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Journal of Energy Chemistry 2023年第12期87卷 105-113,I0004页

作者： Yan Deng Shuai Feng Zhiwen Deng Ye Jia xuemei zhang Changhaoyue Xu Sicheng Miao Meng Yao Kaipeng Wu Yun zhang Wenlong Cai College of Materials Science and Engineering Sichuan UniversityChengdu 610064SichuanChina College of Chemistry and Chemical Engineering Taishan UniversityTaian 271000ShandongChina Engineering Research Center of Alternative Energy Materials and Devices Sichuan UniversityChengdu 610064SichuanChina

Commercial carbonate-based electrolytes feature highly reactive activities with alkali metals,yielding low Coulombic efficiencies and poor cycle life in lithium metal batteries,which possess much higher chemical activity in the rising star sodium metal *** be motivated,we have proposed that decreasing the solvent solvation ability in carbonate-based electrolytes stepwise could enable longterm stable cycling of high-voltage sodium metal *** the solvation capacity reduces,more anions are enticed into the solvation sheath of Na^(+),resulting in the formation of the more desirable interphase layers on the surface of the anode and the *** inorganic-dominated interphases allow highly efficient Na^(+)deposition/stripping processes with a lower rate of dead sodium generation,as well as maintain a stable structure of the high-voltage cathode ***,the assembled Na||Na_(3)V_(2)(PO_(4))_(2)F_(3)battery exhibits an accelerated ion diffusion kinetics and achieves a higher capacity retention of 85.9%with during the consecutive 200 cycles under the high voltage of 4.5 *** is anticipated that the tactics we have proposed could be applicable in other secondary metal battery systems as well.

关键词： Electrolyte Solvation structure Interfacial chemistry Sodium metal anode High-voltage

Three novel rare TP53 fusion mutations in a patient with multiple primary cancers:a case report

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Oncology and Translational Medicine 2024年第1期10卷 47-51页

作者： Mengyao Lu xuemei zhang Qian Chu Yuan Chen Peng zhang Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

As survival rates improve and detection technologies advance,the occurrence of multiple primary cancers(MPCs)has been *** 16%of cancer survivors develop a subsequent malignancy,with lung cancer often developing after esophageal cancer due to potential“field cancerization”*** this observation,the genetic heterogeneity underlying MPCs remains ***,the recent emergence of genetic testing has expanded the scope of investigations into MPCs to investigate signatures underlying cancer *** report reveals 3 unprecedented TP53 fusion mutations in a Chinese patient afflicted by MPCs,namely,AP1M2–TP53(A1;T11)fusion,TP53–ILF3(T10;I13)fusion,and SLC44A2–TP53(S5;T11)*** patient exhibited an extended period of survival after diagnosis of extensive-stage small cell lung cancer,which occurred 6 years after the diagnosis of esophageal squamous cell *** unique reportmay provide supplementary data that enhance our understanding of the genetic landscape ofMPCs.

关键词： Multiple primary cancers TP53 fusion mutation Esophageal squamous cell cancer Extensive-stage small cell lung cancer Immunotherapy Antiangiogenic therapy

An aerosol formulation of R-salbutamol sulfate for pulmonary inhalation

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Acta Pharmaceutica Sinica B 2014年第1期4卷 79-85页

作者： xuemei zhang Qing Liu Junhua Hu Ling Xu Wen Tan School of Bioscience and Bioengineering South China University of TechnologyGuangzhou 510006China Key-Pharma Biomedical Inc. Dongguan 523000China

An aerosol formulation containing 7.5 mg of R-salbutamol sulfate was *** aerosol was nebulized with an air-jet nebulizer,and further assessed according to the new European Medicines Agency(EMA)guidelines.A breath simulator was used for studies of delivery rate and total amount of the active ingredient at volume of 3 mL.A next generation impactor(NGI)with a cooler was used for analysis of the particle size and in vitro lung deposition rate of the active ingredient at *** anti-asthmatic efficacy of the aerosol formulation was assessed in guinea pigs with asthma evoked by intravenous injection of histamine compared with racemic *** results show that this aerosol formulation of R-salbutamol sulfate met all the requirements of the new EMA guidelines for *** efficacy of a half-dose of R-salbutamol equaled that of a normal dose of racemic salbutamol.

关键词： R-salbutamol Nebulizer NGI Particle size Dose uniformity Guinea pigs Asthma

A multi-parameter data acquisition system for the collision research platform at Shanghai EBIT

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Nuclear Science and Techniques 2009年第1期20卷 51-55页

作者： WANG Xincheng WEI Baoren YANG Yang SHEN Yang XIAO Jun zhang xuemei ZOU Yarning Shanghai EBITLab Institute of Modern Physics Fudan University Shanghai 200433 China The Key Lab of Applied Ion Beam Physics Ministry of Education Shanghai 200433 China

In this work we describe a multi-parameter data acquisition system(DAQ)which has been developed for the Shanghai *** system is operated at the collision research platform which includes a recoil-ion momentum spectrometer(RIMS).We have employed DAQ based on the VME system,which is a very fast developing system within the RIMS community,and with which we can reach data transfer rates of up to 160 Mb·s- *** software developed for DAQ based on UnisDX-XP is also described.

关键词： VME TDC ADC 数据采集系统

Leaf phenotypic variation of endangered plant Tetracentron sinense *** influence of geographical and climatic factors

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Journal of Forestry Research 2021年第2期32卷 623-636页

作者： Yang Li Shan Li Xueheng Lu Qinqin Wang Hongyan Han xuemei zhang Yonghong Ma Xiaohong Gan Key Laboratory of Southwest China Wildlife Resources Conservation(Ministry of Education) College of Life ScienceChina West Normal UniversityNanchong 637009China Institute of Plant Adaptation and Utilization in Southwest Mountain China West Normal UniversityNanchong 637009China

To analyze the degree and pattern of phenotypic variation in leaves of Tetracentron sinense Oliv from the perspective of genetic and environmental adaptation and thus contribute to effective evidence-based conservation and management strategies for germplasm resources,we measured 17 morphological and epidermal micromorphological leaf traits from 24 natural populations of *** analysis of variance,multiple comparison,principal component analysis(PCA),cluster analysis,and correlation analysis were used to explore phenotypic leaf variation among and within populations and potential correlations with geographic and environmental *** were significant differences in 17 leaf phenotypic traits among and within *** mean phenotypic differentiation coefficient of the 17 traits was 56.34%,and the variation among populations(36.4%)was greater than that within populations(27.2%).The coefficient of variation(CV)of each trait ranged from 4.6 to 23.8%,and the mean was 11.8%.Phenotypic variation of leaves was related to environmental factors such as average annual sunshine hours,average July temperature,and average annual *** variation changed along gradients of longitude,latitude,and *** PCA clustered the 24 natural populations into four *** study suggests that phenotypic variation in *** occurred primarily among populations,with moderate levels of phenotypic differentiation among populations and low levels of phenotypic variation within *** plant’s poor adaptability to the environment is likely an important contributor to its ***,conservation strategies are proposed to protect and manage the natural populations of ***.

关键词： Tetracentron sinense Leaf phenotypic traits Phenotypic variation Natural population Endangered plant

Coordination structure regulation in non-flammable electrolyte enabling high voltage lithium electrochemistry

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Journal of Energy Chemistry 2024年第9期96卷 282-290页

作者： Zhiwen Deng Ye Jia Yan Deng Changhaoyue Xu xuemei zhang Qiujie He Jianan Peng Hao Wu Wenlong Cai College of Materials Science and Engineering Sichuan UniversityChengdu 610064SichuanChina Engineering Research Center of Alternative Energy Materials and Devices Sichuan UniversityChengdu 610064SichuanChina

High-voltage battery systems bring significant increases in energy density but are also accompanied by fast degradation of electrochemical performance and serious safety ***,Li^(+)coordination structure regulation was conducted to formulate a non-flammable electrolyte,which consists of 1.5 M lithium bis(fluor sulfonyl)imide(LiFSI)in triethyl phosphate and methyl 2,2,2-trifluoromethyl carbonate(FEMC).The renamed TEP-FEMC-FEC(TFF)electrolyte exhibits an FSI^(−)-dominated solvation structure contributed by the weakly-solvating ability of *** generated inorganic-rich interfacial layers are conducive to stabilizing the phase transition of high-voltage cathodes while suppressing the dendritic growth on lithium metal or co-intercalation behavior in graphite *** TFF electrolyte enables LiCoO_(2)||Li batteries to achieve capacity maintenance over 79%after 400 cycles with high-rate of 5 C at an ultra-high voltage of 4.6 V,and an outstanding capacity exceeding 100 mA h g^(−1)even at a super-high current density of 20 ***,the Ah-level LiCoO_(2)||graphite pouch cells also exhibit high capacity retention and satisfactory safety performance even under fast *** work provides a novel research direction for the pursuit of high energy density non-flammable electrolytes.

关键词： Non-flammable Solvation structure High-voltage Lithium batteries

The diversity effect of inductive reasoning under segment manipulation of complex cognition

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Science China(Life Sciences) 2005年第6期48卷 658-668页

作者： CHEN Antao LI Hong FENG Tingyong GAO xuemei zhang Zhongming LI Fuhong YANG Dong School of Psychology Southwest University Key Laboratory of Basic Psychology of Chongqing City Chongqing 400715 China School of Psychology Southwest University Key Laboratory of Basic Psychology of Chongqing City Chongqing 400715 China School of Psychology Southwest University Key Laboratory of Basic Psychology of Chongqing City Chongqing 400715 China School of Psychology Southwest University Key Laboratory of Basic Psychology of Chongqing City Chongqing 400715 China School of Psychology Southwest University Key Laboratory of Basic Psychology of Chongqing City Chongqing 400715 China School of Psychology Southwest University Key Laboratory of Basic Psychology of Chongqing City Chongqing 400715 China School of Psychology Southwest University Key Laboratory of Basic Psychology of Chongqing City Chongqing 400715 China

The present study proposed the idea of segment manipulation of complex cognition (SMCC), and technically made it possible the quantitative treatment and systematical manipula-tion on the premise diversity. The segment manipulation of complex cognition divides the previ-ous inductive strengths judgment task into three distinct steps, attempting to particularly distin-guish the psychological processes and their rules. The results in Experiment 1 showed that compared with the traditional method, the quantitative treatment and systematical manipulation of SMCC on the diversity did not change the task’s nature, and remain rational and a good measurement of inductive strength judgment. The results in Experiment 2 showed that the par-ticipants’ response rules in the triple-step task were expected from our proposal, and that in Step 2 the “feeling of surprise” (FOS), which seems implausible but predicted from the diversity premises, was measured, and its component might be the critical part that produced the diversity effect. The “feeling of surprise” may reflect the impact of emotion on cognition, representing a strong revision to premise probability principle of pure rational hypothesis proposed by Lo et al., and its roles in the diversity effect are worthy of further research. In this regards were discussed the mistakes that the premise probability principle makes when it takes posterity probability as prior probability.

关键词： inductive reasoning, segment manipulation of complex cognition (SMCC), diversity effect, feeling of surprise (FOS), Bayes theorem.

The dysregulated autophagy signaling is partially responsible fordefective podocyte development in wt1a mutant zebrafish

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Aquaculture and Fisheries 2018年第3期3卷 99-105页

作者： xuemei zhang Qiaohong Lin Fan Ren Jin zhang Farman Ullah Dawar Jie Mei Key Laboratory of Freshwater Animal Breeding Ministry of AgricultureCollege of FisheriesHuazhong Agricultural UniversityWuhan 430070China

Podocytes are essential elements of the glomerular filtration barrier and relevant to many kidney *** the molecular mechanism in podocyte development is still *** tumor protein(WT1)is an essential factor for urogenital system *** have two wt1 genes,naming wt1a and ***,we examined the roles of both wt1 genes in zebrafish embryonic development employing the CRISPR/Cas9 *** homozygous wt1a mutants displayed developmental malformations including pericardial edema,yolk sac edema and failure of glomerulus *** of wt1a function disrupted podocyte differentiation and inhibited expression of podocin and *** contrast,the homozygous wt1b mutants were phenotypically normal and had no severe phenotypes of nephrogenesis defects that were observed in wt1b morpholino knockdown ***,wt1a plays an essential role in kidney development,whereas wt1b might not be essential for kidney ***,from previous studies we knew that autophagy is involved in podocyte *** detecting the protein level of P62 and LC3A/B,we found the autophagy signal was greatly reduced in wt1a *** better understand the relationship between autophagy signal and wt1a function in podocyte development,rapamycin was added to activate autophagy in wt1a-mutated *** a result,podocyte injury was ameliorated in wt1a homozygous mutants by rapamycin *** conclusion,our findings not only confirmed the essential function of wt1a during kidney development,but also provided a possible way for treatment of diseases involving podocyte injury.

关键词： CRISPR/Cas9 development. inhibited

枇杷清痤方联合红蓝光交替照射治疗寻常型痤疮临床观察

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中国中医药现代远程教育 2025年第2期23卷 138-141页

作者：张雪美山东省单县中医医院药剂科山东单县274300

目的探讨枇杷清痤方联合红蓝光交替照射治疗寻常型痤疮的效果及对皮肤屏障功能的影响。方法选取2021年1月—2023年1月山东省单县中医医院收治的寻常型痤疮患者82例,分为观察组与对照组,各41例。对照组予红蓝光交替照射,观察组在对照组... 详细信息

目的探讨枇杷清痤方联合红蓝光交替照射治疗寻常型痤疮的效果及对皮肤屏障功能的影响。方法选取2021年1月—2023年1月山东省单县中医医院收治的寻常型痤疮患者82例,分为观察组与对照组,各41例。对照组予红蓝光交替照射,观察组在对照组基础上联合枇杷清痤方治疗,均持续治疗4周。观察两组患者临床疗效及治疗前后中医证候积分、皮肤屏障功能、皮肤油脂分泌程度变化。结果观察组患者治疗总有效率为92.68%(38/41),高于对照组的75.61%(31/41)(P<0.05)。治疗后,两组各中医证候积分均低于治疗前,且观察组均低于对照组(P<0.05);两组的皮肤经皮水丢量、pH值及皮肤油脂量亦均低于治疗前、角质层含水量高于治疗前,且观察组各指标改善情况均优于对照组(P<0.05)。结论枇杷清痤方联合红蓝光交替照射治疗寻常型痤疮,可加快患者皮肤屏障功能修护,提高临床效果。

关键词：肺风粉刺寻常型痤疮枇杷清痤方红蓝光交替照射疗法中西医结合疗法

A cellular response protein induced during HSV-1 infection inhibits viral replication by interacting with ATF5

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Science China(Life Sciences) 2013年第12期56卷 1124-1133页

作者： WU LianQiu zhang xuemei CHE YanChun zhang Ying TANG SongQing LIAO Yun NA RuiXiong XIONG XiangLin LIU LongDing LI QiHan Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Diseases Institute of Medical BiologyChinese Academy of Medical Sciences & Peking Union Medical College Kunming Medical University

Studies of herpes simplex virus type 1 （HSV-1） infection have shown that many known and unknown cellular molecules in- volved in viral proliferation are up-regulated following HSV-1 infection. In this study, using two-dimensional polyacrylamide gel electrophoresis, we found that the expression of the HSV-1 infection response repressive protein （HIRRP, GI 16552881） was up-regulated in human L02 cells infected with HSV-1. HIRRP, an unknown protein, was initially localized in the cytoplasm and then translocated into the nucleus of HSV-l-infected cells. Further analysis showed that HIRRP represses HSV-1 proliferation by inhibiting transcription of the viral genome by interacting with the cellular transcription factor, ATFS, via its N-terminal domain. ATF5 represses the transcription of many host genes but can also act as an activator of genes containing a specific motif. We found that ATF5 promotes the proliferation of HSV-1 via a potential mechanism by which ATF5 enhances the transcription of viral genes during the course of an HSV-1 infection; HIRRP then induces feedback repression of this tran- scription by interacting with ATFS.

关键词： herpes simplex virus type 1 (HSV-1) HSV-1 infection response repressive protein (HIRPP) ATF5 transcriptional regulation