disease(AD).Materials and Methods:Databases were searched to retrieve randomized controlled trials(RCTs)of CHMs combined with tacrine,galantamine,rivastigmine,donepezil,or memantine,following strict inclusion and exclusion *** research papers published in English,Chinese,and Japanese were *** primary outcome was the mini-mental state examination(MMSE)score and the secondary outcomes were AD assessment scale cognitive subscale(ADAS-Cog)score and safety ***-analysis was carried out using Rev Man 5.3 and subgroup analysis was conducted to identify the sources of ***:A total of 15 RCTs with 1386 participants were included in this *** donepezil was used in the retrieved ***-analyses showed that the combination of CHMs with donepezil led to significant improvement in the MMSE score(Z=9.45;P<0.00001;weighted mean difference[WMD]=2.68,95%confidence interval[CI]:2.12-3.24)and a significant decrease in the ADAS-Cog score(Z=5.53;P<0.00001;WMD=-3.79;95%CI:-5.13--2.44).Safety evaluation demonstrated that these combination treatments relieved adverse events such as insomnia(risk ratio[RR]=0.20,95%CI:0.06-0.68;P=0.01)and hive(RR=0.10;95%CI:0.01-0.73;P=0.02).Conclusions:The combination of CHMs with a chemical drug like donepezil led to significant improvements in patient cognition as well as a better safety profile when compared to the application of a chemical drug alone.

关键词： Alzheimer's disease Chinese herbal medicine donepezil memantine meta-analysis randomized controlled trials rivastigmine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A novel septenary high-entropy(oxy)hydroxide electrocatalyst for boosted oxygen evolution reaction

引用

Journal of Materiomics 2024年第2期10卷 348-354页

作者： Lingjie zhang Fangshi Fan Xiaomin Song Weiwei cai jie Ren Hui Yang Ningzhong Bao State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhouZhejiang310027China State Key Laboratory of Material-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjingJiangsu210009China

High-entropy materials(HEMs)have attracted extensive attention in the field of electrochemical catal-ysis due to their unique ***,the preparation of high-entropy catalysts typically relies on high-temperature,energy-intensive,and time-consuming synthesis methods due to their compositional *** this study,a facile low-temperature electrochemical reconstruction approach is adopted to synthesize Ag-decorated septenary Co-Cu-Fe-Mo-Zn-Ag-Ru high-entropy(oxy)hydroxide electro-catalysts for oxygen evolution reaction(OER).By introducing Ag and Ru elements and implanting Ag nanoparticles to co-regulate the electronic structure of the catalysts,the as-prepared catalyst achieves remarkable OER performance with a low overpotential of 298 mV at 100 mA/cm^(2)and a small Tafel slope of 30.1 mV/dec in 1 mol/L *** work offers a valuable strategy for developing high-performance high-entropy OER electrocatalysts.

关键词： High-entropy materials Septenary metallic(oxy)hydroxide Oxygen evolution reaction Electrochemical reconstruction Oxygen vacancy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dammarane-type triterpenoids from Gynostemma longipes and their protective activities on hypoxia-induced injury in PC12 cells

引用

Chinese Journal of Natural Medicines 2024年第5期22卷 466-480页

作者： LIANG Haizhen CHEN Xiaojuan LI Qi zhang Mengmeng LU Pengxin zhang jie SONG Juan zhang tao GUO Baolin MA Baiping Department of Pharmaceutical Sciences Beijing Institute of Radiation MedicineBeijing 100850China Institute of Medicinal Plant Development Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China AnKang Chia Tai Pharmaceutical Co. Ltd.Shaanxi 725000China

Sixteen new dammarane-type triterpenoid saponins(1-16)featuring diverse structural variations in the side chain at C-17,along with twenty-one known analogues(17-37),have been isolated from the rhizomes of Gynostemma longipes ***,a plant renowned for its medicinal and edible *** structural elucidation of these compounds was accomplished through comprehensive analyses of 1D and 2D NMR and HRMS spectroscopic data,supplemented by comparison with previously reported *** assays on the isolates for their protective effects against hypoxia-induced damage in pheochromocytoma cells(PC12 cells)revealed that nine saponins exhibited significant anti-hypoxic *** investigation into the anti-hypoxia mechanisms of the representative saponins demonstrated that compounds 22 and 36 markedly reduced the levels of hypoxia-induced ***,these compounds were found to decrease the release of lactate dehydrogenase(LDH)and malondialdehyde(MDA),while increasing the activity of superoxide dismutase(SOD),thereby indicating that the saponins could mitigate hypoxia-induced injuries by ameliorating apoptosis and oxidative *** findings offer substantial evidence for the future utilization and development of ***,identifying dammarane-type triterpenoid saponins as its active anti-hypoxic constituents.

关键词： Gynostemma longipes Dammarane-type saponins Anti-hypoxia effect Apoptosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

High-current pulsed electron beam modification on microstructure and performance of Cu/CuW diffusion bonding joints

引用

Rare Metals 2024年第6期43卷 2819-2831页

作者： Na-Na Tian Cong-Lin zhang Peng Lyu Jin-Tong Guan jie cai Qing-Feng Guan Shun Guo School of Materials Science and Engineering Jiangsu UniversityZhenjiang 212013China School of Material Science and Engineering Yancheng Institute of TechnologyYancheng 221051China Engineering Institute of Advanced Manufacturing and Modern Equipment Technology Jiangsu UniversityZhenjiang 212013China

This study investigates the influence of high-current pulsed electron beam(HCPEB)modification on the microstructure and shear strength of Cu/CuW *** solid-state diffusion bonding of modified-Cu(MCu)and modified-CuW(M-CuW)was achieved by HCPEB modification pretreatment at a temperature of 800-900℃and a pressure of 5 MPa for 10-50 *** demonstrate that HCPEB modification facilitates the dissolution of W and Cu,resulting in the formation of a Cu_(0.4)W_(0.6)solid solution and thus enhancing the uniform distribution of ***,HCPEB-induced defects play a beneficial role in promoting the diffusion process by providing fast diffusion paths for *** optimal joints with the maximum shear strength of 213.7 MPa were obtained through bonding M-Cu and M-CuW at 900℃and 5 MPa for 30 min,which attributes to the combined effects of fine-grained strengthening and solid solution ***,the application of HCPEB modification showcases its effectiveness in promoting element diffusion and enhancing the mechanical performance of the joints.

关键词： HCPEB Element diffusion Shear strength Crystal defects Surface modification

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Performance-control-orientated hybrid metal additive manufacturing technologies:state of the art,challenges,and future trends

引用

International Journal of Extreme Manufacturing 2024年第3期6卷 274-328页

作者： Jiming Lv Yuchen Liang Xiang Xu Gang Xu Hongmei zhang Haifei Lu Kaiyu Luo jie cai Jinzhong Lu School of Mechanical Engineering Jiangsu UniversityZhenjiang 212013People’s Republic of China School of Mechanical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003People’s Republic of China

Metal additive manufacturing(AM)technologies have made significant progress in the basic theoretical field since their invention in the ***,performance instability during continuous processing,such as thermal history,residual stress accumulation,and columnar grain epitaxial growth,consistently hinders their broad application in standardized industrial *** overcome these challenges,performance-control-oriented hybrid AM(HAM)technologies have been *** technologies,by leveraging external auxiliary processes,aim to regulate microstructural evolution and mechanical properties during metal *** paper provides a systematic and detailed review of performance-control-oriented HAM technology,which is categorized into two main groups:energy field-assisted AM(EFed AM,***,electromagnetic,and heat)technologies and interlayer plastic deformation-assisted AM(IPDed AM,*** shock peening,rolling,ultrasonic peening,and friction stir process)*** review covers the influence of external energy fields on the melting,flow,and solidification behavior of materials,and the regulatory effects of interlayer plastic deformation on grain refinement,nucleation,and ***,the role of performance-control-oriented HAM technologies in managing residual stress conversion,metallurgical defect closure,mechanical property improvement,and anisotropy regulation is thoroughly reviewed and *** review concludes with an analysis of future development trends in EFed AM and IPDed AM technologies.

关键词： hybrid additive manufacturing in-situ/interlayer plastic deformation auxiliary energy fields microstructure customization mechanical properties enhancement

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Joint Design of ISAC Waveform Under PAPR Constraints

引用

China Communications 2024年第7期21卷 186-211页

作者： Chen Yating Wen cai Huang Yan Liang Le Li jie zhang Hui Hong Wei State Key Lab of Millimeter Waves Southeast UniversityNanjing 211100China School of Information Science and Technology Northwest UniversityXi’an 710127China National Mobile Communications Research Laboratory Nanjing 211100China College of Electronic and Information Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211100China

In this paper,we formulate the precoding problem of integrated sensing and communication(ISAC)waveform as a non-convex quadratically constrained quadratic programming(QCQP),in which the weighted sum of communication multi-user interference(MUI)and the gap between dual-use waveform and ideal radar waveform is minimized with peak-toaverage power ratio(PAPR)*** propose an efficient algorithm based on alternating direction method of multipliers(ADMM),which is able to decouple multiple variables and provide a closed-form solution for each *** addition,to improve the sensing performance in both spatial and temporal domains,we propose a new criteria to design the ideal radar waveform,in which the beam pattern is made similar to the ideal one and the integrated sidelobe level of the ambiguity function in each target direction is minimized in the region of *** limited memory Broyden-Fletcher-Goldfarb-Shanno(LBFGS)algorithm is applied to the design of the ideal radar waveform which works as a reference in the design of the dual-function *** results indicate that the designed dual-function waveform is capable of offering good communication quality of service(QoS)and sensing performance.

关键词： ambiguity function integrated sensing and communication MIMO OFDM PAPR waveform design

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

High-performance piezoresistive sensors based on transfer-free large-area PdSe_(2) films for human motion and health care monitoring

引用

InfoMat 2024年第1期6卷 139-149页

作者： Rui zhang jie Lin tao He Jiafang Wu Zhuojun Yang Liwen liu Shaofeng Wen Yimin Gong Haifeng Lv Jing zhang Yi Yin Fangjia Li Changyong Lan Chun Li State Key Laboratory of Electronic Thin Films and Integrated Devices School of Optoelectronic Science and EngineeringUniversity of Electronic Science and Technology of ChinaChengduthe People's Republic of China School of Physics University of Electronic Science and Technology of ChinaChengduthe People's Republic of China Sichuan Academy of Medical Sciences and Sichuan People's Hospital Chengduthe People's Republic of China School of Medicine University of Electronic Science and Technology of ChinaChengduthe People's Republic of China

Two-dimensional transition metal dichalcogenides(TMDs)are needed in highperformance piezoresistive sensors due to their strong strain-induced bandgap modification and thereby large gauge ***,integrating a conventional high-temperature chemical vapor deposition(CVD)-grown TMD with a flexible substrate necessitates a transfer process that inevitably degrades the sensing properties of the TMDs and increases the overall fabrication *** present a high-performance piezoresistive strain sensor that employs largearea PdSe_(2) films grown directly on polyimide(PI)substrates via plasma-assisted selenization of a sputtered Pd *** reliable strain transfer from the substrate to the PdSe_(2) film ensures an outstanding strain-sensing capability of the ***,the sensors have a gauge factor of up to315±2.1,a response time under 25 ms,a detection limit of 8×10^(-6),and an exceptional stability of over 104 loadingunloading *** attaching the sensors to the skin surface,we demonstrate their application for measuring physiological parameters in health care monitoring,including motion,voice,and arterial pulse ***,using the PdSe_(2) film sensor combined with deep learning technology,we achieved intelligent recognition of artery temperature from arterial pulse signals with only a 2%difference between predicted and actual *** excellent sensing performance,together with the advantages of low-temperature fabrication and simple device structure,make the PdSe_(2) film sensor promising for wearable electronics and health care sensing systems.

关键词： layered crystal PdSe_(2) piezoresistive effect strain sensor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Elaborate Design of Two Novel Fluorescent Zinc-based Metal-Organic Frameworks for Highly Efficient Tetracycline Antibiotics Detection

引用

Chemical Research in Chinese Universities 2024年第3期40卷 499-507页

作者： tao He JI Chengshan zhang Jian YIN Yuanyuan JIA Wenwen JIANG Xin XU jie YANG Yulin MIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001P.R.China

The abuse of tetracycline antibiotics has caused great harm to human health and *** inexpensive,convenient and sensitive methods for the detection of tetracycline antibiotics is highly ***,based on the H_(4)ddp ligand[H_(4)ddp=3-(3,5-dicarboxyphenyl)pyridine-2,6-dicarboxylic acid],two novel zinc-based metal-organic frameworks(MOFs){[Zn_(3)(ddp)_(2)(H_(2)O)_(4)]·3H_(2)O}n(Zn1-ddp)and{[Zn_(3)(ddp)_(2)(H_(2)O)_(4)]·3H_(2)O}n(Zn2-ddp)were successfully designed by delicate structural *** Zn1-ddp and Zn2-ddp exhibited excellent water and chemical stability and showed excellent fluorescence quenching performance for tetracycline ***,the more advanced framework structure and better fluorescent performance make Zn1-ddp more sensitive than Zn2-ddp in fluorescent detection with a detection limit of 0.29µmol/L for tetracycline(TC),0.09µmol/L for doxycycline(DOX),0.10µmol/L for minocycline(MIN)and metacycline(MEL),0.19µmol/L for chlortetracycline(CTC),and 0.67µmol/L for oxytetracycline(OTC)among tetracycline *** fluorescence quenching mechanism of Zn1-ddp and Zn2-ddp for tetracycline antibiotics detection was deeply *** reasons for the superior detection performance of Zn1-ddp over Zn2-ddp were also analyzed in depth through Fourier transform infrared spectrophotometry(FTIR),X-ray photoelectron spectroscopy(XPS)analysis and framework structure *** developed method opens up a new perspective for antibiotics detection based on zinc-based MOFs.

关键词： Water system Metal-organic framework Fluorescent detection Tetracycline antibiotic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Identification and Analysis of the WRKY Transcription Factor Gene Family in Verbena bonariensis

引用

Phyton-International Journal of Experimental Botany 2024年第8期93卷 1875-1896页

作者： Dandan Yuan Ju cai tao zhang Sisi Wang Xiuliu Yang Yan Li The Key Laboratory of Plant Resources Conservation and Germplasm Innovation in Mountainous Region(Ministry of Education) Guizhou UniversityGuiyang550025China

The WRKY transcription factor gene family is one of the unique gene families in *** plays an important role in response to abiotic stresses such as cold and drought,hormone signal transduction,regulation of biosynthesis,leaf senescence seed germination,***,little information is available about WRKY transcription factors in Verbena *** this study,70 VbWRKY genes were identified from the whole *** phylogenetic analysis of the WRKY gene family in *** and Arabidopsis shows that the WRKY genes in *** can be divided into three groups:I,II,and III,which contain 13,47,and 10 members,*** II can be further divided into five subclasses:IIa(5),IIb(10),IIc(18),IId(6),and IIe(8).Conservative motif analysis showed that 64 proteins encoded by the VbWRKY gene had conserved motifs 1,2 and 3,and the same subclass motif elements were approximately the *** collinearity analysis showed that there were 44 homologous gene pairs among the VbWRKYs,and these homologous gene pairs may have the same *** sequence analysis showed that the VbWRKY gene has multiple cis-acting elements,including not only cis-acting elements related to low-temperature and light responses,but also cis-acting elements related to hormone regulation,Among them,most VbWRKY genes contain response elements about low-temperature,and 30 VbWRKY genes contain low-temperature response elements(LTR),and 61 VbWRKY genes contain abscisic acid response elements(ABRE),indicating that VbWRKY plays a crucial role in plant growth and abiotic *** to the expression of VbWRKY in the cold stress and different tissues transcriptome,70 VbWRKY genes played their respective roles in various tissues and stages to regulate plant growth,Also,some of them participated in the process of cold stress tolerance,52 VbWRKYs showed significant differences in expression under cold stress,and 37 VbWRKY genes were up-regulated under cold stress.9 VbWRKY genes w

关键词： Verbena bonariensis WRKY gene family cold resistance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ruxolitinib improves the inflammatory microenvironment,restores glutamate homeostasis,and promotes functional recovery after spinal cord injury

引用

Neural Regeneration Research 2024年第11期19卷 2499-2512页

作者： Jiang Cao Xiao Yu Jingcheng liu Jiaju Fu Binyu Wang Chaoqin Wu Sheng zhang Hongtao Chen Zi Wang Yinyang Xu tao Sui jie Chang Xiaojian Cao Department of Orthopedics The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Trauma Surgery Subei People’s Hospital of JiangsuClinical Medical College of Yangzhou UniversityYangzhouJiangsu ProvinceChina Department of Orthopedics Zhongda HospitalSoutheast UniversityNanjingJiangsu ProvinceChina Department of Orthopedic Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina

The inflammatory microenvironment and neurotoxicity can hinder neuronal regeneration and functional recovery after spinal cord ***,a JAK-STAT inhibitor,exhibits effectiveness in autoimmune diseases,arthritis,and managing inflammatory cytokine *** studies have shown the neuroprotective potential of ruxolitinib in neurological trauma,the exact mechanism by which it enhances functional recovery after spinal cord injury,particularly its effect on astrocytes,remains *** address this gap,we established a mouse model of T10 spinal cord contusion and found that ruxolitinib effectively improved hindlimb motor function and reduced the area of spinal cord *** sequencing analysis showed that ruxolitinib alleviated inflammation and immune response after spinal cord injury,restored EAAT2 expression,reduced glutamate levels,and alleviated excitatory ***,ruxolitinib inhibited the phosphorylation of JAK2 and STAT3 in the injured spinal cord and decreased the phosphorylation level of nuclear factor kappa-B and the expression of inflammatory factors interleukin-1β,interleukin-6,and tumor necrosis factor-α.Additionally,in glutamate-induced excitotoxicity astrocytes,ruxolitinib restored EAAT2 expression and increased glutamate uptake by inhibiting the activation of STAT3,thereby reducing glutamate-induced neurotoxicity,calcium influx,oxidative stress,and cell apoptosis,and increasing the complexity of dendritic ***,these results indicate that ruxolitinib restores glutamate homeostasis by rescuing the expression of EAAT2 in astrocytes,reduces neurotoxicity,and effectively alleviates inflammatory and immune responses after spinal cord injury,thereby promoting functional recovery after spinal cord injury.

关键词： astrocytes EAAT2 excitotoxicity glutamate homeostasis JAK-STAT pathway locomotor function neurotoxicity ruxolitinib spinal cord injury transcriptome analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：