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冻融作用下土体无侧限抗压强度变化研究

广东建材 2024年第2期40卷 30-33页

作者：张亚英中国建筑材料工业地质勘查中心甘肃总队

通过设置不同冻融循环温度和循环次数,开展了冻融循环下原状黄土和重塑黄土的无侧限抗压强度试验,研究结果表明:原状黄土在不同冻融温度下,随着提高冻融循环次数,土体无侧限抗压强度均呈现为持续降低趋势,黄土经过冻融循环后,原本土体... 详细信息

通过设置不同冻融循环温度和循环次数,开展了冻融循环下原状黄土和重塑黄土的无侧限抗压强度试验,研究结果表明:原状黄土在不同冻融温度下,随着提高冻融循环次数,土体无侧限抗压强度均呈现为持续降低趋势,黄土经过冻融循环后,原本土体结构受到严重破坏,降低了土体的抗压强度,且随着冻融循环温度的降低,黄土抗压强度的损失程度也越来越大;重塑土的无侧限抗压强度变化趋势和原状黄土大致相同,但重塑黄土0次冻融循环时的无侧限抗压强度与各次冻融循环后的强度差距较小,每次循环后的强度波动范围在2~8kPa内;冻融作用下,黄土渗透系数呈现出先增大后趋于稳定的规律,对其渗透系数影响较大的主要在前4次冻融循环。

关键词：冻融循环原状黄土无侧限抗压强度土体结构

NMR assisted studies on the solution structures and functions of antimicrobial peptides Dedicated to Professor Chaohui Ye on the occasion of his 80th birthday

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Magnetic Resonance Letters 2022年第4期2卷 214-223页

作者： yaying zhang Chunyang Cao College of Chemistry and Materials Science Shanghai Normal University100 Guilin RoadShanghai200234China State Key Laboratory of Bioorganic and Natural Product Chemistry Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryChinese Academy of Sciences345 Lingling RoadShanghai200032China

Microbial resistance has now become a global public health concern,and the spread of multidrug-resistant bacteria also threatens human *** peptides(AMPs)are a class of small peptides with antibacterial,anti-inflammatory,anti-infective,antioxidation,anti-tumor,antiviral functions and immune regulation *** to the small sizes,their structures are easily studied by nuclear magnetic resonance(NMR)*** to traditional antibiotics,AMPs have specific antibacterial mechanisms,and do not easily result in the production of drug-resistant ***,the development of new antimicrobial peptides and their wide use instead of chemical antibiotics are of great significance to human *** this review,we first summarized the relationship between the structures and functions of antimicrobial ***,we focused on examples,cathelicidins,a group of cationic antimicrobial peptides with multiple biological ***,cathelicidin BF30 or BF34,composed of 30 or 34 amino acids,were from the venom glands of the Bungarus fasciatus snake and were considered to be the most active antibacterial peptides among different cathelicidin *** solution structures determined by NMR are a-helixes,which are useful in designing new and stable peptides with similar framework,including stapple peptides by inducing chemical modifications in the sidechains of some residues,as well as cyclic peptides by inducing disulfide bond between cysteines in the sequences.

关键词： Nuclear magnetic resonance Antimicrobial peptides Cathelicidin Structure Function

基于人工智能的影像组学在甲状腺结节临床应用的研究进展

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中国数字医学 2024年第7期19卷 75-80页

作者：张亚莹单广震朱来敏周哲济宁医学院附属医院医学影像科山东济宁272029

对于甲状腺结节,传统影像学诊断通常基于医生肉眼观察影像图像,结果判读受观察者主观影响,且无法识别图像中隐藏的深层信息。影像组学是一种新兴的无创技术,通过高通量的特征提取算法将普通影像图像转变为定量数据特征,从而反映病变潜... 详细信息

对于甲状腺结节,传统影像学诊断通常基于医生肉眼观察影像图像,结果判读受观察者主观影响,且无法识别图像中隐藏的深层信息。影像组学是一种新兴的无创技术,通过高通量的特征提取算法将普通影像图像转变为定量数据特征,从而反映病变潜在的生理及病理学特征。人工智能(AI)的加入,使影像组学成为临床应用研究的热点,在甲状腺结节良恶性鉴别、颈部淋巴结转移预测等方面取得了一定成果,可为甲状腺结节术前决策提供重要信息。该文综述了超声、CT、MRI以及PET/CT多领域影像组学结合AI技术在甲状腺结节临床应用中的研究进展。

关键词：影像组学人工智能甲状腺结节电子计算机断层扫描磁共振成像

1955—2022年上海市杨浦区职业性尘肺病流行病学特征分析

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职业与健康 2024年第11期40卷 1459-1462页

作者：刘友双张亚英刘玉华韩雪上海市杨浦区疾病预防控制中心职业卫生科上海200090

目的分析1955—2022年上海市杨浦区职业性尘肺病的发病特点、尘肺种类等流行病学特征,为职业病防治策略、相关标准及法规的制定提供参考依据。方法收集上海市杨浦区职业病诊断机构报告的所有尘肺病病例和中国疾病预防控制信息系统导出1... 详细信息

目的分析1955—2022年上海市杨浦区职业性尘肺病的发病特点、尘肺种类等流行病学特征,为职业病防治策略、相关标准及法规的制定提供参考依据。方法收集上海市杨浦区职业病诊断机构报告的所有尘肺病病例和中国疾病预防控制信息系统导出1955—2022年诊断的尘肺病患者信息,开展随访与回顾性调查,并对数据进行分析。结果共调查546例尘肺病病例,存活115例,死亡289例,失访142例。诊断的尘肺病病例集中在1970—1989年时间段(360例,占65.93%);以Ⅰ期为主(336例,占61.54%);铸工尘肺占比最高(243例,占44.51%),其次为矽肺(212例,占38.83%);男女性别比为33.125∶1,发病年龄以40~<60岁年龄组病例为主(395例,占72.34%);病例工种以清砂工和型砂工为主(236例,占43.22%)。结论1955—2022年上海市杨浦区职业性尘肺病在所有职业病中占比较多,严重危害人群健康。政府及有关部门要加大对职业性尘肺病的监管和执法力度,加强职业病防治宣传教育工作;用人单位应落实主体责任,加大在职业防护设施设备上的投入力度,加强职业卫生培训及管理工作,切实保护劳动者的健康。

关键词：职业性尘肺病职业病防治流行病学特征

Worm-like micelles facilitate the intestinal mucus diffusion and drug accumulation for enhancing colorectal cancer therapy

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Chinese Chemical Letters 2024年第6期35卷 427-432页

作者： Yihan Zhou Duo Gao yaying Wang Li Liang Qingyu zhang Wenwen Han Jie Wang Chunliu Zhu Xinxin zhang Yong Gan State Key Laboratory of Drug Research and Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China University of Chinese Academy of Sciences Beijing 100049China NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients National Institutes for Food and Drug ControlBeijing 100050China School of Pharmacy Shanghai University of Traditional Chinese MedicineShanghai 201203China

Local delivery of nanoparticles holds promise for colorectal cancer(CRC)***,the presence of the mucus layer on the epithelium poses a significant challenge to drug delivery,thereby adversely affecting treatment *** is crucial to develop efficient drug delivery carriers that can effectively overcome mucus barriers to treat colorectal ***,we utilized poly(1,4-butadiene)-b-poly(ethylene oxide)polymers to prepare four distinct geometries of polymeric micelles,namely linear micelles(LMs),worm-like micelles(WLMs),large spherical micelles(LSMs),and small spherical micelles(SSMs)to investigate the influence of shape effects on overcoming colonic mucosal *** found that the carriers exhibited diverse shapes while maintaining comparable physicochemical *** these,WLMs had an aspect ratio similar to segmented filamentous bacteria,which exhibited superior mucus penetration ability,leading to prolonged drug release kinetics and faster entry into epithelial cells compared to ***,rectally administrated 10-hydroxycamptothecin-loaded WLMs traversed the colorectal mucus in orthotopic CRC nude mice model,penetrated and accumulated within tumor tissue,and effectively aggregated within cancer cells,thereby inducing significantly robust antitumor outcomes in *** findings underscore the significance of shape design in overcoming colonic mucosal absorption barriers,offering a novel approach for the development of drug delivery carriers tailored for effective tumor therapy.

关键词： Worm-like micelles Mucus penetration Shape dependent Transmucosal delivery Colorectal cancer

基于扩散加权成像及MRI对四肢软组织肿瘤的诊断价值

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医学影像学杂志 2024年第4期34卷 103-107,115页

作者：朱来敏张亚莹史志涛孙处然孙占国陈月芹王唯伟济宁医学院附属医院影像科山东济宁272029

目的探讨基于扩散加权成像及MRI对四肢软组织肿瘤(soft tissue tumors,STTs)的诊断价值。方法选取本院经病理证实的四肢STTs患者74例,其中良性46例(良性组)、恶性28例(恶性组),均行常规MRI、DWI、IVIM及DKI扫描,分析两组常规MRI检查... 详细信息

目的探讨基于扩散加权成像及MRI对四肢软组织肿瘤(soft tissue tumors,STTs)的诊断价值。方法选取本院经病理证实的四肢STTs患者74例,其中良性46例(良性组)、恶性28例(恶性组),均行常规MRI、DWI、IVIM及DKI扫描,分析两组常规MRI检查征象及诸参数差异,包括表观扩散系数(ADC)、真实扩散系数(D)、灌注相关扩散系数(D~*)、灌注分数(f)、平均扩散峰度值(MK)和平均扩散率(MD);运用ROC曲线分析其诊断效能。结果恶性组肿瘤边界多不清且呈浸润性生长,以团块状为主,瘤周水肿、筋膜尾征多见,50.0%瘤内可见分隔,两组间差异有统计学意义(P0.05)。ADC、D、MD、MK值在鉴别四肢STTs良恶性方面均具有一定诊断效能:AUC≥0.688,敏感度≥63.0%,特异度≥67.9%,准确度≥64.9%,其中MD值的诊断效能、特异度最高。ADC+D+MD+MK联合后,AUC为0.887,诊断效能均高于单一参数(Z=1.978~3.101;P<0.05),敏感度为76.1%,特异度为92.9%,准确度78.4%。结论基于扩散加权成像及MRI对四肢STTs良恶性有较好的判断价值,值得临床推广。

关键词：软组织肿瘤体素内不相干运动磁共振成像扩散峰度成像

An Efficient Multifunctional Soluble Catalyst for Li-O2 Batteries

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CCS Chemistry 2024年第7期6卷 1810-1820页

作者： Shuochao Xing Zhengcai zhang yaying Dou Minghui Li Jing Wu zhang zhang Zhen Zhou Interdisciplinary Research Center for Sustainable Energy Science and Engineering(IRC4SE2) School of Chemical EngineeringZhengzhou UniversityZhengzhou 450001 Key Laboratory of Advanced Energy Materials Chemistry Ministry of EducationCollege of ChemistryNankai UniversityTianjin 300071

Aprotic lithium-oxygen(Li-O_(2))batteries have a high theoretical energy density,but they face challenges such as cathode blockage,high charge overpotential,and poor cycling *** are caused by sluggish reaction kinetics and severe parasitic *** the performance of Li-O_(2) batteries necessitates the development of efficient *** catalysts not only augment both the oxygen reduction reaction(ORR)and the oxygen evolution reaction(OER)but also inhibit undesirable parasitic *** this work,we demonstrated for the first time a multifunctional soluble catalyst of iridium(III)acetylacetonate(Ir(acac)_(3))that could speed up oxygen ***(acac)_(3) regulated the ORR pathway and the reactivity of superoxide radical species by forming a reversible intermediate complex(Ir(acac)_(3)-O_(2)^(−)).During charging,Ir(acac)_(3) acted as a redox mediator and aided in Li_(2)O_(2) decomposition by reacting with superoxide ***,as demonstrated by operando UV-visible spectroscopy,the lower charge potential significantly reduced the generation of highly reactive singlet oxygen(^(1)O_(2))*** a result,the Ir(acac)_(3)-mediated Li-O_(2) battery showed low overpotential,large capacity,and stable *** study offers a new approach to achieving efficient Li-O_(2) batteries and provides an opportunity to suppress parasitic reactions.

关键词： Li-O2 battery soluble catalyst superoxide species organometallics singlet oxygen

Flexible wearable sensors:An emerging platform for monitoring of bacterial infection in skin wounds

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Engineered Regeneration 2024年第2期5卷 186-198页

作者： Hao Meng Weicheng Zhong Kui Ma Jianlong Su Liqian Ma yaying Hao Yufeng Jiang Xi Liu Xiaobing Fu Cuiping zhang Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department PLA General Hospital and PLA Medical CollegeBeijing 100048PR China PLA Key Laboratory of Tissue Repair and Regenerative Medicine Beijing 100048PR China Beijing Key Research Laboratory of Skin Injury Repair and RegenerationBeijing 100048PR China Research Unit of Trauma Care Tissue Repair and RegenerationChinese Academy of Medical Sciences2019RU051Beijing 100048PR China College of Graduate Tianjin Medical UniversityTianjin300070PR China Department of Tissue Regeneration and Wound Repair PLA General HospitalBeijingPR China

Persistent inflammatory responses often occur when bacteria and other microorganisms frequently invade and colonize open wounds and eventually result in the formation of chronic ***,achieving real-time detection of invasive bacteria accurately and promptly is essential for efficient wound management and accelerat-ing the healing ***,flexible wearable sensors have garnered significant attention,especially those designed for monitoring real-time biophysical or biochemical signals in wound sites in a minimally invasive *** provide more precise and continuous monitoring data,making them as emerging tools for clinical *** this review,we first discuss the species and community distribution of different types of bacteria in chronic ***,we introduce currently developed techniques for detecting bacteria at wound ***-lowing that,we discuss the recent progress and unresolved issues of various flexible wearable sensors in detecting bacteria at wound *** believe that this review can provide meaningful guidance for the development of flexible wearable sensors for bacteria detection.

关键词： Flexible wearable sensors Chronic wounds Bacterial infections Real-time detection

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Case report

功能与分子医学影像学（电子版） 2019年第4期8卷 1768-1770页

作者： zhang yaying 不详

1 History。A 26-year-old female suffered from abdominal discomfort with a pancreatic tail mass for 1 week.2 Image Findings Unenbanced CT revealed a mass measuring 4.7 cm×3.4 cm with mixed density in the pancreas *** mass partly protrudes the outline of *** calcification and cystic necrosis can be *** contrast enhanced images,the tumor shows slight enbancement,and the intensity is lower than normal pancreatic tissue in arterial phase.

关键词： pancreas arterial suffered