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Bayesian network-based survival prediction model for patients having undergone post-transjugular intrahepatic portosystemic shunt for portal hypertension

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World Journal of Gastroenterology 2024年第13期30卷 1859-1870页

作者： Rong Chen Ling Luo Yun-Zhi zhang Zhen Liu An-Lin Liu Yi-Wen zhang Department of Infectious Diseases Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Portal hypertension(PHT),primarily induced by cirrhosis,manifests severe symptoms impacting patient *** transjugular intrahepatic portosystemic shunt(TIPS)is a critical intervention for managing PHT,it carries risks like hepatic encephalopathy,thus affecting patient survival *** our knowledge,existing prognostic models for post-TIPS survival in patients with PHT fail to account for the interplay among and collective impact of various prognostic factors on ***,the development of an innovative modeling approach is essential to address this *** To develop and validate a Bayesian network(BN)-based survival prediction model for patients with cirrhosis-induced PHT having undergone *** The clinical data of 393 patients with cirrhosis-induced PHT who underwent TIPS surgery at the Second Affiliated Hospital of Chongqing Medical University between January 2015 and May 2022 were retrospectively *** were selected using Cox and least absolute shrinkage and selection operator regression methods,and a BN-based model was established and evaluated to predict survival in patients having undergone TIPS surgery for *** Variable selection revealed the following as key factors impacting survival:age,ascites,hypertension,indications for TIPS,postoperative portal vein pressure(post-PVP),aspartate aminotransferase,alkaline phosphatase,total bilirubin,prealbumin,the Child-Pugh grade,and the model for end-stage liver disease(MELD)*** on the above-mentioned variables,a BN-based 2-year survival prognostic prediction model was constructed,which identified the following factors to be directly linked to the survival time:age,ascites,indications for TIPS,concurrent hypertension,post-PVP,the Child-Pugh grade,and the MELD *** Bayesian information criterion was 3589.04,and 10-fold cross-validation indicated an average log-likelihood loss of 5.55 with a standard deviation of *** model’s acc

关键词： Bayesian network Cirrhosis Portal hypertension Transjugular intrahepatic portosystemic shunt Survival prediction model

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High-efficiency and flexible photonic microwave harmonic down-converter based on self-oscillation optical frequency combs

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Chinese Optics Letters 2024年第6期22卷 196-204页

作者： Xin zhang Tao Pu Huatao Zhu Yunshan zhang Gengze Wu Jin Li Jilin Zheng College of Information and Communications National University of Defense TechnologyWuhan 430010China College of Communications Engineering Army Engineering University of PLANanjing 210007China College of Electronic and Optical Engineering&College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023China

Photonic microwave harmonic down-converters (PMHDCs) based on self-oscillation optical frequency combs (OFCs) are interesting because of their broad bandwidth compared with plain optoelectronic oscillators. In this paper, a high-efficiency and flexible PMHDC is proposed and demonstrated. The properties of the OFC, such as the carrier-to-noise ratio (CNR),bandwidth and free spectral range (FSR), and the influence of optical injection, are investigated. The broadband OFC provides a frequency tunable and high-quality local oscillation (LO), which guarantees flexible down-conversion for the radio frequency (RF) signal. The sideband selective amplification (SSA) effect not only improves the conversion efficiency but also promotes single-sideband modulation. The conversion range can reach 100 GHz. The 12–40 GHz RF signal can be downconverted to intermediate frequency (IF) signals with a high conversion efficiency of 14.9 dB. The fixed 40-GHz RF signal is flexibly down-converted to an IF signal with the frequency from 55.4 to 2129.4 MHz. The phase noise of an IF signal at a frequency offset of 10 kHz is the same as that of the input RF signal. The PMHDC shows great performance and will find applications in radio-over-fiber (RoF) networks, electronic warfare receivers, avionics, and wireless communication systems.

关键词： frequency down-conversion optical frequency comb optical injection optoelectronic oscillation

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自然保护区志工旅游产品开发思路探析——以沙坡头为例

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资源开发与市场 2013年第11期29卷 1198-1200页

作者：刘海洋张洵赫长春师范大学历史文化学院吉林长春130032 兰州大学资源环境学院甘肃兰州730000

旅游者的大量进入使自然保护区生态旅游的负效应越来越严重。志工旅游的环保性、公益性符合自然保护区旅游开发的要求,展现出强大的生命力。然而,国内志工旅游发展仍处于初级阶段,还没有形成完整的发展体系,相关的理论研究也相对不足。... 详细信息

旅游者的大量进入使自然保护区生态旅游的负效应越来越严重。志工旅游的环保性、公益性符合自然保护区旅游开发的要求,展现出强大的生命力。然而,国内志工旅游发展仍处于初级阶段,还没有形成完整的发展体系,相关的理论研究也相对不足。因此,有必要针对具体的自然保护区,提出志工旅游产品的设计思路,为志工旅游的全面开展积累必要的经验。在总结志工旅游的特点和利益机制的基础上,分析了自然保护区生态旅游发展现状,提出了自然保护区志工旅游产品创新设计的思路。

关键词：志工旅游自然保护区旅游产品利益机制

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Targeting synaptic pathology in Alzheimer’s disease

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Zoological Research 2024年第4期45卷 875-876页

作者： Jing Cao Yun-Wu zhang Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research Institute of NeuroscienceSchool of MedicineXiamen UniversityXiamenFujian 361102China

Alzheimer’s disease(AD)is a neurodegenerative disorder characterized by memory and cognitive *** two primary pathological hallmarks of AD include the accumulation ofβ-amyloid(Aβ)plaques and formation of neurofibrillary tangles(NFTs)composed predominantly of hyperphosphorylated tau protein(zhang et al.,2023).Moreover,synaptic dysfunction is considered another crucial factor in AD pathogenesis and is closely associated with cognitive ***,synaptic damage,loss,and dysfunction manifest earlier than the pathological features of Aβplaques and NFTs(Knopman et al.,2021).Therefore,understanding the mechanisms underlying synaptic dysfunction in AD is vital for providing insights into disease mechanisms and developing novel therapeutic strategies.

关键词： Alzheimer Aβ tau

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“我今仅守诗书业,汝勿轻捐少壮时”——论陆游的家庭诗教

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阴山学刊 2012年第1期25卷 36-40页

作者：张福勋李素珍包头师范学院文学院内蒙古包头014030

在中华民族的文化传承里,"诗教"始终占据着第一把交椅的位置。这不仅因为我们是一个诗的国度,而且诗在政治、经济、军事、外交等活动中,都是十分重要的工具。无诗,无以立。因此,士大夫家庭都将"诗教"作为家庭教育的首选。陆游即是一个... 详细信息

在中华民族的文化传承里,"诗教"始终占据着第一把交椅的位置。这不仅因为我们是一个诗的国度,而且诗在政治、经济、军事、外交等活动中,都是十分重要的工具。无诗,无以立。因此,士大夫家庭都将"诗教"作为家庭教育的首选。陆游即是一个很典型的例证。

关键词：诗歌家庭教育陆游

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Nano-formulated delivery of active ingredients from traditional Chinese herbal medicines for cancer immunotherapy

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1525-1541页

作者： Qi Shang Wandong Liu Faith Leslie Jiapei Yang Mingmei Guo Mingjiao Sun Guangji zhang Qiang zhang Feihu Wang School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Basic Medical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Key Laboratory of Blood-stasis-toxin Syndrome of Zhejiang Province Hangzhou 310053China Department of Chemical and Biomolecular Engineering Whiting School of Engineeringthe Johns Hopkins UniversityBaltimoreMD 21218USA Traditional Chinese Medicine“Preventing Disease”Wisdom Health Project Research Center of Zhejiang Hangzhou 310053China Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems State Key Laboratory of Natural and Biomimetic DrugsSchool of Pharmaceutical SciencesPeking UniversityBeijing 100191China

Cancer immunotherapy has garnered promise in tumor progression, invasion, and metastasis through establishing durable and memorable immunological activity. However, low response rates, adverse side effects, and high costs compromise the additional benefits for patients treated with current chemical and biological agents. Chinese herbal medicines (CHMs) are a potential treasure trove of natural medicines and are gaining momentum in cancer immunomodulation with multi-component, multi-target, and multi-pathway characteristics. The active ingredient extracted from CHMs benefit generalized patients through modulating immune response mechanisms. Additionally, the introduction of nanotechnology has greatly improved the pharmacological qualities of active ingredients through increasing the hydrophilicity, stability, permeability, and targeting characteristics, further enhancing anti-cancer immunity. In this review, we summarize the mechanism of active ingredients for cancer immunomodulation, highlight nano-formulated deliveries of active ingredients for cancer immunotherapy, and provide insights into the future applications in the emerging field of nano-formulated active ingredients of CHMs.

关键词： Chinese herbal medicines Nano-formulation Activeingredients Drug delivery Cancer immunotherapy Innate immune system Adaptive immune system

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红松多酚与真菌多糖联合清除ABTS自由基活性比较

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北京林业大学学报 2016年第10期38卷 104-111页

作者：张乃珣尹红力赵鑫刘冉于美汇王振宇东北林业大学林学院中国农业科学院农产品加工研究所主食加工技术研究院聊城大学农学院哈尔滨工业大学化工学院食品科学与工程系

本文比较了红松多酚(PKP)与黑木耳多糖(AAP)和灵芝孢子多糖(GLP)单一、联合使用清除ABTS自由基活性的作用。采用Chou-Talaly联合指数方法分析ABTS自由基清除实验结果,并对单一和联合使用的清除效果、联合指数(CI)、等效应图和剂量减少指... 详细信息

本文比较了红松多酚(PKP)与黑木耳多糖(AAP)和灵芝孢子多糖(GLP)单一、联合使用清除ABTS自由基活性的作用。采用Chou-Talaly联合指数方法分析ABTS自由基清除实验结果,并对单一和联合使用的清除效果、联合指数(CI)、等效应图和剂量减少指数(DRI)进行分析评价。结果显示:单独使用红松多酚、黑木耳多糖、灵芝孢子多糖的IC50值分别为72.01μg/m L、2.49 mg/m L、0.93 mg/m L,联合使用红松多酚和黑木耳多糖与红松多酚和灵芝孢子多糖(质量比为1∶3)后,IC50值分别为185.20和237.83μg/m L。联合指数分析表明,从清除率10%到97%,红松多酚和黑木耳多糖的联合指数都小于1;等效应图显示联合使用红松多酚和黑木耳多糖使用剂量降低。剂量减少指数分析显示,从清除率5%到97%,红松多酚和黑木耳多糖的剂量减少指数都大于1,以上结果红松多酚和灵芝孢子多糖均表现不一致。说明红松多酚和黑木耳多糖之间存在协同清除ABTS自由基效应,但红松多酚和灵芝孢子多糖不存在。

关键词：真菌多糖红松多酚联合抗氧化活性

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经上颌骨翻转入路手术切除斜坡脊索瘤

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中华医学杂志 2005年第20期85卷 1379-1381页

作者：郭京张黎张思迅袁越李锐王岩祁永发徐振纲刘少岩卫生部中日友好医院神经外科北京100029 中国医学科学院中国协和医科大学附属肿瘤医院头颈外科

目的探讨采用经上颌骨翻转入路手术切除Al-MeftyⅢ型斜坡脊索瘤的方法及临床意义.方法对10例Al-MeftyⅢ型斜坡脊索瘤患者,采用经上颌骨翻转入路的手术方法切除肿瘤.术后随访10～56个月,平均34个月. 结果 8例患者在显微镜下肿瘤被全部切... 详细信息

目的探讨采用经上颌骨翻转入路手术切除Al-MeftyⅢ型斜坡脊索瘤的方法及临床意义.方法对10例Al-MeftyⅢ型斜坡脊索瘤患者,采用经上颌骨翻转入路的手术方法切除肿瘤.术后随访10～56个月,平均34个月. 结果 8例患者在显微镜下肿瘤被全部切除,2例次全切除(切除90%以上).3例患者分别在术后26、36、40个月带瘤生存,其余7例恢复正常生活.手术并发症包括:创腔感染1例,脑脊液漏1例,咽喉部肿胀致阻塞性通气困难1例,均经保守治疗痊愈. 结论经上颌骨翻转入路手术切除Al-MeftyⅢ型斜坡脊索瘤具有显露充分、肿瘤切除彻底、不损伤脑组织的优点,疗效满意.

关键词：脊索瘤颅底肿瘤神经外科外科手术治疗

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基于NJ1006的GPS接收机射频前端电路设计

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南华大学学报（自然科学版） 2006年第1期20卷 73-76页

作者：唐中文陈世和张迅南华大学电气工程学院湖南衡阳421001

NJ1006是一个高集成度的单片GPS接收机射频前端集成电路,本文介绍了该芯片的作用、基本参数和它应用于GPS接收机射频前端的电路.

关键词： GPS接收机 NJ1006芯片

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Understanding and unveiling the electro-chemo-mechanical behavior in solid-state batteries

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SusMat 2024年第2期4卷 75-88页

作者： Yunlei Zhong Xia zhang Yong zhang Peng Jia Yuebin Xi Lixing Kang Zhenjiang Yu Key Laboratory of Multifunctional Nanomaterials and Smart Systems Division of Advanced MaterialsSuzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhouChina Institute of Applied Materials Helmholtz Centre Berlin for Materials and EnergyBerlinGermany School of Electronic and Information Engineering Changshu Institute of TechnologyChangshuJiangsuChina State Key Laboratory of Biobased Material and Green Papermaking Qilu University of TechnologyJinanShandongChina

Solid-state batteries(SSBs)are attracting growing interest as long-lasting,thermally resilient,and high-safe energy storage *** an emerging area of battery chemistry,there are many issues with SSBs,including strongly reductive lithium anodes,oxidized cathodes(state of charge),the thermodynamic stability limits of solid-state electrolytes(SSEs),and the ubiquitous and critical *** this Review,we provided an overview of the main obstacles in the development of SSBs,such as the lithium anode|SSEs interface,the cathode|SSEs interface,lithium-ion transport in the SSEs,and the root origin of lithium intrusions,as well as the safety issues caused by the *** and overcoming these obstacles are crucial but also extremely challenging as the localized and buried nature of the intimate contact between electrode and SSEs makes direct detection *** reviewed advanced characterization techniques and discussed the complex ion/electron-transport mechanism that have been plaguing ***,we focused on studying and revealing the coupled electro-chemo-mechanical behavior occurring in the lithium anode,cathode,SSEs,and beyond.

关键词： advanced characterization techniques chemo-mechanical effects interface

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