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Silver nanowire ring resonator

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Chinese Science Bulletin 2010年第24期55卷 2649-2651页

作者： GUO xin zhang xining tong LiMin State Key Laboratory of Modern Optical Instrumentation Department of Optical Engineering Zhejiang University Hangzhou 310027 China

We demonstrate a silver nanowire ring resonator with a ring diameter of 10.2μ*** ring cavity is formed by coupling both ends of a 145-nm-diameter single silver nanowire into a closed loop.A Q-factor of 160 and a free spectral range of 10.6 nm are obtained for light centered around 800 *** self-coupled ring structure offers opportunities for realizing compact plasmonic resonators with tight confinement for hybrid optical and plasmonic signal processing.

关键词：银纳米线环形谐振腔自由光谱范围混合信号处理封闭循环共振器耦合腔环结构

鸟氨酸拟肽类外排泵抑制剂合成及增效抗生素对抗铜绿假单胞菌活性研究

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药学学报 2024年第6期59卷 1720-1729页

作者：朱喜马西灿张昕彤刘忆霜何宁解云英宋丹青中国医学科学院、北京协和医学院医药生物技术研究所北京100050

为解决铜绿假单胞菌(***)对多类抗生素耐药难题,寻找***外排泵抑制剂是一条有效途径。本研究以二肽类外排泵抑制剂PAβN为先导物,通过改变天然氨基酸侧链结构,设计合成15个全新的鸟氨酸拟肽类衍生物,评价了其协同单环β-内酰胺类抗生素... 详细信息

为解决铜绿假单胞菌(***)对多类抗生素耐药难题,寻找***外排泵抑制剂是一条有效途径。本研究以二肽类外排泵抑制剂PAβN为先导物,通过改变天然氨基酸侧链结构,设计合成15个全新的鸟氨酸拟肽类衍生物,评价了其协同单环β-内酰胺类抗生素氨曲南对抗***活性。其中,化合物12b不仅可增强β-内酰胺类抗生素,包括氨曲南、头孢他啶、美罗培南的抗菌活性,还可显著增强大环内酯类抗生素克拉霉素的抗菌作用,显示出广谱的协同增敏作用。此外,化合物12b还具有良好的安全性。初步机制显示,12b直接靶向外排转运体MexB发挥作用。研究结果为发展一类新型的对抗MDR ***的外排泵抑制剂提供了新先导化合物。

关键词：外排泵抑制剂合成铜绿假单胞菌协同活性 MexAB-OprM

UV-Vis and Surface Photovoltage Spectra of Fe_2O_3/Polystyrene Composite Microspheres

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Chemical Research in Chinese Universities 2002年第1期18卷 75-78页

作者： QIAN xin-ming zhang xin-tong SHAO Hui-bo BAI Yu-bai LI Tie-jin TANG xin-yi DONG Shao-jun Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022P.R.China Department of Chemistry Jilin UniversityChangchun 130023P.R.China Department of Chemistry Capital Normal UniversityBeijing 100037P.R.China

Fe_2O_3 sol with the particle diameter of 3-5 nm was flocculated by the addition of SDS, and the flocculate formed was redispersed by the further addition of that surfactant. Thus the surfactant bilayer was formed on the surface of Fe_2O_3. The emulsion polymerization of styrene(St) adsolubilized on the surfactant adsorbed bilayer was carried out by initiator potassium persulfate(KPS). The UV-Vis and surface photovoltage spectra(SPS) indicate that the Fe_2O_3 particles were encapsulated in polystyrene(PSt) successfully.

关键词： Fe2O3 nanoparticles Encapsulation Composite microspheres

Surface iodine and pyrenyl-graphdiyne co-modified Bi catalysts for highly efficient CO_(2) electroreduction in acidic electrolyte

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Nano Research 2024年第4期17卷 2381-2387页

作者： Min zhang Juan Wang xin Rong Xiu-Li Lu tong-Bu Lu MOE International Joint Laboratory of Materials Microstructure Institute for New Energy Materials and Low Carbon TechnologiesSchool of Materials Science and EngineeringTianjin University of TechnologyTianjin 300384China

CO_(2) electroreduction to formic acid/formate would contribute to alleviating the energy and climate *** work reports a Bi-based catalyst derived from the in-situ electroreduction of Bi_(2)O_(2)CO_(3) modified with iodine and pyrenyl-graphdiyne(PGDY)on the surface for efficient electroreduction of CO_(2) in acidic electrolyte,with a high partial current density of 98.71 mA·cm^(-2) and high Faradaic efficiency(FE)>90%over the potential range from^(-1).2 to-1.5 V *** hydrogen electrode(RHE),as well as the long-term operational stability over 240 h without degradation in H-type *** results and density function theory calculations show that the synergistic effect of surface iodine and PGDY is responsible for this active and extremely stable process of CO_(2) electroreduction via lowering the energy barriers for formation of*OCHO intermediate,suppressing the competitive HER by enhancing the concentration of both K+and CO_(2) at reaction interface,as well as preventing the dissolution and re-deposition of active Bi atoms on surface during catalytic *** work provides new insight into designing highly active and stable electrocatalysts for CO_(2) reduction.

关键词： CO_(2) reduction electrocatalysis Bi-based catalysts acidic electrolyte

Therapeutic strategies of targeting nonapoptotic regulated cell death (RCD) with smallmolecule compounds in cancer

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2815-2853页

作者： xin Jin Wenke Jin Linlin tong Jia Zhao Lan zhang Na Lin Department of Ultrasound Department of Medical Oncology and Department of Hematologythe First Hospital of China Medical UniversityChina Medical UniversityShenyang 110001China Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs School of Life Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China

Regulated cell death(RCD)is a controlled form of cell death orchestrated by one or more cascading signaling pathways,making it amenable to pharmacological *** subroutines can be categorized as apoptotic or non-apoptotic and play essential roles in maintaining homeostasis,facilitating development,and modulating *** evidence has recently revealed that RCD evasion is frequently the primary cause of tumor *** non-apoptotic RCD subroutines have garnered attention as promising cancer therapies due to their ability to induce tumor regression and prevent relapse,comparable to ***,they offer potential solutions for overcoming the acquired resistance of tumors toward apoptotic *** an increasing understanding of the underlying mechanisms governing these non-apoptotic RCD subroutines,a growing number of small-molecule compounds targeting single or multiple pathways have been discovered,providing novel strategies for current cancer *** this review,we comprehensively summarized the current regulatory mechanisms of the emerging non-apoptotic RCD subroutines,mainly including autophagy-dependent cell death,ferroptosis,cuproptosis,disulfidptosis,necroptosis,pyroptosis,alkaliptosis,oxeiptosis,parthanatos,mitochondrial permeability transition(MPT)-driven necrosis,entotic cell death,NETotic cell death,lysosome-dependent cell death,and immunogenic cell death(ICD).Furthermore,we focused on discussing the pharmacological regulatory mechanisms of related small-molecule *** brief,these insightful findings may provide valuable guidance for investigating individual or collaborative targeting approaches towards different RCD subroutines,ultimately driving the discovery of novel small-molecule compounds that target RCD and significantly enhance future cancer therapeutics.

关键词： Regulated cell death(RCD) Non-apoptotic RCD subroutine Autophagy Ferroptosis Necroptosis Regulatory mechanism Small-molecule compound Cancer therapy

C-V Characterization of α-Fe_2O_3/Block-Copolymer Composite Particulate Films

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Chemical Research in Chinese Universities 2000年第1期16卷 57-60页

作者： QIAN xin-ming AI xin TANG Jun WANG Da-yang zhang xin-tong SONG Qing BAI Yu-bai LI Tie-jin and TANG xin-yi (Department of Chemistry, Jilin University, Changchun 130023, P. R. China) 吉林大学吉林长春 130023

α-Fe_2O_3 nanocrystal was encapsulated by a block-copolymer, hydroxylated poly (styrene-b- butadiene-styrene) (HO-SBS) to fabricate composite microspheres with α-Fe_2O_3 cores and HOSBS shell. Its film fabricated on n-Si wafer acts as the insulator layer in the metal-insulator- semiconductor(MIS) structure. The capacitance-voltage (C-V) properties were measured to characterize the composite particulate films.

关键词： α-Fe_2O_3 nanocrystal/block-copolymer composite Metal-insulator-semiconductor structure Capacitance-voltage

From Early States to Modem States in China： The Changing Concept and Connotation of ＂State＂

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Journal of Literature and Art Studies 2017年第8期7卷 1062-1070页

作者： NI Hao zhang tong-xin Shanghai University Shanghai China

The substantive characteristics of the connotation of ＂State＂ include two parts：（I） the relatively perpetual and impersonalized political system; （II） the ductility of organization forms within the space and politics. And the later part is the absolute attribute of this connotation while the former part tends to show with different forms. Therefore, it is more suitable for the former one to be the objective for study on the evolution process of the connotation of ＂State＂ at different stages. Based on this understanding, the author discusses the specific political system at different stages and the relatively perpetual and impersonalized methods for the realization of the system, then tries to define the connotation of the early state, ancient state and modem state in Chinese history.

关键词： state concept connotation China

Spatial transcriptomics reveals that metabolic characteristics define the tumor immunosuppression microenvironment via iCAF transformation in oral squamous cell carcinoma

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International Journal of Oral Science 2024年第1期16卷 110-121页

作者： Zheqi Liu Zhen zhang Yu zhang Wenkai Zhou Xu zhang Canbang Peng tong Ji xin Zou Zhiyuan zhang Zhenhu Ren Department of Oral and Maxillofacial-Head and Neck Oncology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of Stomatology&Shanghai Research Institute of StomatologyShanghaiChina Department of Oral and Maxillofacial Surgery Zhongshan HospitalFudan UniversityShanghaiChina School and Hospital of Stomatology Kunming Medical UniversityKunmingChina Center for Tumor Diagnosis&Therapy Jinshan HospitalFudan UniversityShanghaiChina Department of Pathology Jinshan HospitalFudan UniversityShanghaiChina Hainan Western Central Hospital Academician Zhang Zhiyuan Team Innovation CenterDanzhouChina

Tumor progression is closely related to tumor tissue metabolism and reshaping of the microenvironment. Oral squamous cell carcinoma (OSCC), a representative hypoxic tumor, has a heterogeneous internal metabolic environment. To clarify the relationship between different metabolic regions and the tumor immune microenvironment (TME) in OSCC, Single cell (SC) and spatial transcriptomics (ST) sequencing of OSCC tissues were performed. The proportion of TME in the ST data was obtained through SPOTlight deconvolution using SC and GSE103322 data. The metabolic activity of each spot was calculated using scMetabolism,and k-means clustering was used to classify all spots into hyper-, normal-, or hypometabolic regions. CD4T cell infiltration and TGF-βexpression is higher in the hypermetabolic regions than in the others. Through CellPhoneDB and NicheNet cell-cell communication analysis, it was found that in the hypermetabolic region, fibroblasts can utilize the lactate produced by glycolysis of epithelial cells to transform into inflammatory cancer-associated fibroblasts (iCAFs), and the increased expression of HIF1A in iCAFs promotes the transcriptional expression of CXCL12. The secretion of CXCL12 recruits regulatory T cells (Tregs), leading to Treg infiltration and increased TGF-β secretion in the microenvironment and promotes the formation of a tumor immunosuppressive microenvironment. This study delineates the coordinate work axis of epithelial cells-iCAFs-Tregs in OSCC using SC, ST and TCGA bulk data, and highlights potential targets for therapy.

关键词： CXCL12 microenvironment squamous

Two-dimensional conjugated coordination polymer monolayer as anode material for lithium-ion batteries:A DFT study

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Chinese Chemical Letters 2024年第6期35卷 180-184页

作者： xin-tong Zhao Jin-Zhi Guo Wen-Liang Li Jing-Ping zhang xing-Long Wu MOE Key Laboratory for UV Light-Emitting Materials and Technology Northeast Normal UniversityChangchun 130024China Faculty of Chemistry Northeast Normal UniversityChangchun 130024China Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province Gannan Normal UniversityGanzhou 341000China

Nowadays,lithium-ion batteries(LIBs)play a crucial role in modern society in the aspect of portable electronic devices and large-scale smart ***,the current performance of lithium-ion batteries has been unable to meet the growing expectations of society and scientific ***,we have synthetically investigated availability of 2D Ni-TABQ monolayer as anode based on DFT for LIBs *** findings have demonstrated that 2D Ni-TABQ monolayer is a semiconductor with a small band gap of 0.2 eV,which suggest that the electronic property of 2D Ni-TABQ monolayer would take place an evident shift from semiconductor property to metallic property after Li ***,we checked the stability of 2D Ni-TABQ monolayer and investigated the viability of exfoliation from bulk multilayer Ni-TABQ to form 2D Ni-TABQ monolayer in the light of exfoliation energy and binding *** continuously studied electrochemical properties of 2D Ni-TABQ monolayer with respect of theoretical specific capacity,Li-ion diffusion barriers and open-circuit *** the charging process,2D Ni-TABQ monolayer can achieve a high specific capacity of 722 m Ah/g with an open-circuit voltage range from 1.12 V to 0.22 *** aforementioned results make the 2D Ni-TABQ monolayer a promising anode for LIBs.

关键词： The first principles Density functional theory Lithium-ion battery Anode material Two-dimensional material